scholarly journals Identifying Metabolomic Profiles of Insulinemic Dietary Patterns

Metabolites ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. 120 ◽  
Author(s):  
Fred K. Tabung ◽  
Raji Balasubramanian ◽  
Liming Liang ◽  
Steven K. Clinton ◽  
Elizabeth M. Cespedes Feliciano ◽  
...  
Keyword(s):  
Dietary Patterns ◽  
Statistical Significance ◽  
Cross Sectional Study ◽  
Validation Dataset ◽  
Cross Sectional ◽  
Independent Dataset ◽  
C Peptide ◽  
Dietary Index ◽  
Liquid Chromatography Tandem Mass ◽  
Tandem Mass Spectroscopy

The food-based empirical dietary index for hyperinsulinemia (EDIH) score assesses the insulinemic potential of diet. This cross-sectional study evaluated associations between EDIH scores from food frequency questionnaires with c-peptide concentrations and with 448 metabolites, from fasting plasma samples, in multivariable linear regression analyses. Metabolites were measured with liquid chromatography tandem mass spectroscopy. Using a robust two-stage study design, discovery of metabolite associations was conducted among 1109 Women’s Health Initiative (WHI) Hormone Therapy (HT) trial participants and results replicated in an independent dataset of 810 WHI Observational Study (OS) participants. In both discovery and replication datasets, statistical significance was based on the false-discovery rate adjusted P < 0.05. In the multivariable-adjusted analyses, EDIH was significantly associated with c-peptide concentrations among 919 women (HT & OS) with c-peptide data. On average, c-peptide concentrations were 18% higher (95% CI, 6%, 32%; P-trend < 0.0001) in EDIH quintile 5 compared to quintile 1. Twenty-six metabolites were significantly associated with EDIH in the discovery dataset, and 19 of these were replicated in the validation dataset. Nine metabolites were found to decrease in abundance with increasing EDIH scores and included: C14:0 CE, C16:1 CE, C18:1 CE, C18:3 CE, C20:3 CE, C20:5 CE, C36:1 PS plasmalogen, trigonelline, and eicosapentanoate, whereas the 10 metabolites observed to increase with increasing EDIH scores were: C18:2 SM, C36:3 DAG, C36:4 DAG-A, C51:3 TAG, C52:3 TAG, C52:4, TAG, C54:3 TAG, C54:4 TAG, C54:6 TAG, and C10:2 carnitine. Cholesteryl esters, phospholipids, acylglycerols, and acylcarnitines may constitute circulating metabolites that are associated with insulinemic dietary patterns.

scholarly journals Identifying Metabolomic Profiles of Insulinemic Dietary Patterns (OR31-03-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Fred Tabung ◽  
Raji Balasubramanian ◽  
Steven Clinton ◽  
Liming Liang ◽  
Clary Clish ◽  
...  
Keyword(s):  
Dietary Patterns ◽  
Statistical Significance ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Validation Dataset ◽  
Plasma Metabolites ◽  
Obese Women ◽  
Cross Sectional ◽  
Funding Sources ◽  
Secondary Analyses

Abstract Objectives The empirical dietary index for hyperinsulinemia (EDIH) is a food-based score derived from correlations with plasma c-peptide. Our aim is to use the EDIH to discover metabolites associated with insulinemic dietary patterns. Methods This baseline cross-sectional study evaluated associations between continuous EDIH scores from food frequency questionnaires and 448 log-transformed plasma metabolites as outcomes in multivariable linear regression analyses. Metabolites were measured with liquid chromatography tandem mass spectroscopy. Metabolite discovery was conducted among 1109 Women's Health Initiative (WHI) Hormone Therapy trial participants and results replicated in an independent dataset of 810 WHI Observational Study participants. In both discovery and replication datasets statistical significance was based on false-discovery rate adjusted P < 0.05. Secondary analyses were conducted in body mass index (BMI: <25, >=25 kg/m2) categories. Results After adjustment for energy intake, BMI, physical activity, and other confounding variables, 26 metabolites were significantly associated with EDIH in the discovery dataset, and included: trigonelline, C14:0 CE, C16:1 CE, C18:1 CE, C18:3 CE, C20:3 CE. C20:5 CE, C36:1 PS plasmalogen and eicosapentaenoate were associated with lower dietary insulinemic potential, whereas C36:3 DAG, C51:3 TAG, C52:3 TAG, C52:4 TAG, C54:2 TAG, C54:3 TAG, C54:4 TAG, C54:6 TAG, C36:4 DAG-A, cystathionine, isoleucine, N4-acetylcytidine, C10:2 carnitine, cAMP, C18:2 SM, C4-OH carnitine, and myristoleic acid were associated with higher dietary insulinemic potential. 25 out of the 26 metabolites replicated in the validation dataset except myristoleic acid. In secondary analyses within BMI strata, Associations differed by BMI category: 12 metabolites were significant among normal weight women whereas 64 metabolites were associated with EDIH among overweight/obese women. Conclusions Cholesterol esters, triglycerides, carnitines and amino acids may constitute metabolites that are associated with insulinemic dietary patterns. Funding Sources R00CA207736, NHLBI HHSN268201300008C.

Clinical Utility of the Ankle-Brachial Index and Toe Brachial Index in Patients with Diabetic Foot Ulcers

2020 ◽  
Vol 16 (3) ◽  
pp. 270-277 ◽  
Author(s):  
Mutasem Ababneh ◽  
Mousab Y. Al Ayed ◽  
Asirvatham A. Robert ◽  
Mohamed A. Al Dawish
Keyword(s):  
Diabetic Foot ◽  
Statistical Significance ◽  
Ankle Brachial Index ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Arterial Disease ◽  
Cross Sectional Study ◽  
Screening Tests ◽  
Cross Sectional ◽  
Toe Brachial Index

Background: This cross sectional study investigated the clinical use of the ankle-brachial index (ABI) and toe brachial index (TBI) in 91 type 2 diabetic foot ulcer patients who visited the diabetic foot clinic, Prince Sultan Military Medical City, Saudi Arabia during July 2017 and January 2018. Materials and Methods: The ABI and TBI facilitated the detection of peripheral arterial disease (PAD) and the patients’ medical records were used to collect the clinical and demographic variables. The variables of duration (p = 0.047) and treatment (p = 0.046) of the ABI showed significant differences. Age (p = 0.034) and duration (p = 0.001) were the factors related to the diagnosis of TBI by the “χ2” test. Results: From the TBI, 26.4% of the patients were found to have PAD, while the ABI showed that 21.8% of patients had the condition. However, no statistical significance was noted. From the regression analysis, the variable duration of diabetes (≥ 20 years of age) was recognized as an independent risk factor for TBI. Conclusion: In conclusion, it is recommended both the ABI and TBI to be used as screening tests for PAD in diabetic foot ulcer patients.

Association of CYP2D6*10 (c. 100 C>T) Genotype with Z-END Concentration in Patients with Breast Cancer Receiving Tamoxifen Therapy in Indonesian Population

2019 ◽  
Vol 19 (8) ◽  
pp. 1198-1206 ◽  
Author(s):  
Yenny ◽  
Sonar S. Panigoro ◽  
Denni J. Purwanto ◽  
Adi Hidayat ◽  
Melva Louisa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Steady State ◽  
Ultra Performance Liquid Chromatography ◽  
Cross Sectional Study ◽  
Threshold Concentration ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
Significant Difference ◽  
Pcr Rflp ◽  
Liquid Chromatography Tandem Mass

Background: Tamoxifen (TAM) is a frequently used hormonal prodrug for patients with breast cancer that needs to be activated by cytochrome P450 2D6 (CYP2D6) into Zusammen-endoxifen (Z-END). Objective: The purpose of the study was to determine the association between CYP2D6*10 (c.100C>T) genotype and attainment of the plasma steady-state Z-END minimal threshold concentration (MTC) in Indonesian women with breast cancer. Methods: A cross-sectional study was performed in 125 ambulatory patients with breast cancer consuming TAM at 20 mg/day for at least 4 months. The frequency distribution of CYP2D6*10 (c.100C>T) genotypes (C/C: wild type; C/T: heterozygous mutant; T/T: homozygous mutant) was detected using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), the results of which were subsequently confirmed by sequencing. The genotypes were categorized into plasma Z- END concentrations of <5.9 ng/mL and ≥5.9 ng/mL, which were measured using ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). Results: Percentages of C/C, CT, and T/T genotypes were 22.4%, 29.6%, and 48.8%, respectively. Median (25-75%) Z-END concentrations in C/C, C/T, and T/T genotypes were 9.58 (0.7-6.0), 9.86 (0.7-26.6), and 3.76 (0.9-26.6) ng/mL, respectively. Statistical analysis showed a significant difference in median Z-END concentration between patients with T/T genotype and those with C/C or C/T genotypes (p<0.001). There was a significant association between CYP2D6*10 (c.100C>T) genotypes and attainment of plasma steady-state Z-END MTC (p<0.001). Conclusion: There was a significant association between CYP2D6*10 (c.100C>T) and attainment of plasma steady-state Z-END MTC in Indonesian breast cancer patients receiving TAM at a dose of 20 mg/day.

scholarly journals A Questionnaire-Based Survey to Assess the Level of Knowledge and Awareness about Drug–Food Interactions among General Public in Western Saudi Arabia

Pharmacy ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 76
Author(s):  
Syed Faisal Zaidi ◽  
Rayan Mgarry ◽  
Abdullah Alsanea ◽  
Sakar Khalid Almutairi ◽  
Yaser Alsinnari ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Statistical Significance ◽  
Cross Sectional Study ◽  
Exclusion Criteria ◽  
Cross Sectional ◽  
Jeddah City ◽  
Fundamental Information ◽  
Inadequate Knowledge ◽  
Level Of Knowledge ◽  
Males And Females

Introduction: Various drug–food interactions exist that may hinder treatment and can sometimes be lethal. Our aim was to assess the level of public knowledge and awareness in Jeddah city, Western Saudi Arabia, about drug–food interactions, along with the effects of demographics on their knowledge. Methods: A survey questionnaire was administered in this cross-sectional study to participants spread across multiple locations in Jeddah, including in malls and public gatherings. Participants included both males and females. Sample size was calculated through Raosoft® software. Data analysis was executed using IBM Statistic SPSS and the level of statistical significance was set at p < 0.05. Results: A total of 410 people participated in the study and only 92.68% (380) of responses were enrolled in the study; 7.32% (30) were not enrolled due to the exclusion criteria. Surprisingly, only six out of eighteen questions regarding drug–food interactions in the administered questionnaire were correctly answered by 380 participants. Data indicated that the participants had a poor to intermediate level of both knowledge and awareness with respect to drug–food interactions. Furthermore, participants showed moderate to strong awareness of the effects of alcohol and tea generally, and their interaction with medication. Conclusion: Participants in our study showed inadequate knowledge of basic and fundamental information about drug–food interactions, which highlights the dire need to increase awareness.

scholarly journals Timely Initiation of Breast Feeding and Associated Factors among Caesarian Section Delivered Mothers in Health Facilities of Dessie City Administration, North Eastern Ethiopia

2020 ◽  
Vol 13 (1) ◽  
pp. 1-8
Author(s):  
Roza Shiferaw ◽  
Sisay Eshete Tadesse ◽  
Tefera Chane Mekonnen ◽  
Aregash Abebayehu Zerga
Keyword(s):  
Cesarean Section ◽  
Breast Feeding ◽  
Associated Factors ◽  
Statistical Significance ◽  
Data Entry ◽  
Binary Logistic Regression ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Timely Initiation ◽  
Eastern Ethiopia

Objective: To assess the magnitude and associated factors of timely initiation of breastfeeding among cesarean section delivered mothers. Methods: A health facility-based cross-sectional study was employed among 421 systematically selected mothers from February to June, 2017. Data were collected by a structured questionnaire. Data entry and analysis was done using Epi Data and SPSS version 24. Binary logistic regression was computed to identify factors. Adjusted odds ratio with a 95% confidence interval was used to declare statistical significance. Result: The magnitude of timely initiation of breast feeding (among mothers who gave birth by cesarean section was 57%. Counseling during antenatal care (AOR = 3.32; 95% CI: 1.80, 6.13), facility where cesarean section (CS) was performed (AOR = 2.55; 95% CI: 1.57, 4.14), and post-CS counseling (AOR = 6.93; 95% CI: 3.99, 12.02) were factors that contributed for the practice of timely initiation among cesarean section delivered mothers. Conclusions: The magnitude of TIBF was good. Counseling during ANC, the facility where CS was performed and post-natal advice were factors associated with TIBF. Implementation of baby-friendly hospital initiatives should be strengthened in order to promote timely initiation of breast feeding.

scholarly journals Cross-sectional study of preprints and final journal publications from COVID-19 studies: discrepancies in results reporting and spin in interpretation

BMJ Open ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. e051821
Author(s):  
Lisa Bero ◽  
Rosa Lawrence ◽  
Louis Leslie ◽  
Kellia Chiu ◽  
Sally McDonald ◽  
...  
Keyword(s):  
Statistical Significance ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Journal Publication ◽  
Reporting Practices ◽  
Subgroup Analyses ◽  
Journal Publications ◽  
Study Characteristics ◽  
Results Reporting

ObjectiveTo compare results reporting and the presence of spin in COVID-19 study preprints with their finalised journal publications.DesignCross-sectional study.SettingInternational medical literature.ParticipantsPreprints and final journal publications of 67 interventional and observational studies of COVID-19 treatment or prevention from the Cochrane COVID-19 Study Register published between 1 March 2020 and 30 October 2020.Main outcome measuresStudy characteristics and discrepancies in (1) results reporting (number of outcomes, outcome descriptor, measure, metric, assessment time point, data reported, reported statistical significance of result, type of statistical analysis, subgroup analyses (if any), whether outcome was identified as primary or secondary) and (2) spin (reporting practices that distort the interpretation of results so they are viewed more favourably).ResultsOf 67 included studies, 23 (34%) had no discrepancies in results reporting between preprints and journal publications. Fifteen (22%) studies had at least one outcome that was included in the journal publication, but not the preprint; eight (12%) had at least one outcome that was reported in the preprint only. For outcomes that were reported in both preprints and journals, common discrepancies were differences in numerical values and statistical significance, additional statistical tests and subgroup analyses and longer follow-up times for outcome assessment in journal publications.At least one instance of spin occurred in both preprints and journals in 23/67 (34%) studies, the preprint only in 5 (7%), and the journal publications only in 2 (3%). Spin was removed between the preprint and journal publication in 5/67 (7%) studies; but added in 1/67 (1%) study.ConclusionsThe COVID-19 preprints and their subsequent journal publications were largely similar in reporting of study characteristics, outcomes and spin. All COVID-19 studies published as preprints and journal publications should be critically evaluated for discrepancies and spin.

scholarly journals 28201 A cross-sectional study of dietary patterns and nutrient intakes in the oldest old

2021 ◽  
pp. 1-2
Author(s):  
Ashley C. Flores ◽  
Yi-Hsuan Liu ◽  
Xiang Gao ◽  
G. Craig Wood ◽  
Brian A. Irving ◽  
...  
Keyword(s):  
Dietary Patterns ◽  
Oldest Old ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Nutrient Intakes ◽  
Cross Sectional

scholarly journals Perceived Loneliness and Severe Sleep Disorders in Adult Women during the Covid-19 Quarantine: A Cross-Sectional Study in Colombia

2021 ◽  
Vol 12 ◽  
pp. 215013272110251
Author(s):  
Álvaro Monterrosa-Castro ◽  
Angélica Monterrosa-Blanco ◽  
Andrea González-Sequeda
Keyword(s):  
Sleep Disorders ◽  
Rating Scale ◽  
Statistical Significance ◽  
Cross Sectional Study ◽  
Bivariate Analysis ◽  
Adult Women ◽  
Sectional Study ◽  
Cross Sectional ◽  
Emotional Loneliness ◽  
Social Loneliness

Background: Quarantine is a measure to control COVID-19 spread, resulting in an increased perception of loneliness. In turn, sleep disorders (SD) may be more frequently reported in uncertain circumstances. Objectives: To identify the association between loneliness and severe SD, in women quarantined due to the COVID-19 pandemic. Methods: A cross-sectional study carried out in women, between 40 and 79 years and living in Colombia. The women were invited through social network to complete 5 digital instruments: de Jong Gierveld Loneliness Scale, Menopause Rating Scale, Fear of COVID-19 Five-item Version, Coronavirus Anxiety Scale, and Francis Religion Scale. Bivariate analysis and adjusted logistic regression between loneliness and SD were performed. Results: 1133 women participated, half of them under 50 years old. 43.1% had emotional loneliness, 39.9% social loneliness and 43.3% general loneliness. SD were identified in 6 out of 10 women, those with mild SD presented an OR of 1.84, 1.85, and 1.64, for emotional, social and general loneliness, respectively. Loneliness was associated twice with moderate SD, and more than twice with severe SD. Very severe SD reached OR:5.81 for emotional loneliness, OR:4.38 social loneliness and OR:4.02 general loneliness. In the presence of religiosity, fear and anxiety due to COVID-19, statistical significance was retained for associations, except intense SD with general loneliness. Conclusions: SD were significantly associated with loneliness in our study population. It is important to assess sleep quality and perception of loneliness in middle-aged women, especially during periods of quarantine due to a pandemic to avoid health implications.

scholarly journals A New Approach to the Identification of Palliative Care Needs and Advanced Chronic Patients among Nursing Home Residents

2021 ◽  
Vol 18 (6) ◽  
pp. 3171
Author(s):  
Ana A. Esteban-Burgos ◽  
María José Lozano-Terrón ◽  
Daniel Puente-Fernandez ◽  
César Hueso-Montoro ◽  
Rafael Montoya-Juárez ◽  
...  
Keyword(s):  
Palliative Care ◽  
Nursing Homes ◽  
Statistical Significance ◽  
Nursing Home Residents ◽  
Cross Sectional Study ◽  
Care Needs ◽  
Chronic Patients ◽  
Cross Sectional ◽  
Surprise Question ◽  
Palliative Care Needs

Background: Proper planning of Palliative Care in nursing homes requires advanced knowledge of the care needs that residents show. The aim of the study was to evaluate Palliative Needs and other conditions such as fragility, complexity, and prognosis and also to suggest new indicators for the establishment of the resident’s advanced chronic condition. Methods: Cross-sectional study conducted in 149 nursing homes Complex Chronic residents evaluated by trained professionals. Palliative Care Needs, assessed by the NECPAL ICO-CCOMS© tool, and fragility, case and palliative complexity and prognosis were evaluate through a comprehensive assessment. Descriptive analyses and association measures were performed setting the statistical significance at 0.05. Results: More than 50% of the residents had positive Surprise Question and other Palliative Needs and were classified as Advanced Chronic Patients. Distress and/or Severe Adaptative Disorder was the most frequent need shown by the residents and significant differences in levels of frailty and other characteristics, were found between the Positive and the Negative Surprise Question Groups. Statistically significant correlations were also found between aspects of both groups. Conclusions: Nursing homes residents show Palliative Needs regardless of the response to the Surprise Question of the NECPAL tool. Other characteristics such as presence of an intermediate level of frailty are suggested as a new perspective to identify advanced chronic patients among nursing homes residents.

scholarly journals Analysis of Surgical Recurrence after Larynx Microsurgery for Benign Lesions

2020 ◽  
Author(s):  
Maria Theresa Costa Ramos de Oliveira Patrial ◽  
Rogério Hamerschmidt ◽  
Jorge Eduardo Fouto Matias ◽  
Evaldo Dacheux de Macedo Filho ◽  
Bettina Carvalho
Keyword(s):  
Statistical Significance ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Associated Lesions ◽  
Surgical Recurrence ◽  
Retrospective Data Collection ◽  
The Mean ◽  
And Gender ◽  
Benign Laryngeal Lesions ◽  
Reinke Edema

Abstract Introduction The study of larynx lesions is of great importance. More than 50% of people with vocal complaints have benign vocal fold alterations and some require surgery. Objective To determine which factors are related to surgical recurrence of benign laryngeal lesions and to determine which videolaryngoscopic diagnoses are related to the risk or protection of surgical relapses over time. Methods Observational, analytical, cross-sectional study with retrospective data collection of 1,383 surgeries in 1,301 patients. Results The mean age at the first surgery was 39.2 years old. The predominant gender was female (65.6%).There were 396 cases of polyps (25.34%), 349 cases of cysts (22.33%), 261 cases of Reinke edema (16.7%), 175 cases of nodules (11.2%), 153 cases of minor structural alterations (MSAs) (9.79%), 94 cases of leukoplakia (6.01%), 77 cases of granulomas (4.93%) and 58 cases of pseudocysts (3.71%). The age presented statistical significance with the risk of surgical relapses (p = 0.016). Male gender was associated with the greatest chance of relapse.Diagnosis of granuloma (p < 0.001) and of leukoplakia (p < 0.001) were associated with a higher risk of surgical recurrence. Cyst diagnosis was associated with protection (p = 0.015) in relation to the chance of further surgeries. Patients with associated lesions, bilaterals or voice professionals did not present a statistically significant association with surgical recurrence. Conclusion Age and gender are statistically related to the increase of surgical relapses. Leukoplakia and granuloma are associated with increased surgical relapses. Patients submitted to cyst microsurgery appear to be protected against surgical recurrence.

Sign in / Sign up

Export Citation Format

Share Document