scholarly journals Biomarkers Suggesting Favorable Prognostic Outcomes in Sudden Sensorineural Hearing Loss

2020 ◽  
Vol 21 (19) ◽  
pp. 7248
Author(s):  
Jeon Gang Doo ◽  
Dokyoung Kim ◽  
Yong Kim ◽  
Myung Chul Yoo ◽  
Sung Su Kim ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Medical Emergency ◽  
High Density Lipoproteins ◽  
Platelet Glycoprotein ◽  
Cholesterol Ratio ◽  
Neutrophil Lymphocyte Ratio ◽  
Cochrane Database

Sudden sensorineural hearing loss (SSNHL) is a medical emergency, making detailed examination to determine possible causes and early treatment important. However, etiological examinations in SSNHL do not always reveal a cause, and several factors have been found to affect treatment outcomes. Various studies are being performed to determine the prognosis and effects of treatment in patients who experience sudden hearing loss, and to identify biomarkers associated with this condition. Embase, PubMed, and the Cochrane database were searched using the key words SSNHL, prognostic, and biomarker. This search identified 4 articles in Embase, 28 articles in PubMed, and 36 in the Cochrane database. Of these 68 articles, 3 were duplicates and 37 were unrelated to the research topic. After excluding these articles, the remaining 28 articles were reviewed. Factors associated with SSNHL were divided into six categories: metabolic, hemostatic, inflammatory, immunologic, oxidative, and other factors. The associations between these factors with the occurrence of SSNHL and with patient prognosis were analyzed. Low monocyte counts, low neutrophil/lymphocyte ratio (NLR) and monocyte/high-density lipoproteins (HDL) cholesterol ratio (MHR), and low concentrations of fibrinogen, platelet glycoprotein (GP) IIIa, and TNF-α were found to be associated with good prognosis. However, these factors alone could not completely determine the onset of and recovery from SSNHL, suggesting the need for future basic and clinical studies.

The Roles Played by Blood Inflammatory Parameters in Sudden Sensorineural Hearing Loss

2021 ◽  
pp. 014556132096035
Author(s):  
Yan Guo ◽  
Jisheng Liu
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Control Group ◽  
Therapeutic Effects ◽  
Hearing Level ◽  
Neutrophil Lymphocyte Ratio ◽  
Reactive Protein ◽  
Inflammatory Parameters

Objective: The etiology of sudden sensorineural hearing loss (SSNHL) remains unknown; inflammation may be one cause. We retrospectively studied SSHNL cases in terms of the inflammatory parameters involved. Methods: We reviewed 169 SSNHL cases. The control group contained 132 patients with vocal cord polyps. The C-reactive protein (CRP) level, CRP/serum albumin (Alb) ratio, and neutrophil/lymphocyte ratio (NLR) were compared between the 2 groups. The relationships between these parameters and the time to treatment after SSHNL onset, hearing level, and therapeutic effects were also analyzed. Results: The CRP level, CRP/Alb ratio, and NLR were higher in SSNHL patients than in controls, but only the NLR differed significantly between the 2 groups. We found no significant differences between patients with different hearing levels, those evaluated at various times after SSNHL onset, and those with different outcomes. Conclusion: The NLR is a reliable SSNHL diagnostic marker. The CRP level and CRP/Alb ratio are not useful indicators.

scholarly journals Management of sudden sensorineural hearing loss among primary care physicians in Canada: a survey study

2021 ◽  
Vol 50 (1) ◽  
Author(s):  
Benjamin Ng ◽  
Matthew G. Crowson ◽  
Vincent Lin
Keyword(s):  
Primary Care ◽  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Primary Care Physicians ◽  
Tuning Fork ◽  
Family Physicians ◽  
Sudden Onset ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Medical Emergency

Abstract Background Sudden Sensorineural Hearing Loss (SSNHL) is a medical emergency requiring immediate attention as delayed treatment can lead to permanent and devastating consequences. Primary care physicians are likely the first to be presented with SSNHL and therefore have the crucial role of recognizing it and initiating timely and appropriate management. The aim of this study was to gain insight into the current knowledge and practice trends pertaining to the diagnosis and management of SSNHL among family physicians in Canada. Methods An 18-question survey targeting Canadian family physicians was marketed through two, physician-only discussion groups on the social media platform Facebook. Responses were collected between August 1st and December 22nd 2019 then aggregated and quantified. Results 52 family physicians submitted responses. 94.2% (n = 49) reported that in their practice, unilateral SSNHL warrants urgent referral to otolaryngology and 84.6% (n = 44) reported that unilateral sudden-onset hearing loss warrants urgent referral for audiological testing. 73.1% of participants (n = 38) reported that they would attempt to differentiate between conductive and sensorineural hearing loss if presented with unilateral, acute or sudden-onset hearing loss. 61.5% (n = 32) would rely on tuning fork tests to inform management decisions, as compared to 94.2% (n = 49) relying on case history and 88.5% (n = 46) on otoscopy. 76.9% (n = 40) would prescribe corticosteroids if presented with confirmed, unilateral SSNHL. Conclusion The majority of family physicians in the study would make appropriate referral and treatment decisions in the management of SSNHL, understanding it is a medical emergency. Tuning fork tests are under-utilized for informing management decisions compared to other means of differentiating conductive and sensorineural hearing loss. Further research is needed to understand why some family physicians do not prescribe corticosteroids for treatment of SSNHL, which may then identify any gaps in knowledge or inform improvements in clinical protocol. Graphical abstract

Bilateral sudden sensorineural hearing loss: review

2013 ◽  
Vol 128 (S1) ◽  
pp. S8-S15 ◽  
Author(s):  
S A Sara ◽  
B M Teh ◽  
P Friedland
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Age Of Onset ◽  
Age Distribution ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Medical Emergency ◽  
Mesh Terms ◽  
Pubmed Database ◽  
Bilateral Condition

AbstractIntroduction:Unilateral and bilateral sudden sensorineural hearing loss represent different disease entities. The unilateral condition is more common and predominantly idiopathic, and up to 65 per cent of patients spontaneously recover hearing. Conversely, the bilateral condition is rare, mostly associated with serious systemic conditions, and has a higher prevalence of morbidity and mortality.Methods:A literature search using the PubMed database was conducted using the MeSH terms ‘sudden’, ‘bilateral’ and ‘sensorineural hearing loss’.Results:One hundred and three reported cases of bilateral sudden sensorineural hearing loss were identified. The condition is most often associated with toxic, autoimmune, neoplastic and vascular conditions. A younger age of onset, with a bimodal age distribution, was seen for bilateral sudden sensorineural hearing loss, compared with the unilateral condition. Patients with the bilateral condition had more profound hearing loss, with poorer recovery and a 35 per cent mortality rate. Vestibular symptoms were also less common than in the unilateral condition.Conclusion:The presentation of bilateral sudden onset sensorineural hearing loss is a medical emergency requiring thorough and urgent investigation to exclude life-threatening and reversible conditions.

scholarly journals Selected Blood Inflammatory and Metabolic Parameters Predicted Successive Bilateral Sudden Sensorineural Hearing Loss

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Xueyuan Zhang ◽  
Yinlun Weng ◽  
Yaodong Xu ◽  
Hao Xiong ◽  
Maojin Liang ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Inflammatory Markers ◽  
Hematological Parameters ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Metabolic Parameters ◽  
Female Ratio ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio

Objectives. To explore whether peripheral inflammatory, metabolic, and hemostatic parameters could predict the pathogenesis of successive bilateral sudden sensorineural hearing loss (SSNHL). Methods. This study reviewed 33 patients with successive bilateral SSNHL and 215 patients with unilateral SSNHL. Clinical characteristics and hematological parameters were compared, including the inflammatory markers (like neutrophil lymphocyte ratio (NLR), monocyte lymphocyte ratio (MLR), and platelet lymphocyte ratio (PLR)) and metabolic features (including hypertension, triglyceridemia, dyslipidemia, and hyperglycemia), as well as hemostatic indices (including prothrombin time (PT), activated partial thromboplastin time (APTT), and fibrinogen). Results. In the successive bilateral SSNHL group, older average onset age (48.67±15.36 vs. 42.71±13.58, p<0.05), higher male to female ratio (18 : 15 vs. 112 : 103, p>0.05), and poorer therapeutic efficacy (12% vs. 59%, p<0.01) were observed than those in the unilateral SSNHL group. Compared to the unilateral SSNHL group, NLR, MLR, and PLR in the successive bilateral SSNHL group were significantly higher (NLR: 5.72±2.23 vs. 4.45±2.82, p=0.01; MLR: 0.25±0.15 vs. 0.17±0.11, p<0.01; PLR: 190.70±69.79 vs. 148.18±65.67; p<0.01); the LDL level was significantly higher; yet, the HDL level was significantly lower (LDL: 3.79±0.53 vs. 3.49±0.74; HDL: 1.33±0.32 vs. 1.44±0.26; p<0.05 for both); fibrinogen was significantly higher (4.03±0.47 vs. 3.70±0.65; p<0.01). Logistic regression analysis demonstrated that the risk factors for successive bilateral SSNHL included age, NLR, MLR, PLR, LDL, HDL, diabetes, and fibrinogen. However, only NLR, MLR, PLR, diabetes, LDL, and HDL independently predicted successive bilateral SSNHL. Conclusion. Selected blood inflammatory markers combined with metabolic parameters were positively correlated with successive bilateral SSNHL.

scholarly journals Evaluation of idiopathic sudden sensorineural hearing loss

2015 ◽  
Vol 1 (1) ◽  
pp. 2
Author(s):  
Çiğdem Fırat Koca
Keyword(s):  
Hearing Loss ◽  
Early Diagnosis ◽  
Sensorineural Hearing Loss ◽  
Complete Recovery ◽  
Critical Issue ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Diagnosis And Treatment ◽  
Medical Emergency

<p class="abstract"><span lang="TR">Idiopathic sudden sensorineural hearing loss (ISSNHL) is a medical emergency. The early diagnosis and treatment should improve the complete recovery. The critical issue is diagnosis.</span></p>

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