scholarly journals Fundamental Studies of Rapidly Fabricated On-Chip Passive Micromixer for Modular Microfluidics

Micromachines ◽  
2021 ◽  
Vol 12 (2) ◽  
pp. 153
Author(s):  
Wenpeng Guo ◽  
Li Tang ◽  
Biqiang Zhou ◽  
Yingsing Fung
Keyword(s):  
Microfluidic Chip ◽  
Dynamics Simulation ◽  
Experimental Result ◽  
Continuous Mixing ◽  
Straight Line ◽  
Smooth Channel ◽  
Computational Flow Dynamics ◽  
Passive Micromixer ◽  
On Chip ◽  
Optimized Conditions

Micromixers play an important role in many modular microfluidics. Complex on-chip mixing units and smooth channel surfaces ablated by lasers on polymers are well-known problems for microfluidic chip fabricating techniques. However, little is known about the ablation of rugged surfaces on polymer chips for mixing uses. This paper provides the first report of an on-chip compact micromixer simply, easily and quickly fabricated using laser-ablated irregular microspheric surfaces on a polymethyl methacrylate (PMMA) microfluidic chip for continuous mixing uses in modular microfluidics. The straight line channel geometry is designed for sequential mixing of nanoliter fluids in about 1 s. The results verify that up to about 90% of fluids can be mixed in a channel only 500 µm long, 200 µm wide and 150 µm deep using the developed micromixer fabricating method under optimized conditions. The computational flow dynamics simulation and experimental result agree well with each other.

Passive micromixer integration with a microfluidic chip for calcium assay based on the arsenazo III method

2011 ◽  
Vol 5 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Yuwadee Boonyasit ◽  
Thitima Maturos ◽  
Assawapong Sappat ◽  
Apichai Jomphoak ◽  
Adisorn Tuantranont ◽  
...  
Keyword(s):  
Microfluidic Chip ◽  
Arsenazo Iii ◽  
Passive Micromixer

scholarly journals Compiler-directed scratchpad memory data transfer optimization for multithreaded applications on a heterogeneous many-core architecture

2021 ◽  
Author(s):  
Xiaohan Tao ◽  
Jianmin Pang ◽  
Jinlong Xu ◽  
Yu Zhu
Keyword(s):  
Energy Consumption ◽  
High Performance ◽  
Scientific Computing ◽  
Data Transfer ◽  
Performance Model ◽  
Experimental Result ◽  
Transfer Model ◽  
Scratchpad Memory ◽  
On Chip ◽  
Many Core

AbstractThe heterogeneous many-core architecture plays an important role in the fields of high-performance computing and scientific computing. It uses accelerator cores with on-chip memories to improve performance and reduce energy consumption. Scratchpad memory (SPM) is a kind of fast on-chip memory with lower energy consumption compared with a hardware cache. However, data transfer between SPM and off-chip memory can be managed only by a programmer or compiler. In this paper, we propose a compiler-directed multithreaded SPM data transfer model (MSDTM) to optimize the process of data transfer in a heterogeneous many-core architecture. We use compile-time analysis to classify data accesses, check dependences and determine the allocation of data transfer operations. We further present the data transfer performance model to derive the optimal granularity of data transfer and select the most profitable data transfer strategy. We implement the proposed MSDTM on the GCC complier and evaluate it on Sunway TaihuLight with selected test cases from benchmarks and scientific computing applications. The experimental result shows that the proposed MSDTM improves the application execution time by 5.49$$\times$$ × and achieves an energy saving of 5.16$$\times$$ × on average.

On-chip cavity-enhanced absorption spectroscopy using a white light-emitting diode and polymer mirrors

Lab on a Chip ◽  
2015 ◽  
Vol 15 (3) ◽  
pp. 711-717 ◽  
Author(s):  
Cathy M. Rushworth ◽  
Gareth Jones ◽  
Martin Fischlechner ◽  
Emma Walton ◽  
Hywel Morgan
Keyword(s):  
Absorption Spectroscopy ◽  
White Light ◽  
Microfluidic Chip ◽  
Path Length ◽  
Light Emitting Diode ◽  
Absorption Path Length ◽  
Light Emitting ◽  
Enhanced Absorption ◽  
Cavity Enhanced Absorption Spectroscopy ◽  
On Chip

We have integrated disposable polymer mirrors within a microfluidic chip to form a multi-pass cell, which increases the absorption path length by a maximum of 28 times, providing micromolar detection limits in a probed volume of 10 nL.

Multistage Isoelectric Focusing: A Novel On-Chip Bio-Separation Technique

2005 ◽  
Author(s):  
Prashanta Dutta ◽  
Keisuke Horiuchi ◽  
Huanchun Cui ◽  
Cornelius F. Ivory
Keyword(s):  
Isoelectric Focusing ◽  
Microfluidic Chip ◽  
Soft Lithography ◽  
Fluorescent Protein ◽  
Ph Gradient ◽  
Resolving Power ◽  
Protein Species ◽  
Second Stage ◽  
On Chip ◽  
Bonding Technique

This experimental study reports a method to increase the resolving power of isoelectric focusing (IEF) on a polymeric microfluidic chip. Microfluidic chip is formed on poly-di-methyl siloxane (PDMS) using soft lithography and multilayer bonding technique. In this novel bioseparation technique, IEF is staged by first focusing protein species in a straight channel using broad-range ampholytes and then refocusing segments of that first channel into secondary channels that branch out from the first one. Experiments demonstrated that three fluorescent protein species within a segment of pH gradient in the first stage were refocused in the second stage with much higher resolution in a shallower pH gradient. A serially performed two-stage IEF was completed in less than 25 minutes under particularly small electric field strength up to 100 V/cm.

From CAD to microfluidic chip within one day: rapid prototyping of lab-on-chip cartridges using generic polymer parts

2020 ◽  
Vol 30 (11) ◽  
pp. 115012 ◽  
Author(s):  
Daniel Podbiel ◽  
Lorenz Boecking ◽  
Hannah Bott ◽  
Julian Kassel ◽  
Daniel Czurratis ◽  
...  
Keyword(s):  
Rapid Prototyping ◽  
Microfluidic Chip ◽  
Lab On Chip ◽  
On Chip

scholarly journals Microfluidic Flow-through SPME Chip for Online Separation and MS Detection of Multiple Analyses in Complex Matrix

Micromachines ◽  
2020 ◽  
Vol 11 (2) ◽  
pp. 120
Author(s):  
Yujun Chen ◽  
Tao Gong ◽  
Cilong Yu ◽  
Xiang Qian ◽  
Xiaohao Wang
Keyword(s):  
Microfluidic Chip ◽  
Solid Phase Microextraction ◽  
Solid Phase ◽  
Sample Pretreatment ◽  
Annular Channel ◽  
Calibration Method ◽  
Extraction Process ◽  
Single Chip ◽  
Calibration Methods ◽  
On Chip

Simplifying tedious sample preparation procedures to improve analysis efficiency is a major challenge in contemporary analytical chemistry. Solid phase microextraction (SPME), a technology developed for rapid sample pretreatment, has flexibility in design, geometry, and calibration strategies, which makes it a useful tool in a variety of fields, especially environmental and life sciences. Therefore, it is important to study the coupling between the microfluidic electrospray ionization (ESI) chip integrated with the solid phase microextraction (SPME) module and the electrospray mass spectrometer (MS). In our previous work, we designed a solid phase microextraction (SPME) module on a microfluidic chip through geometric design. However, automation and calibration methods for the extraction process remain unresolved in the SPME on-chip domain, which will lead to faster and more accurate results. This paper discusses the necessity to design a micromixer structure that can produce different elution conditions on the microfluidic chip. By calculating the channel resistances, the microfluidic chip’s integrated module with the micromixer, SPME, and ESI emitters optimize the geometry structure. We propose the annular channel for SPME to perform the resistances balance of the entire chip. Finally, for SPME on a single chip, this work provides a quantitation calibration method to describe the distribution of the analytes between the sample and the extraction phase before reaching the adsorption equilibrium.

Design and Calibration of MIMU Based on Chip Size Micro Inertial Sensors

2013 ◽  
Vol 849 ◽  
pp. 302-309
Author(s):  
Yun Xu ◽  
Xin Hua Zhu ◽  
Yu Wang
Keyword(s):  
High Performance ◽  
Inertial Sensors ◽  
Low Cost ◽  
Rapid Development ◽  
Experimental Result ◽  
Integrated Navigation ◽  
Bias Stability ◽  
Chip Size ◽  
Order Of Magnitude ◽  
On Chip

With rapid development of micro fabrication technology, the performance of MIMU has gradually improved. The MIMU introduced in this paper is based on the silicon micro machined gyroscope of type MSG7000D and accelerometer of type MSA6000. The volume of it is 3×3×3cm3, the mass is 68.5g and the power consumption is less than 1w. The experimental result shows that the bias stability of the gyroscope and accelerometer for each axis of the designed MIMU is less than 10°/h and 0.5mg respectively. For the non orthogonality in three axes of the structure, MIMU needs to be calibrated. After calibration, the measurement accuracy has improved by an order of magnitude. The designed MIMU can satisfy the requirement of high performance, low cost, light weight and small size for strap-down navigation system, thus it can be widely applied not only to the field of vehicles integrated navigation, attitude measurement but also to the fields of personal goods such as mobile, game consoles and so on.

Programmable Micropatterning of Polymer Nanofibers

2010 ◽  
Author(s):  
Bongsu Kim ◽  
Yi Zhao
Keyword(s):  
Tissue Engineering ◽  
Electrostatic Force ◽  
Electrospun Nanofibers ◽  
Cost Effective ◽  
Experimental Result ◽  
Polymer Nanofibers ◽  
Tissue Engineering Scaffolds ◽  
Effective Manner ◽  
The Difference ◽  
On Chip

This paper reports programmable micropatterning of electrospun nanofibrous materials using a collector chip that consists of an array of independently controllable microelectrodes. The microelectrodes on the collecting chip are prepared by standard photolithography. By programming the local electrical field using excited and floating electrodes, the collector chip allows patterning of microstructures with controllable characteristics. The difference of electrostatic force between the excited and the floating electrodes increases the patterning contrast of electrospun nanofibers. The arbitrary geometries are successfully patterned on the array of 6 × 6 electrodes by independently programmable control of the voltage of each electrode. The experimental result also shows that it is possible to control the porosity and alignment of fibers. This method provides a simple yet highly reliable approach for creating combined micro/nanostructures of polymer nanofibers in a cost effective manner, which has great potential in functional tissue engineering, filtration, and chemical sensing. The work is also expected to foster the use of nanofibers in microdevices for on-chip biochemical analysis, and controlled infiltration and proliferation. The resulting nanofibers with controllable porosity are especially useful for the construction of tissue engineering scaffolds with morphological and functional similarity with natural tissues.

Sign in / Sign up

Export Citation Format

Share Document