scholarly journals Predictive Factors for Massive Transfusion in Trauma: A Novel Clinical Score from an Italian Trauma Center and German Trauma Registry

2020 ◽  
Vol 9 (10) ◽  
pp. 3235
Author(s):  
Sara Giulia Cornero ◽  
Marc Maegele ◽  
Rolf Lefering ◽  
Claudia Abbati ◽  
Shailvi Gupta ◽  
...  
Keyword(s):  
Trauma Registry ◽  
Massive Transfusion ◽  
Damage Control ◽  
Area Under The Curve ◽  
Clinical Score ◽  
Limb Amputation ◽  
Predictive Score ◽  
Trauma Patients ◽  
Early Management ◽  
Critical Bleeding

Early management of critical bleeding and coagulopathy can improve patient survival. The aim of our study was to identify independent predictors of critical bleeding and to build a clinical score for early risk stratification. A prospective analysis was performed on a cohort of trauma patients with at least one hypotensive episode during pre-hospital (PH) care or in the Emergency Department (ED). Patients who received massive transfusion (MT+) (≥4 blood units during the first hour) were compared to those who did not (MT−). Hemodynamics, Glagow Coma Score (GCS), diagnostics and blood tests were evaluated. Using multivariate analysis, we created and validated a predictive score for MT+ patients. The predictive score was validated on a matched cohort of patients of the German Trauma Registry TR-DGU. One hundred thirty-nine patients were included. Independent predictors of MT+ included a prehospital (PH) GCS of 3, PH administration of tranexamic acid, hypotension and tachycardia upon admission, coagulopathy and injuries with significant bleeding such as limb amputation, hemoperitoneum, pelvic fracture, massive hemothorax. The derived predictive score revealed an area under the curve (AUC) of 0.854. Massive transfusion is essential to damage control resuscitation. Altered GCS, unstable hemodynamics, coagulopathy and bleeding injuries can allow early identification of patients at risk for critical hemorrhage.

scholarly journals Development of a delirium predictive model for adult trauma patients in an emergency and critical care center: a retrospective study

2021 ◽  
Vol 6 (1) ◽  
pp. e000827
Author(s):  
Ayaka Matsuoka ◽  
Toru Miike ◽  
Mariko Miyazaki ◽  
Taku Goto ◽  
Akira Sasaki ◽  
...  
Keyword(s):  
Risk Factors ◽  
Scoring System ◽  
Validation Cohort ◽  
Care Center ◽  
Univariate Analysis ◽  
Area Under The Curve ◽  
Predictive Score ◽  
Calibration Plot ◽  
Trauma Patients ◽  
Time Of Admission

BackgroundDelirium has been shown to prolong the length of intensive care unit stay, hospitalization, and duration of ventilatory control, in addition to increasing the use of sedatives and increasing the medical costs. Although there have been a number of reports referring to risk factors for the development of delirium, no model has been developed to predict delirium in trauma patients at the time of admission. This study aimed to create a scoring system that predicts delirium in trauma patients.MethodsIn this single-center, retrospective, observational study, trauma patients aged 18 years and older requiring hospitalization more than 48 hours were included and divided into the development and validation cohorts. Univariate analysis was performed in the development cohort to identify factors significantly associated with prediction of delirium. The final scoring system for predicting delirium was developed using multivariate analysis and internal validation was performed.ResultsOf the 308 patients in the development cohort, 91 developed delirium. Clinical Frailty Score, fibrin/fibrinogen degradation products, low body mass index, lactate level, and Glasgow Coma Scale score were independently associated with the development of delirium. We developed a scoring system using these factors and calculated the delirium predictive score, which had an area under the curve of 0.85. In the validation cohort, 46 of 206 patients developed delirium. The area under the curve for the validation cohort was 0.86, and the calibration plot analysis revealed the scoring system was well calibrated in the validation cohort.DiscussionThis scoring system for predicting delirium in trauma patients consists of only five risk factors. Delirium prediction at the time of admission may be useful in clinical practice.Level of evidencePrognostic and epidemiological, level III.

Massive Transfusion in a Child

2013 ◽  
Author(s):  
Stefan Sabato
Keyword(s):  
Direct Evidence ◽  
Massive Transfusion ◽  
Damage Control ◽  
Damage Control Surgery ◽  
Supporting Evidence ◽  
Damage Control Resuscitation ◽  
Acute Hemorrhage ◽  
Early Management ◽  
Major Morbidity ◽  
The Core

The traditional early management of hemorrhagic shock is currently being challenged, and many centers around the world have already changed their practice. Damage-control resuscitation, in conjunction with damage-control surgery, has been shown to improve major morbidity and mortality outcomes in adults. In children there is little direct evidence for these new approaches, but supporting evidence is accumulating. This chapter will introduce these concepts while also reinforcing the core principles of managing acute hemorrhage in the trauma setting.

Outcomes after Massive Transfusion in Nontrauma Patients in the Era of Damage Control Resuscitation

2012 ◽  
Vol 78 (6) ◽  
pp. 679-684 ◽  
Author(s):  
Bryan C. Morse ◽  
Christopher J. Dente ◽  
Erica I. Hodgman ◽  
Beth H. Shaz ◽  
Anne Winkler ◽  
...  
Keyword(s):  
Trauma Center ◽  
Massive Transfusion ◽  
Damage Control ◽  
Underlying Disease ◽  
Base Deficit ◽  
Trauma Patients ◽  
Damage Control Resuscitation ◽  
Packed Red Blood Cells ◽  
Level I ◽  
Initial Base

There are little data regarding the use of massive transfusion protocols (MTP) outside of the trauma setting. This study compares the use of an MTP between trauma and non-trauma (NT) patients. Data were collected for trauma and NT patients from the prospectively maintained MTP database at a Level I trauma center over a 4-year period. Massive transfusion was defined as $ 10 units packed red blood cells (PRBCs) in a 24-hour period. Of 439 MTP activations, 37 (8%) were NT patients (64% male; mean age = 51 years, initial base deficit = -10.8). Activations were for gastrointestinal bleeding (n = 18), bleeding during surgery (n = 13), obstetrical complications (n = 5), and ruptured aortic aneurysm (n = 1). Over-activation of MTP (< 10 units PRBCs/24 hours) was higher in NT than trauma patients (19/37, 51% vs 118/284, 29%, P < 0.01). For massive transfusion patients, 24-hour mortality was higher in NT compared with trauma patients (10/17, 59% vs 100/284, 35%, P = 0.05), but there was no difference in 30-day mortality (10/17, 59% vs 144/284, 51%, P = 0.51). With over-activation in 51% of NT patients, MTP usage outside of trauma is inefficient. Outcomes in NT patients were worse than trauma patients, which may be related to the underlying disease processes.

scholarly journals Resusitasi Pengendalian Kerusakan Di Unit Perawatan Intensif

2021 ◽  
Vol 36 (2) ◽  
pp. 71-75
Author(s):  
Dhanu Pitra Arianto ◽  
Nurita Dian Kestriani
Keyword(s):  
Damage Control ◽  
Damage Control Surgery ◽  
Massive Bleeding ◽  
Trauma Patients ◽  
Damage Control Resuscitation ◽  
Early Management ◽  
Severe Haemorrhage ◽  
Lethal Triad ◽  
Clotting Cascade ◽  
Injured Patients

Abstrak Resusitasi dengan pengendalian kerusakanmenggambarkan suatu pendekatan ke perawatan awal pada pasien dengan cedera berat. Tujuan pendekatan ini untuk menjaga pasien tetap stabil dengan menghindari intervensi dan kondisi yang berisiko kepada keadaan perburukan dengan mengendalikan trias kematian, yaitu hipotermia, koagulopati, dan asidosis. Merupakan hal yang penting bahwa konsep dan kepraktisan pendekatan ini dipahami oleh semua yang terlibat dalam manajemen awal pasien trauma. Pendekatan ini dimulai dengan pemberian produk darah sejak awal, penghentian perdarahan dan pengembalian volume darah yang bertujuan untuk mengembalikan stabilitas fisiologis dengan cepat. Resusitasi dengan pengendalian kerusakan memilikibeberapa tambahan pendekatan dari bidang farmakologis dan laboratorium untuk meningkatkan perawatan pasien yang mengalami perdarahan. Pendekatan ini termasuk trombelastografi sebagai ukuran rinci kaskade pembekuan, asam traneksamat sebagai antifibrinolitik.   Kata kunci : hipotermia, koagulopati, asidosis, perdarahan masif     Damage Control Resuscitation in Intensive Care Unit   Abstract Damage control resuscitation (DCR) describes an approach to the early care of very seriously injured patients. The aim is to keep the patient alive whilst avoiding interventions and situations that risk worsening their situation by driving the lethal triad of hypothermia, coagulopathy and acidosis.It is critical that the concepts and practicalities of this approach are understood by all those involved in the early management of trauma patients. Damage control resuscitation forms part of an overall approach to patient care rather than a specific intervention and has evolved from damage control surgery. It is characterised by early blood product administration, haemorrhage arrest and restoration of blood volume aiming to rapidly restore physiologic stability. The infusion of large volumes of crystalloid is no longer appropriate, instead the aim is to replace lost blood and avoid dilution and coagulopathy. In specific situations, permissive hypotension may also be of benefit, particularly in patients with severe haemorrhage from an arterial source. Damage control resuscitation has been augmented by both pharmacologic and laboratory adjuncts to improve the care of the hemorrhaging patient. These include thrombelastography as a detailed measure of the clotting cascade, tranexamic acid as an antifibrinolytic.   Keywords: hypothermia, coagulopathy, acidosis, massive bleeding

scholarly journals High Interleukin-6 Plasma Concentration upon Admission Is Predictive of Massive Transfusion in Severely Injured Patients

2021 ◽  
Vol 10 (11) ◽  
pp. 2268
Author(s):  
Nadja Weichselbaum ◽  
Daniel Oberladstätter ◽  
Christoph J. Schlimp ◽  
Johannes Zipperle ◽  
Wolfgang Voelckel ◽  
...  
Keyword(s):  
Large Scale ◽  
Injury Severity ◽  
Massive Transfusion ◽  
Inflammatory Marker ◽  
Area Under The Curve ◽  
Youden Index ◽  
Severe Bleeding ◽  
Fibrinogen Concentration ◽  
Trauma Patients ◽  
Severely Injured

Severe bleeding remains a prominent cause of early in-hospital mortality in major trauma patients. Thus, prompt prediction of patients at risk of massive transfusion (MT) is crucial. We investigated the ability of the inflammatory marker interleukin (IL)-6 to forecast MT in severely injured trauma patients. IL-6 plasma levels were measured upon admission. Receiver operating characteristic curves (ROCs) were calculated, and sensitivity and specificity were determined. In this retrospective study, a total of 468 predominantly male (77.8%) patients, with a median injury severity score (ISS) of 25 (17–34), were included. The Youden index for the prediction of MT within 6 and 24 h was 351 pg/mL. Patients were dichotomized into two groups: (i) low-IL-6 < 350 pg/mL and (ii) high-IL-6 ≥ 350 pg/mL. IL-6 ≥ 350 pg/mL was associated with a lower prothrombin time index, a higher activated partial thromboplastin time, and a lower fibrinogen concentration compared with IL-6 < 350 pg/mL (p <0.0001 for all). Thromboelastometric parameters were significantly different between groups (p <0.03 in all). More patients in the high-IL-6 group received MT (p <0.0001). The ROCs revealed an area under the curve of 0.76 vs. 0.82 for the high-IL-6 group for receiving MT in the first 6 and 24 h. IL-6 ≥ 350 pg/mL predicted MT within 6 and 24 h with a sensitivity of 45% and 58%, respectively, and a specificity of 89%. IL-6 ≥ 350 pg/mL appears to be a reasonable early predictor for coagulopathy and MT within the first 6 and 24 h intervals. Large-scale prospective studies are warranted to confirm these findings.

scholarly journals Development of a Predictive Score for COVID-19 Diagnosis based on Demographics and Symptoms in Patients Attended at a Dedicated Screening Unit

2020 ◽  
Author(s):  
Alexandre P Zavascki ◽  
Marcelo B Gazzana ◽  
Joao Pedro Bidart ◽  
Patricia S Fernandes ◽  
Aline Galiotto ◽  
...  
Keyword(s):  
Area Under The Curve ◽  
High Specificity ◽  
Clinical Score ◽  
Cross Sectional Study ◽  
Predictive Score ◽  
Molecular Diagnostic ◽  
Stepwise Logistic Regression ◽  
Cross Sectional ◽  
Final Model ◽  
Screening Unit

Background: The diagnosis of COVID-19 based on clinical evaluation is difficult because symptoms often overlap with other respiratory diseases. A clinical score predictive of COVID-19 based on readily assessed variables may be useful in settings with restricted or no access to molecular diagnostic tests. Methods: A score based on demographics and symptoms was developed in a cross-sectional study including patients attended in a dedicated COVID-19 screening unit. A backward stepwise logistic regression model was constructed and values for each variable were assigned according to their β coefficient values in the final model. Receiver operating characteristic (ROC) curve was constructed and its area under the curve (AUC) was calculated. Results: A total of 464 patients were included: 98 (21.1%) COVID-19 and 366 (78.9%) non-COVID-19 patients. The score included variables independently associated with COVID-19 in the final model: age equal or above 60 years (2 points), fever (2), dyspnea (1), fatigue (1 point) and coryza (-1). Score values were significantly higher in COVID-19 than non-COVID-19 patients: median (Interquartile Range), 3 (2-4), and 1 (0-2), respectively; P<0.001. The score had an AUC of 0.80 (95% Confidence Interval [CI], 0.76-0.86). The specificity of scores equal or greater than 4 and 5 points were 90.4 (95%CI, 87.0-93.3) and 96.2 (95%CI, 93.7-97.9), respectively. Conclusions: This preliminary score based on patients symptoms is a feasible tool that may be useful in setting with restricted or no access to molecular tests in a pandemic period, owing to the high specificity. Further studies are required to validate the score in other populations.

Surgery in Traumatic Injury and Perioperative Considerations

2019 ◽  
Vol 46 (01) ◽  
pp. 073-082 ◽  
Author(s):  
Nicola Curry ◽  
Karim Brohi
Keyword(s):  
Damage Control ◽  
Traumatic Injury ◽  
Surgical Techniques ◽  
Injured Patient ◽  
Trauma Team ◽  
Current Approach ◽  
Trauma Patients ◽  
Early Management ◽  
Hemostatic Resuscitation ◽  
Life Threatening

AbstractA severely injured patient presents several unique challenges to an admitting trauma team. Not only must the extent of the patient's injuries, particularly those that are life-threatening, be determined within minutes of hospital arrival, but also the trauma team needs to be able to assess whether the patient is bleeding and/or has an attendant coagulopathy. Early management of trauma patients is dictated by the presence (or absence) of significant bleeding. Standard definitive surgical procedures can be conducted in hemodynamically stable patients, but those in hemorrhagic shock should be treated according to damage control resuscitation (DCR) principles. DCR is a practice that has evolved over the last two to three decades, combining limited surgical techniques, which provide early hemorrhage control, and balanced transfusion resuscitation strategies, which mitigate (and ideally) treat trauma-induced coagulopathy (TIC). This review describes the contemporary perioperative management of trauma patients who have significant bleeding and/or TIC and sets out the evidence around the current approach for hemostatic resuscitation in these patients.

scholarly journals The management of critical bleeding in obstetrics

2013 ◽  
Vol 4 (3S) ◽  
pp. 41-51
Author(s):  
Marcus D. Lancé
Keyword(s):  
Vaginal Delivery ◽  
Post Partum ◽  
Damage Control ◽  
Visual Assessment ◽  
Fresh Frozen Plasma ◽  
Severe Bleeding ◽  
Trauma Patients ◽  
Excessive Bleeding ◽  
Risk Of Death ◽  
Critical Bleeding

Post-partum hemorrhage (PPH) is one of the most frequent causes of maternal death: worldwide it contributes for a 25% of deaths. The risk of death from pregnancy complications has decreased dramatically over the last few decades, but several evidences show they have not yet been reduced to a minimum. There is therefore the need for a further improvement in the quality of medical care. Purpose of this paper is to briefly outline an overview of the definition of PPH, with an illustration of the possible causes and treatments currently available. WHO defined PPH as excessive bleeding > 500 ml after vaginal delivery and severe PPH as bleeding in excess of 1,000 ml after vaginal delivery, but a variety of definitions for PPH have been proposed, yet no single satisfactory definition exists. Another crucial item regards the estimation of blood loss, too often based on a visual assessment and, therefore, inaccurate and minimized. However, in medical literature there are no specific classifications for severe bleeding in obstetrics. During pregnancy there are several changes in coagulation state: because haemostatic reference intervals are generally based on samples from non-pregnant women, this can cause a further difficulty in doing an accurate diagnosis and treatment of haemostatic disorders during pregnancy. In the treatment of critical bleeding in trauma patients have been developed some new insights that may be applied, at least partially, in the management of bleeding patients in obstetrics. In recent years it has been developed an approach called “Damage control resuscitation”, which combines to the surgery a medical treatment aimed at correcting the underlying coagulopathy. This approach is based on three items: minimise use of crystalloids and colloids; optimise fresh frozen plasma (FFP) to red blood cells (RBC) ratio; make an appropriate use of antifibrinolitic agents, fibrinogen and cryoprecipitate.

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