scholarly journals A Metabolic Perspective and Opportunities in Pharmacologically Important Safflower

Metabolites ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 253 ◽  
Author(s):  
Vimalraj Mani ◽  
Seon-Kyeong Lee ◽  
Yunsoo Yeo ◽  
Bum-Soo Hahn
Keyword(s):  
Functional Food ◽  
Crop Yields ◽  
Animal Feed ◽  
Carthamus Tinctorius ◽  
Current Medical ◽  
Chemical Components ◽  
Pharmacological Activities ◽  
Comprehensive Knowledge ◽  
Health Factors ◽  
Metabolic Activities

Safflower (Carthamus tinctorius L.) has long been grown as a crop due to its commercial utility as oil, animal feed, and pharmacologically significant secondary metabolites. The integration of omics approaches, including genomics, transcriptomics, metabolomics, and proteomics datasets, has provided more comprehensive knowledge of the chemical composition of crop plants for multiple applications. Knowledge of a metabolome of plant is crucial to optimize the evolution of crop traits, improve crop yields and quality, and ensure nutritional and health factors that provide the opportunity to produce functional food or feedstuffs. Safflower contains numerous chemical components that possess many pharmacological activities including central nervous, cardiac, vascular, anticoagulant, reproductive, gastrointestinal, antioxidant, hypolipidemic, and metabolic activities, providing many other human health benefits. In addition to classical metabolite studies, this review focuses on several metabolite-based working techniques and updates to provide a summary of the current medical applications of safflower.

scholarly journals Functional Metabolomics – a Useful Tool to Characterize Stress-Induced Metabolome Alterations Opening New Avenues Towards Tailoring Food Crop Quality

2018 ◽  
Author(s):  
Corinna Dawid ◽  
Karina Hille
Keyword(s):  
Functional Food ◽  
Crop Yields ◽  
Agronomic Traits ◽  
Animal Feed ◽  
Cultivated Plants ◽  
Food Crops ◽  
Abiotic And Biotic Stress ◽  
Comprehensive Knowledge ◽  
Functional Metabolomics

The breeding of stress-tolerant cultivated plants that would allow for a reduction in harvest losses and undesirable decrease in quality attributes requires a new quality of knowledge on molecular markers associated with relevant agronomic traits, on quantitative metabolic responses of plants on stress challenges, and on the mechanisms controlling the biosynthesis of these molecules. By combining metabolomics with genomics, transcriptomics and proteomics datasets a more comprehensive knowledge of the composition of crop plants used for food or animal feed is possible. In order to optimize crop trait developments, to enhance crop yields and quality, as well as to guarantee nutritional and health factors, that provides the possibility to create functional food or feedstuffs, the knowledge about the plants’ metabolome is crucial. Next to classical metabolomics studies, this review focusses on several metabolomics based working techniques, such as sensomics, lipidomics, hormonomics and phytometabolomics, which were used to characterize metabolome alterations during abiotic and biotic stress, to find resistant food crops with a preferred quality or at least to produce functional food crops are highlighted.

scholarly journals Functional Metabolomics—A Useful Tool to Characterize Stress-Induced Metabolome Alterations Opening New Avenues towards Tailoring Food Crop Quality

Agronomy ◽  
2018 ◽  
Vol 8 (8) ◽  
pp. 138 ◽  
Author(s):  
Corinna Dawid ◽  
Karina Hille
Keyword(s):  
Functional Food ◽  
Crop Yields ◽  
Agronomic Traits ◽  
Animal Feed ◽  
Cultivated Plants ◽  
Food Crops ◽  
Abiotic And Biotic Stress ◽  
Comprehensive Knowledge ◽  
Functional Metabolomics

The breeding of stress-tolerant cultivated plants that would allow for a reduction in harvest losses and undesirable decrease in quality attributes requires a new quality of knowledge on molecular markers associated with relevant agronomic traits, on quantitative metabolic responses of plants to stress challenges, and on the mechanisms controlling the biosynthesis of these molecules. By combining metabolomics with genomics, transcriptomics and proteomics datasets a more comprehensive knowledge of the composition of crop plants used for food or animal feed is possible. In order to optimize crop trait developments, to enhance crop yields and quality, as well as to guarantee nutritional and health factors that provide the possibility to create functional food or feedstuffs, knowledge about the plants’ metabolome is crucial. Next to classical metabolomics studies, this review focuses on several metabolomics-based working techniques, such as sensomics, lipidomics, hormonomics and phytometabolomics, which were used to characterize metabolome alterations during abiotic and biotic stress in order to find resistant food crops with a preferred quality or at least to produce functional food crops.

Agriculture—Things That Are Grown

2017 ◽  
Author(s):  
Peter Rez
Keyword(s):  
Crop Yields ◽  
Animal Feed ◽  
Electrical Power ◽  
Construction Materials ◽  
Embodied Energy ◽  
Liquid Fuels ◽  
Energy Output ◽  
Recycled Paper ◽  
Additional Energy ◽  
Energy Inputs

Timber has the lowest embodied energy of any of the construction materials. Paper production from trees requires much more energy. There is some energy saving in recycling, as recycled paper substitutes for pulp derived from wood chips. Growing crops for food also requires energy. The energy required for plants to grow comes from the sun, but there are additional energy inputs from fertiliser and farm machinery to speed up the growth process and vastly improve crop yields. If grains are used as animal feed, then the energy inputs are much larger than the dietary energy output—the larger the animal and the longer it is fattened up before slaughter, the more inefficient the process. The use of crops to make fuel for electrical power generation or for processing into liquid fuels is horribly inefficient. The problem is simple—the plants do not grow fast enough!

scholarly journals Effect of Seed Priming Techniques on Germination Parameters of Safflower (Carthamus tinctorius L.)

2018 ◽  
Vol 67 (2) ◽  
pp. 157-163
Author(s):  
Milan Jocković ◽  
Petar Čanak ◽  
Vladimir Miklič ◽  
Jelena Ovuka ◽  
Velimir Radić ◽  
...  
Keyword(s):  
Filter Paper ◽  
Low Cost ◽  
Seed Priming ◽  
Carthamus Tinctorius ◽  
Distilled Water ◽  
Significant Difference ◽  
Mean Germination Time ◽  
Metabolic Activities ◽  
Germination Parameters ◽  
Priming Technique

Summary A useful approach for improving seed germination and seedling growth is a seed priming technique. Application of the priming technique enhances water absorption, causing activation of metabolic activities in the seed. The objective of this study was to evaluate the effect of seed priming on germination parameters of safflower and to compare different priming techniques: priming by soaking and priming on filter paper. The priming treatments included hydropriming (distilled water) and osmopriming with 0.1% and 0.5% solutions of KNO3 for 8 and 16 hours. The experiment revealed significant difference between the priming treatments and the control. The highest germination (89.50%) was recorded within the priming treatments by soaking in the solution of 0.1% KNO3 and priming on filter paper moistened with 0.5% KNO3 for 8 hours. Considering germination index, mean germination time and time to 50% germination, the best results were obtained within hydropriming on filter paper for 16 hours. This study has shown that the priming techniques significantly improved germination parameters of safflower. Although priming on filter paper showed better results, the soaking technique – due to its simplicity, low cost and easiness of application – can be successfully used to improve germination parameters of safflower and increase the number of plants per unit of area and thus increase the seed yield per acreage.

scholarly journals A Network Pharmacology-Based Study on Pharmacological Activities and Mechanisms of Essential Oil in Leaves of C. Grandis ‘Tomentosa’

2021 ◽  
Author(s):  
Jieshu You ◽  
Sheng-cai He ◽  
Liang Chen ◽  
Zhen-hui Guo ◽  
Fei Gao ◽  
...  
Keyword(s):  
Essential Oil ◽  
Function Analysis ◽  
Network Pharmacology ◽  
Chemical Components ◽  
Pathway Enrichment Analysis ◽  
Health Food ◽  
Disease Network ◽  
Pharmacological Activities ◽  
Integrated Network ◽  
Target Disease

Abstract Background and Objective: Citrus grandis ‘Tomentosa’, as the fruit epicarp of C. grandis ‘Tomentosa’ or C. grandis (L.) Osbeck, is widely used in health food and medicine. Actually, based on our survey results, there are also rich essential oils with bioativities in leaves, but the chemical compounds in this part and relevant pharmacological activities have never been studied systematically yet. Therefore, this study was to preliminarily decipher the pharmacological activities and mechanisms of the essential oil in leaves of C. grandis ‘Tomentosa’ by an integrated network pharmacology approach. Methods: Essential oil compositions from leaves of C. grandis ‘Tomentosa’ were identified using GC-MS/MS. And then the targets of these oil compositions were predicted and screened from TCMSP, SwissTargetPrediction, STITCH and SEA databases. STRING database was used to construct the protein-protein interaction networks, and the eligible protein targets were input into WebGestalt 2019 to carry out GO enrichment and KEGG pathway enrichment analysis. Based on the potential targets, disease enrichment information was obtained by TTD databases. Cytoscape software was used to construct the component-target-disease network diagrams. Results: Finally, 61 essential oil chemical components were identified by GC-MS/MS, which correspond to 679 potential targets. Biological function analysis showed that there were 12, 19, and 12 GO entries related to biological processes, cell components and molecular functions, respectively. 43 KEGG pathways were identified, of which the most significant categories were terpenoid backbone biosynthesis, TNF signaling pathway and leishmaniasis. The component-target-disease network diagram revealed that the essential oil compositions in leaves of C. grandis ‘Tomentosa’ could treat tumors, immune diseases, neurodegenerative diseases and respiratory diseases, which were highly related to CHRM1, PTGS2, CASP3, MAP2K1 and CDC25B.Conclusion: This study may provide a new insight into C. grandis ‘Tomentosa’ or C. grandis (L.) Osbeck and may provide useful information for future utilization and development.

scholarly journals Seeing the Unseen of the Combination of Two Natural Resins, Frankincense and Myrrh: Changes in Chemical Constituents and Pharmacological Activities

Molecules ◽  
2019 ◽  
Vol 24 (17) ◽  
pp. 3076 ◽  
Author(s):  
Bo Cao ◽  
Xi-Chuan Wei ◽  
Xiao-Rong Xu ◽  
Hai-Zhu Zhang ◽  
Chuan-Hong Luo ◽  
...  
Keyword(s):  
Chronic Diseases ◽  
Chemical Constituents ◽  
Chemical Components ◽  
Pharmacological Effects ◽  
Pharmacological Activities ◽  
Channel Characteristics ◽  
Natural Resins ◽  
Ancient Times ◽  
Traditional Natural ◽  
Natural Drugs

For the treatment of diseases, especially chronic diseases, traditional natural drugs have more effective therapeutic advantages because of their multi-target and multi-channel characteristics. Among many traditional natural medicines, resins frankincense and myrrh have been proven to be effective in the treatment of inflammation and cancer. In the West, frankincense and myrrh have been used as incense in religious and cultural ceremonies since ancient times; in traditional Chinese and Ayurvedic medicine, they are used mainly for the treatment of chronic diseases. The main chemical constituents of frankincense and myrrh are terpenoids and essential oils. Their common pharmacological effects are anti-inflammatory and anticancer. More interestingly, in traditional Chinese medicine, frankincense and myrrh have been combined as drug pairs in the same prescription for thousands of years, and their combination has a better therapeutic effect on diseases than a single drug. After the combination of frankincense and myrrh forms a blend, a series of changes take place in their chemical composition, such as the increase or decrease of the main active ingredients, the disappearance of native chemical components, and the emergence of new chemical components. At the same time, the pharmacological effects of the combination seem magically powerful, such as synergistic anti-inflammation, synergistic anticancer, synergistic analgesic, synergistic antibacterial, synergistic blood-activation, and so on. In this review, we summarize the latest research on the main chemical constituents and pharmacological activities of these two natural resins, along with chemical and pharmacological studies on the combination of the two.

scholarly journals Hydroxysafflor Yellow A: A Systematical Review on Botanical Resources, Physicochemical Properties, Drug Delivery System, Pharmacokinetics, and Pharmacological Effects

2020 ◽  
Vol 11 ◽  
Author(s):  
Feng Zhao ◽  
Ping Wang ◽  
Yuanyuan Jiao ◽  
Xiaoxiao Zhang ◽  
Daquan Chen ◽  
...  
Keyword(s):  
Carthamus Tinctorius ◽  
Clinical Applications ◽  
Detection Methods ◽  
Pharmacological Effects ◽  
Hydroxysafflor Yellow A ◽  
Pharmacological Activities ◽  
Related Research ◽  
Chemical Instability ◽  
Anticancer Effects ◽  
Systematical Review

Hydroxysafflower yellow A (HSYA), as a principal natural ingredient extracted from safflower (Carthamus tinctorius L.), has significant pharmacological activities, such as antioxidant, anti-inflammatory, anticoagulant, and anticancer effects. However, chemical instability and low bioavailability have been severely hampering the clinical applications of HSYA during the treatment of cardiovascular and cerebrovascular disease. Therefore, this present review systematically summarized the materials about HSYA, including acquisition methods, extraction and detection methods, pharmacokinetics, pharmacological effects and molecular mechanism, especially focus on the possible causes and resolutions about the chemical instability and low bioavailability of HSYA, in order to provide relatively comprehensive basic data for the related research of HSYA.

scholarly journals Scutellaria barbata: A Review on Chemical Constituents, Pharmacological Activities and Clinical Applications

2020 ◽  
Vol 26 (1) ◽  
pp. 160-175 ◽  
Author(s):  
Qiong Chen ◽  
Khalid Rahman ◽  
Su-Juan Wang ◽  
Shuang Zhou ◽  
Hong Zhang
Keyword(s):  
Blood Circulation ◽  
Chemical Constituents ◽  
Blood Stasis ◽  
Clinical Applications ◽  
In Vivo Studies ◽  
Chemical Components ◽  
Pharmacological Activities ◽  
Scutellaria Barbata ◽  
Pharmacologically Active

Scutellaria barbata has a long history of medical use in Traditional Chinese Medicine for removing heat and toxic material, promoting blood circulation and removing blood stasis, and inducing diuresis to reduce edema. Recent pharmacology investigations have provided evidence for its anti-cancer, bacteriostasis, anti-virus, anti-inflammation, anti-oxidation and immunity enhancement properties. The efficacy of activating blood circulation and removing blood stasis has unique advantages in the treatment of cardiovascular and cerebrovascular diseases. A total of 84 compounds have been isolated from S. barbata and are characterized mainly as flavonoids, diterpenoids, followed by polysaccharide, volatile oil and steroids. Peer-reviewed articles published over the last few years were gathered by consulting the databases PubMed, Elsevier, Springer, and Chinese Herbal Classics. This review mainly focuses on the pharmacologically active constituents isolated from S. barbata，which have been subjected to in vitro and/or in vivo studies. Although, the chemical components, pharmacological activities, toxicology, clinical applications and mechanisms of action of S. barbata have been investigated, many constituents remain unknown. Further investigations are required to investigate the medicinal properties of S. barbata.

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