scholarly journals Emerging Role of Metabolomics in Ovarian Cancer Diagnosis

Metabolites ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 419
Author(s):  
Asia Saorin ◽  
Emanuela Di Gregorio ◽  
Gianmaria Miolo ◽  
Agostino Steffan ◽  
Giuseppe Corona
Keyword(s):  
Ovarian Cancer ◽  
Small Molecules ◽  
Cancer Diagnosis ◽  
Current Status ◽  
Diagnostic Tools ◽  
Metabolic Alterations ◽  
Host Interactions ◽  
Specific Cancer ◽  
Cancer Phenotypes

Ovarian cancer is considered a silent killer due to the lack of clear symptoms and efficient diagnostic tools that often lead to late diagnoses. Over recent years, the impelling need for proficient biomarkers has led researchers to consider metabolomics, an emerging omics science that deals with analyses of the entire set of small-molecules (≤1.5 kDa) present in biological systems. Metabolomics profiles, as a mirror of tumor–host interactions, have been found to be useful for the analysis and identification of specific cancer phenotypes. Cancer may cause significant metabolic alterations to sustain its growth, and metabolomics may highlight this, making it possible to detect cancer in an early phase of development. In the last decade, metabolomics has been widely applied to identify different metabolic signatures to improve ovarian cancer diagnosis. The aim of this review is to update the current status of the metabolomics research for the discovery of new diagnostic metabolomic biomarkers for ovarian cancer. The most promising metabolic alterations are discussed in view of their potential biological implications, underlying the issues that limit their effective clinical translation into ovarian cancer diagnostic tools.

scholarly journals Role of blood oxygenation saturation in ovarian cancer diagnosis using multi‐spectral photoacoustic tomography

2020 ◽  
Author(s):  
Eghbal Amidi ◽  
Guang Yang ◽  
K. M. Shihab Uddin ◽  
Hongbo Luo ◽  
William Middleton ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Diagnosis ◽  
Blood Oxygenation ◽  
Photoacoustic Tomography

scholarly journals Notch Signaling and MicroRNA: The Dynamic Duo Steering Between Neurogenesis and Glioblastomas

2021 ◽  
Vol 67 (2) ◽  
pp. 33-43
Author(s):  
Zeeshan Javed ◽  
Khushbukhat Khan ◽  
Qamar Raza ◽  
Haleema Sadia ◽  
Faiez Ahmad Shah ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Small Molecules ◽  
Neuronal Cell ◽  
Decisive Role ◽  
Eukaryotic Cells ◽  
Diagnostic Tools ◽  
Special Focus ◽  
Cellular Processes ◽  
Development And Differentiation

Notch signaling is an evolutionary conserved pathway that plays a central role in development and differentiation of eukaryotic cells. It has been well documented that Notch signaling is inevitable for neuronal cell growth and homeostasis. It regulates process of differentiation from early embryonic stages to fully developed brain. To achieve this streamlined development of neuronal cells, a number of cellular processes are being orchestrated by the Notch signaling. Abrogated Notch signaling is related to several brain tumors, including glioblastomas. On the other hand, microRNAs are small molecules that play decisive role in mediating and modulating Notch signaling. This review discusses the crucial role of Notch signaling in development of nervous system and how this versatile pathway interplay with microRNAs in glioblastoma. This review sheds light on interplay between abrogated Notch signaling and miRNAs in the regulation of neuronal differentiation with special focus on miRNAs mediated regulation of tumorigenesis in glioblastoma. Furthermore, it discusses different aspects of neurogenesis modulated by the Notch signaling that could be exploited for the identification of new diagnostic tools and therapies for the treatment of glioblastoma.

scholarly journals Diagnosis and Management of Peritoneal Metastases from Ovarian Cancer

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Evgenia Halkia ◽  
John Spiliotis ◽  
Paul Sugarbaker
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Intraperitoneal Chemotherapy ◽  
Cytoreductive Surgery ◽  
Peritoneal Metastasis ◽  
Hyperthermic Intraperitoneal Chemotherapy ◽  
Peritoneal Metastases ◽  
Diagnostic Tools ◽  
Advanced Epithelial Ovarian Cancer

The management and the outcome of peritoneal metastases or recurrence from epithelial ovarian cancer are presented. The biology and the diagnostic tools of EOC peritoneal metastasis with a comprehensive approach and the most recent literatures data are discussed. The definition and the role of surgery and chemotherapy are presented in order to focuse on the controversial points. Finally, the paper discusses the new data about the introduction of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of advanced epithelial ovarian cancer.

scholarly journals Mosaic Mutations in Blood DNA Sequence Are Associated with Solid Tumor Cancers

2016 ◽  
Author(s):  
Mykyta Artomov ◽  
Manuel A. Rivas ◽  
Giulio Genovese ◽  
Mark J. Daly
Keyword(s):  
Ovarian Cancer ◽  
Solid Tumor ◽  
Case Control Study ◽  
Lung Cancers ◽  
Cancer Types ◽  
Cancer Phenotypes ◽  
Mosaic Protein ◽  
Tumor Dna ◽  
Control Study

AbstractRecent findings in understanding the causal role of blood-detectable somatic protein-truncating DNA variants in leukemia prompt questions about generalizability of such observations for other cancer types. We used exome sequencing to compare 22 different cancer phenotypes from TCGA data (~8,000 samples) with more than 6,000 controls using a case-control study design and demonstrate that mosaic protein truncating variants in these genes are also associated with solid-tumor cancers. We analyzed tumor DNA samples from TCGA and observed that the cancer-associated mosaic variants are absent from the tumors.Through analysis of different cancer phenotypes we observe gene-specificity for mosaic mutations. PPM1D in previous reports has been linked to breast and ovarian cancer, which our analysis confirms as a specifically associated to ovarian cancer. Additionally, glioblastoma, melanoma and lung cancers show gene specific burden of the mosaic protein truncating mutations. Taken together, these results extend existing observations broadly and link solid-tumor cancers to somatic blood DNA changes.

The role of cediranib in ovarian cancer: current status and further investigation

2016 ◽  
Vol 4 (8) ◽  
pp. 855-865
Author(s):  
Josee-Lyne Ethier ◽  
Stephanie Lheureux ◽  
Amit Oza
Keyword(s):  
Ovarian Cancer ◽  
Current Status

scholarly journals Current status and implications of microRNAs in ovarian cancer diagnosis and therapy

2012 ◽  
Vol 5 (1) ◽  
pp. 44 ◽  
Author(s):  
Mohd Saif Zaman ◽  
Diane M Maher ◽  
Sheema Khan ◽  
Meena Jaggi ◽  
Subhash C Chauhan
Keyword(s):  
Ovarian Cancer ◽  
Cancer Diagnosis ◽  
Current Status ◽  
Diagnosis And Therapy ◽  
Cancer Diagnosis And Therapy

scholarly journals Review of Immunohistochemistry Biomarkers in Pancreatic Cancer Diagnosis

2021 ◽  
Vol 11 ◽  
Author(s):  
Tuan Trong Luu
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Diagnosis ◽  
High Rate ◽  
Diagnostic Tools ◽  
Diagnostic Efficacy ◽  
Cancer Types ◽  
Diagnostic Modalities ◽  
Cancer Tissues ◽  
Insight Into

Pancreatic cancer is one of the cancer types with poor prognosis and high rate of mortality. Diagnostic modalities for early detection of pancreatic cancer have been among the academic concerns. On account of the potential role of immunohistochemistry (IHC) biomarkers in overcoming certain limitations of imaging diagnostic tools in discriminating pancreatic cancer tissues from benign ones, a growing scholarly attention has been given to the diagnostic efficacy of IHC biomarkers for pancreatic cancer. This review will analyze and synthesize published articles to provide an insight into potential IHC biomarkers for pancreatic cancer diagnosis.

Psychological Resilience Provides No Independent Protection From Suicidal Risk

Crisis ◽  
2016 ◽  
Vol 37 (2) ◽  
pp. 130-139 ◽  
Author(s):  
Danica W. Y. Liu ◽  
A. Kate Fairweather-Schmidt ◽  
Richard Burns ◽  
Rachel M. Roberts ◽  
Kaarin J. Anstey
Keyword(s):  
Risk Factors ◽  
Well Being ◽  
Current Status ◽  
Psychological Resilience ◽  
Cross Sectional ◽  
Life Project ◽  
Resilience Factors ◽  
First Time

Abstract. Background: Little is known about the role of resilience in the likelihood of suicidal ideation (SI) over time. Aims: We examined the association between resilience and SI in a young-adult cohort over 4 years. Our objectives were to determine whether resilience was associated with SI at follow-up or, conversely, whether SI was associated with lowered resilience at follow-up. Method: Participants were selected from the Personality and Total Health (PATH) Through Life Project from Canberra and Queanbeyan, Australia, aged 28–32 years at the first time point and 32–36 at the second. Multinomial, linear, and binary regression analyses explored the association between resilience and SI over two time points. Models were adjusted for suicidality risk factors. Results: While unadjusted analyses identified associations between resilience and SI, these effects were fully explained by the inclusion of other suicidality risk factors. Conclusion: Despite strong cross-sectional associations, resilience and SI appear to be unrelated in a longitudinal context, once risk/resilience factors are controlled for. As independent indicators of psychological well-being, suicidality and resilience are essential if current status is to be captured. However, the addition of other factors (e.g., support, mastery) makes this association tenuous. Consequently, resilience per se may not be protective of SI.

The current role of gemcitabine in ovarian cancer

2001 ◽  
Vol 28 (2D) ◽  
pp. 18-24
Author(s):  
Robert F. Ozols
Keyword(s):  
Ovarian Cancer ◽  
Current Role
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