Biomaterial Enhanced Regeneration Design Research for Skin and Load Bearing Applications

Biomaterial enhanced regeneration (BER) falls mostly under the broad heading of Tissue Engineering: the use of materials (synthetic and natural) usually in conjunction with cells (both native and genetically modified as well as stem cells) and/or biological response modifiers (growth factors and cytokines as well as other stimuli, which alter cellular activity). Although the emphasis is on the biomaterial as a scaffold it is also the use of additive bioactivity to enhance the healing and regenerative properties of the scaffold. Enhancing regeneration is both moving more toward regeneration but also speeding up the process. The review covers principles of design for BER as well as strategies to select the best designs. This is first general design principles, followed by types of design options, and then specific strategies for applications in skin and load bearing applications. The last section, surveys current clinical practice (for skin and load bearing applications) including limitations of these approaches. This is followed by future directions with an attempt to prioritize strategies. Although the review is geared toward design optimization, prioritization also includes the commercializability of the devices. This means a device must meet both the clinical performance design constraints as well as the commercializability design constraints.

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Mother?infant psychotherapy and perinatal psychiatry: current clinical practice and future directions

Australasian Psychiatry ◽

10.1111/j.1440-1665.2006.02309.x ◽

2006 ◽

Vol 14 (4) ◽

pp. 384-389

Author(s):

Megan Galbally ◽

Andrew Lewis ◽

Martien Snellen ◽

Campbell Paul ◽

Klara Szego ◽

...

Keyword(s):

Clinical Practice ◽

Current Clinical Practice ◽

Future Directions ◽

Perinatal Psychiatry

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Design for Disassembly and the rehabilitation of public housing stock. A case study

TECHNE - Journal of Technology for Architecture and Environment ◽

10.36253/techne-10596 ◽

2021 ◽

pp. 181-191

Author(s):

Lidia Errante ◽

Alberto De Capua

Keyword(s):

Public Housing ◽

Design Research ◽

Housing Stock ◽

Design For Disassembly ◽

Sustainable Building ◽

The Public ◽

Principles Of Design ◽

The One

This contribution presents the meta-design research scenario of the sustainable building redevelopment of the INA Casa “Sbarre Inferiori” district in Reggio Calabria based on a twofold reflection. On the one hand, the transformative potential, both technological and formal, of the public housing stock created under the INA Casa Plan. On the other, the extension of the life cycle of the buildings and the improvement of the spatial quality of the housing according to a circular, low-tech and ecological approach. The result is an abacus of technological additions in bio-xlam conceived according to the principles of Design for Disassembly, which allows the reuse of the modules in new spatial and functional configurations, and the remanufacturing and recycling of the elements at the end of their life.

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Progress on precise regulation of vascular intimal repair by surface coating of vascular stent

Current Drug Delivery ◽

10.2174/1567201818666210212100633 ◽

2021 ◽

Vol 18 ◽

Author(s):

Shihui Liu ◽

Junchao Zhi ◽

Shijie Li ◽

Zhuoyue Song ◽

Tao Gong ◽

...

Keyword(s):

Clinical Performance ◽

Biological Response ◽

Research Direction ◽

Vascular Stent ◽

Functional Layer ◽

Vascular Stents ◽

Drug Eluting ◽

Genetic Level ◽

Disease Related Gene

: In the past few decades, drug-eluting stents have made significant contributions to the treatment of coronary heart disease. However, due to the delayed healing of endothelial injuries caused by antiproliferative drugs and insufficient biocompatibility of vascular stent materials, late in-stent thrombosis and restenosis remain major challenges. Surface modification of cardiovascular materials to construct biological functional layer that can regulate the behavior of blood and vascular cells is an effective way to improve the clinical performance of vascular stents. This paper reviewed the common methods of surface bio-functional modification of cardiovascular materials, and especially proposed that take the advantage of the new concept of precision medicine, as well as the precise and orderly regulation properties of cardiovascular disease-related gene fragments on vascular biological response behavior, the construction of gene-eluting stents which can in-situ regulate vascular intimal repair at the molecular and genetic level will become an important research direction in the future.

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Rethinking Inside the Box:

IDEA JOURNAL ◽

10.37113/ideaj.vi0.155 ◽

2007 ◽

pp. 16-37

Author(s):

Andy Milligan ◽

Ed Hollis ◽

Alex Milton ◽

Drew Plunkett ◽

Frazer Hay ◽

...

Keyword(s):

Interior Design ◽

Design Education ◽

Design Research ◽

Design Thinking ◽

Discussion Paper ◽

Future Directions ◽

International Audience ◽

New Challenges ◽

The Uk ◽

The City

This discussion paper describes key findings from the international IFS (Interiors Forum Scotland) conference, ‘Thinking Inside the Box’, held at The Lighthouse, Scotland’s Centre for Architecture, Design and the City in March 2007. In conjunction with an historical overview of interior design education in the UK, the authors describe the intention behind the conference, outlining its origins, aims and ambitions. The Interior Forum Scotland’s lead role within the UK sector is discussed, as is its collaboration with the UK wide Interior Educators Council. Similarly, the IFS, in its first conference, is positioned against more established international interior design research communities, such as IDEA, (Interior Design / Interior Architecture Educators Association), amongst others. The authors speculate on the issues and themes highlighted by an international audience of interior design educators, researchers, authors and practitioners, and consider the future directions, challenges and issues driving interior design thinking internationally and design generally, and in particular, how these may influence the independent Scottish interior design sector. The paper and conference underpins interior design as an exceptionally broad and increasingly self confident spatial field, albeit one which operates within distinct interior frequencies from decoration to architecture. It also examines the ways in which interior design educators, organisations and practitioners are reclaiming, refining and redefining this field. Interior design’s initial co- architectural / pro-decorative role is placed into context against new environmental territories and new challenges.

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3D polymeric scaffolds for oral tissue regeneration

Revista Ciencias Veterinarias ◽

10.15359/rcv.37-3.10 ◽

2019 ◽

Vol 37 (3) ◽

pp. 28

Author(s):

Daniel Chavarría-Bolaños ◽

Diana Villalobos ◽

José Roberto Vega-Baudrit

Keyword(s):

Tissue Regeneration ◽

Clinical Performance ◽

Correct Diagnosis ◽

Three Dimensional ◽

Biological Response ◽

Active Role ◽

Innovative Idea ◽

Design Selection ◽

Selection Of ◽

The Ideal

A fundamental base of bioengineering and tissue regeneration is the selection and development of the scaffolds responsible for cell growth. However, finding the “ideal” scaffold depends not only on proposing an innovative idea, but also on considering multiple chemical, biological, and physical aspects that can be manipulated to optimize their future clinical performance. Multiple local variables (such as local inflammation, vascularity, tissue damage, immune response, among others), as well as systemic variables (diseases or concomitant treatments) can favor or affect the scaffold behavior in each case. The selection of the ideal scaffold for each case involves three indispensable steps: design, selection of manufacturing material, and visualization of the future biological function that each biomaterial will perform. The design is always a parallel process with the selection of the ideal biomaterial. Certain “light” scaffolds (such as membranes, hydrogels, or sponges) will require the use of polymers that allow their simple manipulation and early degradation, which in turn can favor the release of charged molecules previously included, obtaining an active scaffold known as drug delivery system. On the other hand, structural scaffolds that are prone to replace block compromised structures may need different designs and production techniques, where three-dimensional printing is included. All of these options should consider important aspects such as bioactivity, regenerative capacity, and biological response of the surrounding tissues. Some alternatives may induce greater cell adhesion and proliferation, while optimizing the osseointegration and healing processes. Other alternatives may play a more “active” role while promoting regeneration processes and controlling local infectious diseases or painful responses. In order to look for the best translational approach of the biomaterial, each option must be chosen with the correct diagnosis of the case to be treated.

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Cyberbullying

Handbook of Research on School Violence in American K-12 Education - Advances in Early Childhood and K-12 Education ◽

10.4018/978-1-5225-6246-7.ch013 ◽

2019 ◽

pp. 286-304

Author(s):

Michelle F. Wright

Keyword(s):

Risk Factors ◽

Social Work ◽

Children And Adolescents ◽

Design Research ◽

Prevalence Rates ◽

Mixed Design ◽

Research Methodologies ◽

Future Directions ◽

Research Findings

The purpose of this chapter is to examine cyberbullying among children and adolescents. This chapter is organized into six sections, including (1) explaining the definitions, technologies used, the role of anonymity, and prevalence rates of cyberbullying, (2) discussing the characteristics and risk factors associated with cyberbullying involvement, (3) reviewing research findings on the psychological and behavioral consequences resulting from cyberbullying involvement, (4) discussing solutions and recommendations, (5) exploring future directions, and (6) providing conclusions. The chapter will draw on qualitative, quantitative, and mixed-design research methodologies from psychology, sociology, social work, and criminology.

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Biological response to self-assembly of preadsorbed proteins at biointerfaces: significance, cellular activity and perspective

Materials Technology ◽

10.1179/1753555713y.0000000110 ◽

2013 ◽

Vol 29 (sup1) ◽

pp. B41-B48 ◽

Cited By ~ 6

Author(s):

R. D. K. Misra ◽

C. Nune

Keyword(s):

Self Assembly ◽

Biological Response ◽

Cellular Activity

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Tensile properties, tension–tension fatigue and biological response of polyetheretherketone–hydroxyapatite composites for load-bearing orthopedic implants

Biomaterials ◽

10.1016/s0142-9612(03)00028-0 ◽

2003 ◽

Vol 24 (13) ◽

pp. 2245-2250 ◽

Cited By ~ 246

Author(s):

M.S. Abu Bakar ◽

M.H.W. Cheng ◽

S.M. Tang ◽

S.C. Yu ◽

K. Liao ◽

...

Keyword(s):

Tensile Properties ◽

Biological Response ◽

Orthopedic Implants ◽

Load Bearing

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R2C2 in Action: Testing an Evidence-Based Model to Facilitate Feedback and Coaching in Residency

Journal of Graduate Medical Education ◽

10.4300/jgme-d-16-00398.1 ◽

2017 ◽

Vol 9 (2) ◽

pp. 165-170 ◽

Cited By ~ 30

Author(s):

Joan Sargeant ◽

Karen Mann ◽

Sarah Manos ◽

Ian Epstein ◽

Andrew Warren ◽

...

Keyword(s):

Internal Medicine ◽

Content Analysis ◽

Qualitative Study ◽

Design Research ◽

Residency Education ◽

Evidence Based ◽

Factors Influencing ◽

Collaborative Conversation ◽

Principles Of Design ◽

Evidence Based Model

ABSTRACT Background Feedback is increasingly seen as a collaborative conversation between supervisors and learners, where learners are actively and reflectively engaged with feedback and use it to improve. Based on this, and through earlier research, we developed an evidence- and theory-informed, 4-phase model for facilitating feedback and practice improvement—the R2C2 model (relationship, reaction, content, coaching). Objective Our goal was to explore the utility and acceptability of the R2C2 model in residency education, specifically for engaging residents in their feedback and in using it to improve, as well as the factors influencing its use. Methods This qualitative study used the principles of design research. We recruited residents and their supervisors in 2 programs, internal medicine and pediatrics. We prepared supervisors to use the R2C2 model during their regular midrotation and/or end-of-rotation feedback sessions with participating residents to discuss their progress and assessment reports. We conducted debriefing interviews with supervisors and residents after each session. We analyzed transcripts as a team using template and content analysis. Results Of 61 residents, 7 residents (11%) participated with their supervisors (n = 5). Schedules and sensitivity to feedback prevented broader enrollment. Supervisors found the structured R2C2 format useful. Residents and supervisors reported that the coaching phase was novel and helpful, and that the R2C2 model engaged both groups in collaborative, reflective, goal-oriented feedback discussions. Conclusions Participants found that using the R2C2 model enabled meaningful feedback conversations, identification of goals for improvement, and development of strategies to meet those goals.

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