scholarly journals Predicting Venous Thrombosis in Osteoarthritis Using a Machine Learning Algorithm: A Population-Based Cohort Study

2022 ◽  
Vol 12 (1) ◽  
pp. 114
Author(s):  
Chao Lu ◽  
Jiayin Song ◽  
Hui Li ◽  
Wenxing Yu ◽  
Yangquan Hao ◽  
...  
Keyword(s):  
Machine Learning ◽  
Cohort Study ◽  
High Risk ◽  
Venous Thrombosis ◽  
Learning Algorithm ◽  
Population Based ◽  
Joint Disease ◽  
Recursive Feature Elimination ◽  
Machine Learning Algorithm ◽  
Interpretable Machine Learning

Osteoarthritis (OA) is the most common joint disease associated with pain and disability. OA patients are at a high risk for venous thrombosis (VTE). Here, we developed an interpretable machine learning (ML)-based model to predict VTE risk in patients with OA. To establish a prediction model, we used six ML algorithms, of which 35 variables were employed. Recursive feature elimination (RFE) was used to screen the most related clinical variables associated with VTE. SHapley additive exPlanations (SHAP) were applied to interpret the ML mode and determine the importance of the selected features. Overall, 3169 patients with OA (average age: 66.52 ± 7.28 years) were recruited from Xi’an Honghui Hospital. Of these, 352 and 2817 patients were diagnosed with and without VTE, respectively. The XGBoost algorithm showed the best performance. According to the RFE algorithms, 15 variables were retained for further modeling with the XGBoost algorithm. The top three predictors were Kellgren–Lawrence grade, age, and hypertension. Our study showed that the XGBoost model with 15 variables has a high potential to predict VTE risk in patients with OA.

scholarly journals Physically interpretable machine learning algorithm on multidimensional non-linear fields

2021 ◽  
Vol 428 ◽  
pp. 110074
Author(s):  
Rem-Sophia Mouradi ◽  
Cédric Goeury ◽  
Olivier Thual ◽  
Fabrice Zaoui ◽  
Pablo Tassi
Keyword(s):  
Machine Learning ◽  
Learning Algorithm ◽  
Machine Learning Algorithm ◽  
Interpretable Machine Learning ◽  
Non Linear

scholarly journals Ability of a Machine Learning Algorithm to Predict the Need for Perioperative Red Blood Cells Transfusion in Pelvic Fracture Patients: A Multicenter Cohort Study in China

2021 ◽  
Vol 8 ◽  
Author(s):  
Xueyuan Huang ◽  
Yongjun Wang ◽  
Bingyu Chen ◽  
Yuanshuai Huang ◽  
Xinhua Wang ◽  
...  
Keyword(s):  
Machine Learning ◽  
Cohort Study ◽  
Random Forest ◽  
Blood Cells ◽  
Nearest Neighbor ◽  
Learning Algorithm ◽  
Kappa Coefficient ◽  
Gradient Boosting ◽  
Machine Learning Algorithm ◽  
K Nearest Neighbor

Background: Predicting the perioperative requirement for red blood cells (RBCs) transfusion in patients with the pelvic fracture may be challenging. In this study, we constructed a perioperative RBCs transfusion predictive model (ternary classifications) based on a machine learning algorithm.Materials and Methods: This study included perioperative adult patients with pelvic trauma hospitalized across six Chinese centers between September 2012 and June 2019. An extreme gradient boosting (XGBoost) algorithm was used to predict the need for perioperative RBCs transfusion, with data being split into training test (80%), which was subjected to 5-fold cross-validation, and test set (20%). The ability of the predictive transfusion model was compared with blood preparation based on surgeons' experience and other predictive models, including random forest, gradient boosting decision tree, K-nearest neighbor, logistic regression, and Gaussian naïve Bayes classifier models. Data of 33 patients from one of the hospitals were prospectively collected for model validation.Results: Among 510 patients, 192 (37.65%) have not received any perioperative RBCs transfusion, 127 (24.90%) received less-transfusion (RBCs < 4U), and 191 (37.45%) received more-transfusion (RBCs ≥ 4U). Machine learning-based transfusion predictive model produced the best performance with the accuracy of 83.34%, and Kappa coefficient of 0.7967 compared with other methods (blood preparation based on surgeons' experience with the accuracy of 65.94%, and Kappa coefficient of 0.5704; the random forest method with an accuracy of 82.35%, and Kappa coefficient of 0.7858; the gradient boosting decision tree with an accuracy of 79.41%, and Kappa coefficient of 0.7742; the K-nearest neighbor with an accuracy of 53.92%, and Kappa coefficient of 0.3341). In the prospective dataset, it also had a food performance with accuracy 81.82%.Conclusion: This multicenter retrospective cohort study described the construction of an accurate model that could predict perioperative RBCs transfusion in patients with pelvic fractures.

scholarly journals Machine Learning Approaches for Early Prediction of Gestational Diabetes Mellitus Based on Prospective Cohort Study

2021 ◽  
Author(s):  
Jingyuan Wang ◽  
Xiujuan Chen ◽  
Yueshuai Pan ◽  
Kai Chen ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Machine Learning ◽  
Cohort Study ◽  
Gestational Diabetes ◽  
Learning Algorithm ◽  
Training Dataset ◽  
Machine Learning Algorithm ◽  
Early Prediction ◽  
Test Dataset ◽  
Svm Model

Abstract Purpose: To develop and verify an early prediction model of gestational diabetes mellitus (GDM) using machine learning algorithm.Methods: The dataset collected from a pregnant cohort study in eastern China, from 2017 to 2019. It was randomly divided into 75% as the training dataset and 25% as the test dataset using the train_test_split function. Based on Python, four classic machine learning algorithm and a New-Stacking algorithm were first trained by the training dataset, and then verified by the test dataset. The four models were Logical Regression (LR), Random Forest (RT), Artificial Neural Network (ANN) and Support Vector Machine (SVM). The sensitivity, specificity, accuracy, and area under the Receiver Operating Characteristic Curve (AUC) were used to analyse the performance of models.Results: Valid information from a total of 2811 pregnant women were obtained. The accuracies of the models ranged from 80.09% to 86.91% (RF), sensitivities ranged from 63.30% to 81.65% (SVM), specificities ranged from 79.38% to 97.53% (RF), and AUCs ranged from 0.80 to 0.82 (New-Stacking).Conclusion: This paper successfully constructed a New-Stacking model theoretically, for its better performance in specificity, accuracy and AUC. But the SVM model got the highest sensitivity, the SVM model was recommends as the prediction model for clinical.

Uncovering the Most Important Factors for Predicting Sexual Desire using Interpretable Machine Learning

2020 ◽  
Author(s):  
Laura Marika Vowels ◽  
Matthew J Vowels ◽  
Kristen P Mark
Keyword(s):  
Machine Learning ◽  
Random Forest ◽  
Sexual Desire ◽  
Learning Algorithm ◽  
Predictor Variable ◽  
Machine Learning Algorithm ◽  
Societal Factors ◽  
Interpretable Machine Learning ◽  
Several Variables ◽  
Two Samples

Previous studies have found a number of individual, relational, and societal factors that are associated with sexual desire. However, no studies to date have examined which of these variables are the most predictive of sexual desire. We used a machine learning algorithm, random forest (a type of interpretable highly non-linear decision tree), to predict sexual desire from a large number of predictors across two samples (N = 1846; includes 754 individuals forming 377 couples). We also used a Shapley value technique to estimate the size and direction of the effect of each predictor variable on the model outcome. The model predicted around 40% of variance in dyadic and solitary desire with women’s desire being more predictable than men’s. Several variables consistently predicted sexual desire including individual, relational, and societal factors. The study provides the strongest evidence to date of the most important predictors for dyadic and solitary desire.

Sign in / Sign up

Export Citation Format

Share Document