scholarly journals A Novel Voltametric Measurements of Beta Blocker Drug Propranolol on Glassy Carbon Electrode Modified with Carbon Black Nanoparticles

Materials ◽  
2021 ◽  
Vol 14 (24) ◽  
pp. 7582
Author(s):  
Izabela Bargiel ◽  
Joanna Smajdor ◽  
Anna Górska ◽  
Beata Paczosa-Bator ◽  
Robert Piech
Keyword(s):  
Carbon Black ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Limit Of Detection ◽  
Supporting Electrolyte ◽  
Carbon Electrode ◽  
Freeze Dried ◽  
Carbon Black Nanoparticles ◽  
Relative Standard ◽  
Preconcentration Time

A new voltametric method for highly sensitive propranolol (PROP) determination was developed. A glassy carbon electrode modified with a hybrid material made of carbon black (CB) and Nafion was used as the working electrode. The preconcentration potential and time were optimized (550 mV and 15 s), as well as the supporting electrolyte (0.1 mol L−1 H2SO4). For 15 s preconcentration time, linearity was achieved in the range 0.5–3.5 μmol L−1 and for 120 s in 0.02–0.14 μmol L−1. Based on the conducted calibration (120 s preconcentration time) limit of detection (LOD) was calculated and was equal to 7 nmol L−1. To verify the usefulness of the developed method, propranolol determination was carried out in real samples (tablets and freeze-dried urine). Recoveries were calculated and were in the range 92–102%, suggesting that the method might be considered as accurate. The repeatability of the signal expressed as relative standard deviation (RSD) was equal to 1.5% (n = 9, PROP concentration 2.5 µmol L−1). The obtained results proved that the developed method for propranolol determination might be successfully applied in routine laboratory practice.

scholarly journals Nimesulide Determination on Carbon Black-Nafion Modified Glassy Carbon Electrode by Means of Adsorptive Stripping Voltammetry

2021 ◽  
Author(s):  
Marcelina Łysoń ◽  
Anna Górska ◽  
Beata Paczosa-Bator ◽  
Robert Piech
Keyword(s):  
Carbon Black ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Limit Of Detection ◽  
Stripping Voltammetry ◽  
Pulse Amplitude ◽  
Pharmaceutical Products ◽  
Carbon Electrode ◽  
Step Potential ◽  
Preconcentration Time

AbstractAdsorptive Stripping Voltammetric method for Nimesulide (NIM) determination was developed. As a working electrode, glassy carbon electrode (GCE) modified with carbon black and Nafion (CB-Nafion GCE) was used. All measurements were carried out in 0.1 M acetate buffer (pH 4.6). Conducted experiments allowed to optimize differential pulse voltammetry (DPV) instrumental parameters: sampling and waiting time ts = tw = 10 ms, step potential Es = 4 mV, and pulse amplitude ΔE = 50 mV. The best results were obtained for preconcentration potential and time equal to 400 mV and 20 s, respectively. Limit of detection was calculated and was equal to 0.14 µM for 20-s preconcentration time and 0.06 µM for 40-s preconcentration time. In order to prove the applicability of the developed method, concentration of nimesulide in pharmaceutical products was determined. Calculated recoveries were in the range 94–99%, which indicates that the method might be assumed as accurate. Coefficient of variation was equal to 5.0% (n = 7, NIM concentration 1 µM) Obtained results of NIM determination were in good agreement with the content declared by producers.

scholarly journals Electrochemical Behaviour of a Gold Film- Glassy Carbon Electrode for Determination of Chromium (VI)

2021 ◽  
Author(s):  
Nevila Broli ◽  
Loreta Vallja ◽  
Majlinda Vasjari
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Electrochemical Behaviour ◽  
Supporting Electrolyte ◽  
Anodic Stripping Voltammetry ◽  
Carbon Electrode ◽  
Modulation Amplitude ◽  
Chromium Vi ◽  
Relative Standard

A gold nanostructured film modified glassy carbon electrode (Aufilm/GCE) was developed for the determination of chromium (VI) in water sample. GCE was immersed into HAuCl4 solution (10-3M) and electrodeposition of thin gold layer was conducted at –0.4 V (vs Ag/AgCl) for 10 min. The strong affinity between Au and Cr species resulted with increasing of Cr (VI) signal, compared with the bare glassy carbon electrode. The electrodepositing time, type of supporting electrolyte, pH, the scan rate, modulation amplitude, and modulation time were optimized using differential pulse anodic stripping voltammetry (DP-ASV). The calibration graph using accumulation time of 120 s was linear from 10 to 120 µgL-1 with a sensitivity 1.3 x 10-2 µA/µgL-1. Under optimum experimental conditions, a good correlation coefficient R2=0.9971, and a low detection limit 5.5 µg/L Cr (VI) was obtained. The signal was reproducible with a relative standard deviation ±4.5 %. The developed Aufilm/GCE sensor was applied for the Cr (VI) determination of in sewage water samples.

scholarly journals Voltammetric determination of dopamine in the presence of ascorbic and uric acids using partial least squares regression: determination of dopamine in human urine and plasma

2009 ◽  
Vol 7 (3) ◽  
pp. 524-531 ◽  
Author(s):  
Morteza Bahram ◽  
Khalil Farhadi ◽  
Farzin Arjmand
Keyword(s):  
Least Squares ◽  
Partial Least Squares ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Limit Of Detection ◽  
Relative Standard Error ◽  
Carbon Electrode ◽  
Least Squares Regression ◽  
Relative Standard

AbstractA new differential pulse voltammetric method for dopamine determination at a bare glassy carbon electrode has been developed. Dopamine, ascorbic acid (AA) and uric acid (UA) usually coexist in physiological samples. Because AA and UA can be oxidized at potentials close to that of DA it is difficult to determine dopamine electrochemically, although resolution can be achieved using modified electrodes. Additionally, oxidized dopamine mediates AA oxidation and the electrode surface can be easily fouled by the AA oxidation product. In this work a chemometrics strategy, partial least squares (PLS) regression, has been applied to determine dopamine in the presence of AA and UA without electrode modification. The method is based on the electrooxidation of dopamine at a glassy carbon electrode in pH 7 phosphate buffer. The dopamine calibration curve was linear over the range of 1–313 μM and the limit of detection was 0.25 μM. The relative standard error (RSE %) was 5.28%. The method has been successfully applied to the measurement of dopamine in human plasma and urine.

scholarly journals Electroanalysis of Diazepam on Nanosize Conducting Poly (3-Methylthiophene) Modified Glassy Carbon Electrode

2014 ◽  
Vol 17 (3) ◽  
pp. 185-190 ◽  
Author(s):  
A. Lakshmi ◽  
G. Gopu ◽  
S. Thanikaikarasan ◽  
T. Mahalingam ◽  
Peggy Alvarez ◽  
...  
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Electrochemical Impedance ◽  
Limit Of Detection ◽  
Detection Sensitivity ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Peak Current ◽  
Real Sample Analysis ◽  
Relative Standard

A glassy carbon electrode (GCE) was modified with nanosize poly (3-methylthiophene) (P3MT) and used for the sensitive voltammetric determination of diazepam. The cyclic voltammetric response of the bare GCE was compared with the P3MT modified electrode. Electrochemical impedance response of diazepam on modified GCE was studied by various concentrations of diazepam from 0.2 μM to 0.6 μM. The poly (3-methylthiophene) modified glassy carbon electrode (P3MT/GCE) can greatly enhance the peak currents and the detection sensitivity of diazepam under optimal conditions. The quantitative analysis of diazepam was made by the DPSV method. The experimental results showed that the peak current increased with the increase in concentration of diazepam. A calibration was made, which indicated the linear dependence of peak current with concentration (ip = 13.31Conc. + 0.4359R2 = 0.9948) in the range od determination and ot was found to be good between 0.2 and 1.07 μg/L. The limit of detection was 0.1μg/mL. The reproducibility of the stripping signal was realized in terms of relative standard deviation for 6 identical measurements and was found to be 2.6%. The effect of interference of different cations and anions on the oxidation of diazepam was studied. Real sample analysis of diazepam was also studied through DPSV.

Application of a glassy carbon electrode modified with carbon black nanoparticles for highly sensitive voltammetric determination of quetiapine

2017 ◽  
Vol 9 (47) ◽  
pp. 6662-6668 ◽  
Author(s):  
M. Ławrywianiec ◽  
J. Smajdor ◽  
B. Paczosa-Bator ◽  
R. Piech
Keyword(s):  
Carbon Black ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Voltammetric Determination ◽  
Carbon Electrode ◽  
Quetiapine Fumarate ◽  
Carbon Black Nanoparticles ◽  
Highly Sensitive

A novel highly sensitive voltammetric quetiapine fumarate (QF) sensor based on a glassy carbon electrode (GCE) modified with carbon black nanoparticles (CB) was successfully developed.

scholarly journals Simultaneous electrochemical sensing of dihydroxy benzene isomers at cost-effective allura red polymeric film modified glassy carbon electrode

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Pattan-Siddappa Ganesh ◽  
Ganesh Shimoga ◽  
Seok-Han Lee ◽  
Sang-Youn Kim ◽  
Eno E. Ebenso
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Limit Of Detection ◽  
Tap Water ◽  
Differential Pulse ◽  
Oxidation Potential ◽  
Electrochemical Sensing ◽  
Carbon Electrode ◽  
Buffer Solution ◽  
Allura Red

Abstract Background A simple and simultaneous electrochemical sensing platform was fabricated by electropolymerization of allura red on glassy carbon electrode (GCE) for the interference-free detection of dihydroxy benzene isomers. Methods The modified working electrode was characterized by electrochemical and field emission scanning electron microscopy methods. The modified electrode showed excellent electrocatalytic activity for the electrooxidation of catechol (CC) and hydroquinone (HQ) at physiological pH of 7.4 by cyclic voltammetric (CV) and differential pulse voltammetric (DPV) techniques. Results The effective split in the overlapped oxidation signal of CC and HQ was achieved in a binary mixture with peak to peak separation of 0.102 V and 0.103 V by CV and DPV techniques. The electrode kinetics was found to be adsorption-controlled. The oxidation potential directly depends on the pH of the buffer solution, and it witnessed the transfer of equal number of protons and electrons in the redox phenomenon. Conclusions The limit of detection (LOD) for CC and HQ was calculated to be 0.126 μM and 0.132 μM in the linear range of 0 to 80.0 μM and 0 to 110.0 μM, respectively, by ultra-sensitive DPV technique. The practical applicability of the proposed sensor was evaluated for tap water sample analysis, and good recovery rates were observed. Graphical abstract Electrocatalytic interaction of ALR/GCE with dihydroxy benzene isomers.

scholarly journals Electrochemical Detection of Endosulfan Using an AONP-PANI-SWCNT Modified Glassy Carbon Electrode

Materials ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 723
Author(s):  
Kgotla K. Masibi ◽  
Omolola E. Fayemi ◽  
Abolanle S. Adekunle ◽  
Amal M. Al-Mohaimeed ◽  
Asmaa M. Fahim ◽  
...  
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Limit Of Detection ◽  
Modified Electrodes ◽  
Antimony Oxide ◽  
Current Response ◽  
Carbon Electrode ◽  
Trace Detection ◽  
Limit Of Quantification ◽  
Walled Carbon Nanotubes

This report narrates the successful application of a fabricated novel sensor for the trace detection of endosulfan (EDS). The sensor was made by modifying a glassy-carbon electrode (GCE) with polyaniline (PANI), chemically synthesized antimony oxide nanoparticles (AONPs), acid-functionalized, single-walled carbon nanotubes (fSWCNTs), and finally, the AONP-PANI-SWCNT nanocomposite. The electrochemical properties of the modified electrodes regarding endosulfan detection were investigated via cyclic voltammetry (CV) and square-wave voltammetry. The current response of the electrodes to EDS followed the trend GCE-AONP-PANI-SWCNT (−510 µA) > GCE-PANI (−59 µA) > GCE-AONPs (−11.4 µA) > GCE (−5.52 µA) > GCE-fSWCNTs (−0.168 µA). The obtained results indicated that the current response obtained at the AONP-PANI-SWCNT/GCE was higher with relatively low overpotential compared to those from the other electrodes investigated. This demonstrated the superiority of the AONP-PANI-SWCNT-modified GCE. The AONP-PANI-SWCNT/GCE demonstrated good electrocatalytic activities for the electrochemical reduction of EDS. The results obtained in this study are comparable with those in other reports. The sensitivity, limit of detection (LoD), and limit of quantification (LoQ) of AONP-PANI-SWCNT/GCE towards EDS was estimated to be 0.0623 µA/µM, 6.8 µM, and 20.6 µM, respectively. Selectivity, as well as the practical application of the fabricated sensor, were explored, and the results indicated that the EDS-reduction current was reduced by only 2.0% when interfering species were present, whilst average recoveries of EDS in real samples were above 97%.

scholarly journals Electrochemical Oxidation of Paracetamol Mediated byMgB2Microparticles Modified Glassy Carbon Electrode

2011 ◽  
Vol 8 (2) ◽  
pp. 553-560 ◽  
Author(s):  
Mohammed Zidan ◽  
Tan Wee Tee ◽  
A. Halim Abdullah ◽  
Zulkarnain Zainal ◽  
Goh Joo Kheng
Keyword(s):  
Cyclic Voltammetry ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Supporting Electrolyte ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Diffusion Controlled ◽  
Scan Rate ◽  
Degree Of Stability ◽  
A Current

A MgB2microparticles modified glassy carbon electrode (MgB2/GCE) was fabricated by adhering microparticles of MgB2onto the electrode surface of GCE. It was used as a working electrode for the detection of paracetamol in 0.1 M KH2PO4aqueous solution during cyclic voltammetry. Use of the MgB2/GCE the oxidation process of paracetamol with a current enhancement significantly by about 2.1 times. The detection limit of this modified electrode was found to be 30 μM. The sensitivity under conditions of cyclic voltammetry is significantly dependent on pH, supporting electrolyte, temperature and scan rate. The current enhancement observed in different electrolytic media varied in the following order: KH2PO4> KCl > K2SO4> KBr. Interestingly, the oxidation of paracetamol using modified GC electrode remain constant even after 15 cycling. It is therefore evident that the MgB2modifiedGCelectrode possesses some degree of stability. A slope of 0.52 dependent of scan rate on current indicates that the system undergoes diffusion-controlled process.

Sign in / Sign up

Export Citation Format

Share Document