Encapsulation of Low-Molecular-Weight Drugs into Polymer Multilayer Capsules Templated on Vaterite CaCO3 Crystals

Polyelectrolyte multilayer capsules (PEMCs) templated onto biocompatible and easily degradable vaterite CaCO3 crystals via the layer-by-layer (LbL) polymer deposition process have served as multifunctional and tailor-made vehicles for advanced drug delivery. Since the last two decades, the PEMCs were utilized for effective encapsulation and controlled release of bioactive macromolecules (proteins, nucleic acids, etc.). However, their capacity to host low-molecular-weight (LMW) drugs (<1–2 kDa) has been demonstrated rather recently due to a limited retention ability of multilayers to small molecules. The safe and controlled delivery of LMW drugs plays a vital role for the treatment of cancers and other diseases, and, due to their tunable and inherent properties, PEMCs have shown to be good candidates for smart drug delivery. Herein, we summarize recent progress on the encapsulation of LMW drugs into PEMCs templated onto vaterite CaCO3 crystals. The drug loading and release mechanisms, advantages and limitations of the PEMCs as LMW drug carriers, as well as bio-applications of drug-laden capsules are discussed based upon the recent literature findings.

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Development of a Layer-by-Layer Assembled Film on Hydrogel for Ocular Drug Delivery

International Journal of Polymer Science ◽

10.1155/2015/535092 ◽

2015 ◽

Vol 2015 ◽

pp. 1-9 ◽

Cited By ~ 8

Author(s):

Pin Chen ◽

Xin Wang ◽

Yan Dong ◽

Xiaohong Hu

Keyword(s):

Drug Delivery ◽

Self Assembly ◽

Ph Value ◽

Drug Loading ◽

Drug Carriers ◽

Ocular Drug Delivery ◽

Layer By Layer ◽

Uv Spectrum ◽

Modification Technique ◽

Assembly Procedure

Hydrogel is a kind of attractive drug carriers because of its good biocompatibility and transparency. But traditional hydrogel showed some restrictions in its application in ocular drug delivery. A simple surface modification technique based on layer-by-layer (LbL) self-assembled multilayer for ocular drug delivery was developed in this work. Polycarboxymethyl-β-cyclodextrin (poly(CM-β-CD))/poly-l-lysine (PLL) multilayer film was designed and constructed for ocular drug delivery, sinceβ-CD showed good drug delivery property. The properties such as the contact angle and transparency varied a little with the deposition of poly(CM-β-CD)/PLL multilayer. Orfloxacin and puerarin were loaded into multilayer during the self-assembly procedure by two methods, which were tracked by the largest drug absorbance of UV spectrum. The loaded drug amount by incorporating drugs into poly(CM-β-CD) solution was larger than that by incorporating drugs into PLL solution. The loaded drug in the multilayer could gradually be released from multilayer in some period either for orfloxacin or for puerarin. The drug release behavior was influenced by drug loading method and pH value of released medium. Moreover, the balanced released drug amount by incorporating drugs into poly(CM-β-CD) solution is much smaller than that by incorporating drugs into PLL solution.

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Graphene-based nanomaterials for breast cancer treatment: promising therapeutic strategies

Journal of Nanobiotechnology ◽

10.1186/s12951-021-00902-8 ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Guangman Cui ◽

Junrong Wu ◽

Jiaying Lin ◽

Wenjing Liu ◽

Peixian Chen ◽

...

Keyword(s):

Breast Cancer ◽

Drug Delivery ◽

Cancer Treatment ◽

Drug Loading ◽

Drug Carriers ◽

Therapeutic Strategies ◽

Breast Cancer Treatment ◽

Therapeutic Effects ◽

Improved Function ◽

Smart Drug

AbstractBreast cancer is the most common malignancy in women, and its incidence increases annually. Traditional therapies have several side effects, leading to the urgent need to explore new smart drug-delivery systems and find new therapeutic strategies. Graphene-based nanomaterials (GBNs) are potential drug carriers due to their target selectivity, easy functionalization, chemosensitization and high drug-loading capacity. Previous studies have revealed that GBNs play an important role in fighting breast cancer. Here, we have summarized the superior properties of GBNs and modifications to shape GBNs for improved function. Then, we focus on the applications of GBNs in breast cancer treatment, including drug delivery, gene therapy, phototherapy, and magnetothermal therapy (MTT), and as a platform to combine multiple therapies. Their advantages in enhancing therapeutic effects, reducing the toxicity of chemotherapeutic drugs, overcoming multidrug resistance (MDR) and inhibiting tumor metastasis are highlighted. This review aims to help evaluate GBNs as therapeutic strategies and provide additional novel ideas for their application in breast cancer therapy.

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Peptide and Low Molecular Weight Proteins Based Kidney Targeted Drug Delivery Systems

Protein and Peptide Letters ◽

10.2174/0929866525666180530123441 ◽

2018 ◽

Vol 25 (6) ◽

pp. 522-527 ◽

Cited By ~ 1

Author(s):

Pengfei Xu ◽

Hailiang Zhang ◽

Ruili Dang ◽

Pei Jiang

Keyword(s):

Drug Delivery ◽

Molecular Weight ◽

Targeted Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Low Molecular Weight ◽

Targeted Drug ◽

Low Molecular Weight Proteins ◽

Targeted Drug Delivery Systems

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Advances in Nanoparticles as Anticancer Drug Delivery Vector: Need of this Century

Current Pharmaceutical Design ◽

10.2174/1381612826666200203124330 ◽

2020 ◽

Vol 26 (15) ◽

pp. 1637-1649 ◽

Cited By ~ 3

Author(s):

Imran Ali ◽

Sofi D. Mukhtar ◽

Heyam S. Ali ◽

Marcus T. Scotti ◽

Luciana Scotti

Keyword(s):

Drug Delivery ◽

Anticancer Drug ◽

Medical Science ◽

Drug Carriers ◽

Anticancer Drug Delivery ◽

Ph Values ◽

Delivery Vector ◽

Future Challenges ◽

Smart Drug ◽

Smart Drug Delivery

Background: Nanotechnology has contributed a great deal to the field of medical science. Smart drugdelivery vectors, combined with stimuli-based characteristics, are becoming increasingly important. The use of external and internal stimulating factors can have enormous benefits and increase the targeting efficiency of nanotechnology platforms. The pH values of tumor vascular tissues are acidic in nature, allowing the improved targeting of anticancer drug payloads using drug-delivery vectors. Nanopolymers are smart drug-delivery vectors that have recently been developed and recommended for use by scientists because of their potential targeting capabilities, non-toxicity and biocompatibility, and make them ideal nanocarriers for personalized drug delivery. Method: The present review article provides an overview of current advances in the use of nanoparticles (NPs) as anticancer drug-delivery vectors. Results: This article reviews the molecular basis for the use of NPs in medicine, including personalized medicine, personalized therapy, emerging vistas in anticancer therapy, nanopolymer targeting, passive and active targeting transports, pH-responsive drug carriers, biological barriers, computer-aided drug design, future challenges and perspectives, biodegradability and safety. Conclusions: This article will benefit academia, researchers, clinicians, and government authorities by providing a basis for further research advancements.

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Advances in the use of MOFs for Cancer Diagnosis and Treatment: An Overview

Current Pharmaceutical Design ◽

10.2174/1381612826666200406153949 ◽

2020 ◽

Vol 26 (33) ◽

pp. 4174-4184

Author(s):

Marina P. Abuçafy ◽

Bruna L. da Silva ◽

João A. Oshiro-Junior ◽

Eloisa B. Manaia ◽

Bruna G. Chiari-Andréo ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Rational Design ◽

Gas Adsorption ◽

Drug Loading ◽

Drug Carriers ◽

Delivery Systems ◽

Academic Community ◽

Anticancer Drug Delivery ◽

Diagnostic Agents

Nanoparticles as drug delivery systems and diagnostic agents have gained much attention in recent years, especially for cancer treatment. Nanocarriers improve the therapeutic efficiency and bioavailability of antitumor drugs, besides providing preferential accumulation at the target site. Among different types of nanocarriers for drug delivery assays, metal-organic frameworks (MOFs) have attracted increasing interest in the academic community. MOFs are an emerging class of coordination polymers constructed of metal nodes or clusters and organic linkers that show the capacity to combine a porous structure with high drug loading through distinct kinds of interactions, overcoming the limitations of traditional drug carriers explored up to date. Despite the rational design and synthesis of MOFs, structural aspects and some applications of these materials like gas adsorption have already been comprehensively described in recent years; it is time to demonstrate their potential applications in biomedicine. In this context, MOFs can be used as drug delivery systems and theranostic platforms due to their ability to release drugs and accommodate imaging agents. This review describes the intrinsic characteristics of nanocarriers used in cancer therapy and highlights the latest advances in MOFs as anticancer drug delivery systems and diagnostic agents.

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The Potential of Milk-derived Exosomes for Drug Delivery

Current Drug Delivery ◽

10.2174/1567201817666200817112503 ◽

2020 ◽

Vol 17 ◽

Author(s):

Shuyuan Li ◽

Yue Tang ◽

Yushun Dou

Keyword(s):

Drug Delivery ◽

Oral Delivery ◽

Therapeutic Potential ◽

Current Knowledge ◽

Biological Fluids ◽

Drug Loading ◽

Drug Carriers ◽

Current Application ◽

Therapeutic Benefits ◽

Loading Methods

Background: Exosomes, one of the extracellular vesicles, are widely present in all biological fluids and play an important role in intercellular communication. Because of its hydrophobic lipid bilayer and aqueous hydrophilic core structure, it is considered a possible alternative to liposome drug delivery systems. Not only do they protect the cargo like liposomes during delivery, they are less toxic and better tolerated. However, due to the lack of sources and methods for obtaining enough exosomes, the therapeutic application of exosomes as drug carriers is limited. Methods: A literature search was performed using the ScienceDirect and PubMed electronic databases to obtain information from published literature on milk exosomes related to drug delivery. Results: Here, we briefly reviewed the current knowledge of exosomes, expounded the advantages of milk-derived exosomes over other delivery vectors, including a higher yield, the oral delivery characteristic and additional therapeutic benefits. The purification and drug loading methods of milk exosomes, and the current application of milk exosomes were also introduced. Conclusion: The emergence of milk-derived exosomes is expected to break through the limitations of exosomes as therapeutic carriers of drugs. We hope to raise awareness of the therapeutic potential of milk-derived exosomes as a new drug delivery system.

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A Hydrogel-based Implantable Multidrug Antitubercular Formulation Outperforms Oral Delivery.

Nanoscale ◽

10.1039/d0nr08806d ◽

2021 ◽

Author(s):

Sanjay Pal ◽

Vijay Soni ◽

Sandeep Kumar ◽

Somesh K Jha ◽

Nihal Medatwal ◽

...

Keyword(s):

Drug Delivery ◽

Molecular Weight ◽

Drug Delivery System ◽

Delivery System ◽

Oral Delivery ◽

Low Molecular Weight ◽

Front Line ◽

Antitubercular Drugs

We present a non-immunogenic, injectable, low molecular weight, amphiphilic hydrogel-based drug delivery system (TB-Gel) that can entrap a cocktail of four front-line antitubercular drugs isoniazid, rifampicin, pyrazinamide, and ethambutol. We...

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