scholarly journals Dihydrotestosterone (DHT) Enhances Wound Healing of Major Burn Injury by Accelerating Resolution of Inflammation in Mice

2020 ◽  
Vol 21 (17) ◽  
pp. 6231
Author(s):  
Huaikai Shi ◽  
Tsun-Ho Lo ◽  
Duncan Ma ◽  
Brenton Condor ◽  
Brian Lesmana ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Rate ◽  
Burn Injury ◽  
Inflammatory Responses ◽  
Burn Injuries ◽  
Resolution Of Inflammation ◽  
Androgen Treatment ◽  
Major Burn ◽  
Improve Wound Healing

Androgens have been known to inhibit cutaneous wound healing in men and male mice. However, in children with major burn injuries, a synthetic androgen was reported clinically to improve wound healing. The aim of this study is to investigate the role of dihydrotestosterone (DHT) as a new therapeutic approach in treating major burn injury. In the present study, mice received systemic androgen treatment post major burn injury. Wound healing rate and body weight were monitored over 21 days. The serum level of inflammatory cytokines/chemokines were measured using multiplex immunoassays. In addition, splenocyte enumeration was performed by flow cytometry. Healing phases of inflammation, re-epithelialization, cell proliferation and collagen deposition were also examined. In results, DHT treated mice lost less weight and displayed accelerated wound healing but has no impact on hypermetabolism. Mice, after burn injury, displayed acute systemic inflammatory responses over 21 days. DHT treatment shortened the systemic inflammatory response with reduced splenic weight and monocyte numbers on day 14 and 21. DHT treatment also reduced wound infiltrating macrophage numbers. In conclusion, DHT treatment facilitates local wound healing by accelerating the resolution of inflammation, but not through alterations of post-burn hypermetabolic response.

Role of topical insulin therapy as an adjunct in the management of pressure ulcer

2020 ◽  
Vol 2 (3) ◽  
pp. 01-03
Author(s):  
Ravi Chittoria
Keyword(s):  
Wound Healing ◽  
Insulin Therapy ◽  
Pressure Ulcer ◽  
Healing Rate ◽  
Pressure Sore ◽  
Pressure Sores ◽  
Established Method ◽  
Wound Bed Preparation ◽  
Wound Healing Rate

Pressure ulcer or pressure sore is one of the complications seen in bedridden patients. Management of these ulcers is often challenging. But there is no well-established method that accelerates the wound healing rate. Various adjunctive methods are used for wound bed preparation before definitive reconstruction plan is made. Here we describe our experience in the role of insulin therapy as an adjunct in the management of pressure sores.

scholarly journals Effect of small molecular weight soybean protein-derived peptide supplementation on attenuating burn injury-induced inflammation and accelerating wound healing in a rat model

RSC Advances ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 1247-1259 ◽  
Author(s):  
Fen Zhao ◽  
Wei Liu ◽  
Yonghui Yu ◽  
Xinqi Liu ◽  
Huinan Yin ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Wound Healing ◽  
Rat Model ◽  
Burn Injury ◽  
Soybean Protein ◽  
Burn Injuries ◽  
Small Molecular Weight

The populations most afflicted by burn injuries have limited abilities to support the significant specialized requirements and costs for acute and long-term burn injury care.

scholarly journals A Review of Burn Patients Requiring Extracorporeal Membrane Oxygenation at a Burns Facility

2021 ◽  
Vol 2 (4) ◽  
pp. 293-300
Author(s):  
Stephen Frost ◽  
Liz Davies ◽  
Claire Porter ◽  
Avinash Deodhar ◽  
Reena Agarwal
Keyword(s):  
Extracorporeal Membrane Oxygenation ◽  
Burn Injury ◽  
Burn Injuries ◽  
Burn Patients ◽  
Review Of The Literature ◽  
Respiratory Compromise ◽  
Burn Care ◽  
Membrane Oxygenation ◽  
Regular Time ◽  
Major Burn

Respiratory compromise is a recognised sequelae of major burn injuries, and in rare instances requires extracorporeal membrane oxygenation (ECMO). Over a ten-year period, our hospital trust, an ECMO centre and burns facility, had five major burn patients requiring ECMO, whose burn injuries would normally be managed at trusts with higher levels of burn care. Three patients (60%) survived to hospital discharge, one (20%) died at our trust, and one patient died after repatriation. All patients required regular, time-intensive dressing changes from our specialist nursing team, beyond their regular duties. This review presents these patients, as well as a review of the literature on the use of ECMO in burn injury patients. A formal review of the overlap between the networks that cater to ECMO and burn patients is recommended.

scholarly journals Amputation Following Burn Injury

2019 ◽  
Vol 40 (4) ◽  
pp. 430-436
Author(s):  
Colleen N Bartley ◽  
Kenisha Atwell ◽  
Laura Purcell ◽  
Bruce Cairns ◽  
Anthony Charles
Keyword(s):  
Risk Factors ◽  
Odds Ratio ◽  
Logistic Regression Model ◽  
Burn Injury ◽  
Burn Injuries ◽  
Multivariate Logistic Regression Model ◽  
Multivariate Logistic Regression ◽  
Black Race ◽  
Burn Center

AbstractAmputation following burn injury is rare. Previous studies describe the risk of amputation after electrical burn injuries. Therefore, we describe the distribution of amputations and evaluate risk factors for amputation following burn injury at a large regional burn center. We conducted a retrospective analysis of patients ≥17 years admitted from January 2002 to December 2015. Patients who did and did not undergo an amputation procedure were compared. A multivariate logistic regression model was used to determine the risk factors for amputation. Amputations were further categorized by extremity location and type (major, minor) for comparison. Of the 8313 patients included for analysis, 1.4% had at least one amputation (n = 119). Amputees were older (46.7 ± 17.4 years) than nonamputees (42.6 ± 16.8 years; P = .009). The majority of amputees were white (47.9%) followed by black (39.5%) when compared with nonamputees (white: 57.1%, black: 27.3%; P = .012). The most common burn etiology for amputees was flame (41.2%) followed by electrical (23.5%) and other (21.9%). Black race (odds ratio [OR]: 2.29; 95% confidence interval [CI]: 1.22–4.30; P = .010), electric (OR: 13.54; 95% CI: 6.23–29.45; P < .001) and increased %TBSA (OR: 1.03; 95% CI: 1.02–1.05; P < .001) were associated with amputation. Burn etiology, the presence of preexisting comorbidities, black race, and increased %TBSA increase the odds of post burn injury. The role of race on the risk of amputation requires further study.

An investigation of the role of diet and burn injury on wound healing

Burns ◽  
1991 ◽  
Vol 17 (1) ◽  
pp. 14-16 ◽  
Author(s):  
H.J.C.R. Belcher ◽  
H. Ellis
Keyword(s):  
Wound Healing ◽  
Burn Injury

scholarly journals Role of Autophagy Biomarkers In Burn-Age Estimation and Progression

2019 ◽  
Vol 9 (3-4) ◽  
pp. 163-171
Author(s):  
Heba A. Yassa ◽  
Randa T. Hanna ◽  
Hala Zein El Abdin
Keyword(s):  
Normal Level ◽  
Burn Injury ◽  
Burn Injuries ◽  
Male Rats ◽  
Thermal Burn ◽  
Histopathological Effects ◽  
Skin Samples ◽  
Second Degree

Background: Determination of time passed since burn injury in the living is critical in forensic science. Autophagy biomarkers and vitronectin can play an important role in determination of the age of burn injuries through their levels in the tissue. Objective: The aim of this study was to investigate the role of autophagy biomarkers in dating burn injury and to correlate them with the histopathological effects of deep second-degree thermal burn. Method: Fifty-four male rats were used in this study after infliction of second-degree thermal burns to their skin. Samples were taken from them after 30 minutes and one, four, 24, 48, and 72 hours following burn to be examined histologically and also for autophagy biomarkers and vitronectin. Results: Significant reduction in the autophagy biomarkers (p < 0.001) over the first 24 hours then began to increase but still not reach the normal level up to 72 hours after burn. Vitronectin level increased after burn infliction 1.5-fold after first hour, then up to four-fold after four hours and after that began to decline but still did not reach the normal level up to 72 hours. Conclusion: Autophagy biomarkers can be used as a forensic tool in determination of the time passed since burn infliction in living.

Role of HES 130/0.4 in resuscitation of patients with major burn injury

2008 ◽  
Vol 10 (2) ◽  
pp. 43-50 ◽  
Author(s):  
GOGULAPATI VENKATA SUDHAKAR ◽  
PULUKURI LAKSHMI
Keyword(s):  
Burn Injury ◽  
Major Burn

scholarly journals Hyaluronan Fragments Improve Wound Healing on In Vitro Cutaneous Model through P2X7 Purinoreceptor Basal Activation: Role of Molecular Weight

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e48351 ◽  
Author(s):  
Kamelia Ghazi ◽  
Uriell Deng-Pichon ◽  
Jean-Michel Warnet ◽  
Patrice Rat
Keyword(s):  
Molecular Weight ◽  
Wound Healing ◽  
Improve Wound Healing

scholarly journals SAT-006 Dihydrotestosterone (DHT) Enhances Major Burn Injury Wound Healing by Regulating the Inflammatory Response in Mice

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Huaikai Shi ◽  
Kevin Lo ◽  
Ulla Simanainen ◽  
Duncan Ma ◽  
Brian Lesmana ◽  
...  
Keyword(s):  
Wound Healing ◽  
Inflammatory Response ◽  
Burn Injury ◽  
Major Burn

scholarly journals Shedding Light on the Role of Extracellular Vesicles in HIV Infection and Wound Healing

Viruses ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 584 ◽  
Author(s):  
Aseel Alqatawni ◽  
Adhikarimayum Lakhikumar Sharma ◽  
Beatrice Attilus ◽  
Mudit Tyagi ◽  
Rene Daniel
Keyword(s):  
Wound Healing ◽  
Hiv Infection ◽  
Extracellular Vesicles ◽  
Inflammatory Responses ◽  
Current Knowledge ◽  
Matrix Remodeling ◽  
Ongoing Research ◽  
Post Entry ◽  
And Function

Extracellular vesicles (EVs) play an important role in intercellular communication. They are naturally released from cells into the extracellular environment. Based on their biogenesis, release pathways, size, content, and function, EVs are classified into exosomes, microvesicles (MVs), and apoptotic bodies (ApoBDs). Previous research has documented that EVs, specifically exosomes and MVs, play an important role in HIV infection, either by promoting HIV infection and pathogenesis or by inhibiting HIV-1 to a certain extent. We have also previously reported that EVs (particularly exosomes) from vaginal fluids inhibit HIV at the post-entry step (i.e., reverse transcription, integration). Besides the role that EVs play in HIV, they are also known to regulate the process of wound healing by regulating both the immune and inflammatory responses. It is noted that during the advanced stages of HIV infection, patients are at greater risk of wound-healing and wound-related complications. Despite ongoing research, the data on the actual effects of EVs in HIV infection and wound healing are still premature. This review aimed to update the current knowledge about the roles of EVs in regulating HIV pathogenesis and wound healing. Additionally, we highlighted several avenues of EV involvement in the process of wound healing, including coagulation, inflammation, proliferation, and extracellular matrix remodeling. Understanding the role of EVs in HIV infection and wound healing could significantly contribute to the development of new and potent antiviral therapeutic strategies and approaches to resolve impaired wounds in HIV patients.

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