Modular Synthetic Approach to Carboranyl‒Biomolecules Conjugates

The development of novel, tumor-selective and boron-rich compounds as potential agents for use in boron neutron capture therapy (BNCT) represents a very important field in cancer treatment by radiation therapy. Here, we report the design and synthesis of two promising compounds that combine meta-carborane, a water-soluble monosaccharide and a linking unit, namely glycine or ethylenediamine, for facile coupling with various tumor-selective biomolecules bearing a free amino or carboxylic acid group. In this work, coupling experiments with two selected biomolecules, a coumarin derivative and folic acid, were included. The task of every component in this approach was carefully chosen: the carborane moiety supplies ten boron atoms, which is a tenfold increase in boron content compared to the l-boronophenylalanine (l-BPA) presently used in BNCT; the sugar moiety compensates for the hydrophobic character of the carborane; the linking unit, depending on the chosen biomolecule, acts as the connection between the tumor-selective component and the boron-rich moiety; and the respective tumor-selective biomolecule provides the necessary selectivity. This approach makes it possible to develop a modular and feasible strategy for the synthesis of readily obtainable boron-rich agents with optimized properties for potential applications in BNCT.

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Surface functionalization of aluminosilicate nanotubes with organic molecules

Beilstein Journal of Nanotechnology ◽

10.3762/bjnano.3.10 ◽

2012 ◽

Vol 3 ◽

pp. 82-100 ◽

Cited By ~ 16

Author(s):

Wei Ma ◽

Weng On Yah ◽

Hideyuki Otsuka ◽

Atsushi Takahara

Keyword(s):

Surface Functionalization ◽

Organic Molecules ◽

Photophysical Properties ◽

Acid Group ◽

Water Soluble ◽

Dimensional Structure ◽

Inorganic Nanotubes ◽

Surface Initiated Polymerization ◽

Recent Developments ◽

Potential Applications

The surface functionalization of inorganic nanostructures is an effective approach for enriching the potential applications of existing nanomaterials. Inorganic nanotubes attract great research interest due to their one-dimensional structure and reactive surfaces. In this review paper, recent developments in surface functionalization of an aluminosilicate nanotube, “imogolite”, are introduced. The functionalization processes are based on the robust affinity between phosphate groups of organic molecules and the aluminol (AlOH) surface of imogolite nanotubes. An aqueous modification process employing a water soluble ammonium salt of alkyl phosphate led to chemisorption of molecules on imogolite at the nanotube level. Polymer-chain-grafted imogolite nanotubes were prepared through surface-initiated polymerization. In addition, the assembly of conjugated molecules, 2-(5’’-hexyl-2,2’:5’,2’’-terthiophen-5-yl)ethylphosphonic acid (HT3P) and 2-(5’’-hexyl-2,2’:5’,2’’-terthiophen-5-yl)ethylphosphonic acid 1,1-dioxide (HT3OP), on the imogolite nanotube surface was achieved by introducing a phosphonic acid group to the corresponding molecules. The optical and photophysical properties of these conjugated-molecule-decorated imogolite nanotubes were characterized. Moreover, poly(3-hexylthiophene) (P3HT) chains were further hybridized with HT3P modified imogolite to form a nanofiber hybrid.

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Faculty Opinions recommendation of A novel approach of water-soluble paclitaxel prodrug with no auxiliary and no byproduct: design and synthesis of isotaxel.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1015189.195954 ◽

2003 ◽

Author(s):

Thomas W von Geldern

Keyword(s):

Water Soluble ◽

Design And Synthesis ◽

Novel Approach

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Short Review and opinion: New matter properties and applications based on Hybrids Graphene based Metamaterials

Current Graphene Science ◽

10.2174/2452273204999200528141157 ◽

2020 ◽

Vol 04 ◽

Author(s):

A. Guillermo Bracamonte

Keyword(s):

Short Review ◽

New Materials ◽

Design And Synthesis ◽

Chemical Structures ◽

Current State ◽

Potential Applications ◽

Fundamental Research ◽

Miniaturized Instrumentation ◽

And Control ◽

Conductive Properties

: Graphene as Organic material showed special attention due to their electronic and conductive properties. Moreover, its highly conjugated chemical structures and relative easy modification permitted varied design and control of targeted properties and applications. In addition, this Nanomaterial accompanied with pseudo Electromagnetic fields permitted photonics, electronics and Quantum interactions with their surrounding that generated new materials properties. In this context, this short Review, intends to discuss many of these studies related with new materials based on graphene for light and electronic interactions, conductions, and new modes of non-classical light generation. It should be highlighted that these new materials and metamaterials are currently in progress. For this reason it was showed and discussed some representative examples from Fundamental Research with Potential Applications as well as for their incorporations to real Advanced devices and miniaturized instrumentation. In this way, it was proposed this Special issue entitled “Design and synthesis of Hybrids Graphene based Metamaterials”, in order to open and share the knowledge of the Current State of the Art in this Multidisciplinary field.

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Facile fractionation of bamboo hydrolysate and characterization of isolated lignin and lignin-carbohydrate complexes

Holzforschung ◽

10.1515/hf-2020-0040 ◽

2020 ◽

Vol 0 (0) ◽

Author(s):

Xiaodi Wang ◽

Yongchao Zhang ◽

Luyao Wang ◽

Xiaoju Wang ◽

Qingxi Hou ◽

...

Keyword(s):

Solvent Extraction ◽

Organic Solvent ◽

Extraction Process ◽

Water Soluble ◽

Organic Solvent Extraction ◽

Glycoside Linkage ◽

Potential Applications ◽

Tremendous Amount ◽

Main Components ◽

Hemicellulosic Sugars

AbstractAn efficient separation technology for hydrolysates towards a full valorization of bamboo is still a tough challenge, especially regarding the lignin and lignin-carbohydrate complexes (LCCs). The present study aimed to develop a facile approach using organic solvent extraction for efficiently fractionating the main components of bamboo hydrolysates. The high-purity lignin with only a trace of carbohydrates was first obtained by precipitation of the bamboo hydrolysate. The water-soluble lignin (WSL) fraction was extracted in organic solvent through a three-stage organic solvent extraction process, and the hemicellulosic sugars with increased purity were also collected. Furthermore, a thorough characterization including various NMR techniques (31P, 13C, and 2D-HSQC), GPC, and GC-MS was conducted to the obtained lignin-rich-fractions. It was found that the WSL fraction contained abundant functional groups and tremendous amount of LCC structures. As compared to native LCC of bamboo, the WSL fraction exhibited more typical LCC linkages, i.e. phenyl glycoside linkage, which is the main type of chemical linkage between lignin and carbohydrate in both LCC samples. The results demonstrate that organic phase extraction is a highly efficient protocol for the fractionation of hydrolysate and the isolation of LCC-rich streams possessing great potential applications.

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The Design and Synthesis of Water-Soluble Analogues of CB30865, a Quinazolin-4-one-Based Antitumor Agent

Journal of Medicinal Chemistry ◽

10.1021/jm011081s ◽

2002 ◽

Vol 45 (17) ◽

pp. 3692-3702 ◽

Cited By ~ 20

Author(s):

V. Bavetsias ◽

L. A. Skelton ◽

F. Yafai ◽

F. Mitchell ◽

S. C. Wilson ◽

...

Keyword(s):

Antitumor Agent ◽

Water Soluble ◽

Design And Synthesis

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Bioinspired and Multifunctional Phospholipid Polymer Nanoparticles

Advances in Science and Technology ◽

10.4028/www.scientific.net/ast.102.3 ◽

2016 ◽

Vol 102 ◽

pp. 3-11

Author(s):

Kazuhiko Ishihara ◽

Wei Xin Chen ◽

Yuuki Inoue

Keyword(s):

Acid Group ◽

Covalent Bonding ◽

Water Soluble ◽

Polymer Nanoparticles ◽

Butyl Methacrylate ◽

Carboxylic Acid Group ◽

Cleavage Reaction ◽

Phospholipid Polymer ◽

Biodegradable Poly ◽

Immobilized Proteins

Photoreactive and cytocompatible polymer nanoparticles for immobilizing and photoinduced releasing proteins were prepared. A water-soluble and amphiphilic phospholipid polymer, poly (2-methacryloyloxyethyl phosphorylcholine (MPC)-co-n-butyl methacrylate (BMA)-co-4-(4-(1-methacryloyloxyethyl)-2-methoxy-5-nitrophenoxy) butyric acid (PL)) (PMB-PL) was synthesized. The PMB-PL underwent a cleavage reaction at the PL unit by photoirradiation at a wavelength of 365 nm. Additionally, the PMB-PL took polymer aggregate in aqueous medium and was used to modify the surface of biodegradable poly (L-lactic acid) (PLA) nanoparticle as an emulsifier. The morphology of the PMB-PL/PLA nanoparticle was spherical and approximately 130 nm in diameter. The carboxylic acid group in the PL unit could be used for immobilization of proteins by covalent bonding. The bound proteins were released by a photoinduced cleavage reaction. Within 60 sec, up to 90% of the immobilized proteins were released by photoirradiation and activity of the protein released in the medium was maintained as well as that the original proteins before immobilization. Octa-arginine (R8) could promote internalization of the protein/PLA/PMB-PL nanoparticles into cells when the R8 was co-immobilized on the nanoparticles. After that, photoirradiation induced protein release from the nanoparticles and proteins distributed more evenly inside cells. From these results, we concluded that PMB-PL/PLA nanoparticles have the potential to be used as smart carriers to deliver proteins to biological systems, such as the inside of living cells.

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Evaluation of anthocyanin encapsulation efficiency into yeast cell by plasmolysis, ethanol, and ultrasound treatments using alone or in combination

Food Research ◽

10.26656/fr.2017.4(2).283 ◽

2019 ◽

Vol 4 (2) ◽

pp. 557-562

Author(s):

M.D. Lieu ◽

T.T.H. Hoang ◽

H.N.T. Nguyen ◽

T.K.T. Dang

Keyword(s):

Yeast Cell ◽

Encapsulation Efficiency ◽

Color Stability ◽

Water Soluble ◽

Impact Factors ◽

Time Treatment ◽

Treated Sample ◽

Potential Applications ◽

The Individual ◽

First Time

Anthocyanin is a water-soluble color compound of the flavonoid which was successfully encapsulation in Saccharomyces cerevisiae by plasmolysis, ethanol, and ultrasound treatments using alone or in combination in the first time. Treatment agents significantly enhanced the encapsulation efficiency of anthocyanin fluid. The encapsulation yield (EY) of the combined factors was higher than the individual impact factors. Ethanol 10% (v/v) and ultrasound 180 seconds for the highest EY 40.22±0.67%, then ethanol 10% (v/v) and NaCl 10% (w/v) for EY 36.45±0.35%, NaCl 10% and ultrasound for EY 32.14±0.98% lowest. The color stability evaluation of the capsules was carried out at 80°C for 30 minutes. The color lost rate was determined by the spectrometer. The color loss of samples with the un-treatment yeast was 20.45±1.21%, higher than the treated sample. This suggests that anthocyanin encapsulation by yeast cell is efficient in overcoming the effects of high temperatures and having potential applications in food processing.

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