scholarly journals The Urinary Metabolome of Healthy Newborns

Metabolites ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 165 ◽  
Author(s):  
Yamilé López-Hernández ◽  
Juan José Oropeza-Valdez ◽  
Jorge O. Blanco-Sandate ◽  
Ana Sofia Herrera-Van Oostdam ◽  
Jiamin Zheng ◽  
...  
Keyword(s):  
Literature Review ◽  
Urinary Metabolites ◽  
Urine Concentration ◽  
Full Term ◽  
Concentration Data ◽  
Lack Of Information ◽  
Reference Concentration ◽  
Term Newborns ◽  
Normal Urine ◽  
First Time

The knowledge of normal metabolite values for neonates is key to establishing robust cut-off values to diagnose diseases, to predict the occurrence of new diseases, to monitor a neonate’s metabolism, or to assess their general health status. For full term-newborns, many reference biochemical values are available for blood, serum, plasma and cerebrospinal fluid. However, there is a surprising lack of information about normal urine concentration values for a large number of important metabolites in neonates. In the present work, we used targeted tandem mass spectrometry (MS/MS)-based metabolomic assays to identify and quantify 136 metabolites of biomedical interest in the urine from 48 healthy, full-term term neonates, collected in the first 24 h of life. In addition to this experimental study, we performed a literature review (covering the past eight years and over 500 papers) to update the references values in the Human Metabolome Database/Urine Metabolome Database (HMDB/UMDB). Notably, 86 of the experimentally measured urinary metabolites are being reported in neonates/infants for the first time and another 20 metabolites are being reported in human urine for the first time ever. Sex differences were found for 15 metabolites. The literature review allowed us to identify another 78 urinary metabolites with concentration data. As a result, reference concentration values and ranges for 378 neonatal urinary metabolites are now publicly accessible via the HMDB.

scholarly journals Postpartum Sleep and Breastfeeding Outcomes Among First-Time Mothers of Full-Term Newborns

2019 ◽  
Vol 48 (3) ◽  
pp. S138
Author(s):  
Joanna Carrega ◽  
Shih-Yu Lee ◽  
Patricia Clark ◽  
Joan Cranford ◽  
Steven Lloyd
Keyword(s):  
Full Term ◽  
First Time Mothers ◽  
Term Newborns ◽  
First Time

Decreasing podocyte number during human kidney intrauterine development

2014 ◽  
Vol 307 (9) ◽  
pp. F1033-F1040 ◽  
Author(s):  
A. Crobe ◽  
M. Desogus ◽  
A. Sanna ◽  
M. Fraschini ◽  
C. Gerosa ◽  
...  
Keyword(s):  
Gestational Age ◽  
Maternal Diet ◽  
Clinical Importance ◽  
Human Kidney ◽  
Full Term ◽  
Intrauterine Development ◽  
Intrauterine Life ◽  
Term Newborns ◽  
Hematoxylin And Eosin ◽  
First Time

Nephron number at birth has relevant clinical importance with implications for long-term renal health. In recent years, the podocyte depletion hypothesis has emerged as an important concept in kidney pathology. This study was aimed at verifying whether human podocyte number changes significantly during intrauterine life. To this end, 62 subjects with gestational ages ranging from 20 to 41 wk were examined. Kidney sections were stained with hematoxylin and eosin and digitally scanned at ×400 magnification. Subjects were subdivided into fetuses (gestational age ≤24 wk, n = 5), preterms (gestational age ≥25 and ≤36 wk, n = 39), and full-term newborns (gestational age ≥37 wk, n = 18). The average podocyte number of 1,908 ± 645, 1,394 ± 498, and 1,126 ± 256 was, respectively, observed in fetuses, preterms, and full-term newborns. A significant main effect ( P = 0.0051) of gestational age on podocyte number was observed with a significantly lower number in full-term newborns than in fetuses ( P < 0.01). Intragroup variability was also observed. We speculate that variations in podocyte number could be correlated with factors such as drugs and maternal diet occurring during intrauterine life. In conclusion, this study shows, for the first time, a decreasing trend in podocyte number during gestation.

The effect of early-onset infections on serum apelin-12 concentration in full-term newborns

2018 ◽  
Vol 2018 (2) ◽  
pp. 81-85
Author(s):  
Urszula Godula-Stuglik ◽  
Małgorzata Koba ◽  
Aneta Stachurska ◽  
Alicja Nawrat ◽  
Katarzyna Staśkiewicz ◽  
...  
Keyword(s):  
Early Onset ◽  
Full Term ◽  
Term Newborns

Weight/length ratio: is it a good index to assess the nutritional status of full-term newborns?

2002 ◽  
Vol 78 (3) ◽  
pp. 219-24 ◽  
Author(s):  
Taciana D. de A. Braga ◽  
Marília C. Lima
Keyword(s):  
Nutritional Status ◽  
Full Term ◽  
Length Ratio ◽  
Good Index ◽  
Term Newborns

scholarly journals Levels of Predominant Intestinal Microorganisms in 1 Month-Old Full-Term Babies and Weight Gain During the First Year of Life

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2412
Author(s):  
Sonia González ◽  
Marta Selma-Royo ◽  
Silvia Arboleya ◽  
Cecilia Martínez-Costa ◽  
Gonzalo Solís ◽  
...  
Keyword(s):  
Weight Gain ◽  
Gut Microbiota ◽  
Early Life ◽  
Later Life ◽  
Full Term ◽  
First Year ◽  
Term Infants ◽  
Term Newborns ◽  
Infant Weight Gain ◽  
First Year Of Life

The early life gut microbiota has been reported to be involved in neonatal weight gain and later infant growth. Therefore, this early microbiota may constitute a target for the promotion of healthy neonatal growth and development with potential consequences for later life. Unfortunately, we are still far from understanding the association between neonatal microbiota and weight gain and growth. In this context, we evaluated the relationship between early microbiota and weight in a cohort of full-term infants. The absolute levels of specific fecal microorganisms were determined in 88 vaginally delivered and 36 C-section-delivered full-term newborns at 1 month of age and their growth up to 12 months of age. We observed statistically significant associations between the levels of some early life gut microbes and infant weight gain during the first year of life. Classifying the infants into tertiles according to their Staphylococcus levels at 1 month of age allowed us to observe a significantly lower weight at 12 months of life in the C-section-delivered infants from the highest tertile. Univariate and multivariate models pointed out associations between the levels of some fecal microorganisms at 1 month of age and weight gain at 6 and 12 months. Interestingly, these associations were different in vaginally and C-section-delivered babies. A significant direct association between Staphylococcus and weight gain at 1 month of life was observed in vaginally delivered babies, whereas in C-section-delivered infants, lower Bacteroides levels at 1 month were associated with higher later weight gain (at 6 and 12 months). Our results indicate an association between the gut microbiota and weight gain in early life and highlight potential microbial predictors for later weight gain.

Interhemispheric amplitude symmetry in the EEGs of full-term newborns

1977 ◽  
Vol 43 (6) ◽  
pp. 846-852 ◽  
Author(s):  
Jerald L Varner ◽  
Robert J Ellingson ◽  
Theresa Dahahy ◽  
Bessmarie Nelson
Keyword(s):  
Full Term ◽  
Term Newborns

scholarly journals Randomized clinical trial of the effect of the onset time of skin-to-skin contact at birth, immediate compared to early, on the duration of breastfeeding in full term newborns

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Sergio I Agudelo ◽  
Oscar A Gamboa ◽  
Eduardo Acuña ◽  
Lina Aguirre ◽  
Sarah Bastidas ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Exclusive Breastfeeding ◽  
Negative Impact ◽  
Onset Time ◽  
Full Term ◽  
Breastfeeding Duration ◽  
Bivariate Analysis ◽  
Skin Contact ◽  
Term Newborns ◽  
Skin To Skin

Abstract Background Skin-to-skin contact (SSC) compared to separation at birth has a positive effect on breastfeeding. However, separation at birth is common with negative impact on breastfeeding. The aim was to determine the effect of immediate SSC compared to early SSC on the duration of exclusive breastfeeding. Methods A randomized multicentre parallel clinical trial was conducted in two hospitals in Cundinamarca (Colombia) between November 2018 and January 2020. Low-risk full term newborns at birth were included. Neonates were assigned to immediate (in the first minute after birth) or early onset (start exactly at 60 min of life) skin to skin contact. Monthly follow-up was performed until 6 months of age. The primary outcome was the percentage of exclusively breastfed infants at 6 months (time in months with human milk as the only source of food). Secondary outcomes were the percentage of infants with exclusive breastfeeding at 3 months, duration in months of exclusive breastfeeding, neonate’s breastfeeding ability, percentage of weight change between birth and the first week of life and hospitalization in the neonatal unit in the first week. A bivariate analysis was performed to determine the variables associated with exclusive breastfeeding at 6 months. A survival analysis was performed to evaluate the effect of the onset of SSC on exclusive breastfeeding duration. Results A total of 297 newborns were included: 49.8% (n = 148) in the immediate SSC group, and 50.2% (n = 149) in the early SSC group. The mean duration of exclusive breastfeeding in both groups was 5 months. There were no differences between the groups in the percentage of exclusive breastfeeding at 6 months (relative risk [RR] 1.06, 95% CI 0.72, 1.58) or in the duration of exclusive breastfeeding (hazard ratio [HR] 0.98, 95% CI 0.74, 1.28). Conclusions The percentage of infants and the duration of exclusive breastfeeding in the first 6 months of age were the same between the two groups of SSC interventions. Given the current barriers to its implementation, the results of this study could positively impact the use of SSC at birth and standardize the intervention and improve breastfeeding indicators. Trial registration ClinicalTrials.gov NCT02687685.

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