scholarly journals The Mitochondrial Prohibitin (PHB) Complex in C. elegans Metabolism and Ageing Regulation

Metabolites ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 636
Author(s):  
Artur B. Lourenço ◽  
Marta Artal-Sanz
Keyword(s):  
Lipid Metabolism ◽  
Energy Production ◽  
Large Scale ◽  
Mitochondrial Respiratory Chain ◽  
Membrane Lipid ◽  
Membrane Lipid Composition ◽  
C Elegans ◽  
Evolutionarily Conserved ◽  
Biochemical Function ◽  
The Impact

The mitochondrial prohibitin (PHB) complex, composed of PHB-1 and PHB-2, is an evolutionarily conserved context-dependent modulator of longevity. This extremely intriguing phenotype has been linked to alterations in mitochondrial function and lipid metabolism. The true biochemical function of the mitochondrial PHB complex remains elusive, but it has been shown to affect membrane lipid composition. Recent work, using large-scale biochemical approaches, has highlighted a broad effect of PHB on the C. elegans metabolic network. Collectively, the biochemical data support the notion that PHB modulates, at least partially, worm longevity through the moderation of fat utilisation and energy production via the mitochondrial respiratory chain. Herein, we review, in a systematic manner, recent biochemical insights into the impact of PHB on the C. elegans metabolome.

scholarly journals Impact of a Complex Food Microbiota on Energy Metabolism in the Model OrganismCaenorhabditis elegans

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Elena Zanni ◽  
Chiara Laudenzi ◽  
Emily Schifano ◽  
Claudio Palleschi ◽  
Giuditta Perozzi ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Model System ◽  
Lactobacillus Delbrueckii ◽  
Altered Expression ◽  
C Elegans ◽  
Gut Colonization ◽  
Evolutionarily Conserved ◽  
Before And After ◽  
Leuconostoc Lactis ◽  
The Impact

The nematodeCaenorhabditis elegansis widely used as a model system for research on aging, development, and host-pathogen interactions. Little is currently known about the mechanisms underlying the effects exerted by foodborne microbes. We took advantage ofC. elegansto evaluate the impact of foodborne microbiota on well characterized physiological features of the worms. Foodborne lactic acid bacteria (LAB) consortium was used to feed nematodes and its composition was evaluated by 16S rDNA analysis and strain typing before and after colonization of the nematode gut.Lactobacillus delbrueckii, L. fermentum, andLeuconostoc lactiswere identified as the main species and shown to display different worm gut colonization capacities. LAB supplementation appeared to decrease nematode lifespan compared to the animals fed with the conventionalEscherichia colinutrient source or a probiotic bacterial strain. Reduced brood size was also observed in microbiota-fed nematodes. Moreover, massive accumulation of lipid droplets was revealed by BODIPY staining. Altered expression ofnhr-49, pept-1, and tub-1genes, associated with obesity phenotypes, was demonstrated by RT-qPCR. Since several pathways are evolutionarily conserved inC. elegans, our results highlight the nematode as a valuable model system to investigate the effects of a complex microbial consortium on host energy metabolism.

scholarly journals The impact of membrane lipid composition on antimicrobial function of an α-helical peptide

2008 ◽  
Vol 151 (2) ◽  
pp. 92-102 ◽  
Author(s):  
Sarah R. Dennison ◽  
Leslie H.G. Morton ◽  
Frederick Harris ◽  
David A. Phoenix
Keyword(s):  
Lipid Composition ◽  
Membrane Lipid ◽  
Membrane Lipid Composition ◽  
Helical Peptide ◽  
Antimicrobial Function ◽  
The Impact

scholarly journals ROADS AND DAMS: INFRASTRUCTURE-DRIVEN TRANSFORMATIONS IN THE BRAZILIAN AMAZON

2016 ◽  
Vol 19 (2) ◽  
pp. 207-220 ◽  
Author(s):  
EMILIO F. MORAN
Keyword(s):  
Energy Production ◽  
Large Scale ◽  
National Development ◽  
Brazilian Amazon ◽  
Hydroelectric Dam ◽  
Development Goals ◽  
Negative Impacts ◽  
The Impact ◽  
Belo Monte ◽  
Social And Environmental Impacts

Abstract From the construction of the Trans-Amazon Highway in the 1970's to the current construction of the third largest hydroelectric dam in the world at Belo Monte, the Brazilian Amazon has experienced the impact of large-scale infrastructure projects. When announced, all these projects purported to be the means to achieve progress, national integration, and economic development. The outcomes after several decades are less clear: national indebtedness, significant social and environmental impacts, and regional development taking second place to other goals such as energy production and national GDP. Solutions are suggested to reduce the negative impacts and achieve the goal of improved livelihoods and sustainable development without giving up on national development goals.

Impact of anthracene on the arbuscular mycorrhizal fungus lipid metabolism

Botany ◽  
2014 ◽  
Vol 92 (2) ◽  
pp. 173-178 ◽  
Author(s):  
M. Calonne ◽  
J. Fontaine ◽  
D. Debiane ◽  
F. Laruelle ◽  
A. Grandmougin-Ferjani ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Mycorrhizal Fungi ◽  
Negative Impact ◽  
Anthropogenic Activities ◽  
Organic Pollutant ◽  
Mycorrhizal Fungus ◽  
Arbuscular Mycorrhizal ◽  
Membrane Lipid ◽  
Acetate Incorporation ◽  
The Impact

Anthracene, a low-molecular-weight polycyclic aromatic hydrocarbon (PAH) originating mainly from anthropogenic activities, represents one of the major persistent organic pollutants frequently detected in polluted soils. A few studies have reported the negative effect of PAH on the main steps of the arbuscular mycorrhizal fungi (AMF) life cycle resulting from lipid peroxidation; however, little is known regarding the impact of anthracene on extraradical AMF lipid metabolism. Radiolabelling experiments showed significant decreases of [1-14C]acetate incorporation into the sterol precursors (4,4-dimethylsterols and 4α-methylsterols) and in the total phospholipids (PL) of Rhizophagus irregularis (Blaszk., Wubet, Renker & Buscot) extraradical mycelium when grown in the presence of anthracene. These findings suggested a slowing down of the sterol and total PL biosynthesis pathways in AMF treated with anthracene. The negative impact of the organic pollutant on AMF membrane lipid biosynthesis may explain the growth inhibition of the fungus after PAH exposure. This study increases the understanding of the biochemical mechanisms involved in PAH ecotoxicity on AMF.

scholarly journals C13C4.5/Spinster, an evolutionarily conserved protein that regulates fertility in C. elegans through a lysosome-mediated lipid metabolism process

2013 ◽  
Vol 4 (5) ◽  
pp. 364-372 ◽  
Author(s):  
Mei Han ◽  
Hao Chang ◽  
Peng Zhang ◽  
Tao Chen ◽  
Yanhua Zhao ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
C Elegans ◽  
Evolutionarily Conserved

scholarly journals High throughput small molecule screening reveals NRF2-dependent and - independent pathways of cellular stress resistance

2019 ◽  
Author(s):  
David B. Lombard ◽  
William Kohler ◽  
Angela H. Guo ◽  
Christi Gendron ◽  
Melissa Han ◽  
...  
Keyword(s):  
Small Molecules ◽  
Stress Resistance ◽  
Large Scale ◽  
Cellular Stress ◽  
Biological Aging ◽  
Methyl Methanesulfonate ◽  
Ampk Signaling ◽  
C Elegans ◽  
Small Molecule Screening ◽  
Evolutionarily Conserved

AbstractBiological aging is the dominant risk factor for most chronic diseases. Development of anti-aging interventions offers the promise of preventing many such illnesses simultaneously. Cellular stress resistance is an evolutionarily conserved feature of longevity. Here, we identify compounds that induced resistance to the superoxide generator paraquat (PQ), the heavy metal cadmium (Cd), and the DNA alkylator methyl methanesulfonate (MMS). Some rescue compounds conferred resistance to a single stressor, while others provoked multiplex resistance. Induction of stress resistance in fibroblasts was predictive of longevity extension in a published large-scale longevity screen in C. elegans. Transcriptomic analysis implicated Nrf2 signaling in stress resistance provided by two protective compounds, cardamonin and AEG 3482. Molecules that conferred stress resistance also induced cellular inflammatory pathways, and other core pathways such as AMPK signaling. Small molecules identified in this work may represent attractive candidates to evaluate for their potential pro-health and pro-longevity effects in mammals.

scholarly journals OPTIMUM TILT ANGLE FOR MAXIMIZING LARGE SCALE SOLAR ELECTRICAL ENERGY OUTPUT

2021 ◽  
Vol 83 (3) ◽  
pp. 133-141
Author(s):  
Mohamed Nageh ◽  
Md Pauzi Abdullah ◽  
Belal Yousef
Keyword(s):  
Tilt Angle ◽  
Energy Production ◽  
Large Scale ◽  
Tracking System ◽  
Electrical Energy ◽  
Energy Output ◽  
Maintenance Cost ◽  
Construction Operation ◽  
Electrical Energy Production ◽  
The Impact

Many large-scale solar (LSS) plants that are being installed today have solar photovoltaic (PV) panels mounted on fixed structures, which limits its electrical energy production. Tracking system can be installed so that the PV panels could change its tilt angle automatically in accordance with the sun’s movement. However, it will increase the construction, operation and maintenance cost significantly. Another option is to manually adjust the tilt angle on periodically basis, but the time period and the optimum tilt angle need to be systematically determined. This paper investigates the impact of using monthly and seasonal optimum tilt angle, βopt on electrical energy production of LSS plant. The proposed strategy can be implemented by using tiltable solar panel mounting structures which is far cheaper than the tracking system. For the study, 1 MW LSS system model is used. Twelve cities around the globe with latitude angle ranging from 0º to 55º are strategically selected. The electrical energy output from the 1 MW LSS plant is simulated by using PV mathematical model that is developed in Matlab software. The overall results show that by adjusting the tilt angle of the PV modules into its optimum angle on monthly or seasonal basis, it would increase the generated energy output between 1.91% and 7.24% for monthly adjustments and between 1.59% and 6.06% for seasonal adjustments.

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