Anaemia in reproductive-aged women is a worldwide health problem. This study was aimed to assess prevalence and determinants of anaemia among reproductive-aged women in Ethiopia. Data for the study were obtained from 2016 Ethiopian demographic and health survey data, which is a national representative cross-sectional data. A Multivariable logistic regression model was applied to identify determinants of anaemia among reproductive-aged women. A total of 14460 women who aged 15 to 49 years were included in the study. Prevalence of anaemia of among reproductive-aged women was 27.08% (95% CI: 22.88, 31.08%). Women living in Afar (AOR=2.439; 95% CI: 2.006, 2.968), Amhara (AOR=1.269; 95% CI: 1.035, 1.556), Somalia (AOR=2.592; 95% CI: 2.142, 3.133), Benshangul-Gumuz (AOR=2.019; 95% CI: 1.666, 2.447), Gambela (AOR=2.465; 95% CI: 2.026, 2.998) were associated with high risk of anaemia. Women with 1 or 2 children (AOR=1.272; 95% CI: 1.103, 1.466), 3 or 4 children (AOR=1.277; 95% CI: 1.059, 1.539) and 5 or more (AOR=1.420; 95% CI: 1.213, 1.662) were associated with high risk of anaemia. Further, pregnant women (AOR=1.408; 95% CI: 1.263, 1.570) were associated with high risk of anaemia. Hence, concerned bodies need to pay special attention to women regarding anaemia based on place of residence and the region.