scholarly journals Serum Levels of Commonly Detected Persistent Organic Pollutants and Per- and Polyfluoroalkyl Substances (PFASs) and Mammographic Density in Postmenopausal Women

2020 ◽  
Vol 17 (2) ◽  
pp. 606
Author(s):  
Eunjung Lee ◽  
April Kinninger ◽  
Giske Ursin ◽  
Chiuchen Tseng ◽  
Susan Hurley ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Mammographic Density ◽  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Polybrominated Diphenyl Ethers ◽  
Multiple Testing ◽  
Serum Levels ◽  
P Value ◽  
Polyfluoroalkyl Substances ◽  
The Impact

There are little epidemiological data on the impact of persistent organic pollutants (POPs) and endocrine disruptors on mammographic density (MD), a strong predictor of breast cancer. We assessed MD in 116 non-Hispanic white post-menopausal women for whom serum concentrations of 23 commonly detected chemicals including 3 polybrominated diphenyl ethers (PBDEs), 8 per- and polyfluoroalkyl substances (PFASs), and 12 polychlorinated biphenyls (PCBs) had been measured. Linear regression analyses adjusting for potential confounders were used to examine the associations between the levels of the chemical compounds, modeled as continuous and dichotomized (above/below median) variables, and square-root-transformed MD. None of the associations were statistically significant after correcting for multiple testing. Prior to correction for multiple testing, all chemicals with un-corrected p-values < 0.05 had regression coefficients less than zero, suggesting inverse associations between increased levels and MD, if any. The smallest p-value was observed for PCB-153 (regression coefficient for above-median vs. below-median levels: −0.87, un-corrected p = 0.008). Neither parity nor body mass index modified the associations. Our results do not support an association between higher MD and serum levels of PBDEs, PCBs, or PFASs commonly detected in postmenopausal women.

scholarly journals Persistent organic pollutants and couple fecundability: a systematic review

2020 ◽  
Author(s):  
Linda G Kahn ◽  
Kim G Harley ◽  
Eva L Siegel ◽  
Yeyi Zhu ◽  
Pam Factor-Litvak ◽  
...  
Keyword(s):  
Systematic Review ◽  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Polybrominated Diphenyl Ethers ◽  
Flame Retardants ◽  
Data Extraction ◽  
Epidemiologic Studies ◽  
Health Concern ◽  
Future Research ◽  
The Impact

Abstract BACKGROUND Despite increasing regulation, exposure to persistent organic pollutants (POPs) remains a serious public health concern due to their accumulation in the environment and ability to biomagnify up the food chain. POPs are associated with endocrine-disrupting effects including adverse reproductive outcomes that could affect fecundability, i.e. the capacity to conceive a pregnancy, quantified as time to pregnancy (TTP). OBJECTIVE AND RATIONALE Results of epidemiologic studies that examine the impact of various chemical classes of POPs on TTP have not been synthesised. We undertook a systematic review to summarise the strength of evidence for associations of four common groups of POPs with couple fecundability and to identify gaps and limitations in the literature in order to inform policy decisions and future research. SEARCH METHODS We performed an electronic search of literature published between 1 January 2007 and 6 August 2019 in MEDLINE, EMBASE.com, Global Health, DART/TOXLINE and POPLINE. We included empirical research papers that examined human exposure to organochlorine (OC) pesticides, brominated flame retardants, polychlorinated organic compounds and/or per- and polyfluoroalkyl substances (PFAS) and considered TTP or fecundability as an outcome. Standardised forms for screening, data extraction and study quality were developed using DistillerSR software, and all reviews were completed in duplicate. We used the Newcastle-Ottawa Scale to assess risk of bias and devised additional quality metrics based on specific methodological features of fecundability studies. OUTCOMES The search returned 4573 articles, and 28 papers from 19 different studies met inclusion criteria. Among them, four studies measured TTP prospectively, three had data on participants’ prenatal exposure, three examined associations in both male and female partners and one focused exclusively on males. Analyses varied widely in terms of exposure characterisation, precluding a meta-analytic approach. Evidence was strongest for adverse associations of female exposure to polychlorinated biphenyls with TTP, with some additional support for associations of female exposure to polybrominated diphenyl ethers and PFAS with longer TTP. Our review provided little or no support for associations between female exposure to OC pesticides or male exposure to any of the POP groups and TTP. WIDER IMPLICATIONS Evidence suggests that female exposure to at least some POPs may reduce fecundability. Although many of these chemicals are no longer in production, they are still detectable in human biosamples because of their persistence in the environment. Replacement chemicals that are being introduced as older ones are restricted may have similar reproductive consequences. Future studies should examine these newer POPs, assess interactions between POPs and other chemical and non-chemical exposures, investigate how POPs are distributed in and metabolised by the human body and focus on populations that may be disproportionately exposed.

scholarly journals Impact of persistent organic pollutants sources on the ecological state of the environment

2019 ◽  
pp. 72-76
Author(s):  
T.I. Висоцька ◽  
Т.В. Пічкур
Keyword(s):  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
State Level ◽  
Negative Influence ◽  
Health Maintenance ◽  
World Community ◽  
Soil Ecosystems ◽  
Long Time ◽  
State Of The Environment ◽  
The Impact

The article studies the impact of persistent organic pollutants (POPs) on the environment. POPs are artificial substances for the environment. Nowadays, scientists have created more than 18 million chemical compounds, almost 100 000 of which are used in industry. It is widely understood that the pollution of the environment by persistent organic pollutants is due to their constant movement between the natural envelopes. Environmental studies show that regardless of sources (POPs) all the components of the biosphere are under their negative influence: surface water and groundwater, atmosphere, soil ecosystems, flora, and fauna. Measures that can be taken to prevent and reduce the impact of POPs on human health are conventionally divided into measures applied at the state level, and measures for the health maintenance, which should be used by each person, possessing certain knowledge about potential sources and properties of persistent organic pollutants. Considering the fact that POPs can remain in the environment for a long time, there is only one way to protect ourselves and future generations – it is to stop the production and use of POPs and to stop those production processes that use POPs. But this requires the efforts of the world community.

scholarly journals Concentration Levels and Ecological Risks of Persistent Organic Pollutants in the Surface Sediments of Tianjin Coastal Area, China

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Xiaoxia Lu ◽  
Chaoqi Chen ◽  
Shu Zhang ◽  
Zhen Hou ◽  
Junjun Yang
Keyword(s):  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Coastal Area ◽  
Polybrominated Diphenyl Ethers ◽  
Ecological Risks ◽  
Diphenyl Ethers ◽  
Polycyclic Aromatic ◽  
Probable Effect ◽  
Total Concentrations ◽  
Concentration Levels

Sediments were sampled from different surface water bodies in Tianjin coastal area, China, and persistent organic pollutants (POPs) including polycyclic aromatic hydrocarbons (PAHs), organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), and polybrominated diphenyl ethers (PBDEs) were measured using GC/MS or GC/ECD. The purposes were to investigate the concentration levels of the POPs and to assess their ecological risks. The results showed that all the 16 priority PAHs were detected from the 10 sediments sampled with the total concentrations of the 16 PAHs ranging from 274.06 μg/kg to 2656.65 μg/kg, while the concentrations of the halogenated POPs were generally low except in the Dagu waste discharging river where the total concentrations of 24 OCPs, 35 PCBs, and 14 PBDEs were 3103.36 μg/kg, 87.31 μg/kg, and 13.88 μg/kg, respectively. In the studied sediments, PAHs exhibited risks to benthonic organisms; particularly the concentrations of naphthalene and/or acenaphthene exceeded their probable effect concentrations in several locations. In comparison, only in the Dagu waste discharging river, OCPs exhibited risks with the concentrations of heptachlor epoxide and lindane exceeding their probable effect concentrations. PCBs and PBDEs posed rare risks in the studied area.

scholarly journals Global marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structure

2016 ◽  
Vol 2 (4) ◽  
pp. e1600001 ◽  
Author(s):  
Sascha C. T. Nicklisch ◽  
Steven D. Rees ◽  
Aaron P. McGrath ◽  
Tufan Gökirmak ◽  
Lindsay T. Bonito ◽  
...  
Keyword(s):  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Polybrominated Diphenyl Ethers ◽  
Specific Binding ◽  
Diphenyl Ether ◽  
Environmental Toxicants ◽  
Glycoprotein P ◽  
P Glycoprotein ◽  
Defense Protein ◽  
Cocrystal Structure

The world’s oceans are a global reservoir of persistent organic pollutants to which humans and other animals are exposed. Although it is well known that these pollutants are potentially hazardous to human and environmental health, their impacts remain incompletely understood. We examined how persistent organic pollutants interact with the drug efflux transporter P-glycoprotein (P-gp), an evolutionarily conserved defense protein that is essential for protection against environmental toxicants. We identified specific congeners of organochlorine pesticides, polychlorinated biphenyls, and polybrominated diphenyl ethers that inhibit mouse and human P-gp, and determined their environmental levels in yellowfin tuna from the Gulf of Mexico. In addition, we solved the cocrystal structure of P-gp bound to one of these inhibitory pollutants, PBDE (polybrominated diphenyl ether)–100, providing the first view of pollutant binding to a drug transporter. The results demonstrate the potential for specific binding and inhibition of mammalian P-gp by ubiquitous congeners of persistent organic pollutants present in fish and other foods, and argue for further consideration of transporter inhibition in the assessment of the risk of exposure to these chemicals.

scholarly journals Modelling the impact of climate change on the atmospheric transport and the fate of persistent organic pollutants in the Arctic

2015 ◽  
Vol 15 (11) ◽  
pp. 6549-6559 ◽  
Author(s):  
K. M. Hansen ◽  
J. H. Christensen ◽  
C. Geels ◽  
J. D. Silver ◽  
J. Brandt
Keyword(s):  
Climate Change ◽  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Atmospheric Transport ◽  
Climate Scenario ◽  
The Arctic ◽  
Model Studies ◽  
Environmental Concentrations ◽  
Mean Temperature ◽  
The Impact

Abstract. The Danish Eulerian Hemispheric Model (DEHM) was applied to investigate how projected climate changes will affect the atmospheric transport of 13 persistent organic pollutants (POPs) to the Arctic and their environmental fate within the Arctic. Three sets of simulations were performed, one with present day emissions and initial environmental concentrations from a 20-year spin-up simulation, one with present day emissions and with initial environmental concentrations set to zero and one without emissions but with initial environmental concentrations from the 20-year spin-up simulation. Each set of simulations consisted of two 10-year time slices representing the present (1990–2000) and future (2090–2100) climate conditions. DEHM was driven using meteorological input from the global circulation model, ECHAM/MPI-OM, simulating the SRES (Special Report on Emissions Scenarios) A1B climate scenario. Under the applied climate and emission scenarios, the total mass of all compounds was predicted to be up to 55 % lower across the Northern Hemisphere at the end of the 2090s than in the 1990s. The mass of HCHs within the Arctic was predicted to be up to 38 % higher, whereas the change in mass of the PCBs was predicted to range from 38 % lower to 17 % higher depending on the congener and the applied initial environmental concentrations. The results of this study also indicate that contaminants with no or a short emission history will be more rapidly transported to and build up in the arctic environment in a future warmer climate. The process that dominates the environmental behaviour of POPs in the Arctic under a future warmer climate scenario is the shift in mass of POPs from the surface media to the atmosphere induced by the higher mean temperature. This is to some degree counteracted by higher degradation rates also following the higher mean temperature. The more dominant of these two processes depends on the physical-chemical properties of the compounds. Previous model studies have predicted that the effect of a changed climate on the transport of POPs to the Arctic is moderate relative to the effect of proposed changes in emissions, which is confirmed in this study. However, the model studies do not agree on whether climate change acts to reduce or increase environmental concentrations of POPs in the Arctic, and further work is needed to resolve this matter.

scholarly journals In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid Levels

Metabolites ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 657
Author(s):  
Maegan E. Boutot ◽  
Brian W. Whitcomb ◽  
Nadia Abdelouahab ◽  
Andrea A. Baccarelli ◽  
Amélie Boivin ◽  
...  
Keyword(s):  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Polybrominated Diphenyl Ethers ◽  
Animal Studies ◽  
Human Study ◽  
Later Life ◽  
In Utero ◽  
High Density Lipoproteins ◽  
Lipid Levels ◽  
In Utero Exposures

Animal studies have shown that developmental exposures to polybrominated diphenyl ethers (PBDE) permanently affect blood/liver balance of lipids. No human study has evaluated associations between in utero exposures to persistent organic pollutants (POPs) and later life lipid metabolism. In this pilot, maternal plasma levels of PBDEs (BDE-47, BDE-99, BDE-100, and BDE-153) and polychlorinated biphenyls (PCB-138, PCB-153, and PCB-180) were determined at delivery in participants of GESTation and Environment (GESTE) cohort. Total cholesterol (TCh), triglycerides (TG), low- and high-density lipoproteins (LDL-C and HDL-C), total lipids (TL), and PBDEs were determined in serum of 147 children at ages 6–7. General linear regression was used to estimate the relationship between maternal POPs and child lipid levels with adjustment for potential confounders, and adjustment for childhood POPs. In utero BDE-99 was associated with lower childhood levels of TG (p = 0.003), and non-significantly with HDL-C (p = 0.06) and TL (p = 0.07). Maternal PCB-138 was associated with lower childhood levels of TG (p = 0.04), LDL-C (p = 0.04), and TL (p = 0.02). Our data indicate that in utero exposures to POPs may be associated with long lasting decrease in circulating lipids in children, suggesting increased lipid accumulation in the liver, a mechanism involved in NAFLD development, consistent with previously reported animal data.

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