scholarly journals S100A6, Calumenin and Cytohesin 2 as Biomarkers for Cutaneous Involvement in Systemic Sclerosis Patients: A Case Control Study

2021 ◽  
Vol 11 (5) ◽  
pp. 368
Author(s):  
Paul Balanescu ◽  
Eugenia Balanescu ◽  
Cristian Baicus ◽  
Anca Balanescu
Keyword(s):  
Systemic Sclerosis ◽  
Case Control Study ◽  
Digital Ulcers ◽  
Raynaud Phenomenon ◽  
Predictive Capacity ◽  
Age And Gender ◽  
Future Studies ◽  
Complement Level ◽  
And Gender ◽  
Control Study

Background: Systemic sclerosis (Ssc) is an autoimmune disease with incomplete known physiopathology. There is a high number of candidate proteomic biomarkers for Ssc that have not yet been confirmed on independent Ssc cohorts. The aim of the study was to confirm circulating S100A6, calumenin, and cytohesin 2 as biomarkers for Ssc. Methods: 53 Ssc patients and 26 age- and gender-matched controls were included. Serum S100A6, calumenin, and cytohesin 2 were evaluated with commercial ELISA kits. Associations between serum expression and clinical Ssc characteristics were evaluated. Results: Serum calumenin, S100A6, and cytohesin 2 were higher in Ssc patients compared to controls. Calumenin associated with extensive cutaneous fibrosis, frequency of Raynaud phenomenon, and low complement level, and had a tendency to be higher in Ssc patients with pulmonary fibrosis. S100A6 correlated with the number of active digital ulcers. Serum cytohesin 2 levels were higher in patients with teleangiectasia and associated with pulmonary artery pressure. Conclusions: Serum calumenin, S100A6, and cytohesin 2 were confirmed as biomarkers on an independent group of Ssc patients. Calumenin had the best predictive capacity for cutaneous Ssc manifestations. Future studies are needed to evaluate the prognostic value of these biomarkers and evaluate them as possible therapeutic targets.

scholarly journals Influence of Gender on Cardiac and Encephalic Inflammation in the Elderly with Cysticercosis: A Case Control Study

2012 ◽  
Vol 2012 ◽  
pp. 1-6
Author(s):  
Camila Lourencini Cavellani ◽  
Rosana Rosa Miranda Corrêa ◽  
Mara Lúcia Fonseca Ferraz ◽  
Laura Penna Rocha ◽  
Ana Carolina Guimarães Faleiros ◽  
...  
Keyword(s):  
Inflammatory Infiltrate ◽  
Case Control Study ◽  
The Elderly ◽  
Brain Parenchyma ◽  
Elderly Group ◽  
University Hospital ◽  
Evolutionary Stage ◽  
Age And Gender ◽  
And Gender ◽  
Control Study

Background. The present study explores the influence of the host’s age and gender upon the inflammatory infiltrate. We aimed to quantify the inflammatory infiltrate caused by cysticercosis, which is related to aging, in the heart and in the encephalon.Methods. 75 autopsy protocols with cysticercosis diagnosis from department of pathology at a university hospital from 1970 to 2008 were reviewed. Two groups were formed: elderly with cysticercosis and nonelderly with cysticercosis. We used KS-300 (Kontron-Zeiss) software for morphometric analysis of the inflammation.Results.The elderly had an average of3.1±2.5cysticerci, whereas the non-elderly had2.7±3.8parasites. The non-elderly group with cysticercosis had significantly more inflammation, both cardiac and encephalic, than the elderly group. The elderly females with cysticercosis had more cardiac and encephalic inflammation.Conclusions. In this study, we showed that the non-elderly had significantly more cardiac and encephalic inflammation than the elderly, and that such inflammatory infiltrate decreases with age and depends upon the evolutionary stage of the cysticercus. Furthermore, there are differences concerning gender in the intensity of the inflammatory response due to cysticerci in the heart and brain parenchyma during senescence. Even during this period, women continue to have a more intense response to the parasitosis.

scholarly journals Effects of Ninjurin 2 Polymorphisms on Susceptibility of Coronary Heart Disease 

2020 ◽  
Author(s):  
Yuping Yan ◽  
Xiaoyan Du ◽  
Xiaoxi liu ◽  
Jingjie Li ◽  
Zichao Xiong ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Case Control Study ◽  
Case Control ◽  
Nucleotide Polymorphisms ◽  
Age And Gender ◽  
Single Nucleotide ◽  
Chd Risk ◽  
And Gender ◽  
Control Study

Abstract Objective: The aim of this study was to explore the effects of NINJ2 polymorphisms on susceptibility of coronary heart disease (CHD).Methods: We conducted a case-control study with 499 CHD cases and 505 age- and sex- matched controls. Five single nucleotide polymorphisms (SNP) in NINJ2 (rs118050317, rs75750647, rs7307242, rs10849390 and rs11610368) were genotyped by Agena MassARRAY platform. Odd ratios (OR) and 95% confidence intervals (CI) were calculated using logistic regression to assess the association of NINJ2 polymorphism and CHD risk adjusting for age and gender..Results: NINJ2 rs118050317 significantly increased the risk of CHD in people over 60 years old (allele: P = 0.010; heterozygote: P = 0.016; dominant: P = 0.015; additive: P = 0.021) and women (allele: P = 0.026; heterozygote: P = 0.015; dominant: P = 0.018; additive: P = 0.030). Rs118050317 and rs7307242 were closely related to the risk of hypertension in CHD patients. Additionally, rs75750647 significantly increased diabetes risk in multiple models among CHD cases (allele: P = 0.014; homozygote: P = 0.037; heterozygote: P = 0.044; dominant: P = 0.019; additive: P = 0.013), whereas rs10849390 could protect CHD patients from diabetes in allele (P = 0.035), homozygote (P = 0.047) and additive (P = 0.037) models. We also observed two block (block 1: rs118050317 and rs75750647; block 2: rs7307242, rs10849390 and rs11610368) in NINJ2.Conclusion: Our results suggested that the relationships of NINJ2 polymorphisms and CHD risk were dependent on age, sex or complications.

scholarly journals Effects of Ninjurin 2 Polymorphisms on Susceptibility of Coronary Heart Disease

2020 ◽  
Author(s):  
Yuping Yan ◽  
Xiaoyan Du ◽  
Xiaoxi Liu ◽  
Jingjie Li ◽  
Zichao Xiong ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Case Control Study ◽  
Strong Relationship ◽  
Nucleotide Polymorphisms ◽  
Age And Gender ◽  
Single Nucleotide ◽  
Chd Risk ◽  
And Gender ◽  
Control Study

Abstract Objective The aim of this study was to explore the effects of NINJ2 polymorphisms on susceptibility of coronary heart disease (CHD). Methods We conducted a case-control study with 499 CHD cases and 505 age- and sex- matched controls. Five single nucleotide polymorphisms (SNP) in NINJ2 (rs118050317, rs75750647, rs7307242, rs10849390 and rs11610368) were genotyped by Agena MassARRAY platform. Odd ratios (OR) and 95% confidence intervals (CI) were calculated using logistic regression to assess the association of NINJ2 polymorphism and CHD risk adjusting for age and gender.. Results NINJ2 rs118050317 significantly increased CHD risk among people older than 60 years old (allele: P = 0.010; heterozygote: P = 0.016; dominant: P = 0.015; additive: P = 0.021) and women (allele: P = 0.026; heterozygote: P = 0.015; dominant: P = 0.018; additive: P = 0.030). Rs118050317 and rs7307242 had strong relationship with hypertension risk in CHD patients. Additionally, rs75750647 significantly increased diabetes risk in multiple models among cases (allele: P = 0.014; homozygote: P = 0.037; heterozygote: P = 0.044; dominant: P = 0.019; additive: P = 0.013), whereas rs10849390 could protect CHD patients from diabetes in allele ( P = 0.035), homozygote ( P = 0.047) and additive ( P = 0.037) models. We also observed two block (block 1: rs118050317 and rs75750647; block 2: rs7307242, rs10849390 and rs11610368) in NINJ2 . Conclusion Our results suggest that NINJ2 polymorphisms are associated with CHD risk.

scholarly journals Association of vitamin D and FGF23 with serum Ferritin in hypoparathyroid thalassemia, a case control study

2019 ◽  
Author(s):  
Forough Saki ◽  
azita salehifar ◽  
Seyed Reza Kassaee ◽  
Gholamhossein Ranjbar omrani
Keyword(s):  
Case Control Study ◽  
Fractional Excretion ◽  
Case Control ◽  
Beta Thalassemia ◽  
Phosphate Homeostasis ◽  
Intact Pth ◽  
Age And Gender ◽  
Parathyroid Function ◽  
And Gender ◽  
Control Study

Abstract Background:FGF23 controls serum l,25(OH)2D3 levels and phosphate homeostasis. This study evaluates the effects of Ferritin on intact PTH, FGF23 and l,25(OH)2D3 in patients with major thalassemia. It evaluates FGF23 changes in patients with hypoparathyroidism to clarify the interaction between FGF23 and PTH in the absence of proper PTH function in human. Methods:In this case-control study,25 patients with major-beta thalassemia with hypoparathyroidism and their age- and gender-matched patients with major-beta thalassemia having normal parathyroid function were enrolled. Biochemical studies assessed serum calcium, albumin phosphorus, alkaline phosphatase, PTH, FGF23, 25(OH)D, 1,25(OH)2D3, Ferritin and Fractional excretion of phosphorous. Results:FGF23 was higher in the patients with hypoparathyroidism compared to controls(p=0.002). Fractional excretion of phosphorous was lower in patients with hypoparathyroidism, despite of high FGF23(p=0.001). There was a correlation between serum1,25(OH)2D3 and FGF23 with ferritin in the controls(P=<0.001and P=<0.001,respectively). Conclusions: The present study suggested that rise in FGF23 in patients with thalassemia, may be due to either stimulating effect of PTH and 1,25(OH)2D3 on FGF23 production, or might be direct stimulating effect of ferritin. It seems that in hypoparathyroid patients with insufficient PTH action, the FGF23 is not able to exert its full function in reducing serum phosphorus level by its phosphaturic action.

scholarly journals Association between Serum Adiponectin and Atrial Fibrillation: A Case-Control Study Stratified by Age and Gender

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Tongjian Zhu ◽  
Zhuo Wang ◽  
Songyun Wang ◽  
Wei Hu ◽  
Hui Chen ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Regression Analysis ◽  
Case Control Study ◽  
Multivariate Logistic Regression Analysis ◽  
Case Control ◽  
Serum Adiponectin ◽  
Multivariate Logistic Regression ◽  
Age And Gender ◽  
And Gender ◽  
Control Study

Background. Circulating adiponectin has been suggested to be associated with atrial fibrillation (AF). However, whether the association differs by age and gender remains unknown. We performed a case-control study to evaluate the above association. Methods. AF patients who underwent 24-hour long-range 12-channel electrocardiogram examination at our center were included in this study, and people with normal sinus rhythm (NSR) were included as controls. All participants underwent echocardiography and heart rate variability tests. Biochemical parameters and adiponectin levels were also evaluated. Receiver operating characteristic (ROC) analyses were used to determine the predictive efficacy of adiponectin for AF, and multivariate logistic regression analysis was performed to evaluate the potential independent predictors of AF. Results. Overall, 84 patients with AF and 84 people with NSR were included. Serum adiponectin was significantly higher in AF patients compared to that in controls ( P < 0.001 ). ROC analysis showed that higher serum adiponectin (>6.098 μg/mL) had predictive efficacy for AF, with an area under the curve of 0.660 (95% confidence interval [CI]: 577–0.742). The results of multivariate logistic regression analysis showed that higher adiponectin was an independent predictor of AF in the overall participants (odds ratio [OR] 1.224, 95% CI 1.018–1.471, P = 0.032 ). Subgroup analysis showed that higher adiponectin was independently associated with AF in women (OR 1.893, 95% CI 1.160–3.089, P = 0.011 ) and in patients aged < 65 years (OR 1.453, 95% CI 1.023–2.064, P = 0.037 ), but not in men or those aged ≥ 65 years. Conclusions. Higher serum adiponectin level was independently associated with higher odds for AF in women and in participants <65 years old, but not in men or those aged ≥65 years.

scholarly journals CYP3A4 and CYP11A1 Variants are Risk Factors for Ischemic Stroke: a Case Control Study

2019 ◽  
Author(s):  
Ning Gao ◽  
Hong Tang ◽  
Ling Gao ◽  
Guolong Tu ◽  
Han Luo ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Case Control Study ◽  
Density Lipoprotein ◽  
Case Control ◽  
Nucleotide Polymorphisms ◽  
Chinese Han ◽  
Age And Gender ◽  
Single Nucleotide ◽  
And Gender ◽  
Control Study

Abstract Background This study aimed to investigate the roles of CYP3A4 and CYP11A1 variants in ischemic stroke (IS) susceptibility among the Han Chinese population. Methods 477 patients with IS and 493 healthy controls were enrolled. Seven single-nucleotide polymorphisms (SNPs) of CYP3A4 and CYP11A1 were genotyped by Agena MassARRAY. Odds ratio (OR) and 95% confidence intervals (CI) were calculated by logistic regression adjusted for age and gender. Results We found that CYP3A4 rs3735451 (OR = 0.81, p = 0.039) and rs4646440 (OR = 0.72, p = 0.021) polymorphisms decreased the risk of IS. CYP3A4 rs4646440 (OR = 0.74, p = 0.038) and CYP11A1 rs12912592 (OR = 1.58, p = 0.034) polymorphisms were correlated with IS risk in males. CYP3A4 rs3735451 (OR = 0.63, p = 0.031) and rs4646440 (OR = 0.57, p = 0.012) possibly weaken the IS susceptibility at age > 61 years. Besides, CYP3A4 rs4646437 (OR = 0.59, p = 0.029), CYP11A1 rs12912592 (OR = 1.84, p = 0.017) and rs28681535 (OR = 0.66, p = 0.038) were associated with IS risk at age ≤ 61 years. CYP11A1 rs28681535 TT genotype was higher high-density lipoprotein cholesterol level than the GT and GG genotype (p = 0.027). Conclusions Our findings indicated that rs3735451, rs4646440, rs4646437 in CYP3A4 and rs28681535 in CYP11A1 might be protective factors for IS, while CYP11A1 rs12912592 polymorphism be a risk factor for IS in Chinese Han population.

scholarly journals Effect of Socioeconomic Status on Risk of Developing COVID-19: a Community-based Case-control Study

2021 ◽  
Author(s):  
Hüseyin Küçükali ◽  
Osman Hayran ◽  
Şeyda İleri ◽  
Berkay Kurt ◽  
Fatmanur Kuru ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Case Control Study ◽  
Case Control ◽  
Community Based ◽  
Age And Gender ◽  
Individual Level ◽  
The Mean ◽  
And Gender ◽  
The Relationship ◽  
Control Study

Abstract BackgroundMost of the studies regarding the relationship between socioeconomic status and occurrence of COVID-19 are usually ecological studies and have limitations due to ecological fallacy. The aim of this study is to investigate the relationship between socioeconomic status and individual-level risk of developing COVID-19.MethodsWe conducted a community-based, age and gender matched, case-control study in a district of Istanbul. The case group was defined as all confirmed COVID-19 cases (n=232) that were reported to the district health directorate in a week of August 2020. Control group was defined as people who were matched with cases in terms of age and gender and selected randomly from the directory of the same primary care provider in the district in 1:1 ratio. Participants were communicated via telephone. The socioeconomic status score was measured by Turkish Socioeconomic Status Index which considers three dimensions of it: education, occupation, and income.Results168 cases (72.4% response) and 168 controls are included in the study. 48.8% of participants are female and the mean age is 37.66±15.32 for each group. The mean socioeconomic status score is 70.28±7.09 for cases and 69.25±7.46 for controls (p=0.201). 15.2% (n=25) of cases and 22.4% (n=37) of controls is in lower socioeconomic status group (p=0.091). Neither bivariate nor logistic regression analysis revealed a statistically significant difference between study groups.ConclusionsOur findings indicate that socioeconomic status is not a significant predictor of COVID-19 occurrence at individual-level. The disease seems to be a common threat to all individuals of the global community.

Effect of Age and Gender on Quality of Life in patients of Obstructive Jaundice

2021 ◽  
Vol 15 (12) ◽  
pp. 3150-3151
Author(s):  
Farhana Memon ◽  
Ashfaque Ahmed ◽  
Saima Sagheer ◽  
Fariya Usmani ◽  
Muhammad Naveed ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Obstructive Jaundice ◽  
Case Control Study ◽  
Sampling Technique ◽  
Age And Gender ◽  
Sf 36 ◽  
And Gender ◽  
Effect Of Age ◽  
Control Study

Aim: Effect of age and gender on quality of life in patients of obstructive jaundice. Methodology: This was a case control study conducted in OPD of General Surgery, Unit-1, Civil Hospital, Karachi. It is non-probability, consecutive sampling technique. The sample size was 195 subjects. 87 patients had an age between 18-60 years whereas 108 patients had >60 years of age. Either gender was included. QoL was measured by using SF-36 based on 8 domains. Data were analyzed through SPSS version-21 Results: Significant effect of age in obstructive jaundice patients on their QOL (p<0.01) where patients aged from 18 to 60 years had significantly higher SF-36 quality of life scores, both overall and in all eight individual domains than patients aged >60 years. Gender of the obstructive jaundice patients did not have a significant effect on their QOL, though the female patients had higher SF-36 quality of life scores, both overall and in all eight individual domains. Conclusion: Quality of life of obstructive jaundice patients were more improved with the age between 20-60 years than age >60 years, whereas gender had no significant impact on the quality of life. Keywords: Obstructive jaundice, age, gender, quality of life

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