The Effect of Glycerin Content in Sodium Alginate/Poly(vinyl alcohol)-Based Hydrogels for Wound Dressing Application

The impact of different amounts of glycerin, which was used in the system of sodium alginate/poly(vinyl alcohol) (SA/PVA) hydrogel materials on the properties, such as gel fraction, swelling ability, degradation in simulated body fluids, morphological analysis, and elongation tests were presented. The study shows a significant decrease in the gel fraction from 80.5 ± 2.1% to 45.0 ± 1.2% with the increase of glycerin content. The T5 values of the tested hydrogels were varied and range from 88.7 °C to 161.5 °C. The presence of glycerin in the matrices significantly decreased the thermal resistance, which was especially visible by T10 changes (273.9 to 163.5 °C). The degradation tests indicate that most of the tested materials do not degrade throughout the incubation period and maintain a constant ion level after 7-day incubation. The swelling abilities in distilled water and phosphate buffer solution are approximately 200–300%. However, we noticed that these values decrease with the increase in glycerin content. All tested matrices are characterized by the maximum elongation rate at break in a range of 37.6–69.5%. The FT-IR analysis exhibits glycerin changes in hydrogel structures, which is associated with the cross-linking reaction. Additionally, cytotoxicity results indicate good adhesion properties and no toxicity towards normal human dermal fibroblasts.

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Drug-loaded ultrafine poly(vinyl alcohol) fibre mats prepared by electrospinning

e-Polymers ◽

10.1515/epoly.2005.5.1.750 ◽

2005 ◽

Vol 5 (1) ◽

Cited By ~ 4

Author(s):

Chunxue Zhang ◽

Xiaoyan Yuan ◽

Lili Wu ◽

Jing Sheng

Keyword(s):

Drug Release ◽

Photoelectron Spectroscopy ◽

Vinyl Alcohol ◽

Phosphate Buffer Solution ◽

Poly Vinyl Alcohol ◽

High Porosity ◽

Buffer Solution ◽

Drug Molecules ◽

Alcohol Fibre

AbstractSubmicron poly(vinyl alcohol) (PVA) fibre mats embedded with Aspirin and bovine serum albumin (BSA) were prepared by electrospinning of their aqueous solutions. Fibre morphology was investigated by scanning electron microscopy. The composition of the fibre mats was characterized by Fourier transform IR spectroscopy and X-ray photoelectron spectroscopy. The in vitro drug release was investigated by immersing the fibre mats in phosphate buffer solution at 37°C. Results indicated that the morphology of fibre mats was influenced by the amount of drug, and more beaded and irregularly shaped fibres were found with increasing drug amounts. There were drug molecules distributed on the surface of the PVA fibres. Studies of in vitro drug release showed that both Aspirin and BSA were released more quickly from PVA fibre mats than from PVA films because of the large surface area and high porosity of the fibre mats.

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Computer simulation and comparative study on the pervaporation separation characteristics of sodium alginate and its blend membranes with poly(vinyl alcohol) to separate aqueous mixtures of 1,4-dioxane or tetrahydrofuran

Journal of Applied Polymer Science ◽

10.1002/app.21143 ◽

2004 ◽

Vol 94 (4) ◽

pp. 1827-1840 ◽

Cited By ~ 22

Author(s):

Tejraj M. Aminabhavi ◽

B. Vijaya Kumar Naidu ◽

S. Sridhar

Keyword(s):

Computer Simulation ◽

Comparative Study ◽

Sodium Alginate ◽

Vinyl Alcohol ◽

Poly Vinyl Alcohol ◽

Aqueous Mixtures ◽

Blend Membranes ◽

Pervaporation Separation

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Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels

Molecules ◽

10.3390/molecules26082381 ◽

2021 ◽

Vol 26 (8) ◽

pp. 2381

Author(s):

Katarzyna Bialik-Wąs ◽

Ewelina Królicka ◽

Dagmara Malina

Keyword(s):

Sodium Alginate ◽

Aqueous Extract ◽

Vinyl Alcohol ◽

Crosslinking Agent ◽

Echinacea Purpurea ◽

Poly Vinyl Alcohol ◽

Spectra Analysis ◽

Natural Origin ◽

Glycol Diacrylate ◽

Soxhlet Apparatus

Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin. First, an aqueous extract of Echinacea purpurea was prepared using a Soxhlet apparatus. Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution. The compositions of SA/PVA/E. purpurea-based hydrogels contained a polymer of natural origin—sodium alginate (SA, 1.5% solution)—and a synthetic polymer—poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)—in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea—5, 10, 15 or 20% (v/v). Additionally, the release behavior of echinacoside from the polymeric matrix was evaluated in phosphate-buffered saline (PBS) at 37 °C. The results indicate that the type of the crosslinking method has a direct impact on the release profile. Consequently, it is possible to design a system that delivers an active substance in a way that depends on the application.

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Controlled mechanical and swelling properties of poly(vinyl alcohol)/sodium alginate blend hydrogels prepared by freeze-thaw followed by Ca2+ crosslinking

Journal of Applied Polymer Science ◽

10.1002/app.35083 ◽

2011 ◽

Vol 124 (1) ◽

pp. 823-831 ◽

Cited By ~ 40

Author(s):

Liang Xie ◽

Man Jiang ◽

Xiaogang Dong ◽

Xia Bai ◽

Jin Tong ◽

...

Keyword(s):

Sodium Alginate ◽

Vinyl Alcohol ◽

Poly Vinyl Alcohol ◽

Swelling Properties ◽

Freeze Thaw

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Preparation and thermally induced adhesion properties of a poly(vinyl alcohol)-g-N-isopropylacrylamide copolymer membrane

Reactive and Functional Polymers ◽

10.1016/j.reactfunctpolym.2012.04.006 ◽

2012 ◽

Vol 72 (7) ◽

pp. 438-445 ◽

Cited By ~ 11

Author(s):

Jing Yang ◽

Dao-Dao Hu ◽

Hui Zhang

Keyword(s):

Vinyl Alcohol ◽

Poly Vinyl Alcohol ◽

Adhesion Properties ◽

Thermally Induced

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Preparation of sodium alginate-poly (vinyl alcohol) blend beads for base-triggered release of dinotefuran in Spodoptera litera midgut

Ecotoxicology and Environmental Safety ◽

10.1016/j.ecoenv.2020.110935 ◽

2020 ◽

Vol 202 ◽

pp. 110935 ◽

Cited By ~ 1

Author(s):

Shiying Wang ◽

Qianli Ma ◽

Ruifei Wang ◽

Qizhan Zhu ◽

Liupeng Yang ◽

...

Keyword(s):

Sodium Alginate ◽

Vinyl Alcohol ◽

Poly Vinyl Alcohol ◽

Triggered Release

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Design and Characterization of Sodium Alginate and Poly(vinyl) Alcohol Hydrogels for Enhanced Skin Delivery of Quercetin

Pharmaceutics ◽

10.3390/pharmaceutics12121149 ◽

2020 ◽

Vol 12 (12) ◽

pp. 1149

Author(s):

Ludovico Esposito ◽

Ana Isabel Barbosa ◽

Tânia Moniz ◽

Sofia Costa Lima ◽

Paulo Costa ◽

...

Keyword(s):

Antioxidant Activity ◽

Sodium Alginate ◽

Vinyl Alcohol ◽

Fruits And Vegetables ◽

Radical Scavenging ◽

Entrapment Efficiency ◽

Interesting Property ◽

Poly Vinyl Alcohol ◽

Skin Delivery ◽

Potential Applications

Nature has led to the discovery of biopolymers with noteworthy pharmaceutical applications. Blended biopolymers have demonstrated promising characteristics when compared with their individual counterparts. Sodium alginate (SA) is a marine polymer that has demonstrated the ability to form hydrogels, an interesting property for the development of cutaneous formulations. Predicting the good performance of blended biopolymers, a novel series of hybrid hydrogels based on SA and poly(vinyl) alcohol (PVA) were prepared. Quercetin, a natural polyphenolic flavonoid commonly found in fruits and vegetables, is widely known for its strong anti-inflammatory and antioxidant activity, thus with potential applications against melanoma, dermatitis, psoriasis, and skin ageing. Here, hydrogels were produced at different ratios of SA and PVA. The surface morphology, structure, interaction of polymers, the capacity to absorb water and the entrapment efficiency of quercetin were evaluated for the blended hydrogels. Targeting the cutaneous application of the formulations, the rheological properties of all unloaded and quercetin-loaded hydrogels revealed pseudoplastic behavior, evidence of non-thixotropy, good resistance to deformation, and profile maintenance with temperatures ranging from 20 °C up to 40 °C. The incorporation of quercetin in the hydrogel retained its antioxidant activity, confirmed by radical scavenging assays (ABTS and DPPH). The permeability of quercetin through the skin showed different penetration/permeation profiles according to the hydrogel’s blend. This behavior will allow the selection of SA-PVA at 2/1 ratio for a local and prolonged skin effect, making the use of these hydrogels a good solution to consider for the treatment of skin ageing and inflammation.

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