Identification and Reproducibility of Plasma Metabolomic Biomarkers of Habitual Food Intake in a US Diet Validation Study

Previous metabolomic studies have identified putative blood biomarkers of dietary intake. These biomarkers need to be replicated in other populations and tested for reproducibility over time for the potential use in future epidemiological studies. We conducted a metabolomics analysis among 671 racially/ethnically diverse men and women included in a diet validation study to examine the correlation between >100 food groups/items (101 by a food frequency questionnaire (FFQ), 105 by 24-h diet recalls (24HRs)) with 1141 metabolites measured in fasting plasma sample replicates, six months apart. Diet–metabolite associations were examined by Pearson’s partial correlation analysis. Biomarker reproducibility was assessed using intraclass correlation coefficients (ICCs). A total of 677 diet–metabolite associations were identified after Bonferroni adjustment for multiple comparisons and restricting absolute correlation coefficients to greater than 0.2 (601 associations using the FFQ and 395 using 24HRs). The median ICCs of the 238 putative biomarkers was 0.56 (interquartile range 0.46–0.68). In this study, with repeated FFQs, 24HRs and plasma metabolic profiles, we identified several potentially novel food biomarkers and replicated others found in our previous study. Our findings contribute to the growing literature on food-based biomarkers and provide important information on biomarker reproducibility which could facilitate their utilization in future nutritional epidemiological studies.

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Assessment of Physical Activity in Adults: A Review of Validated Questionnaires From a Nutritionist’s Point of View

Evaluation & the Health Professions ◽

10.1177/0163278720928500 ◽

2020 ◽

Vol 43 (4) ◽

pp. 235-254

Author(s):

Angela Patricia Bacelis-Rivero ◽

Anabel Vázquez-Rodríguez ◽

Claudia E. Carrasco-Legleu ◽

Lidia G. De León ◽

Sandra Alicia Reza-López

Keyword(s):

Physical Activity ◽

Energy Expenditure ◽

Intraclass Correlation ◽

Reliability And Validity ◽

Correlation Coefficients ◽

Epidemiological Studies ◽

Point Of View ◽

Eligibility Criteria ◽

Good Reliability ◽

Intraclass Correlation Coefficients

Physical activity (PA) is a component of total energy expenditure. PA and PA energy expenditure (PAEE) can be estimated by objective techniques (OTs). However, the use of questionnaires is frequent in clinical settings and epidemiological studies. We conducted a search on PubMed, Scopus, and Google Scholar databases to perform a review of studies reporting the reliability and validity of PA questionnaires validated against OTs—doubly labeled water (DLW) or accelerometers—in free-living adults. We selected original articles published between 2009 and 2019 that reported validation studies of PA questionnaires. We identified 53 studies that fulfilled the eligibility criteria. Four PA questionnaires were validated against DLW and the remaining against accelerometers. Three questionnaires were compared with both DLW and accelerometer results. The correlation between questionnaire-estimated PAEE and DLW results ranged from r = .22 to r = .46, while that between questionnaire-estimated total PA (TPA) and accelerometer results ranged from r = .11 to r = .54 The intraclass correlation coefficients were between .56 and .84. Despite having good reliability, most of the questionnaires included in this review have shown limited validity for estimating TPA in adults. OTs should be considered as a first option, when possible. Further research is warranted on techniques to obtain more accurate PA and PAEE estimates.

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Self-administered Expanded Disability Status Scale with functional system scores correlates well with a physician-administered test

Multiple Sclerosis Journal ◽

10.1177/135245850100700311 ◽

2001 ◽

Vol 7 (3) ◽

pp. 201-206 ◽

Cited By ~ 122

Author(s):

James Bowen ◽

Laura Gibbons ◽

Ann Gianas ◽

George H Kraft

Keyword(s):

Multiple Sclerosis ◽

Intraclass Correlation ◽

Correlation Coefficients ◽

Functional System ◽

Epidemiological Studies ◽

Female Age ◽

Intraclass Correlation Coefficients ◽

Disability Status ◽

Definite Multiple Sclerosis ◽

Clinically Definite Multiple Sclerosis

Background: Patient-administered measures are needed to assess disability cost-effectively in large epidemiological studies. Setting: An outpatient clinic in a large multiple sclerosis center. Methods: A self-administered EDSS questionnaire was developed (EDSS-S). Consecutive patients with clinically definite multiple sclerosis completed the EDSS-S (n=95). During the same visit, a physician completed an EDSS (EDSS-P). Scores below 4.0 were determined using functional system (FS) scores. Scores above 4.0 were calculated by two methods, using gait alone and using gait and functional system scores combined. Results: EDSS-P scores ranged from 0-9.5 (mean 5.1, median 5.0, 78% female, age 17-78, mean age 45). Mean EDSS-P, EDSS-S and intraclass correlation coefficients of agreement were: EDSS using ambulation alone (4.6, 5.1, 0.89), EDSS using ambulation and FS scores (4.6, 5.3, 0.87), bowel/bladder FS scores (1.6, 1.7, 0.79), pyramidal FS scores (2.1, 2.4, 0.67), sensory FS scores (1.6, 2.1, 0.60), cerebellar FS scores (1.1, 1.6, 0.55), brainstem FS scores (0.5, 1.2, 0.45), vision FS scores (1.9, 1.3, 0.38), cerebral FS scores (0.6, 2.3, 0.27). Conclusions: Very good correlation was seen between patient and physician scores for EDSS and the bowel/bladder FS score. Four other FS scores correlated moderately. In general, patients scored themselves more disabled than physicians.

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Online Food Frequency Questionnaire From the Cohort of Universities of Minas Gerais (CUME Project, Brazil): Construction, Validity, and Reproducibility

Frontiers in Nutrition ◽

10.3389/fnut.2021.709915 ◽

2021 ◽

Vol 8 ◽

Author(s):

Heloísa Gambarelli de Araújo Azarias ◽

José Luiz Marques-Rocha ◽

Aline Elizabeth da Silva Miranda ◽

Luana Caroline dos Santos ◽

Ana Luíza Gomes Domingos ◽

...

Keyword(s):

Food Consumption ◽

Food Frequency Questionnaire ◽

Intraclass Correlation ◽

Correlation Coefficients ◽

Fats And Oils ◽

Target Population ◽

Epidemiological Studies ◽

Minas Gerais ◽

Food Frequency ◽

Intraclass Correlation Coefficients

Background: The Food Frequency Questionnaire (FFQ) is usually used in epidemiological studies to assess food consumption. However, the FFQ must have good accuracy, requiring its validation and reproducibility for the target population. Thus, this study aimed to describe the construction of the online Food Frequency Questionnaire (oFFQ) used at the Cohort of Universities of Minas Gerais (CUME project, Brazil) and evaluate its validity and reproducibility.Methods: The oFFQ was answered two times in 1 year (March/August 2018—March/April 2019; n = 108 participants—reproducibility), and four 24-h dietary recalls (24hRs) were applied in two seasons of the southern hemisphere [two 24hRs in autumn (March/June 2018) and two 24hRs in winter (August/September 2018); n = 146 participants—validity]. To assess the validity and reproducibility, the intraclass correlation coefficients (ICCs) were estimated.Results: The oFFQ had 144 food items separated into eight groups (dairy products; meat and fish; cereals and legumes; fruits; vegetables; fats and oils; drinks; other foods). In assessing the validity, ICCs for energy and macronutrients were considered moderate, ranging from 0.41 (energy) to 0.59 (protein), while the ICCs for micronutrients were considered low to moderate, ranging from 0.25 (fibers) to 0.65 (vitamin B6). Regarding reproducibility assessment, ICCs for energy and all the assessed items were considered moderate to excellent, ranging from 0.60 (vegetables) to 0.91 (vitamin E and retinol).Conclusions: The self-reported oFFQ had satisfactory validity and reproducibility. So, it can be used to analyze the association between food consumption and chronic diseases in the participants of the Cohort of Universities of Minas Gerais (CUME project—Brazil).

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Reproducibility of food and nutrient intake estimates using a semi-quantitative FFQ in Australian adults

Public Health Nutrition ◽

10.1017/s1368980009005023 ◽

2009 ◽

Vol 12 (12) ◽

pp. 2359-2365 ◽

Cited By ~ 49

Author(s):

Torukiri I Ibiebele ◽

Sanjoti Parekh ◽

Kylie-ann Mallitt ◽

Maria Celia Hughes ◽

Peter K O’Rourke ◽

...

Keyword(s):

Vegetable Intake ◽

Adult Population ◽

Intraclass Correlation ◽

Correlation Coefficients ◽

Weighted Kappa ◽

Kappa Statistics ◽

Food Groups ◽

Intraclass Correlation Coefficients ◽

One Year ◽

General Community

AbstractObjectiveTo assess the reproducibility of a 135-item self-administered semi-quantitative FFQ.DesignControl subjects who had previously completed an FFQ relating to usual dietary intake in a nationwide case–control study of cancer between November 2003 and April 2004 were randomly selected, re-contacted, and invited to complete the same FFQ a second time approximately one year later (between January and April 2005). Agreement between the two FFQ was compared using weighted kappa statistics and intraclass correlation coefficients (ICC) for food groups and nutrients. Summary questions, included in the FFQ, were used to assess overall intakes of vegetables, fruits and meat.SettingGeneral community in Australia.SubjectsOne hundred men and women aged 22–79 years, randomly selected from the previous control population.ResultsThe weighted κ and ICC measures of agreement for food groups were moderate to substantial for seventeen of the eighteen food groups. For nutrients, weighted κ ranged from 0·44 for starch to 0·83 for alcohol while ICC ranged from 0·51 to 0·91 for the same nutrients. Estimates of meat, fruit and vegetable intake using summary questions were similar for both survey periods, but were significantly lower than estimates from summed individual food items.ConclusionsThe FFQ produced reproducible results and is reasonable in assessing the usual intake of various foods and nutrients among an Australian adult population.

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Development and Validation of a Semiquantitative Food Frequency Questionnaire to Assess Dietary Intake in 40–65-Year-Old Mexican Women

Annals of Nutrition and Metabolism ◽

10.1159/000506920 ◽

2020 ◽

Vol 76 (1) ◽

pp. 73-82

Author(s):

Alexandra Tijerina ◽

Josep A. Tur

Keyword(s):

Pearson Correlation ◽

Intraclass Correlation ◽

Correlation Coefficients ◽

Reference Method ◽

Epidemiological Studies ◽

Test Method ◽

Mexican Women ◽

Food Groups ◽

Nutrient Intakes ◽

Food Frequency

Background and Aims: Food frequency questionnaires (FFQ) have been widely used in epidemiologic studies since 1990s, but instruments need to be validated. The aim of this work was to create and assess the validity and reproducibility of an interview administered FFQ to be used in a Mexican women’s bone health cohort study, located in Monterrey city, Mexico. Methods: Validation of FFQ formed by 11 food groups and 136 food and beverage items was performed on 40–65-year-old Mexican women (n = 200) by applying 2 FFQ (test method) and six 24-h dietary recalls (24hR, reference method; 1 per season on weekdays and 2 on weekends). Pearson correlation coefficient was calculated of both logs, transformed intakes and energy-adjusted nutrient intakes based on the residual method, and intraclass correlation coefficients were calculated. Results: The relative validity of FFQ against the average of six 24hR for intakes of energy, macronutrients, cholesterol, water, vitamins and minerals required for bone metabolism such as vitamin D, calcium, magnesium, phosphorus were obtained. Pearson coefficients of correlation show significance (p < 0.05) for the validity, 0.244–0.820 and 0.258–0.794, for energy-unadjusted and adjusted data, respectively. Reproducibility coefficients range 0.186–0.810 for energy-unadjusted data and 0.174–0.597 for energy-adjusted data. Most nutrients showed lower than 5% of misclassification. Conclusion: The designed 136-item FFQ shows acceptable validity and reproducibility, and it is useful to be applied on 40–65-year-old Mexican women for the estimation of nutrient intakes in epidemiological studies.

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Validity and Reliability of a Food Frequency Questionnaire (FFQ) to Assess Dietary Intake of Preschool Children

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph16234722 ◽

2019 ◽

Vol 16 (23) ◽

pp. 4722 ◽

Cited By ~ 2

Author(s):

Yatiman Noor Hafizah ◽

Lee Choo Ang ◽

Fendy Yap ◽

Wan Nurul Najwa ◽

Whye Lian Cheah ◽

...

Keyword(s):

Preschool Children ◽

Dietary Intake ◽

Validation Study ◽

Intraclass Correlation ◽

Correlation Coefficients ◽

Food Groups ◽

Validity And Reliability ◽

Food Frequency ◽

Dietary Record ◽

Spearman’S Correlation

As there are few food frequency questionnaires (FFQ) to assess the dietary intake of preschool children, this study examined the validity and reliability of an FFQ for this purpose. A total of 210 preschoolers aged 4 to 6 years participated in the validation study, while a subsample of 66 participants joined the reliability study. The FFQ is modified from the ToyBox-study and South East Asian Nutrition Surveys (SEANUTS), and comprised 108 food items from 13 food groups. A three-day estimated dietary record (3DR) was used as reference and reliability was assessed through a second administration of the FFQ (FFQ2), four weeks after the first administration (FFQ1). For the validation study, Spearman’s correlation coefficients showed moderate to high correlations (p < 0.001) between FFQ and 3DR. Cross-classification of quartile analysis showed moderate agreement between the two methods. As for reliability, Spearman’s correlation coefficients showed moderate to high correlations (p < 0.001) between FFQ1 and FFQ2. Cronbach’s alpha values (0.708 to 0.824) and intraclass correlation coefficients (0.710 to 0.826) showed good agreement between repeated FFQs. The results suggest that the FFQ has acceptable validity and good reliability. Hence, the FFQ can be used to assess preschool children’s food intake.

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Interobserver Reliability Using the Phonetic Level Evaluation With Severely and Profoundly Hearing-Impaired Children

Journal of Speech Language and Hearing Research ◽

10.1044/jshr.3405.989 ◽

1991 ◽

Vol 34 (5) ◽

pp. 989-999 ◽

Cited By ~ 6

Author(s):

Stephanie Shaw ◽

Truman E. Coggins

Keyword(s):

Interrater Reliability ◽

Interobserver Reliability ◽

Intraclass Correlation ◽

Correlation Coefficients ◽

Hearing Impaired ◽

Intraclass Correlation Coefficients ◽

Assessment Measure ◽

Impaired Children ◽

Speech Assessment ◽

Hearing Impaired Children

This study examines whether observers reliably categorize selected speech production behaviors in hearing-impaired children. A group of experienced speech-language pathologists was trained to score the elicited imitations of 5 profoundly and 5 severely hearing-impaired subjects using the Phonetic Level Evaluation (Ling, 1976). Interrater reliability was calculated using intraclass correlation coefficients. Overall, the magnitude of the coefficients was found to be considerably below what would be accepted in published behavioral research. Failure to obtain acceptably high levels of reliability suggests that the Phonetic Level Evaluation may not yet be an accurate and objective speech assessment measure for hearing-impaired children.

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Is there a relationship between the overhead press and split jerk maximum performance? Influence of sex

International Journal of Sports Science & Coaching ◽

10.1177/17479541211020452 ◽

2021 ◽

pp. 174795412110204

Author(s):

Marcos A Soriano ◽

G Gregory Haff ◽

Paul Comfort ◽

Francisco J Amaro-Gahete ◽

Antonio Torres-González ◽

...

Keyword(s):

Confidence Intervals ◽

Body Mass ◽

Upper Limb ◽

High Reliability ◽

Intraclass Correlation ◽

Correlation Coefficients ◽

Training Experience ◽

Maximum Performance ◽

Repetition Maximum ◽

Intraclass Correlation Coefficients

The aims of this study were to (I) determine the differences and relationship between the overhead press and split jerk performance in athletes involved in weightlifting training, and (II) explore the magnitude of these differences in one-repetition maximum (1RM) performances between sexes. Sixty-one men (age: 30.4 ± 6.7 years; height: 1.8 ± 0.5 m; body mass 82.5 ± 8.5 kg; weightlifting training experience: 3.7 ± 3.5 yrs) and 21 women (age: 29.5 ± 5.2 yrs; height: 1.7 ± 0.5 m; body mass: 62.6 ± 5.7 kg; weightlifting training experience: 3.0 ± 1.5 yrs) participated. The 1RM performance of the overhead press and split jerk were assessed for all participants, with the overhead press assessed on two occasions to determine between-session reliability. The intraclass correlation coefficients (ICC) and 95% confidence intervals showed a high reliability for the overhead press ICC = 0.98 (0.97 – 0.99). A very strong correlation and significant differences were found between the overhead press and split jerk 1RM performances for all participants (r = 0.90 [0.93 – 0.85], 60.2 ± 18.3 kg, 95.7 ± 29.3 kg, p ≤ 0.001). Men demonstrated stronger correlations between the overhead press and split jerk 1RM performances (r = 0.83 [0.73-0.90], p ≤ 0.001) compared with women (r = 0.56 [0.17-0.80], p = 0.008). These results provide evidence that 1RM performance of the overhead press and split jerk performance are highly related, highlighting the importance of upper-limb strength in the split jerk maximum performance.

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Patient-Reported Dysphagia in Adults with Eosinophilic Esophagitis: Translation and Validation of the Swedish Eosinophilic Esophagitis Activity Index

Dysphagia ◽

10.1007/s00455-021-10277-5 ◽

2021 ◽

Author(s):

Sofie Albinsson ◽

Lisa Tuomi ◽

Christine Wennerås ◽

Helen Larsson

Keyword(s):

Eosinophilic Esophagitis ◽

Activity Index ◽

Intraclass Correlation ◽

Correlation Coefficients ◽

Control Group ◽

Cronbach’S Alpha ◽

Intraclass Correlation Coefficients ◽

Cronbach's Alpha ◽

Patient Reported ◽

Eortc Qlq

AbstractThe lack of a Swedish patient-reported outcome instrument for eosinophilic esophagitis (EoE) has limited the assessment of the disease. The aims of the study were to translate and validate the Eosinophilic Esophagitis Activity Index (EEsAI) to Swedish and to assess the symptom severity of patients with EoE compared to a nondysphagia control group. The EEsAI was translated and adapted to a Swedish cultural context (S-EEsAI) based on international guidelines. The S-EEsAI was validated using adult Swedish patients with EoE (n = 97) and an age- and sex-matched nondysphagia control group (n = 97). All participants completed the S-EEsAI, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Oesophageal Module 18 (EORTC QLQ-OES18), and supplementary questions regarding feasibility and demographics. Reliability and validity of the S-EEsAI were evaluated by Cronbach’s alpha and Spearman correlation coefficients between the domains of the S-EEsAI and the EORTC QLQ-OES18. A test–retest analysis of 29 patients was evaluated through intraclass correlation coefficients. The S-EEsAI had sufficient reliability with Cronbach’s alpha values of 0.83 and 0.85 for the “visual dysphagia question” and the “avoidance, modification and slow eating score” domains, respectively. The test–retest reliability was sufficient, with good to excellent intraclass correlation coefficients (0.60–0.89). The S-EEsAI domains showed moderate correlation to 6/10 EORTC QLQ-OES18 domains, indicating adequate validity. The patient S-EEsAI results differed significantly from those of the nondysphagia controls (p < 0.001). The S-EEsAI appears to be a valid and reliable instrument for monitoring adult patients with EoE in Sweden.

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Diagnosis of left ventricular hypertrophy using non-ECG-gated 15O-water PET

Journal of Nuclear Cardiology ◽

10.1007/s12350-021-02734-3 ◽

2021 ◽

Author(s):

Jens Sörensen ◽

Jonny Nordström ◽

Tomasz Baron ◽

Stellan Mörner ◽

Sven-Olof Granstam ◽

...

Keyword(s):

Method Development ◽

Intraclass Correlation ◽

Correlation Coefficients ◽

Roc Curves ◽

Left Ventricular ◽

Intraclass Correlation Coefficients ◽

Concentric Hypertrophy ◽

2D Echocardiography ◽

Positron Emission ◽

Septal Wall Thickness

Abstract Aim To develop a method for diagnosing left ventricular (LV) hypertrophy from cardiac perfusion 15O-water positron emission tomography (PET). Methods We retrospectively pooled data from 139 subjects in four research cohorts. LV remodeling patterns ranged from normal to severe eccentric and concentric hypertrophy. 15O-water PET scans (n = 197) were performed with three different PET devices. A low-end scanner (66 scans) was used for method development, and remaining scans with newer devices for a blinded evaluation. Dynamic data were converted into parametric images of perfusable tissue fraction for semi-automatic delineation of the LV wall and calculation of LV mass (LVM) and septal wall thickness (WT). LVM and WT from PET were compared to cardiac magnetic resonance (CMR, n = 47) and WT to 2D-echocardiography (2DE, n = 36). PET accuracy was tested using linear regression, Bland–Altman plots, and ROC curves. Observer reproducibility were evaluated using intraclass correlation coefficients. Results High correlations were found in the blinded analyses (r ≥ 0.87, P < 0.0001 for all). AUC for detecting increased LVM and WT (> 12 mm and > 15 mm) was ≥ 0.95 (P < 0.0001 for all). Reproducibility was excellent (ICC ≥ 0.93, P < 0.0001). Conclusion 15O-water PET might detect LV hypertrophy with high accuracy and precision.

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