Current Evidence on Long-Term Prognostic Factors in Vasospastic Angina

Vasospastic angina (VSA) is characterized by a reversible spasm of the coronary arteries and is more prevalent in Asians. Vasodilators, such as calcium channel blockers, are effective in relieving coronary spasms and preventing clinical events. Therefore, the prognosis of VSA is generally known to be better than for significant organic stenosis caused by atherosclerosis. However, coronary vasospasm is sometimes associated with fatal complications such as sudden death, ventricular arrhythmia, and myocardial infarction. Thus, it is very important to identify and actively treat high-risk patients to prevent VSA complications. Here, we will review clinical factors associated with long-term prognosis in patients with VSA.

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Elevated CK-MB values after routine angioplasty predicts worse long-term prognosis in low-risk patients

Scandinavian Cardiovascular Journal ◽

10.3109/14017430903171230 ◽

2010 ◽

Vol 44 (2) ◽

pp. 69-75 ◽

Cited By ~ 2

Author(s):

Kjell Vikenes ◽

Tor Melberg ◽

Mikael Farstad ◽

Jan Erik Nordrehaug

Keyword(s):

Low Risk ◽

Risk Patients ◽

Long Term Prognosis

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Effect of insulin resistance associated with compensatory hyperinsulinemia on the long-term prognosis in patients with vasospastic angina

International Journal of Cardiology ◽

10.1016/j.ijcard.2012.06.016 ◽

2013 ◽

Vol 167 (5) ◽

pp. 2222-2227 ◽

Cited By ~ 11

Author(s):

Akihiro Nakagomi ◽

Yoshiyuki Saiki ◽

Munenori Kosugi ◽

Keiichi Kohashi ◽

Yoshitomo Yoshikawa ◽

...

Keyword(s):

Insulin Resistance ◽

Vasospastic Angina ◽

Long Term Prognosis

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Impact of Stent Type on the Long-Term Prognosis of Patients With Vasospastic Angina　― Can We Judge a Stent Just by Its Cover? ―

Circulation Journal ◽

10.1253/circj.cj-17-1342 ◽

2018 ◽

Vol 82 (2) ◽

pp. 328-329

Author(s):

Hiroto Suzuyama ◽

Tomohiro Sakamoto ◽

Koich Nakao

Keyword(s):

Vasospastic Angina ◽

Stent Type ◽

Long Term Prognosis

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Clinical factors associated with long-term benefit in patients with metastatic renal cell carcinoma treated with axitinib: Real-world AXILONG study

Clinical Genitourinary Cancer ◽

10.1016/j.clgc.2021.09.006 ◽

2021 ◽

Author(s):

Álvaro Pinto ◽

Oscar Reig ◽

Clara Iglesias ◽

Enrique Gallardo ◽

Xavier García-del Muro ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Metastatic Renal Cell Carcinoma ◽

Real World ◽

Renal Cell ◽

Clinical Factors ◽

Factors Associated ◽

Term Benefit

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Long-term prognosis and factors associated with damage accrual in Japanese patients with systemic lupus erythematosus

Clinical and Experimental Nephrology ◽

10.1007/s10157-017-1491-9 ◽

2017 ◽

Vol 22 (3) ◽

pp. 597-602 ◽

Cited By ~ 7

Author(s):

Yoko Wada ◽

Hisashi Hasegawa ◽

Takako Saeki ◽

Satoshi Ito ◽

Takeshi Kuroda ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Japanese Patients ◽

Systemic Lupus ◽

Factors Associated ◽

Damage Accrual ◽

Long Term Prognosis

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Clinical Factors Associated with a Shorter or Longer Course of Antibiotic Treatment in Patients with Exacerbations of Bronchiectasis: A Prospective Cohort Study

Journal of Clinical Medicine ◽

10.3390/jcm8111950 ◽

2019 ◽

Vol 8 (11) ◽

pp. 1950

Author(s):

Giulia Scioscia ◽

Rosanel Amaro ◽

Victoria Alcaraz-Serrano ◽

Albert Gabarrús ◽

Patricia Oscanoa ◽

...

Keyword(s):

Antibiotic Therapy ◽

Antibiotic Treatment ◽

Prospective Observational Study ◽

Antibiotic Use ◽

Community Acquired Pneumonia ◽

Clinical Factors ◽

Treatment Results ◽

Factors Associated ◽

Long Term Oxygen Therapy

Background: Bronchiectasis exacerbations are often treated with prolonged antibiotic use, even though there is limited evidence for this approach. We therefore aimed to investigate the baseline clinical and microbiological findings associated with long courses of antibiotic treatment in exacerbated bronchiectasis patients. Methods: This was a bi-centric prospective observational study of bronchiectasis exacerbated adults. We compared groups receiving short (≤14 days) and long (15–21 days) courses of antibiotic treatment. Results: We enrolled 191 patients (mean age 72 (63, 79) years; 108 (56.5%) females), of whom 132 (69%) and 59 (31%) received short and long courses of antibiotics, respectively. Multivariable logistic regression of the baseline variables showed that long-term oxygen therapy (LTOT), moderate–severe exacerbations, and microbiological isolation of Pseudomonas aeruginosa were associated with long courses of antibiotic therapy. When we excluded patients with a diagnosis of community-acquired pneumonia (n = 49), in the model we found that an etiology of P. aeruginosa remained as factor associated with longer antibiotic treatment, with a moderate and a severe FACED score and the presence of arrhythmia as comorbidity at baseline. Conclusions: Decisions about the duration of antibiotic therapy should be guided by clinical and microbiological assessments of patients with infective exacerbations.

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Predictors of thromboprophylaxis in hospitalised medical patients

Thrombosis and Haemostasis ◽

10.1160/th14-06-0525 ◽

2015 ◽

Vol 113 (05) ◽

pp. 1127-1134 ◽

Cited By ~ 5

Author(s):

David Spirk ◽

Mathieu Nendaz ◽

Drahomir Aujesky ◽

Daniel Hayoz ◽

Jürg H. Beer ◽

...

Keyword(s):

Cohort Study ◽

Venous Thromboembolism ◽

High Risk ◽

Risk Score ◽

Low Risk ◽

Medical Patients ◽

Clinical Factors ◽

Thromboembolic Risk ◽

Factors Associated ◽

Risk Patients

summaryBoth, underuse and overuse of thromboprophylaxis in hospitalised medical patients is common. We aimed to explore clinical factors associated with the use of pharmacological or mechanical thromboprophylaxis in acutely ill medical patients at high (Geneva Risk Score ≥ 3 points) vs low (Geneva Risk Score < 3 points) risk of venous thromboembolism. Overall, 1,478 hospitalised medical patients from eight large Swiss hospitals were enrolled in the prospective Explicit ASsessment of Thromboembolic RIsk and Prophylaxis for Medical PATients in SwitzErland (ESTIMATE) cohort study. The study is registered on ClinicalTrials. gov, number NCT01277536. Thromboprophylaxis increased stepwise with increasing Geneva Risk Score (p< 0.001). Among the 962 high-risk patients, 366 (38 %) received no thromboprophylaxis; cancer-associated thrombocytopenia (OR 4.78, 95 % CI 2.75–8.31, p< 0.001), active bleeding on admission (OR 2.88, 95 % CI 1.69–4.92, p< 0.001), and thrombocytopenia without cancer (OR 2.54, 95 % CI 1.31–4.95, p=0.006) were independently associated with the absence of prophylaxis. The use of thromboprophylaxis declined with increasing severity of thrombocytopenia (p=0.001). Among the 516 low-risk patients, 245 (48 %) received thromboprophylaxis; none of the investigated clinical factors predicted its use. In conclusion, in acutely ill medical patients, bleeding and thrombocytopenia were the most important factors for the absence of thromboprophylaxis among highrisk patients. The use of thromboprophylaxis among low-risk patients was inconsistent, without clearly identifiable predictors, and should be addressed in further research.

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