scholarly journals Safety Evaluation of Individual Pillboxes to Control Cross-Contamination in the Drug Circuit in Hospitals

2019 ◽  
Vol 16 (20) ◽  
pp. 3878
Author(s):  
Dussart Claude ◽  
Boulliat Caroline ◽  
Camal Isabelle ◽  
Bourgeois Denis ◽  
Carrouel Florence
Keyword(s):  
Potential Role ◽  
Safety Evaluation ◽  
Contamination Rate ◽  
Cross Contamination ◽  
Medical Treatments ◽  
Bacterial Contaminants ◽  
Colony Forming Units ◽  
Resistant Strains ◽  
The Military

This study aims to evaluate the potential role of pillboxes used for the preparation and delivery of individual daily medical treatments in the drug circuit of the Military Instruction Hospital (France) as reservoirs of bacterial contaminants. Samples were obtained from 32 pillboxes after decontamination (T1), after preparation in the pharmacy (T2), after use in two different medical units (T3), and again after usual mechanical washing (T4). Qualitative (identification and antibiotic susceptibility) and quantitative (contamination rate and number of colony forming units—CFUs) bacteriological tests were performed. Susceptible and resistant strains of environmental saprophytes were identified. The pillbox contamination rate was relatively low at T1 (13%). It was significantly increased at T2 (63%, p = 0.001 vs. T1), again at T3 (88%, p < 0.05 vs. T2, p < 0.001 vs. T1), and finally decreased dramatically at T4 (31%, p < 0.001 vs. T3, p > 0.05 vs. T1). The number of CFUs was significantly increased at T2 compared with that of T1 (36.7 ± 13.4 and 5.36 ± 3.64, respectively, p < 0.001) and again at T3 (84.4 ± 19.4, p < 0.001 vs. T1 and T2) and was significantly reduced at T4 (7.0 ± 2.0 vs. T3, p < 0.001) to a level that was not significantly different from that at T1. So, the use of pillboxes to deliver individual medications to patients in the hospital is a potential risk factor for bacterial cross-contamination.

Potential Role of Darvyadi Kwatha in the Management of Diabetes

The Healer ◽  
2021 ◽  
Vol 2 (1) ◽  
pp. 80-86
Author(s):  
Shankar Gautam ◽  
Abhishek Upadhyay ◽  
Rashmi Mutha ◽  
BINOD KUMAR SINGH ◽  
Ram Kishor Joshi
Keyword(s):  
Causes Of Death ◽  
Potential Role ◽  
Critical Role ◽  
Animal Experiments ◽  
Safety Evaluation ◽  
New Drugs ◽  
Effective Management ◽  
The Individual ◽  
Glucose 6 Phosphate Dehydrogenase

Diabetes is a clinical condition characterized by a spike in blood glucose in plasma. It is one of the 21st century's greatest public health crises and is among the top 10 causes of death worldwide. Although new drugs and therapeutics are emerging for its management but the prevalence is increasing at an alarming pace; thus, every system must contribute for effective management. An effort is made to review the efficacy and safety evaluation of the individual herbs of Darvyadi Kwatha (DK), an Ayurvedic formulation mentioned in Charaka Samhita. The constituents of the DK has some strong efficient antidiabetic/hypoglycaemic chemical principle having insulin-triggering and insulin-like behaviors which increases the activity of glucose-6-phosphate dehydrogenase (G6PD) and glucokinase and decreases glucose-6-phosphatase activity, reduce oxidative stress and prevention of glutathione reductase, superoxide dismutase, and catalase activity play a critical role in glucose homeostasis. DK also improve biochemical parameters such as SGPT, SGOT, cholesterol and triglycerides and is found to be safe in animal experiments. The various evidences clearly indicates that DK has definite hypoglycemic potential as well as anti-diabetic activity.

Il Master Plan per le aree militari di Piacenza. Processo, attori e forme di conoscenza

TERRITORIO ◽  
2012 ◽  
pp. 58-63
Author(s):  
Gabriele Pasqui
Keyword(s):  
Potential Role ◽  
Planning Process ◽  
Master Plan ◽  
Great Uncertainty ◽  
Service Areas ◽  
Exploratory Stage ◽  
The Military ◽  
Forms Of Knowledge

The engagement to produce a Master Plan for the redevelopment of military areas (barracks and service areas) constitutes an interesting example of the problems connected with the reuse of land and property assets used by the Ministry of Defence. The essay describes the context in which the planning process was introduced, the characteristics of the military areas to be redeveloped and the complex affairs which led to the suspension of the Master Plan after the conclusion of the first exploratory stage. The story told enables some general considerations to be made on four subjects: the more or less particular nature of military areas compared to other types of underused areas; the great uncertainty over the rules and strategies of the actors; the potential role of municipal administrations in the management of these processes; the forms of knowledge in use and the skills needed to manage them effectively.

scholarly journals A community outbreak of Salmonella berta associated with a soft cheese product

1998 ◽  
Vol 120 (1) ◽  
pp. 29-35 ◽  
Author(s):  
A. ELLIS ◽  
M. PRESTON ◽  
A. BORCZYK ◽  
B. MILLER ◽  
P. STONE ◽  
...  
Keyword(s):  
Public Health ◽  
Potential Role ◽  
Farmers Markets ◽  
Cross Contamination ◽  
Large Fragment ◽  
Health Unit ◽  
Genomic Fingerprinting ◽  
Home Based ◽  
Soft Cheese

In September 1994, a complaint was registered at a public health unit concerning a cheese product. In addition, public health laboratories in Ontario reported an increase in the number of isolates of Salmonella berta from patients with diarrhoeal illness. A clinical, environmental and laboratory investigation was initiated to determine the nature of this outbreak. Isolates of Salmonella berta were compared using large fragment genomic fingerprinting by pulsed-field gel electrophoresis (PFGE). By late October, 82 clinical cases had been identified including 35 confirmed, 44 suspected and 3 secondary. The investigation linked illness to consumption of an unpasteurized soft cheese product produced on a farm and sold at farmers' markets. Subtyping results of patient, cheese and chicken isolates were indistinguishable, suggesting that the cheese was contaminated by chicken carcasses during production. The outbreak illustrates the potential role of uninspected home-based food producers and of cross-contamination in the transmission of foodborne bacterial pathogens.

scholarly journals Contamination of Unused, Nonsterile Gloves in the Critical Care Setting: A Comparison of Bacterial Glove Contamination in Medical, Surgical and Burn Intensive Care Units

2014 ◽  
Vol 2 (5) ◽  
pp. 3
Author(s):  
Matthew Hall ◽  
Urvish Trivedi ◽  
Kendra Rumbaugh ◽  
Sharmila Dissanaike
Keyword(s):  
Intensive Care ◽  
Infection Control ◽  
Intensive Care Units ◽  
Tertiary Care ◽  
Agar Plate ◽  
Contamination Rate ◽  
Cross Sectional ◽  
Convenience Sample ◽  
Bacterial Contaminants ◽  
Colony Forming Units

Objective: To assess the rate and burden of bacterial contamination on unused, nonsterile gloves found in glove boxes in three different specialty intensive care units (ICUs).Design: Descriptive, cross-sectional studySetting: A burn, trauma/surgical, and medical ICU in a 412-bed tertiary care hospital.Subjects: Convenience sample of 90 non-sterile vinyl exam glove pairsMethods: Thirty occupied rooms in each ICU were utilized for collection of glove pair samples. Gloves from opened glove boxes placed in wall-mounted racks for use by healthcare staff were donned by one investigator in a routine, aseptic fashion. The surfaces of both gloves were swabbed, plated onto a contact agar plate and incubated for 48 hours. Resulting colony forming units (CFUs) were counted and recorded for each glove pair sample.Results: Bacterial contaminants were cultured from 73 of 90 (81.1%) glove pairs sampled across all ICUs. Contamination rates of glove samples from the BICU, SICU and MICU were 66.7%, 86.7% and 90.0% respectively. The differences in contamination rate among units was statistically significant (p=0.044). The average contamination burden was 5.83 CFU per glove pair and was not significantly different among units.Conclusions: Despite differences in infection control practices and the composition of pathologies managed in each ICU, the average bioburden of gloves left exposed in the environment was not significantly different. Further research is needed to assess for an association of glove bioburden with nosocomial infection rates and the effects of different infection control practices on the reduction of glove bioburdens.

scholarly journals Antifungal Susceptibility Testing of Ascomycetous Yeasts Isolated from Animals

2016 ◽  
Vol 60 (8) ◽  
pp. 5026-5028 ◽  
Author(s):  
Sergio Álvarez-Pérez ◽  
Marta E. García ◽  
Teresa Peláez ◽  
Eva Martínez-Nevado ◽  
José L. Blanco
Keyword(s):  
Amphotericin B ◽  
Continuous Monitoring ◽  
Potential Role ◽  
Susceptibility Testing ◽  
Antifungal Susceptibility ◽  
Antifungal Susceptibility Testing ◽  
Ascomycetous Yeast ◽  
Resistant Strains ◽  
Ascomycetous Yeasts

ABSTRACTRecent studies suggest that antifungal resistance in yeast isolates of veterinary origin may be an underdiagnosed threat. We tested a collection of 92 ascomycetous yeast isolates that were obtained in Spain from birds, mammals and insects for antifungal susceptibility. MICs to amphotericin B and azoles were low, and no resistant isolates were detected. Despite these results, and given the potential role of animals as reservoirs of resistant strains, continuous monitoring of antifungal susceptibility in the veterinary setting is recommended.

scholarly journals Potential role of stem cells for neuropathic pain disorders

2013 ◽  
Vol 35 (3) ◽  
pp. E11 ◽  
Author(s):  
Sudhakar Vadivelu ◽  
Matthew Willsey ◽  
Daniel J. Curry ◽  
John W. McDonald
Keyword(s):  
Stem Cells ◽  
Neuropathic Pain ◽  
Potential Role ◽  
Disease Process ◽  
Cellular Delivery ◽  
Chronic Neuropathic Pain ◽  
Medical Treatments ◽  
Medical Disorders ◽  
Experimental Therapies

Chronic neuropathic pain is a debilitating disease process associated with several medical disorders. Different from pain caused by inflammation, neuropathic pain is a diffuse pain disorder often found to be recalcitrant to the limited medical treatments available. Intractable nerve pain may benefit from other therapies capable of longer-lasting pain coverage or greater efficacy. A growing number of reports have emerged suggesting a role for stem cells as a cellular delivery source with neuroprotective agents opposing the effects of nerve damage. Here, the authors review the current experimental therapies examining the use of stem cells for the treatment of neuropathic pain disorders.

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

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