PET/CT Imaging and Physiology of Mice on High Protein Diet

Background: High protein (HP) diets have been proposed to reduce body weight in humans. The diets are known to alter energy metabolism, which can affect the quality of [18F]FDG PET heart images. In this preclinical study, we therefore explore the impact of a prolonged HP diet on myocardial [18F]FDG uptake. Methods: C57BL/6J (Black six (Bl6)) and apolipoprotein E-deficient (apoE−/−) mice were fed chow, a HP diet, or a low protein (LP) diet for 12 weeks. At baseline and after treatment, the animals were injected with 33.0 MBq of [18F]FDG and a 30 min PET/CT scan was made. Myocardial volume and [18F]FDG uptake were quantified using PET and the % of body fat was calculated from CT. Results: Myocardial [18F]FDG uptake was similar for all diets at the follow-up scan but an increase between baseline and follow-up scans was noticed in the LP groups. Myocardial volume was significantly smaller in the C57BL HP group compared to the other Bl6 groups. Body weight increased less in the two HP groups compared to the chow and LP groups. Body fat percentage was significantly higher in the LP groups. This effect was stronger in C57BL mice (28.7%) compared to apoE−/− mice (15.1%). Conclusions: Myocardial uptake of [18F]FDG in mice is not affected by increased protein intake but [18F]FDG uptake increases when the amount of protein is lowered. A lower body weight and percentage of body fat were noticed when applying a HP diet.

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Quantitative, Dynamic 18F-FDG PET/CT in Monitoring of Smoldering Myeloma: A Case Report

Diagnostics ◽

10.3390/diagnostics11040649 ◽

2021 ◽

Vol 11 (4) ◽

pp. 649

Author(s):

Christos Sachpekidis ◽

Matthias Türk ◽

Antonia Dimitrakopoulou-Strauss

Keyword(s):

Bone Marrow ◽

Plasma Cells ◽

Autologous Transplantation ◽

Standardized Uptake Value ◽

Focal Lesions ◽

Fdg Uptake ◽

Pet Ct ◽

18F Fdg ◽

Smoldering Myeloma

We report on a 52-year-old patient with an initial diagnosis of smoldering myeloma (SMM), who was monitored by means of dynamic and static positron emission tomography/computed tomography (PET/CT) with the radiotracer 1⁸F-fluorodeoxyglucose (18F-FDG). Baseline PET/CT revealed no pathological signs. Six months later, a transition to symptomatic, multiple myeloma (MM) was diagnosed. The transition was not accompanied by focal, hypermetabolic lesions on PET/CT. However, a diffusely increased 18F-FDG uptake in the bone marrow, accompanied by a marked increase of semi-quantitative (standardized uptake value, SUV) and quantitative, pharmacokinetic 18F-FDG parameters, was demonstrated. After successful treatment, including tandem autologous transplantation, the diffuse uptake in the bone marrow as well as the semi-quantitative and quantitative parameters showed a marked remission. This response was also confirmed by the clinical follow-up of the patient. These findings suggest that in MM a diffuse 18F-FDG uptake in the bone marrow may indeed reflect an actual bone marrow infiltration by plasma cells. Moreover, SUV values and kinetic parameters, not only from myeloma lesions but also from random bone marrow samples, may be used for MM monitoring. This could be particularly helpful in the follow-up of myeloma patients negative for 18F-FDG-avid focal lesions.

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Diffusely Increased 18F-FDG Uptake in the Thyroid Gland and Risk of Thyroid Dysfunction: A Cohort Study

Journal of Clinical Medicine ◽

10.3390/jcm8040443 ◽

2019 ◽

Vol 8 (4) ◽

pp. 443 ◽

Cited By ~ 1

Author(s):

Young Kim ◽

Yoosoo Chang ◽

Yejin Kim ◽

Soo Kim ◽

Eun-Jung Rhee ◽

...

Keyword(s):

Cohort Study ◽

Thyroid Dysfunction ◽

Fdg Uptake ◽

Increased Risk ◽

Pet Ct ◽

Thyroid Uptake ◽

18F Fdg ◽

Fdg Pet Ct ◽

Pet Ct Scan

The impact of incidentally identified diffuse thyroid FDG uptake on 18F-FDG PET/CT scan on the incidence of thyroid dysfunction remains unclear. We examined the association of diffuse thyroid FDG uptake with the development of thyroid dysfunction. This cohort study involved 39,098 Korean adults who were free of malignancy and thyroid disease at baseline and underwent regular health checkup examinations including an 18F-FDG whole body PET/CT scan, thyroid-stimulating hormone and free thyroxine. The participants were annually or biennially followed for up to 5 years. A parametric proportional hazard model was used to estimate the adjusted hazard ratio (HR) and 95% confidence interval (CI). Diffuse thyroid uptake was positively associated with increased risk of thyroid dysfunction in both the cross-sectional and cohort studies. During 104,261.4 person-years of follow-up, 102 incident hypothyroidism cases and 172 hyperthyroidism cases were identified. Multivariable-adjusted HR (95% CI) for incident hypothyroidism or hyperthyroidism comparing diffuse thyroid uptake to no uptake were 15.72 (9.23–26.77) and 7.38 (4.23–12.87), respectively. In this large cohort, incidentally, identified diffuse thyroid uptake on 18F-FDG PET/CT was associated with increased risk of both prevalent and incident thyroid dysfunction. Therefore, baseline and follow-up evaluations in individuals with diffuse thyroid uptake may help identify individuals with thyroid dysfunction.

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Occasionally increased 18F-FDG uptake in apical hypertrophic cardiomyopathy on serial follow-up PET/CT

Journal of Nuclear Cardiology ◽

10.1007/s12350-019-01623-0 ◽

2019 ◽

Vol 26 (6) ◽

pp. 2125-2128 ◽

Cited By ~ 1

Author(s):

Takashi Norikane ◽

Yuka Yamamoto ◽

Yasukage Takami ◽

Katsuya Mitamura ◽

Ryosuke Tani ◽

...

Keyword(s):

Hypertrophic Cardiomyopathy ◽

Apical Hypertrophic Cardiomyopathy ◽

Fdg Uptake ◽

Pet Ct ◽

18F Fdg

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Intake of ruminanttrans-fatty acids, assessed by diet history interview, and changes in measured body size, shape and composition

Public Health Nutrition ◽

10.1017/s1368980015001858 ◽

2015 ◽

Vol 19 (3) ◽

pp. 494-502 ◽

Cited By ~ 2

Author(s):

Camilla P Hansen ◽

Berit L Heitmann ◽

Thorkild IA Sørensen ◽

Kim Overvad ◽

Marianne U Jakobsen

Keyword(s):

Fatty Acids ◽

Body Weight ◽

Body Size ◽

Waist Circumference ◽

Body Fat ◽

Body Fat Percentage ◽

Fat Percentage ◽

Hip Circumference ◽

Diet History

AbstractObjectiveStudies have suggested that total intake oftrans-fatty acids (TFA) is positively associated with changes in body weight and waist circumference, whereas intake of TFA from ruminant dairy and meat products (R-TFA) has not been associated with weight gain. However, these previous studies are limited by self-reported measures of body weight and waist circumference or by a cross-sectional design. The objective of the present study was to investigate if R-TFA intake was associated with subsequent changes in anthropometry (body weight, waist and hip circumference) measured by technicians and body composition (body fat percentage).DesignA 6-year follow-up study. Information on dietary intake was collected through diet history interviews, and anthropometric and bioelectrical impedance measurements were obtained by trained technicians at baseline (1987–1988) and at follow-up (1993–1994). Multiple regression with cubic spline modelling was used to analyse the data.SettingCopenhagen County, Denmark.SubjectsTwo hundred and sixty-seven men and women aged 35–65 years from the Danish MONICA (MONItoring of trends and determinants in CArdiovascular diseases) cohort.ResultsThe median R-TFA intake was 1·3 g/d (5th, 95th percentile: 0·4, 2·7 g/d) or 0·6 % of the total energy intake (5th, 95th percentile: 0·2, 1·1 %). No significant associations were observed between R-TFA intake and changes in body weight, waist and hip circumference or body fat percentage.ConclusionsR-TFA intake within the range present in the Danish population was not significantly associated with subsequent changes in body size, shape or composition and the 95 % confidence intervals indicate that any relevant associations are unlikely to have produced these observations.

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IMPACT OF ACQUISITION PARAMETERS ON THE QUANTITATIVE ASSESSMENT OF PET IMAGING – ANALYSIS OF THE NEMA PHANTOM

Medical Imaging and Radiotherapy journal ◽

10.47724/mirtj.2020.i01.a005 ◽

2020 ◽

Vol 37 (1) ◽

Author(s):

Sebastijan Rep ◽

Keyword(s):

Body Weight ◽

Pet Imaging ◽

Quantitative Assessment ◽

Common Factors ◽

Ct Imaging ◽

Imaging Analysis ◽

Pet Ct ◽

18F Fdg ◽

The Impact

Aim: The aim of the research was to analyse the most common factors that influence SUV values. Material and methods: In the study, I used a NEMA body phantom filled with a mixture of water and 18F-FDG in a ratio 1:4 (background/spheres), and analysed the most common factors that influence SUV values. The most common factors include the impact of the patient's body weight, the impact of time between application and PET/CT imaging, and the impact of differently prepared and administered RP activities. Results: Different values of patient body weight, time between application and PET/CT imaging, and differently prepared and administered RF activities have a statistically significant effect on the quantitative assessment of SUVmax (p < 0.001) and SUVmean (p < 0.001). Conclusion: The results showed that all factors can significantly influence the quantitative assessment of SUVmax and SUVmean.

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Comparison of Fluorine(18)-fluorodeoxyglucose and Gallium(68)-citrate PET/CT in patients with tuberculosis

Nuklearmedizin ◽

10.1055/a-1000-6951 ◽

2019 ◽

Vol 58 (05) ◽

pp. 371-378

Author(s):

Alfred O. Ankrah ◽

Ismaheel O. Lawal ◽

Tebatso M.G. Boshomane ◽

Hans C. Klein ◽

Thomas Ebenhan ◽

...

Keyword(s):

Tracer Uptake ◽

Pet Ct ◽

The Mean ◽

18F Fdg ◽

Definition Of ◽

Gallium 68 ◽

Attending Physician ◽

Pet Scans ◽

The Brain

Abstract 18F-FDG and 68Ga-citrate PET/CT have both been shown to be useful in the management of tuberculosis (TB). We compared the abnormal PET findings of 18F-FDG- and 68Ga-citrate-PET/CT in patients with TB. Methods Patients with TB on anti-TB therapy were included. Patients had a set of PET scans consisting of both 18F-FDG and 68Ga-citrate. Abnormal lesions were identified, and the two sets of scans were compared. The scan findings were correlated to the clinical data as provided by the attending physician. Results 46 PET/CT scans were performed in 18 patients, 11 (61 %) were female, and the mean age was 35.7 ± 13.5 years. Five patients also had both studies for follow-up reasons during the use of anti-TB therapy. Thirteen patients were co-infected with HIV. 18F-FDG detected more lesions than 68Ga-citrate (261 vs. 166, p < 0.0001). 68Ga-citrate showed a better definition of intracerebral lesions due to the absence of tracer uptake in the brain. The mean SUVmax was higher for 18F-FDG compared to 68Ga-citrate (5.73 vs. 3.01, p < 0.0001). We found a significant correlation between the SUVmax of lesions that were determined by both tracers (r = 0.4968, p < 0.0001). Conclusion Preliminary data shows 18F-FDG-PET detects more abnormal lesions in TB compared to 68Ga-citrate. However, 68Ga-citrate has better lesion definition in the brain and is therefore especially useful when intracranial TB is suspected.

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Restaging of patients with lymphoma

Nuklearmedizin ◽

10.3413/nukmed-0114 ◽

2008 ◽

Vol 47 (01) ◽

pp. 37-42 ◽

Cited By ~ 12

Author(s):

T. Pfluger ◽

V. Schneider ◽

M. Hacker ◽

N. Bröckel ◽

D. Morhard ◽

...

Keyword(s):

Low Dose ◽

Non Hodgkin Lymphoma ◽

Contrast Enhanced ◽

Pet Ct ◽

Significant Difference ◽

18F Fdg ◽

Sensitivity Specificity ◽

Fdg Pet Ct

SummaryAim: Assessment of the clinical benefit of i.v. contrast enhanced diagnostic CT (CE-CT) compared to low dose CT with 20 mAs (LD-CT) without contrast medium in combined [18F]-FDG PET/CT examinations in restaging of patients with lymphoma. Patients, methods: 45 patients with non-Hodgkin lymphoma (n = 35) and Hodgkin's disease (n = 10) were included into this study. PET, LD-CT and CECT were analyzed separately as well as side-by-side. Lymphoma involvement was evaluated separately for seven regions. Indeterminate diagnoses were accepted whenever there was a discrepancy between PET and CT findings. Results for combined reading were calculated by rating indeterminate diagnoses according the suggestions of either CT or PET. Each patient had a clinical follow-up evaluation for >6 months. Results: Region-based evaluation suggested a sensitivity/specificity of 66/93% for LD-CT, 87%/91% for CE-CT, 95%/96% for PET, 94%/99% for PET/LD-CT and 96%/99% for PET/CE-CT. The data for PET/CT were obtained by rating indeterminate results according to the suggestions of PET, which turned out to be superior to CT. Lymphoma staging was changed in two patients using PET/ CE-CT as compared to PET/LD-CT. Conclusion: Overall, there was no significant difference between PET/LD-CT and PET/CE-CT. However, PET/CE-CT yielded a more precise lesion delineation than PET/LD-CT. This was due to the improved image quality of CE-CT and might lead to a more accurate investigation of lymphoma.

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