Serum Osteocalcin Level is Negatively Associated with Vascular Reactivity Index by Digital Thermal Monitoring in Kidney Transplant Recipients

Background and Objectives: Osteocalcin is the most abundant noncollagenous protein in bone matrix, which is considered a marker of bone formation. Previous studies indicate that circulating osteocalcin can be expressed by osteoblasts and even by osteoblast-like cells in vessel walls, and it is often associated with arterial stiffness. Our study aims to examine the potential association between osteocalcin levels and endothelial function among kidney transplant (KT) recipients. Materials and Methods: Fasting blood samples were obtained from 68 KT recipients. To measure the endothelial function and vascular reactivity index (VRI), a digital thermal monitoring test (VENDYS) was used. A commercial enzyme-linked immunosorbent assay kit was also utilized to measure serum total osteocalcin levels. In this study, a VRI of less than 1.0 indicated poor vascular reactivity; a VRI of 1.0–2.0 indicated intermediate vascular reactivity; and a VRI of 2.0 or higher indicated good vascular reactivity. Results: Our findings show that 8 KT recipients (11.8%) had poor vascular reactivity (VRI < 1.0), 26 (38.2%) had intermediate vascular reactivity (1.0 ≤ VRI < 2.0), and 34 (50%) had good vascular reactivity. Increased serum osteocalcin levels (p < 0.001) were found to be associated with poor vascular reactivity. Advanced age (r = −0.361, p = 0.002), serum alkaline phosphate level (r = −0.254, p = 0.037), and log-transformed osteocalcin levels (r = − 0.432, p < 0.001) were identified to be negatively correlated with VRI in KT recipients. Multivariable forward stepwise linear regression analysis revealed that the serum level of osteocalcin (β = −0.391, adjusted R2 change = 0.174; p < 0.001) and advanced age (β = −0.308, adjusted R2 change = 0.084; p = 0.005) were significantly and independently associated with VRI in KT recipients. Conclusions: Higher serum osteocalcin level was associated with lower VRI and poorer endothelial dysfunction among KT recipients.

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Serum Adipocyte Fatty Acid-Binding Protein Level is Negatively Associated with Vascular Reactivity Index Measured by Digital Thermal Monitoring in Kidney Transplant Patients

Metabolites ◽

10.3390/metabo9080159 ◽

2019 ◽

Vol 9 (8) ◽

pp. 159 ◽

Cited By ~ 2

Author(s):

Tai-Li Chen ◽

Ming-Che Lee ◽

Ching-Chung Ho ◽

Bang-Gee Hsu ◽

Jen-Pi Tsai

Keyword(s):

Fatty Acid ◽

Endothelial Function ◽

Kidney Transplant ◽

Vascular Reactivity ◽

Fatty Acid Binding Protein ◽

Reactivity Index ◽

Thermal Monitoring ◽

Fatty Acid Binding ◽

Negatively Associated ◽

Acid Binding Protein

Adipocyte fatty acid-binding protein (A-FABP) is abundantly found in mature adipocytes and is involved in cardiovascular disease. Our aim is to investigate the association between serum A-FABP levels and endothelial function among kidney transplant (KT) patients. Fasting blood samples were obtained from 80 KT patients. Serum A-FABP levels were measured using a commercially available enzyme immunoassay kit. Endothelial function and vascular reactivity index (VRI) were measured using digital thermal monitoring test. In this study, VRI < 1.0, VRI 1.0–1.9, and VRI ≥ 2.0 were defined as poor, intermediate, and good vascular reactivity, respectively. There were 12 (15.0%), 30 (37.5%), and 38 (47.5%) KT patients categorized as having poor, intermediate, and good vascular reactivity, respectively. Increased serum levels of alkaline phosphatase (p = 0.012), γ-glutamyltranspeptidase (GGT; p = 0.032), and A-FABP (p < 0.001) were associated with decreased vascular reactivity. Multivariable forward stepwise linear regression analysis revealed that age (β = −0.283, adjusted R2 change = 0.072; p = 0.003) and serum log-A-FABP level (β = −0.514, adjusted R2 change = 0.268; p < 0.001) were significantly associated with VRI values in KT patients. We concluded that serum fasting A-FABP level is negatively associated with VRI values and plays a role in endothelial dysfunction of KT patients.

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SP737Serum osteocalcin level is negatively associated with vascular reactivity index by digital thermal monitoring in kidney transplant patient

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfz103.sp737 ◽

2019 ◽

Vol 34 (Supplement_1) ◽

Author(s):

Lin Lin ◽

Liang-Te Chiu ◽

Ming-Che Lee ◽

Bang-Gee Hsu

Keyword(s):

Kidney Transplant ◽

Vascular Reactivity ◽

Transplant Patient ◽

Reactivity Index ◽

Kidney Transplant Patient ◽

Thermal Monitoring ◽

Negatively Associated ◽

Osteocalcin Level

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New Indices of Endothelial Function Measured by Digital Thermal Monitoring of Vascular Reactivity: Data from 6084 Patients Registry

International Journal of Vascular Medicine ◽

10.1155/2016/1348028 ◽

2016 ◽

Vol 2016 ◽

pp. 1-8 ◽

Cited By ~ 7

Author(s):

Morteza Naghavi ◽

Albert A. Yen ◽

Alex W. H. Lin ◽

Hirofumi Tanaka ◽

Stanley Kleis

Keyword(s):

Blood Pressure ◽

Endothelial Function ◽

Diastolic Blood Pressure ◽

Vascular Reactivity ◽

Cardiovascular Health ◽

Patient Characteristics ◽

Reactivity Index ◽

Thermal Monitoring ◽

Reactivity Measurement ◽

Large Patient

Background. Endothelial function is viewed as a barometer of cardiovascular health and plays a central role in vascular reactivity. Several studies showed digital thermal monitoring (DTM) as a simple noninvasive method to measure vascular reactivity that is correlated with atherosclerosis risk factors and coronary artery disease. Objectives. To further evaluate the relations between patient characteristics and DTM indices in a large patient registry. Methods. DTM measures were correlated with age, sex, heart rate, and systolic and diastolic blood pressure in 6084 patients from 18 clinics. Results. DTM vascular reactivity index (VRI) was normally distributed and inversely correlated with age (r=-0.21, p<0.0001). Thirteen percent of VRI tests were categorized as poor vascular reactivity (VRI < 1.0), 70 percent as intermediate (1.0 ≤ VRI < 2.0), and 17 percent as good (VRI ≥ 2.0). Poor VRI (<1.0) was noted in 6% of <50 y, 10% of 50–70 y, and 18% of ≥70 y. In multiple linear regression analyses, age, sex, and diastolic blood pressure were significant but weak predictors of VRI. Conclusions. As the largest database of finger-based vascular reactivity measurement, this report adds to prior findings that VRI is a meaningful physiological marker and reflects a high level of residual risk found in patients currently under care.

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Serum Galectin-3 Level Is Positively Associated with Endothelial Dysfunction in Patients with Chronic Kidney Disease Stage 3 to 5

Toxins ◽

10.3390/toxins13080532 ◽

2021 ◽

Vol 13 (8) ◽

pp. 532

Author(s):

Bang-Gee Hsu ◽

Chih-Hsien Wang ◽

Yu-Hsien Lai ◽

Jen-Pi Tsai

Keyword(s):

Chronic Kidney Disease ◽

Endothelial Dysfunction ◽

Kidney Disease ◽

Endothelial Function ◽

Vascular Reactivity ◽

Chronic Kidney Disease Stage ◽

Disease Stage ◽

Reactivity Index ◽

Enzyme Linked Immunosorbent Assay ◽

Galectin 3

Galectin-3, which is a novel biomarker of cardiovascular stress and related to inflammation, could predict adverse cardiovascular events. However, its relationship with endothelial function in patients with chronic kidney disease (CKD) remains inconclusive. This study aimed to investigate the association between serum galectin-3 levels and endothelial function in patients with stages 3–5 CKD. Fasting blood samples were obtained from 130 patients. Serum galectin-3 levels were determined using the enzyme-linked immunosorbent assay. The endothelial function, demonstrated as a vascular reactivity index (VRI), was measured noninvasively through digital thermal monitoring test. Then, we sorted the patients into poor, intermediate, and good vascular reactivity (VRI < 1.0, 1.0 ≤ VRI < 2.0, and VRI ≥ 2.0), accounting for 24 (18.5%), 44 (33.8%), and 62 (47.7%) patients, respectively. As the VRI decreased, the serum galectin-3 and C-reactive protein (CRP) levels significantly increased. The galectin-3 value positively correlated with the CRP value but negatively correlated with estimated glomerular filtration rate. In multivariable stepwise linear regression analysis, serum log-transformed galectin-3 level and log-transformed CRP were significantly negatively associated with VRI values. Therefore, galectin-3 together with CRP is associated with VRI values and is a potential endothelial function modulator and a valuable biomarker of endothelial dysfunction in patients with CKD.

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Abstract P111: Sleep duration is associated with serum osteocalcin level in an elderly Korean population: the Korean Urban and Rural Elderly (KURE) study

Circulation ◽

10.1161/circ.129.suppl_1.p111 ◽

2014 ◽

Vol 129 (suppl_1) ◽

Author(s):

Ju-Mi Lee ◽

Hansol Choi ◽

Kyung Min Kim ◽

YooSik Youm ◽

Yumie Rhee ◽

...

Keyword(s):

Bone Formation ◽

Sleep Duration ◽

Linear Regression Analysis ◽

Korean Population ◽

Health Examination ◽

Central Research ◽

Serum Osteocalcin ◽

Cross Sectional ◽

Osteocalcin Level ◽

Serum Osteocalcin Level

Importance: Association between sleep duration and health related outcome studies have been published consistently. However there have been few studies of the association between sleep duration and bone formation in elderly. Objective: The aim of this study is to examine association between sleep duration and serum osteocalcin level in an elderly Korean population. Design: Cross sectional analysis using baseline cohort data. Setting: Community based setting Participants: Among the total of 927 participants, we excluded 1 participant because of the absence on sleep duration answer. A final total of 926 participants (624 women and 302 men aged 64-87 years) who completed baseline health examination in 2012 were enrolled in this study. Measurement: Sleep duration was measured by interviewer-assisted questionnaire. Participants answered their regular time of going to bed, time of opening eyes in the morning, and time of regular nap using open questions during the passing year. Serum osteocalcin level, a known biomarker of osteogenesis, was measured by electrochemiluminescence immunoassay method in the central research laboratory. The association between sleep duration (minutes/day) and serum osteoclacin level (ng/ml) was assessed by multiple linear regression analysis. Results: In the total population, sleep duration had significant association with serum osteocalcin level (ß=-0.008, p=0.013). One hour increase in sleep duration was associated with 0.48 ng/ml increase in serum osteocalcin level. This association remained after controlling for age, sex, body mass index, cigarette smoking, alcohol drinking, physical activity, and serum 25(OH) vitamin D (ß=0.012, p<0.001). This association was consistent before and after adjusting confounders in women (ß=-0.010, p=0.019, ß=-0.011, p=0.009, respectively) and men (ß=-0.013, p=0.012, ß=-0.013, p=0.011, respectively). Conclusions: Our findings suggest that longer sleep duration is associated with higher bone formation process in an elderly of Korean.

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Mitral annular calcification and the serum osteocalcin level in patients with chronic kidney disease

Renal Failure ◽

10.3109/0886022x.2014.962421 ◽

2014 ◽

Vol 36 (10) ◽

pp. 1481-1485 ◽

Cited By ~ 1

Author(s):

Hilmi Umut Unal ◽

Murat Çelik ◽

Yalçın Gökoğlan ◽

Hakkı Çetinkaya ◽

Mahmut Gök ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Serum Osteocalcin ◽

Mitral Annular Calcification ◽

Osteocalcin Level ◽

Serum Osteocalcin Level ◽

Annular Calcification

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Raynaud Phenomenon in Systemic Sclerosis: Does Digital Thermal Monitoring Correlate to Specific Nailfold Videocapillaroscopy Abnormalities?

The Journal of Rheumatology ◽

10.3899/jrheum.191371 ◽

2020 ◽

pp. jrheum.191371

Author(s):

Julie Thomas ◽

Mislav Radic ◽

Jordan R. Tucker ◽

Rebecca Overbury ◽

Tracy M. Frech

Keyword(s):

Systemic Sclerosis ◽

Vascular Function ◽

Vascular Reactivity ◽

Clinical Care ◽

Density Measurement ◽

Nonparametric Tests ◽

Reactivity Index ◽

Thermal Monitoring ◽

Nailfold Videocapillaroscopy ◽

Raynaud Phenomenon

Objective Early diagnosis of systemic sclerosis (SSc) is imperative, and Raynaud phenomenon (RP) is an important component of progressive vasculopathy. Nailfold videocapillaroscopy (NVC) is a well-established tool that can quantify structural vascular abnormalities. Digital thermal monitoring (DTM) assesses microvascular functional dysfunction related to thermoregulation. In this study, we investigated the correlation of NVC patterns and DTM variables in patients with SSc. Methods Patients with SSc according to the 2013 American College of Rheumatology/European League Against Rheumatism criteria who consented and enrolled in the clinical care registry had NVC and DTM performed. For NVC, the number of capillaries (density), measurement of apical diameter (dimension), presence or absence of hemorrhages, and number of abnormal shapes were assessed to categorize 3 different qualitative patterns: early, active, and late. For DTM, Doppler ultrasound hyperemic, low frequency, blood velocity of radial artery, and fingertip vascular function were assessed, and a vascular reactivity index (VRI) measurement was automated. Statistical evaluation was performed by nonparametric tests to assess the correlation of NVC and VRI. Results Thirty-one SSc subjects with interpretable NVC and DTM performed on the same day were included in the study. VRI was progressively higher in SSc patients with early, active, and late NVC patterns of microangiopathy (P < 0.0001). There was a significant negative correlation between VRI and microhemorrhages scores (r = –0.363, P = 0.044). Conclusion Our study suggests that more advanced vasculopathy correlates to reduced microvascular function as detected by DTM and more advanced structural abnormalities detected by NVC. NVC and DTM may provide different aspects of vasculopathy quantification and complement each other as investigative tools.

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