scholarly journals Experimental Assessment of Leptomeningeal Metastasis Diagnosis in Medulloblastoma Using Cerebrospinal Fluid Metabolomic Profiles

Metabolites ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 851
Author(s):  
Ji Hye Im ◽  
Byong Chul Yoo ◽  
Jun Hwa Lee ◽  
Kyue-Yim Lee ◽  
Kyung-Hee Kim ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Diagnostic Accuracy ◽  
Leptomeningeal Metastasis ◽  
Test Results ◽  
Liquid Chromatography Mass Spectrometry ◽  
Csf Cytology ◽  
Resonance Imaging ◽  
Diagnostic Potential ◽  
Low Mass ◽  
Magnetic Resonance Imaging Mri

Diagnosing leptomeningeal metastasis (LM) in medulloblastoma is currently based on positive cerebrospinal fluid (CSF) cytology or magnetic resonance imaging (MRI) finding. However, the relevance of discordant results has not been established. We evaluated the diagnostic potential of CSF metabolomic profiles in the medulloblastoma LM assessment. A total of 83 CSF samples from medulloblastoma patients with documented MRI and CSF cytology results at the time of sampling for LM underwent low-mass ions (LMIs) analysis using liquid chromatography-mass spectrometry. Discriminating LMIs were selected by a summed sensitivity and specificity (>160%) and LMI discriminant equation (LOME) algorithms, evaluated by measuring diagnostic accuracy for verifying LM groups of different MRI/cytology results. Diagnostic accuracy of LM in medulloblastoma was 0.722 for cytology and 0.889 for MRI. Among 6572 LMIs identified in all sample, we identified 27 discriminative LMIs differentiating MRI (+)/cytology (+) from MRI (−)/cytology (−). Using LMI discriminant equation (LOME) analysis, we selected 9 LMIs with a sensitivity of 100% and a specificity of 93.6% for differentiating MRI (+)/cytology (+) from MRI (−)/cytology (−). Another LOME of 20 LMIs significantly differentiated sampling time relative to treatment (p = 0.007) and the presence or absence of LM-related symptoms (p = 0.03) in the MRI (+)/cytology (−) group. CSF metabolomics of medulloblastoma patients revealed significantly different profiles among LM diagnosed with different test results. We suggest that LM patients could be screened by appropriately selected LOME-generated LMIs to support LM diagnosis by either MRI or cytology alone.

HaNDL Syndrome: Case Report and Literature Review

2018 ◽  
Vol 34 (3) ◽  
pp. 161-167 ◽  
Author(s):  
Amy Armstrong-Javors ◽  
Kalpathy Krishnamoorthy
Keyword(s):  
Cerebrospinal Fluid ◽  
Literature Review ◽  
Severe Headache ◽  
Resonance Imaging ◽  
Neurologic Deficits ◽  
Elevated Protein ◽  
Episodic Nature ◽  
Magnetic Resonance Imaging Mri ◽  
Fundoscopic Examination ◽  
Pathophysiologic Mechanisms

Headache and Neurologic Deficits with cerebrospinal fluid Lymphocytosis (HaNDL) syndrome is a rare stroke mimicker characterized by moderate to severe headache temporally associated with transient neurologic deficits, typically hemiparesis, hemisensory disturbance, and/or aphasia. Cerebrospinal fluid studies reveal a lymphocytosis and elevated protein. Episodes recur over a period no longer than 3 months. Here we describe the case of a 16-year-old boy who presented with 3 episodes of self-resolving neurologic deficits, papilledema on fundoscopic examination, and leptomeningeal enhancement on magnetic resonance imaging (MRI). We additionally review the 30 previously reported pediatric cases of HaNDL syndrome, with a focus on possible etiologic and pathophysiologic mechanisms of disease. The reported case and literature review highlight the benign episodic nature of this likely underrecognized syndrome as well as the higher than expected frequency of abnormal neuroimaging findings.

Preliminary Study Evaluating the Accuracy of MRI Images on CBCT Images in the Field of Orthodontics

2011 ◽  
Vol 36 (2) ◽  
pp. 211-218 ◽  
Author(s):  
Kiyoshi Tai ◽  
Jae Hyun Park ◽  
Kunio Hayashi ◽  
Yoshinobu Yanagi ◽  
Jun-ichi Asaumi ◽  
...  
Keyword(s):  
Measurement Errors ◽  
Linear Measurement ◽  
Cone Beam ◽  
Test Results ◽  
Resonance Imaging ◽  
Japanese Adult ◽  
Linear Measurements ◽  
3 Dimensional ◽  
Preliminary Study ◽  
Magnetic Resonance Imaging Mri

Objective: The purpose of this study was to explore the 3-dimensional (3D) accuracy of magnetic resonance imaging (MRI) on cone-beam computed tomography (CBCT) images after the registration of MRI images on CBCT images. Materials and Methods: Three Japanese adult females volunteered for this study. To transform digital imaging and communication in medicine (DICOM) data derived from MRI and CBCT images into polygon data, five software programs were used. CBCT and MRI images were obtained within one week, and both were registered by the iterative closest point (ICP) method. To assess the accuracy of the composite MRI-CBCT, the measurement errors of the MRI-CBCT were verified. Measurement values were compared using frontal and cephalometric soft-tissue landmarks. Differences were analyzed using the non-parametric Mann-Whitney U test. Results: There were no significant linear measurement errors (P ≯ 0.05) when the images were measured from the superimposed MRI-CBCT images. Conclusion: The MRI images attained from MRI - CBCT registration showed accurate 3D linear measurements.

scholarly journals Magnetic resonance imaging findings in probable Creutzfeld-Jacob disease: comparison with electroencephalography and cerebrospinal fluid characteristics

2014 ◽  
Vol 3 (10) ◽  
pp. 204798161455221
Author(s):  
Melda Bozluolcay ◽  
Ayse D Elmali ◽  
Sukriye F Menku ◽  
Burcu Zeydan ◽  
Gulcin Benbir ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cerebrospinal Fluid ◽  
Magnetic Resonance ◽  
Laboratory Data ◽  
Disease Onset ◽  
Initial Symptom ◽  
Resonance Imaging ◽  
Diffusion Weighted Images ◽  
Magnetic Resonance Imaging Mri ◽  
Age Range

Background Creutzfeld-Jacob disease (CJD) is a rare, progressive disease that has a vast clinical manifestation range. Cranial magnetic resonance imaging (MRI), electroencephalography (EEG), and measurement of 14-3-3 in cerebrospinal fluid (CSF) may offer a pragmatic approach in the diagnosis of CJD as an alternative to histopathological confirmation. Purpose To present the symptoms and signs of the CJD patients in regard to radiological and neurophysiological findings. Material and Methods We collected all cases with the diagnosis of probable CJD admitted to our neurology department between June 2010 and June 2014. The medical records and laboratory data, clinical features, results of MRI (including diffusion weighted images), EEG and CSF evaluations, and other laboratory data to exclude other possible diagnoses were recorded. None of the patients underwent biopsy or autopsy for histological diagnosis. Results Of 20 patients, 11 (55%) were men and nine (45%) were women. The mean age at disease onset was 60.0 ± 9.5 years (age range, 47–80 years). All patients without exception had characteristic abnormalities in DWI and/or FLAIR on admission, about 4 months after the initial symptom. Periodic complexes on EEGs characteristic for CJD were detected only in 10 patients (50%) on admission and in 13 patients (65%) during disease course. Out of 14 patients who underwent CSF examination, 11 (78.5%) were positive for 14-3-3 protein. Conclusion Although the definite diagnosis of CJD is made histopathologically, we aimed to discuss the value of magnetic resonance imaging in the diagnosis of CJD in respect to EEG findings and protein 14-3-3 levels in CSF.

scholarly journals Prognostic validation and clinical implications of the EANO ESMO classification of leptomeningeal metastasis from solid tumors

2020 ◽  
Author(s):  
Emilie Le Rhun ◽  
Patrick Devos ◽  
Johannes Weller ◽  
Katharina Seystahl ◽  
Francesca Mo ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Leptomeningeal Metastasis ◽  
Rank Test ◽  
Type I ◽  
Type Ii ◽  
Csf Cytology ◽  
Kaplan Meier ◽  
Clinical Magnetic Resonance Imaging ◽  
Magnetic Resonance Imaging Mri

Abstract Background The EANO ESMO guidelines have proposed a classification of leptomeningeal metastases (LM) from solid cancers based on clinical, magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) cytology presentation. MRI patterns are classified as linear, nodular, both, or neither. Type I LM is defined by positive CSF cytology (confirmed LM) whereas type II LM is defined by typical clinical and MRI signs (probable or possible LM). Here we explored the clinical utility of these LM subtypes. Patients and methods We retrospectively assembled data from 254 patients with newly diagnosed LM from solid tumors. Survival curves were derived using the Kaplan-Meier method and compared by Log-rank test. Results Median age at LM diagnosis was 56 years. Typical clinical LM features were noted in 225 patients (89%); 13 patients (5%) were clinically asymptomatic. Tumor cells in the CSF were observed in 186 patients (73%) whereas the CSF was equivocal in 24 patients (9.5%) and negative in 44 patients (17.5%). Patients with confirmed LM had inferior outcome compared with patients with probable or possible LM (p=0.006). Type I patients had inferior outcome than type II patients (p=0.002). Nodular disease on MRI was a negative prognostic factor in type II LM (p=0.014), but not in type I LM. Administration of either intrathecal pharmacotherapy (p=0.020) or systemic pharmacotherapy (p=0.0004) was associated with improved outcome in type I LM, but not in type II LM. Conclusion The EANO ESMO LM subtypes are highly prognostic and should be considered for stratification and overall design of clinical trials.

scholarly journals Utility of PCR Assay in Diagnosis of En-Plaque Tuberculoma of the Brain

1999 ◽  
Vol 37 (2) ◽  
pp. 467-470 ◽  
Author(s):  
K. K. Singh ◽  
M. D. Nair ◽  
K. Radhakrishnan ◽  
J. S. Tyagi
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cerebrospinal Fluid ◽  
Resonance Imaging ◽  
Pcr Assay ◽  
Mri Findings ◽  
Antitubercular Drugs ◽  
Specific Pcr ◽  
Specific Pcr Assay ◽  
Magnetic Resonance Imaging Mri ◽  
The Brain

This is the first report of a case in which diagnosis of en-plaque tuberculoma on the basis of magnetic resonance imaging (MRI) findings was confirmed by a Mycobacterium tuberculosiscomplex-specific PCR assay of cerebrospinal fluid. The accuracy of the diagnosis was supported by good response to antitubercular drugs, which was shown by repeat MRI studies performed after treatment.

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