Decreasing podocyte number during human kidney intrauterine development

2014 ◽  
Vol 307 (9) ◽  
pp. F1033-F1040 ◽  
Author(s):  
A. Crobe ◽  
M. Desogus ◽  
A. Sanna ◽  
M. Fraschini ◽  
C. Gerosa ◽  
...  
Keyword(s):  
Gestational Age ◽  
Maternal Diet ◽  
Clinical Importance ◽  
Human Kidney ◽  
Full Term ◽  
Intrauterine Development ◽  
Intrauterine Life ◽  
Term Newborns ◽  
Hematoxylin And Eosin ◽  
First Time

Nephron number at birth has relevant clinical importance with implications for long-term renal health. In recent years, the podocyte depletion hypothesis has emerged as an important concept in kidney pathology. This study was aimed at verifying whether human podocyte number changes significantly during intrauterine life. To this end, 62 subjects with gestational ages ranging from 20 to 41 wk were examined. Kidney sections were stained with hematoxylin and eosin and digitally scanned at ×400 magnification. Subjects were subdivided into fetuses (gestational age ≤24 wk, n = 5), preterms (gestational age ≥25 and ≤36 wk, n = 39), and full-term newborns (gestational age ≥37 wk, n = 18). The average podocyte number of 1,908 ± 645, 1,394 ± 498, and 1,126 ± 256 was, respectively, observed in fetuses, preterms, and full-term newborns. A significant main effect ( P = 0.0051) of gestational age on podocyte number was observed with a significantly lower number in full-term newborns than in fetuses ( P < 0.01). Intragroup variability was also observed. We speculate that variations in podocyte number could be correlated with factors such as drugs and maternal diet occurring during intrauterine life. In conclusion, this study shows, for the first time, a decreasing trend in podocyte number during gestation.

scholarly journals Head circumference and anterior fontanel measurements in newborns

2012 ◽  
Vol 52 (3) ◽  
pp. 145 ◽  
Author(s):  
Rizal Agus Tiansyah ◽  
Irawan Mangunatmadja ◽  
Aman Pulungan
Keyword(s):  
Gestational Age ◽  
Head Circumference ◽  
Full Term ◽  
Brain Growth ◽  
Anterior Fontanel ◽  
Term Infants ◽  
Head Growth ◽  
Term Newborns ◽  
Male Subjects ◽  
The Brain

Background Head growth and anterior fontanel (AP) closureare passive processes in response to brain growth. The growthof the brain and skull starts in the third week of intrauterinegestation. roth processes run simultaneously as a part of integralgrowth, along 'With increasing gestational age, until post􀀿birth.Measurement of head circumference (He) and AF in newbornsis done to determine if the brain and skull grew normally duringthe intrauterine period.Objectives To investigate the differences in He and AF sizebetween preterm and full􀀿term infants, and the relationshipbetween gestational age (GA) and birth weight (BW) to Heand AF size.Methods This was a descriptive analytic study on preterm andfull􀀿term newborns. Measurement of HC and AF was conductedin three phases: just after birth, 1x24 and 2x24 hours of age.Analysis of HC and AF size differences between preterm and fullterm subjects was performed, as well as analysis of the correlationbetween GA and BW to HC and AF size.Results Two hundred fifty newborns completed the study. Therewere 180 full􀀿term and 70 preterm subjects. Median HC in full􀀿term and preterm male subjects were 34 cm (range 31􀀿37 cm)and 31 cm (27􀀿34 cm), respectively. Median HC in full􀀿termand preterm female subjects were 33 cm (31􀀿36 cm) and 32 cm(27􀀿3S.S cm), respectively. Median AF in full􀀿term and pretermmale subjects were 2.17 cm (1.0SA.6 cm) and 2.22 cm (1.3SA.Scm), respectively, and in full􀀿term and preterm female subjectswere 2.02 cm (lA.1S cm) and 2.22 cm (0.7SA cm), respectively.The HC of preterms were significantly lower than the fullterms(P<O.OOl), however the AF size was not different between these2 groups of newborns (P =0 .28). Correlation test between GA andBW to HC size revealed a positive correlation (r=0.620, P<O.OO 1and r=0.801, P<O.OOl, respectively), but not to AF size (r=􀀿 0.06,p􀁀 0.279 and F- 0.049, P􀁀0.44, respectively).Concl usions We found that the HC size of pre terms wassignificantly lower than thefullterms, but no significant differences in AF size between the two groups. GA and BW were associatedwith HC size, but not associated to AF size. [paediatr lndones.2012;52:145-51].

Complete blood count parameters for healthy, small-for-gestational-age, full-term newborns

2006 ◽  
Vol 28 (2) ◽  
pp. 97-104 ◽  
Author(s):  
E. OZYUREK ◽  
S. CETINTAS ◽  
T. CEYLAN ◽  
E. OGUS ◽  
A. HABERAL ◽  
...  
Keyword(s):  
Gestational Age ◽  
Small For Gestational Age ◽  
Blood Count ◽  
Complete Blood Count ◽  
Full Term ◽  
Term Newborns

scholarly journals Postpartum Sleep and Breastfeeding Outcomes Among First-Time Mothers of Full-Term Newborns

2019 ◽  
Vol 48 (3) ◽  
pp. S138
Author(s):  
Joanna Carrega ◽  
Shih-Yu Lee ◽  
Patricia Clark ◽  
Joan Cranford ◽  
Steven Lloyd
Keyword(s):  
Full Term ◽  
First Time Mothers ◽  
Term Newborns ◽  
First Time

Gestational Age and Thyroid Economy at Birth in Full-Term Newborns

1981 ◽  
Vol 13 (07) ◽  
pp. 412-413
Author(s):  
F. De Luca ◽  
M. Gemelli ◽  
T. Arrigo ◽  
R. Melluso ◽  
S. Benvenga ◽  
...  
Keyword(s):  
Gestational Age ◽  
Full Term ◽  
Term Newborns

scholarly journals The Urinary Metabolome of Healthy Newborns

Metabolites ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 165 ◽  
Author(s):  
Yamilé López-Hernández ◽  
Juan José Oropeza-Valdez ◽  
Jorge O. Blanco-Sandate ◽  
Ana Sofia Herrera-Van Oostdam ◽  
Jiamin Zheng ◽  
...  
Keyword(s):  
Literature Review ◽  
Urinary Metabolites ◽  
Urine Concentration ◽  
Full Term ◽  
Concentration Data ◽  
Lack Of Information ◽  
Reference Concentration ◽  
Term Newborns ◽  
Normal Urine ◽  
First Time

The knowledge of normal metabolite values for neonates is key to establishing robust cut-off values to diagnose diseases, to predict the occurrence of new diseases, to monitor a neonate’s metabolism, or to assess their general health status. For full term-newborns, many reference biochemical values are available for blood, serum, plasma and cerebrospinal fluid. However, there is a surprising lack of information about normal urine concentration values for a large number of important metabolites in neonates. In the present work, we used targeted tandem mass spectrometry (MS/MS)-based metabolomic assays to identify and quantify 136 metabolites of biomedical interest in the urine from 48 healthy, full-term term neonates, collected in the first 24 h of life. In addition to this experimental study, we performed a literature review (covering the past eight years and over 500 papers) to update the references values in the Human Metabolome Database/Urine Metabolome Database (HMDB/UMDB). Notably, 86 of the experimentally measured urinary metabolites are being reported in neonates/infants for the first time and another 20 metabolites are being reported in human urine for the first time ever. Sex differences were found for 15 metabolites. The literature review allowed us to identify another 78 urinary metabolites with concentration data. As a result, reference concentration values and ranges for 378 neonatal urinary metabolites are now publicly accessible via the HMDB.

scholarly journals Maternal risk factors in full-term newborns with early onset sepsis related with Interleukin-6 in umbilical blood

2019 ◽  
Vol 19 (2) ◽  
Author(s):  
Fabricio González Andrade
Keyword(s):  
Risk Factors ◽  
Urinary Tract ◽  
Gestational Age ◽  
Interleukin 6 ◽  
Neonatal Sepsis ◽  
Full Term ◽  
Maternal Risk ◽  
Umbilical Blood ◽  
Term Newborns ◽  
Relationship Of

Background: to determine the relationship and association of early sepsis with interleukin-6 measured in umbilical blood, as well as gestational age and birth weight, prenatal history of the mother pathologies during pregnancy, in full-term newborns at the Neonatology Service of Carlos Andrade Marín Hospital (Quito). Subjects and methods: epidemiological, observational, analytical, cross-sectional. 200 newborns were analyzed. IL-6 was determined by Elisa. Results: newborn mean gestational age 38.4±2 weeks, mean weight 2871±532.4 grams,  cutoff point interleukin 6 ≤14pg/uL; mean of IL6. 58±99,1 pg/uL; male sex was 43.9%, female sex 56.1%; preeclampsia of the mother 22.4%, prenatal infection of the urinary tract 20.4%; vaginitis/vaginosis 19.4%; IL6 values ≤ 14 pg/uL in 63.3% of patients; IL6 values of >14 pg/uL 36.7%; relationship with sepsis in all, p<0.05; relationship of prenatal pre-maternity of the mother and neonatal sepsis. p<0.05; relationship between vaginitis/vaginosis of the mother with neonatal sepsis; p<0.05; OR: 38.88 IC95% (4.912-307.728); association between sepsis and risk factors, IL6, gestational age in weeks, weight, prenatal preeclampsia, prenatal urinary tract infection, vaginitis/vaginosis, p<0.05. Conclusion: It is concluded that there is a relationship of risk factors, such as, gestational age in weeks, weight, prenatal preeclampsia, prenatal UTI, vaginitis/vaginosis and values of interleukin 6 ≤ 14 pg/uL. The mean gestational age was 38.4 weeks, and average weight 2871 grams in the newborns analyzed.

scholarly journals Capillary blood reference intervals for platelet parameters in healthy full-term neonates in China

2020 ◽  
Author(s):  
Dongyan Cui ◽  
Yan Hou ◽  
Ling Feng ◽  
Guo Li ◽  
Chi Zhang ◽  
...  
Keyword(s):  
Platelet Count ◽  
Gestational Age ◽  
Reference Interval ◽  
Reference Intervals ◽  
Capillary Blood ◽  
Full Term ◽  
Term Neonates ◽  
First Time ◽  
Early Phases

Abstract Background No consensus has been reached on reference intervals for platelet parameters in full-term neonates. We aimed to establish neonatal capillary blood reference intervals for platelet parameters and evaluate influences of gender, gestational age and postnatal age on platelet parameters. Methods This study was implemented in 594 healthy full-term neonates from 12 to 84 hours of age, using SYSMEX XN-9000 haematology automatic analyser by means of capillary blood. Reference intervals for platelet parameters were defined by an interval of 2.5th − 97.5th percentiles. Results Capillary reference interval for platelet count was (152–464) × 109/L. No significance was found between gender-divided reference intervals for platelet parameters. The values of platelet count changed significantly across gestational age and postnatal age. Reference intervals for other platelet parameters were affected by these factors to a different extent. Conclusions We established capillary blood reference intervals for platelet parameters in the early phases after birth of full-term neonates in China for the first time.

ABSENCE OF TRANSIENT SUPPRESSION OF SEX CHROMATIN IN FEMALE PREMATURE NEWBORNS

PEDIATRICS ◽  
1968 ◽  
Vol 42 (3) ◽  
pp. 437-440
Author(s):  
Takemi Homma ◽  
Tadashi Kajii
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Oral Mucosa ◽  
Gestational Age ◽  
Full Term ◽  
The Other ◽  
Premature Newborns ◽  
Other Hand ◽  
Sex Chromatin ◽  
Term Newborns

The frequency of sex chromatin-positive nuclei during the first 7 days of life was determined in oral mucosa smears stained with lactic acetic orcein in three groups of newborn female infants: 28 cases of full-term newborns, 17 cases of infants with low birth weight (less than 2,000 gm) and high gestational age (more than 32 weeks), and 11 cases of infants with low birth weight and low gestational age (32 weeks or less). A transient suppression of sex chromatin frequency was observed for the first 3 days of life in the full-term females, as has been reported by previous workers. The infants with low birth weight and high gestational age likewise showed transient suppression. The infants with low birth weight and low gestational age, on the other hand, exhibited no comparable suppression of sex chromatin. The findings suggest that the mechanism responsible for sex chromatin suppression is related to a physiologic process that develops in the last 8 weeks of gestation.

scholarly journals Serotonin and cyclic sleep organization in healthy full-term newborns

2021 ◽  
Vol 70 (1) ◽  
pp. 69-76
Author(s):  
Natalia A. Zvereva ◽  
Yulia P. Milyutina ◽  
Inna I. Evsyukova
Keyword(s):  
Umbilical Cord ◽  
Gestational Age ◽  
Platelet Rich Plasma ◽  
Venous Blood ◽  
General Pattern ◽  
Full Term ◽  
Serotonin Content ◽  
Platelet Suspension ◽  
Neuropsychiatric Diseases ◽  
Term Newborns

Relevance: The growth of neuropsychiatric diseases caused by perinatal pathology indicates the need to study the biochemical markers of brain damage in the newborn for the timely prevention of adverse consequences. Serotonin in early ontogenesis provides intensive development of neuronal structures and cortical networks involved in the mechanisms of formation of cyclic sleep organization a fine criterion of morphofunctional development of the brain. aim: The aim of the work is to study the content of serotonin in healthy full-term newborns in comparison with the quantitative and qualitative characteristics of the electropoligraphic sleep pattern. Material and methods: 84 healthy newborns were examined, which, depending on the gestational age, were divided into 3 groups: I 37 weeks (20 people), II 38 weeks (24 people), III 39-40 weeks (40 people). The content of serotonin in platelet-rich plasma of blood from the umbilical cord vein and in platelet suspension prepared from venous blood taken from mothers and children on the first day of life and again on day 5 was determined by high-performance liquid chromatography with electrochemical detection. A quantitative and qualitative analysis of the sleep electropoligram was performed 7-12 hours after birth. Results: The content of serotonin in platelet-rich plasma in umbilical cord blood in children does not depend on the method of birth, is 2 times lower than in the venous blood of mothers (0.379 0.116 microns/l, versus 0.756 0.200 microns/l, but there is a high correlation between the indicators (r = 0.8, p 0.05). At the gestational age of 39-40 weeks, the level of serotonin in platelet-rich plasma and in venous blood platelets is significantly higher than in those born at 37 weeks. In the latter, the increase in the content of serotonin in platelets continues after birth (at day 1, 0.539 0.149 nM/109 Tr, and on day 5 0.846 0.094 nM/109 Tr; p 0.05), whereas the indicators for those born at 39-40 weeks of pregnancy. They do not change (0.797 0.190 nM/109 Tr and 0.749 0.142 nM/109 Tr, respectively). A significant increase in the content of serotonin in the platelet-rich plasma and in the platelets of the child in the period from 37 to 39 weeks, both during intrauterine development and in the first days of life, correlates with an increase in the representation of the orthodox phase in the sleep cycle. Conclusion: The general pattern of changes in serotonin content and cyclic sleep organization in the early neonatal period in healthy newborns, depending on gestational age, indicates the possibility of using the obtained standard values of serotonin as a biochemical marker of functional brain development.

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