scholarly journals Synthesis and Characterization of N,N,N-trimethyl-O-(ureidopyridinium)acetyl Chitosan Derivatives with Antioxidant and Antifungal Activities

Marine Drugs ◽  
2020 ◽  
Vol 18 (3) ◽  
pp. 163 ◽  
Author(s):  
Jingjing Zhang ◽  
Wenqiang Tan ◽  
Qing Li ◽  
Fang Dong ◽  
Zhanyong Guo
Keyword(s):  
Quaternary Ammonium ◽  
Water Solubility ◽  
Radical Scavenging ◽  
Antioxidant Property ◽  
Inhibitory Effect ◽  
Biological Properties ◽  
Chitosan Derivatives ◽  
Ammonium Group ◽  
Quaternary Ammonium Group ◽  
Radical Scavenging Ability

Chitosan is an active biopolymer, and the combination of it with other active groups can be a valuable method to improve the potential application of the resultant derivatives in food, cosmetics, packaging materials, and other industries. In this paper, a series of N,N,N-trimethyl-O-(ureidopyridinium)acetyl chitosan derivatives were synthesized. The combination of chitosan with ureidopyridinium group and quaternary ammonium group made it achieve developed water solubility and biological properties. The structures of chitosan and chitosan derivatives were confirmed by FTIR, 1H NMR spectra, and elemental analysis. The prepared chitosan derivatives were evaluated for antioxidant property by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging ability, hydroxyl radical scavenging ability, and superoxide radical scavenging ability. The results revealed that the synthesized chitosan derivatives exhibited improved antioxidant activity compared with chitosan. The chitosan derivatives were also investigated for antifungal activity against Phomopsis asparagus as well as Botrytis cinerea, and they showed a significant inhibitory effect on the selected phytopathogen. Meanwhile, CCK-8 assay was used to test the cytotoxicity of chitosan derivatives, and the results showed that most derivatives had low toxicity. These data suggested to develop analogs of chitosan derivatives containing ureidopyridinium group and quaternary ammonium group, which will provide a new kind of promising biomaterials having decreased cytotoxicity as well as excellent antioxidant and antimicrobial activity.

scholarly journals Water Extractable Phytochemicals from Peppers (Capsicumspp.) Inhibit Acetylcholinesterase and Butyrylcholinesterase Activities and Prooxidants Induced Lipid Peroxidation in Rat BrainIn Vitro

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Omodesola O. Ogunruku ◽  
Ganiyu Oboh ◽  
Ayokunle O. Ademosun
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Capacity ◽  
Radical Scavenging ◽  
Antioxidant Property ◽  
Inhibitory Effect ◽  
Dependent Manner ◽  
Significant Difference ◽  
Radical Scavenging Ability ◽  
Dose Dependent ◽  
Anticholinesterase Properties

Background. This study sought to investigate antioxidant capacity of aqueous extracts of two pepper varieties (Capsicum annuumvar.accuminatum(SM) andCapsicum chinense(RO)) and their inhibitory effect on acetylcholinesterase and butyrylcholinesterase activities.Methods. The antioxidant capacity of the peppers was evaluated by the 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical scavenging ability and ferric reducing antioxidant property. The inhibition of prooxidant induced lipid peroxidation and cholinesterase activities in rat brain homogenates was also evaluated.Results. There was no significant difference (P>0.05) in the total phenol contents of the unripe and ripeCapsicumspp. extracts. Ripe and unripe SM samples had significantly higher (P<0.05) ABTS*scavenging ability than RO samples, while the ripe fruits had significantly higher (P<0.05) ferric reducing properties in the varieties. Furthermore, the extracts inhibited Fe2+and quinolinic acid induced lipid peroxidation in rats brain homogenates in a dose-dependent manner. Ripe and unripe samples from SM had significantly higher AChE inhibitory abilities than RO samples, while there was no significant difference in the BuChE inhibitory abilities of the pepper samples.Conclusion. The antioxidant and anticholinesterase properties ofCapsicumspp. may be a possible dietary means by which oxidative stress and symptomatic cognitive decline associated with neurodegenerative conditions could be alleviated.

A Highly Active Aqueous Olefin Metathesis Catalyst Bearing a Quaternary Ammonium Group

ChemSusChem ◽  
2008 ◽  
Vol 1 (1-2) ◽  
pp. 103-109 ◽  
Author(s):  
Łukasz Gułajski ◽  
Anna Michrowska ◽  
Joanna Narożnik ◽  
Zuzanna Kaczmarska ◽  
Leszek Rupnicki ◽  
...  
Keyword(s):  
Quaternary Ammonium ◽  
Olefin Metathesis ◽  
Ammonium Group ◽  
Highly Active ◽  
Metathesis Catalyst ◽  
Quaternary Ammonium Group

scholarly journals A biocompatible betaine-functionalized polycation for coacervation

Soft Matter ◽  
2018 ◽  
Vol 14 (3) ◽  
pp. 387-395 ◽  
Author(s):  
Mintai P. Hwang ◽  
Xiaochu Ding ◽  
Jin Gao ◽  
Abhinav P. Acharya ◽  
Steven R. Little ◽  
...  
Keyword(s):  
Amino Acid ◽  
Quaternary Ammonium ◽  
Bacterial Activity ◽  
Complex Coacervation ◽  
Ammonium Group ◽  
Naturally Occurring ◽  
Quaternary Ammonium Group

Betaine, a naturally occurring amino acid, is conjugated onto a polyester backbone, in which the quaternary ammonium group imparts additional functionality to the resulting polycation (B-PED). B-PED demonstrates excellentin vitroandin vivobiocompatibility and is also assessed for its effect on angiogenesis, anti-bacterial activity, and complex coacervation.

Structure Investigations of Agonists of the Natural Neurotransmitter Acetylcholine II [1]. X-ray Structure Analysis of Trimethyl(4-oxopentyl)ammonium-chloride

1982 ◽  
Vol 37 (3-4) ◽  
pp. 282-288 ◽  
Author(s):  
Gieren Gieren ◽  
Michail Kokkinidis
Keyword(s):  
Crystal Structure ◽  
Ammonium Chloride ◽  
Structure Analysis ◽  
Quaternary Ammonium ◽  
Fourier Synthesis ◽  
Orthorhombic Space Group ◽  
X Ray ◽  
Ammonium Group ◽  
Significant Difference ◽  
Quaternary Ammonium Group

Abstract The crystal structure of Trimethyl(4-oxopentyl)ammonium-chloride ([(CH3)3N+-(CH2)3COCH3]Cl-) (1) was determined by an X-ray structure analysis. 1 crystallizes in the orthorhombic space group P212121 with a = 10.440 (3), b = 14.600 (9), c = 6.804 (9) Å and with four formula units per unit cell. The structure was solved by a Patterson and a successive Fourier synthesis. The least squares refinement yielded an R-value of 0.064 for 1077 observed reflections. The cation of 1 is derived from acetylcholine by replacement of the ester oxygen with a CH2 group. It shows a potent nicotinic activity and a significant difference in conformation as compared with acetylcholine. In the crystal structure the anions are oriented stereospecifically with respect to the tetrahedron of the quaternary ammonium group. The geometry of two triangles formed by the quaternary nitrogen atom, the oxygen atom of the carbonyl group, and by either of the two anions nearest to the quaternary ammonium group is characteristic for the nicotinic activity of 1.

Sign in / Sign up

Export Citation Format

Share Document