scholarly journals Recent Advances in Catalytic Synthesis of Benzosultams

Molecules ◽  
2020 ◽  
Vol 25 (19) ◽  
pp. 4367
Author(s):  
Quan-Qing Zhao ◽  
Xiao-Qiang Hu
Keyword(s):  
Medicinal Chemistry ◽  
Catalytic Synthesis ◽  
Chiral Catalysts ◽  
Catalytic Systems ◽  
The Past ◽  
Recent Advances ◽  
Efficient Construction

Benzosultams represent one category of multi-heteroatom heterocyclic scaffolds, which have been frequently found in pharmaceuticals, agricultural agents, and chiral catalysts. Given the diversely significant functions of these compounds in organic and medicinal chemistry, great efforts have been made to develop novel catalytic systems for the efficient construction of benzosultam motifs over the past decades. Herein, in this review, we mainly summarize the recent advances in the field of catalytic synthesis of benzosultams from 2017 to August of 2020, with an emphasis on the scopes and mechanisms of representative reactions.

scholarly journals A Review on Recent Advances in Nitrogen-Containing Molecules and Their Biological Applications

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1909 ◽  
Author(s):  
Nagaraju Kerru ◽  
Lalitha Gummidi ◽  
Suresh Maddila ◽  
Kranthi Kumar Gangu ◽  
Sreekantha B. Jonnalagadda
Keyword(s):  
Drug Design ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Therapeutic Agents ◽  
Biological Applications ◽  
Valuable Source ◽  
The Past ◽  
Recent Advances ◽  
Physiological Properties ◽  
One Year

The analogs of nitrogen-based heterocycles occupy an exclusive position as a valuable source of therapeutic agents in medicinal chemistry. More than 75% of drugs approved by the FDA and currently available in the market are nitrogen-containing heterocyclic moieties. In the forthcoming decade, a much greater share of new nitrogen-based pharmaceuticals is anticipated. Many new nitrogen-based heterocycles have been designed. The number of novel N-heterocyclic moieties with significant physiological properties and promising applications in medicinal chemistry is ever-growing. In this review, we consolidate the recent advances on novel nitrogen-containing heterocycles and their distinct biological activities, reported over the past one year (2019 to early 2020). This review highlights the trends in the use of nitrogen-based moieties in drug design and the development of different potent and competent candidates against various diseases.

Recent advances in organic reactions catalyzed by graphene oxide and sulfonated graphene as heterogeneous nanocatalysts: a review

2017 ◽  
Vol 41 (20) ◽  
pp. 11471-11497 ◽  
Author(s):  
Ozra Mohammadi ◽  
Mohsen Golestanzadeh ◽  
Majid Abdouss
Keyword(s):  
Thermal Stability ◽  
Graphene Oxide ◽  
Organic Reactions ◽  
Successive Reaction ◽  
Catalytic Systems ◽  
The Past ◽  
Recent Advances ◽  
Sulfonated Graphene ◽  
Thermal Stability Of

Over the past decade, the application of carbocatalyst systems has been preferred over that of homogeneous catalytic systems because of their advantages such as physical and thermal stability of the catalysts in successive reaction runs and reusability.

Recent advances in cyclization reactions of isatins or thioisatins via C-N or C-S bond cleavage

2021 ◽  
Author(s):  
Jinhui Shen ◽  
Lei Zhang ◽  
Xiangtai Meng
Keyword(s):  
Medicinal Chemistry ◽  
Raw Materials ◽  
Bond Cleavage ◽  
Synthetic Methods ◽  
Cyclization Reactions ◽  
Recent Advances ◽  
Efficient Construction

The exploration of new reactivity modes and synthetic methods has always been an attractive goal of organic and medicinal chemistry. As potential raw materials for the efficient construction of nitrogen-...

Recent Advances in the Synthesis of β-Ketonitriles

Synthesis ◽  
2017 ◽  
Vol 50 (03) ◽  
pp. 485-498 ◽  
Author(s):  
Kensuke Kiyokawa ◽  
Satoshi Minakata ◽  
Takaya Nagata
Keyword(s):  
Transition Metal ◽  
Carbonyl Compounds ◽  
Medicinal Chemistry ◽  
Short Review ◽  
Coupling Reactions ◽  
Important Class ◽  
The Past ◽  
Recent Advances ◽  
Ketone Enolates ◽  
Metal Catalyzed

β-Ketonitriles are an important class of compounds in the field of organic and medicinal chemistry. Over the past decades, numerous efforts have been devoted to the development of new and efficient methodologies for the synthesis of these derivatives, and a number of efficient methods to accomplish this have been developed in recent years. In this context, this short review highlights recent advances in the synthesis of β-ketonitriles.1 Introduction2 Acylation of Alkyl Nitriles3 Electrophilic Cyanation of Ketone Enolates4 Electrophilic Cyanation of β-Keto Carbonyl Compounds5 Transition-Metal-Catalyzed Carbonylative Coupling Reactions6 Miscellaneous Examples7 Outlook

Recent Advances in Therapeutic Applications of Bisbenzimidazoles

2020 ◽  
Vol 16 (4) ◽  
pp. 454-486 ◽  
Author(s):  
Smita Verma ◽  
Vishnuvardh Ravichandiran ◽  
Nihar Ranjan ◽  
Swaran J.S. Flora
Keyword(s):  
Heterocyclic Compounds ◽  
Wide Spectrum ◽  
Dna Recognition ◽  
Present Review ◽  
Pharmacological Activities ◽  
Structural Motifs ◽  
Therapeutic Applications ◽  
The Past ◽  
Recent Advances

Nitrogen-containing heterocycles are one of the most common structural motifs in approximately 80% of the marketed drugs. Of these, benzimidazoles analogues are known to elicit a wide spectrum of pharmaceutical activities such as anticancer, antibacterial, antiparasitic, antiviral, antifungal as well as chemosensor effect. Based on the benzimidazole core fused heterocyclic compounds, crescent-shaped bisbenzimidazoles were developed which provided an early breakthrough in the sequence-specific DNA recognition. Over the years, a number of functional variations in the bisbenzimidazole core have led to the emergence of their unique properties and established them as versatile ligands against several classes of pathogens. The present review provides an overview of diverse pharmacological activities of the bisbenzimidazole analogues in the past decade with a brief account of its development through the years.

Chiral imidazolidinones: A class of priviliged organocatalysts in stereoselective organic synthesis

2020 ◽  
Vol 5 (5) ◽  
Author(s):  
Laura Raimondi ◽  
Chiara Faverio ◽  
Monica Fiorenza Boselli
Keyword(s):  
Pharmaceutical Industry ◽  
Green Chemistry ◽  
Organic Synthesis ◽  
Catalytic Synthesis ◽  
Biological Chemistry ◽  
Chiral Molecules ◽  
Catalytic Systems ◽  
Drug Synthesis ◽  
Industry Needs

AbstractChiral molecules hold a mail position in Organic and Biological Chemistry, so pharmaceutical industry needs suitable strategies for drug synthesis. Moreover, Green Chemistry procedures are increasingly required in order to avoid environment deterioration. Catalytic synthesis, in particular organocatalysis, in thus a continuously expanding field. A survey of more recent researches involving chiral imidazolidinones is here presented, with a particular focus on immobilized catalytic systems.

scholarly journals Recent Advances in the Development of Sigma Receptor Ligands as Cytotoxic Agents: A Medicinal Chemistry Perspective

2021 ◽  
Author(s):  
Antonino N. Fallica ◽  
Valeria Pittalà ◽  
Maria N. Modica ◽  
Loredana Salerno ◽  
Giuseppe Romeo ◽  
...  
Keyword(s):  
Medicinal Chemistry ◽  
Cytotoxic Agents ◽  
Sigma Receptor ◽  
Receptor Ligands ◽  
Sigma Receptor Ligands ◽  
Recent Advances

Recent advances in storage and flooding theory

1969 ◽  
Vol 1 (1) ◽  
pp. 90-110 ◽  
Author(s):  
J. Gani
Keyword(s):  
Queueing Theory ◽  
Applied Probability ◽  
The Past ◽  
Continuous Flows ◽  
Recent Advances ◽  
A Minor ◽  
Queueing Processes ◽  
Theory Of Storage ◽  
Storage Processes

The theory of storage processes, originally formulated by Moran [1] in 1954, has developed in the past fourteen years into a minor subfield of Applied Probability, closely allied to queueing theory. While dam models with discrete inputs are analogous to queueing processes, the essentially continuous nature of water inflows has distinguished generalized storage processes from queues. Indeed, some of the most complex of storage problems have arisen in the case of continuous flows.

Recent advances and new concepts for the synthesis of axially stereoenriched biaryls

2015 ◽  
Vol 44 (11) ◽  
pp. 3418-3430 ◽  
Author(s):  
J. Wencel-Delord ◽  
A. Panossian ◽  
F. R. Leroux ◽  
F. Colobert
Keyword(s):  
Chiral Compounds ◽  
The Past ◽  
Recent Advances ◽  
New Concepts ◽  
Axially Chiral ◽  
Recent Developments ◽  
Synthetic Routes

Over the past decade the field of the synthesis of axially chiral compounds has been rapidly expanding. Not only key advances have been achieved concerning the already established strategies but also new synthetic routes have been devised. This review showcases the recent developments in this domain.

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