scholarly journals Nanotechnology-Based Topical Drug Delivery Systems for Management of Dandruff and Seborrheic Dermatitis: An overview

2020 ◽  
Vol 29 (1) ◽  
pp. 12-32
Author(s):  
Lena M. Thomas ◽  
Abeer H. Khasraghi
Keyword(s):  
Drug Delivery ◽  
Patient Compliance ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Seborrheic Dermatitis ◽  
Delivery Systems ◽  
Drug Formulation ◽  
Topical Drug Delivery ◽  
Skin Disorders ◽  
Common Skin

Dandruff and seborrheic dermatitis (SD) are common skin disorders affecting the scalp and extending to other body sites in the case of SD. They are associated with pruritus and scaling, causing an esthetical disturbance in the population affected.   Treatment of such conditions involves using a variety of drugs for long terms, thus optimizing drug formulation is essential to improve therapeutic efficacy and patient compliance. Conventional topical formulations like shampoos and creams have been widely used but their use is associated with disadvantages. To overcome such effects, novel topical nanotechnology-based formulations are currently under investigation. In the following article, we highlight recently published formulation approaches used to improve topical dandruff/SD therapy

Improved Therapeutic Efficacy of Topotecan Against A549 Lung Cancer Cells with Folate-targeted Topotecan Liposomes

2020 ◽  
Vol 21 (11) ◽  
pp. 902-909
Author(s):  
Jingxin Zhang ◽  
Weiyue Shi ◽  
Gangqiang Xue ◽  
Qiang Ma ◽  
Haixin Cui ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Lung Tumor ◽  
A549 Cells ◽  
Delivery Systems ◽  
Lung Cancer Cells

Background: Among all cancers, lung cancer has high mortality among patients in most of the countries in the world. Targeted delivery of anticancer drugs can significantly reduce the side effects and dramatically improve the effects of the treatment. Folate, a suitable ligand, can be modified to the surface of tumor-selective drug delivery systems because it can selectively bind to the folate receptor, which is highly expressed on the surface of lung tumor cells. Objective: This study aimed to construct a kind of folate-targeted topotecan liposomes for investigating their efficacy and mechanism of action in the treatment of lung cancer in preclinical models. Methods: We conjugated topotecan liposomes with folate, and the liposomes were characterized by particle size, entrapment efficiency, cytotoxicity to A549 cells and in vitro release profile. Technical evaluations were performed on lung cancer A549 cells and xenografted A549 cancer cells in female nude mice, and the pharmacokinetics of the drug were evaluated in female SD rats. Results: The folate-targeted topotecan liposomes were proven to show effectiveness in targeting lung tumors. The anti-tumor effects of these liposomes were demonstrated by the decreased tumor volume and improved therapeutic efficacy. The folate-targeted topotecan liposomes also lengthened the topotecan blood circulation time. Conclusion: The folate-targeted topotecan liposomes are effective drug delivery systems and can be easily modified with folate, enabling the targeted liposomes to deliver topotecan to lung cancer cells and kill them, which could be used as potential carriers for lung chemotherapy.

Nanostructured Ketorolac-Tromethamine/MCF: Synthesis, Characterization and Application in Drug Release System

2018 ◽  
Vol 14 (5) ◽  
pp. 432-439 ◽  
Author(s):  
Juliana M. Juarez ◽  
Jorgelina Cussa ◽  
Marcos B. Gomez Costa ◽  
Oscar A. Anunziata
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
The Body ◽  
Fickian Diffusion ◽  
Ketorolac Tromethamine

Background: Controlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. Mesostructured Cellular Foam (MCF) material is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Methods: Ketorolac-Tromethamine/MCF composite was synthesized. The material synthesis and loading of ketorolac-tromethamine into MCF pores were successful as shown by XRD, FTIR, TGA, TEM and textural analyses. Results: We obtained promising results for controlled drug release using the novel MCF material. The application of these materials in KETO release is innovative, achieving an initial high release rate and then maintaining a constant rate at high times. This allows keeping drug concentration within the range of therapeutic efficacy, being highly applicable for the treatment of diseases that need a rapid response. The release of KETO/MCF was compared with other containers of KETO (KETO/SBA-15) and commercial tablets. Conclusion: The best model to fit experimental data was Ritger-Peppas equation. Other models used in this work could not properly explain the controlled drug release of this material. The predominant release of KETO from MCF was non-Fickian diffusion.

scholarly journals Elastic and Ultradeformable Liposomes for Transdermal Delivery of Active Pharmaceutical Ingredients (APIs)

2021 ◽  
Vol 22 (18) ◽  
pp. 9743
Author(s):  
Eliana B. Souto ◽  
Ana S. Macedo ◽  
João Dias-Ferreira ◽  
Amanda Cano ◽  
Aleksandra Zielińska ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
First Generation ◽  
Delivery Systems ◽  
Topical Drug Delivery ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients

Administration of active pharmaceutical ingredients (APIs) through the skin, by means of topical drug delivery systems, is an advanced therapeutic approach. As the skin is the largest organ of the human body, primarily acting as a natural protective barrier against permeation of xenobiotics, specific strategies to overcome this barrier are needed. Liposomes are nanometric-sized delivery systems composed of phospholipids, which are key components of cell membranes, making liposomes well tolerated and devoid of toxicity. As their lipid compositions are similar to those of the skin, liposomes are used as topical, dermal, and transdermal delivery systems. However, permeation of the first generation of liposomes through the skin posed some limitations; thus, a second generation of liposomes has emerged, overcoming permeability problems. Various mechanisms of permeation/penetration of elastic/ultra-deformable liposomes into the skin have been proposed; however, debate continues on their extent/mechanisms of permeation/penetration. In vivo bioavailability of an API administered in the form of ultra-deformable liposomes is similar to the bioavailability achieved when the same API is administered in the form of a solution by subcutaneous or epi-cutaneous injection, which demonstrates their applicability in transdermal drug delivery.

scholarly journals Self-Nano-Emulsifying Drug-Delivery Systems: From the Development to the Current Applications and Challenges in Oral Drug Delivery

Pharmaceutics ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1194
Author(s):  
Aristote B. Buya ◽  
Ana Beloqui ◽  
Patrick B. Memvanga ◽  
Véronique Préat
Keyword(s):  
Drug Delivery ◽  
Patient Compliance ◽  
Oral Delivery ◽  
Drug Delivery Systems ◽  
Water Solubility ◽  
Oral Drug Delivery ◽  
Delivery Systems ◽  
Oral Drug ◽  
Statistical Design Of Experiments

Approximately one third of newly discovered drug molecules show insufficient water solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems (SNEDDSs) are one of the emerging strategies developed to tackle the issues associated with their oral delivery. SNEDDSs are composed of an oil phase, surfactant, and cosurfactant or cosolvent. SNEDDSs characteristics, their ability to dissolve a drug, and in vivo considerations are determinant factors in the choice of SNEDDSs excipients. A SNEDDS formulation can be optimized through phase diagram approach or statistical design of experiments. The characterization of SNEDDSs includes multiple orthogonal methods required to fully control SNEDDS manufacture, stability, and biological fate. Encapsulating a drug in SNEDDSs can lead to increased solubilization, stability in the gastro-intestinal tract, and absorption, resulting in enhanced bio-availability. The transformation of liquid SNEDDSs into solid dosage forms has been shown to increase the stability and patient compliance. Supersaturated, mucus-permeating, and targeted SNEDDSs can be developed to increase efficacy and patient compliance. Self-emulsification approach has been successful in oral drug delivery. The present review gives an insight of SNEDDSs for the oral administration of both lipophilic and hydrophilic compounds from the experimental bench to marketed products.

The potential application of novel drug delivery systems for phytopharmaceuticals and natural extracts – current status and future perspectives

2020 ◽  
Vol 20 ◽  
Author(s):  
Mohamad Fawzi Mahomoodally ◽  
Nabeelah Sadeer ◽  
Mehtaab Edoo ◽  
Katharigatta N. Venugopala
Keyword(s):  
Drug Delivery ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Current Status ◽  
Novel Technologies ◽  
Alternative Drug ◽  
Low Toxicity ◽  
Novel Drug ◽  
Herbal Formulations

: Phytocompounds isolated from plants are well appraised for their broad pharmacological propensities in several pathologies. One key benefit of phytoconstituents is their relatively low toxicity and adverse effects. Nonetheless, poor solubility, permeation, and poor specificity at the target site tend to hinder its therapeutic efficacy. Hence, novel technologies for drug delivery systems are being developed via the use of various nanoformulation strategies to overcome these challenges and give uniform medication focusing at the dynamic site in desired concentration and improved therapeutic efficacy. Such approaches comprise of novel drug delivery systems (NDDS). The utilisation of herbal formulations for NDDS is more beneficious and advantageous as opposed to others. The utilisation of ethosome, liposome, emulsion, phytosomes, microsphere, and strong lipid nanoparticles of herbal formulation have improved the remedial impacts of plant extricates. With the utilisation of all these, directed delivery of the formulation is accomplished, because of which the formulation exhibits impact on the site, and the bioavailability of the formulation is likewise expanded. With these novel medication conveyance frameworks, the actives and concentrates which are utilised as part of natural formulations exhibit sustained release of formulation, enhancement in stability, improved therapeutic efficacy, and protection from toxicity. The primary motivation behind creating alternative drug delivery technologies is to expand the effectiveness of drug conveyance and safety in the process of drug conveyance and give more comfort to the patient. In this review, the importance of various phytocompounds in the delivery of drugs are highlighted as well as their importance in reducing the risk or diseases.

Emulgel: A Review

2021 ◽  
pp. 263-268
Author(s):  
Sahil Hasan ◽  
Saloni Bhandari ◽  
Anshu Sharma ◽  
Poonam Garg
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Control Release ◽  
Delivery Systems ◽  
Antifungal Drugs ◽  
Therapeutic Drug ◽  
Topical Drug Delivery ◽  
Drug Molecules ◽  
Control Release System ◽  
Conventional Systems

Emulgel systems are currently attention to the pharmaceutical sectors because of their substantial potential to act as drug delivery vehicle by incorporating a broad range of drug molecules and higher stability compared to the other dosage form like cream, lotion, gel, etc. Emulsions are either available in an oil in water or water in oil type. These are prepared by the incorporation of the emulsion into the gel with constant stirring at a moderate speed. Incorporation of emulsion into a gel makes it a dual control release system, thereby, increasing its stability. It has better drug release if we compare to other topical drug delivery system. It is non greasy because of the presence of gel phase which enhances patient compliance. Gels has a major limitation for the delivery of hydrophobic drugs, so to overcome this limitation an emulsion based approach is being used so that even a hydrophobic therapeutic drug can enjoy the unique properties of gels. In recent years, these have also been a great interest in the use of novel polymers. These emulgels are having major advantages on vesicular drug delivery systems as well as on conventional systems in various aspects. Various permeation enhancers can enhance the effect; due to this emulgels can be used as better topical drug delivery systems over current drug delivery systems. The emulsion can be use for analgesics and antifungal drugs.

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