scholarly journals Cutaneous wound healing: Current concepts and advances in wound care

2014 ◽  
Vol 47 (03) ◽  
pp. 303-317 ◽  
Author(s):  
Kenneth C Klein ◽  
Somes Chandra Guha
Keyword(s):  
Wound Healing ◽  
Wound Care ◽  
Standard Of Care ◽  
Medical Community ◽  
Medical Society ◽  
Cutaneous Wounds ◽  
General Acceptance ◽  
Healing Wound ◽  
The Usa ◽  
Variable Success

ABSTRACTA non-healing wound is defined as showing no measurable signs of healing for at least 30 consecutive treatments with standard wound care.[1] It is a snapshot of a patient’s total health as well as the ongoing battle between noxious factors and the restoration of optimal macro and micro circulation, oxygenation and nutrition. In practice, standard therapies for non-healing cutaneous wounds include application of appropriate dressings, periodic debridement and eliminating causative factors.[2] The vast majority of wounds would heal by such approach with variable degrees of residual morbidity, disability and even mortality. Globally, beyond the above therapies, newer tools of healing are selectively accessible to caregivers, for various logistical or financial reasons. Our review will focus on the use of hyperbaric oxygen therapy (HBOT), as used at our institution (CAMC), and some other modalities that are relatively accessible to patients. HBOT is a relatively safe and technologically simpler way to deliver care worldwide. However, the expense for including HBOT as standard of care for recognized indications per UHMS(Undersea and Hyperbaric Medical Society) may vary widely from country to country and payment system.[3] In the USA, CMS (Centers for Medicare and Medicaid Services) approved indications for HBOT vary from that of the UHMS for logistical reasons.[1] We shall also briefly look into other newer therapies per current clinical usage and general acceptance by the medical community. Admittedly, there would be other novel tools with variable success in wound healing worldwide, but it would be difficult to include all in this treatise.

scholarly journals EFEKTIFITAS ANTARA PERAWATAN LUKA DENGAN MENGGUNAKAN NaCl 0,9% DAN BETADIN TERHADAP PROSES PENYEMBUHAN LUKA POST OPERASI

2020 ◽  
Vol 7 (1) ◽  
pp. 782-788
Author(s):  
Sri Lestari ◽  
Kunidah Kunidah
Keyword(s):  
Wound Healing ◽  
Wound Care ◽  
Healing Process ◽  
Care Patient ◽  
Sectio Caesarea ◽  
Wound Healing Process ◽  
P Value ◽  
Purposive Sampling ◽  
Healing Wound ◽  
Post Operation

Penyembuhan luka merupakan suatu proses yang kompleks karena berbagai kegiatan bio-seluler, bio-kimia terjadi berkesinambungan. Sifat penyembuhan pada semua luka sama, dengan variasinya bergantung pada lokasi, keparahan, dan luasnya cedera. Tujuan penelitian ini untuk mengetahui efektifitas antara perawatan luka menggunakan NaCl 0,9% dengan betadin terhadap proses penyembuhan luka post operasi pada pasien sectio caesarea. Penelitian ini merupakan jenis penelitian Quaisy Experimen. Dengan populasi seluruh pasien perawatan luka post operasi sectio caesarea yaitu 26, dan menggunakan teknik sampel purposive sampling dengan jumlah 13 responden setiap kelompok. Penelitian ini dilakukan di Rumah Sakit Ciremai Kota Cirebon. Hasil penelitian ini adalah perawatan luka post operasi sectio caesarea menggunakan NaCl 0,9% sebanyak 13 responden dengan proses penyembuhan luka ≤ 3 hari di dapatkan rata-rata 7,07. Dan hasil bivariate menunjukkan bahwa ada perbedaan antara efektifitas proses penyembuhan luka pada perawatan luka pasien post operasi sectio caesarea menggunakan NaCl 0,9% dengan nilai p value = 0,000 < (a=0,05).Kata kunci     : Proses penyembuhan luka, perawatan luka, NaCl 0,9%, Betadin ABSTRACTWound healing is a complex process because of the various activies of bio-chemical, bio-cell occurs continuosly. Wound healing properties on the all the same, with variations depending on the location, saverity, and the extent of the injury. The purpose of this reseach was to determine the effectiveness of wound care using NaCl 0,9 % with using betadin to wound healing process post operation on patients sectio caesarea. This research is a kind of the quaisy experimental. With a population of whole patients wound care post operatition sectio caesarea which is 26, and using the tecnique of purposive sampling with a total of 13 respondents per-group. The research was conducted at the ciremai hospital of cirebon city.The results of this research are wound care post operation sectio caesarea using NaCl 0,9% as much 13 respondents with the healing process of wound ≤ 3 days obtained of average 7,07. Bivariate and result showed the there is between the effectiveness of the process of wound healing in wound care patient post operation sectio caesarea using NaCl 0,9% with a value p = 0,000 < (a=0,05).Keywords      :     The process of wound healing, wound care, NaCl 0,9%, betadin

scholarly journals Effects of Strong Acidic Electrolyzed Water in Wound Healing via Inflammatory and Oxidative Stress Response

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Ailyn Fadriquela ◽  
Ma Easter Joy Sajo ◽  
Johny Bajgai ◽  
Dong-Heui Kim ◽  
Cheol-Su Kim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wound Healing ◽  
Growth Factor ◽  
Inflammatory Responses ◽  
Wound Care ◽  
Antioxidant Responses ◽  
Electrolyzed Water ◽  
Cutaneous Wounds ◽  
Wound Healing Effect ◽  
Factor Α

Strong acidic electrolyzed water (StAEW) is known to inactivate microorganisms but is not fully explored in the medical field. This study is aimed at exploring StAEW as a potential wound care agent and its mechanism. StAEW (pH: 2.65, ORP: 1159 mV, ACC: 32.1 ppm) was sprayed three times a day to the cutaneous wounds of hairless mice for seven days. Wound morphological and histological features and immune-redox markers were compared with saline- (Sal-) and alcohol- (Alc-) treated groups. Results showed that the StAEW group showed a significantly higher wound healing percentage than the Sal group on days 2, 4, 5, and 6 and the Alc group on day 4. The StAEW group also showed earlier mediation on proinflammatory cytokines such as tumor necrosis factor-α, interleukin- (IL-) 6, IL-1β, and keratinocyte chemoattractant. In addition, basic fibroblast growth factor and platelet-derived growth factor were found to be significantly changed in favor of the fibroblast synthesis and angiogenesis. In line, the StAEW group showed a controlled amount of ROS and significantly decreased compared to the Alc group. The StAEW group also favored oxidative stress balance through antioxidant responses. Additionally, matrix metalloproteinases (MMP) 9 and MMP1 were also modulated for keratinocyte and cell migration. Taken together, this study has proven the wound healing effect of StAEW and its earlier mediation through oxidative and inflammatory responses.

scholarly journals Disrupting the biofilm matrix improves wound healing outcomes

2015 ◽  
Vol 24 (8) ◽  
pp. 366-371 ◽  
Author(s):  
R. Wolcott
Keyword(s):  
Wound Healing ◽  
Extracellular Polymeric Substances ◽  
Wound Care ◽  
Controlled Trial ◽  
Standard Of Care ◽  
Surrogate Endpoint ◽  
Topical Antibiotics ◽  
Slime Layer ◽  
The Matrix ◽  
Biofilm Matrix

Objective: The most unyielding molecular component of biofilm communities is the matrix structure that it can create around the individual microbes that constitute the biofilm. The type of polymeric substances (polymeric sugars, bacterial proteins, bacterial DNA and even co-opted host substances) are dependent on the microbial species present within the biofilm. The extracellular polymeric substances that make up the matrix give the wound biofilm incredible colony defences against host immunity, host healing and wound care treatments. This polymeric slime layer, which is secreted by bacteria, encases the population of microbes, creating a physical barrier that limits the ingress of treatment agents to the bacteria. The aim of this study was to determine if degrading the wound biofilm matrix would improve wound healing outcomes and if so, if there was a synergy between treating agents that disrupted biofilm defenses with Next Science Wound Gel (wound gel) and cidal agents (topical antibiotics). Method: A three-armed randomised controlled trial was designed to determine if standard of care (SOC) was superior to SOC plus wound gel (SOC + gel) and wound gel alone. The wound gel used in this study contains components that directly attack the biofilm extracellular polymeric substance. The gel was applied directly to the wound bed on a Monday–Wednesday–Friday interval, either alone or with SOC topical antibiotics. Results: Using a surrogate endpoint of 50% reduction in wound volume, the results showed that SOC healed at 53%, wound gel healed at 80%, while SOC plus wound gel showed 93% of wounds being successfully treated. Conclusion: By directly targeting the wound biofilm matrix, wound healing outcomes are improved.

scholarly journals Novel Application of Immunomodulatory Mushroom Polysaccharide (β-Glucan) and Triterpenes for Diabetic Wound Care

2020 ◽  
Author(s):  
Shiu-Nan Chen ◽  
Yu-Sheng Wu ◽  
Sherwin Chen ◽  
Ya-Chin Chang ◽  
Chung-Lun Lu
Keyword(s):  
Wound Healing ◽  
Ganoderma Lucidum ◽  
Cellular Proliferation ◽  
Wound Care ◽  
Immunomodulatory Activity ◽  
Diabetic Patients ◽  
Medicinal Mushroom ◽  
Positive Effects ◽  
Inflammatory Status ◽  
Healing Wound

β-Glucan and triterpenes are two important derivative compounds from traditional medicinal mushroom, such as Ganoderma lucidum and Antrodia cinnamomea. β-glucan and triterpenes are considered to have immunoregulatory properties in disease treatment for long years. The immunoregulatory effects are usually activated through some transcription of pro-inflammatory genes and possess immunomodulatory activity. Difficulty in healing wound now is a common condition that occurred in diabetic patients, and the physiological hyperglycemic status of diabetic patients resulting in the wounds continue to produce an inflammatory response. Thus, we hope to use β-glucan and triterpenes for difficult wound healing that possess immunomodulatory activity on the wound micro-environment and stimulate the positive effects on healing. In this chapter, these two important derivative compounds from traditional medicinal mushroom were examined by diabetic mammal’s wound healing models. In these models, the skin wounds’ microenvironment is expected close to diabetic foot, suffering in hyperglycemic and inflammatory status. The results are clearly presented, with the immunomodulatory effects from mushroom β-glucan and triterpenes that involved in modulating the cell-mediated immune system to cause cellular proliferation and further to introduce healing performance of the chronic inflammation wounds.

scholarly journals Wound dressings: curbing inflammation in chronic wound healing

2021 ◽  
Author(s):  
Davide Vincenzo Verdolino ◽  
Helen A. Thomason ◽  
Andrea Fotticchia ◽  
Sarah Cartmell
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Chronic Wound ◽  
Wound Care ◽  
Healing Process ◽  
Standard Of Care ◽  
The Elderly ◽  
Wound Dressings ◽  
Wound Healing Process

Chronic wounds represent an economic burden to healthcare systems worldwide and a societal burden to patients, deeply impacting their quality of life. The incidence of recalcitrant wounds has been steadily increasing since the population more susceptible, the elderly and diabetic, are rapidly growing. Chronic wounds are characterised by a delayed wound healing process that takes longer to heal under standard of care than acute (i.e. healthy) wounds. Two of the most common problems associated with chronic wounds are inflammation and infection, with the latter usually exacerbating the former. With this in mind, researchers and wound care companies have developed and marketed a wide variety of wound dressings presenting different compositions but all aimed at promoting healing. This makes it harder for physicians to choose the correct therapy, especially given a lack of public quantitative data to support the manufacturers’ claims. This review aims at giving a brief introduction to the clinical need for chronic wound dressings, focusing on inflammation and evaluating how bio-derived and synthetic dressings may control excess inflammation and promote healing.

scholarly journals Advances in Nanotechnology towards Development of Silver Nanoparticle-Based Wound-Healing Agents

2021 ◽  
Vol 22 (20) ◽  
pp. 11272
Author(s):  
Zimkhitha B. Nqakala ◽  
Nicole R. S. Sibuyi ◽  
Adewale O. Fadaka ◽  
Mervin Meyer ◽  
Martin O. Onani ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Silver Nanoparticle ◽  
Broad Spectrum ◽  
Bacterial Resistance ◽  
Wound Care ◽  
Wound Treatment ◽  
Healing Wound ◽  
As Toxicity

Since antiquity, silver-based therapies have been used in wound healing, wound care and management of infections to provide adequate healing. These therapies are associated with certain limitations, such as toxicity, skin discolouration and bacterial resistance, which have limited their use. As a result, new and innovative wound therapies, or strategies to improve the existing therapies, are sought after. Silver nanoparticles (AgNPs) have shown the potential to circumvent the limitations associated with conventional silver-based therapies as described above. AgNPs are effective against a broad spectrum of microorganisms and are less toxic, effective at lower concentrations and produce no skin discolouration. Furthermore, AgNPs can be decorated or coupled with other healing-promoting materials to provide optimum healing. This review details the history and impact of silver-based therapies leading up to AgNPs and AgNP-based nanoformulations in wound healing. It also highlights the properties of AgNPs that aid in wound healing and that make them superior to conventional silver-based wound treatment therapies.

Experience of negative pressure wound therapy over sternal wound healing: A retrospective review

WCET Journal ◽  
2019 ◽  
Vol 39 (2) ◽  
pp. 9-18
Author(s):  
Wai Sze Ho ◽  
Wai Kuen Lee ◽  
Ka Kay Chan ◽  
Choi Ching Fong
Keyword(s):  
Wound Healing ◽  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
Assessment Tool ◽  
Wound Care ◽  
Wound Therapy ◽  
Treatment Pathways ◽  
Wound Assessment ◽  
One Year

Objectives The aim of this study was to retrospectively review the effectiveness of negative pressure wound therapy (NPWT) in sternal wound healing with the use of the validated Bates-Jensen Wound Assessment Tool (BWAT), and explore the role of NPWT over sternal wounds and future treatment pathways. Methods Data was gathered from patients' medical records and the institution's database clinical management system. Seventeen subjects, who had undergone cardiothoracic surgeries and subsequently consulted the wound care team in one year were reviewed. Fourteen of them were included in the analysis. Healing improvement of each sternal wound under continuous NPWT and continuous conventional dressings was studied. In total, 23 continuous NPWT and 13 conventional dressing episodes were analysed with the BWAT. Results Among conventional dressing episodes, sternal wound improvement was 2.5–3% over 10 days to 3.5 weeks, whereas 4–5% sternal healing was achieved in 5 days to 2 weeks with sternal wire presence. Better healing at 11% in 1 week by conventional dressing was attained after sternal wire removal. In NPWT episodes, 8–29%, 13–24%, and 15–46% of healing was observed in 2 weeks, 3.5 to 5 weeks and 6 to 7 weeks, respectively. Only 39% wound healing was acquired at the 13th week of NPWT in one subject. With sternal wire present, 6%–29% wound healing progress was achieved by NPWT in 1–4 weeks, and 16–23% wound improvement in 2 to 4.5 weeks by NWPT after further surgical debridement. After sternal wire removal, 6–34% sternal wound healing occurred by continuous NPWT for 1–2 weeks, and maximum healing at 46% after 2.5 weeks of NPWT were observed. Conclusions Better wound healing was achieved in the NPWT group in comparison to conventional dressings alone. However, suboptimal sternal wound healing by NPWT alone was observed. Removal of sternal wire may improve the effectiveness of NPWT. Successful tertiary closure after NPWT among subjects supports the important bridging role of NPWT in sternal wound healing. Factors causing stagnant sternal wound healing by NPWT alone are discussed.

Short Report: The Moisture Balance with Aloe Vera Gel in Diabetic Wound Healing

2018 ◽  
Vol 1 (1) ◽  
pp. 21-23
Author(s):  
Fahrianto Selamet ◽  
Andi Mayasari Usman ◽  
Rian Adi Pamungkas
Keyword(s):  
Diabetes Mellitus ◽  
Wound Healing ◽  
Wound Care ◽  
Aloe Vera ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Short Report ◽  
Bacterial Reduction ◽  
Moisture Balance ◽  
Patients With Diabetes

Diabetic foot ulcer (DF) is a chronic complication of diabetes mellitus (DM), which impact on the morbidity, mortality and quality of patients’ lives.Of those patients with diabetes mellitus, approximately 15% to 25% developed to the foot ulcer. Beside has the infection and debridement of devitalized tissue downloading; the moisture imbalance becomes the factors of recalcitrant to healing. Moist wound healing is often contraindicated to the non-healable wounds. While wound care involves the debridement, bacterial reduction, and moisture balance in order to achieve the good granulation of the tissue development and adequate blood supply.

HUBUNGAN MOBILISASI DINI TERHADAP PENYEMBUHAN LUKA POST OPERASI SECTIO CESARIA

2019 ◽  
Vol 2 (1) ◽  
pp. 14-17
Author(s):  
Nurul Aini Siagian ◽  
Syafira Nusaibah ◽  
Andayani Boang Manalu
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Early Mobilization ◽  
Sectio Caesarea ◽  
Wound Healing Process ◽  
P Value ◽  
Cross Sectional ◽  
Care Services ◽  
Healing Wound ◽  
Rapid Healing

Early mobilization includes factors that can affect the process of wound healing after surgery. Immediate mobilization in stages is very useful for the process of healing wounds and preventing infection and venous thrombosis. The purpose of this study was to determine whether there is a relationship between early mobilization and the process of healing wound post operative sectio caesarea at Sinar Husni General Hospital Medan Helvetia. The research design used was analytic survey with cross sectional approach. The sample in this study used the Consecutive Sampling method of data collection using a checklist sheet conducted on a sample of 19 respondents. The results of the study in this study are the majority of respondents who did early mobilization and who experienced rapid wound healing process as many as 4 people (21%) while the minority of respondents who did early mobilization and who experienced slow wound healing process were 1 person (5.3%). The majority of respondents who did not mobilize early and who experienced a slow wound healing process were 11 people (57.9%) and a minority who did not mobilize early and who experienced rapid healing as many as 4 people (21.1%). Statistical test results obtained p value = 0.046 <0.005. The conclusions of the results of this study indicate there is a relationship between early mobilization and the process of healing post operative sectio of caesarea. Suggestions The results of this study can be applied as a reference to improve nursing care services, especially in providing counseling and assistance to patients.

Neonatal Intravenous Extravasation Injuries: Evaluation of a Wound Care Protocol

2006 ◽  
Vol 25 (1) ◽  
pp. 13-19 ◽  
Author(s):  
Doris Sawatzky-Dickson ◽  
Karen Bodnaryk
Keyword(s):  
Wound Healing ◽  
Birth Weight ◽  
Wound Infection ◽  
Gestational Age ◽  
Wound Care ◽  
Systemic Infection ◽  
Coagulase Negative Staphylococcus ◽  
Evidence Based ◽  
Infection Rates ◽  
Care Protocol

Purpose:To evaluate an evidence-based wound protocol for intravenous extravasation injuries in neonates.Sample:Nine newborns with intravenous extravasation injuries. Birth weight: 582–4,404 gm, gestational age: 24–40 weeks.Results:Five wounds were colonized with coagulase-negative Staphylococcus species, two with diphtheroids, three with Enterococcus. There was no evidence of wound infection or systemic infection. Rates of wound healing ranged from one to six weeks.

Sign in / Sign up

Export Citation Format

Share Document