A Non-Invasive, Low-Cost Study Design to Determine the Release Profile of Colon Drug Delivery Systems: A Feasibility Study

2012 ◽  
Vol 29 (8) ◽  
pp. 2070-2078 ◽  
Author(s):  
Marina J. M. Maurer ◽  
Reinout C. A. Schellekens ◽  
Klaus D. Wutzke ◽  
Gerard Dijkstra ◽  
Herman J. Woerdenbag ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Feasibility Study ◽  
Study Design ◽  
Drug Delivery Systems ◽  
Low Cost ◽  
Delivery Systems ◽  
Release Profile ◽  
Cost Study ◽  
Non Invasive ◽  
Colon Drug Delivery

scholarly journals Diatoms Green Nanotechnology for Biosilica-Based Drug Delivery Systems

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 242 ◽  
Author(s):  
Monica Terracciano ◽  
Luca De Stefano ◽  
Ilaria Rea
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Low Cost ◽  
Release Kinetics ◽  
Drug Carrier ◽  
Drug Loading ◽  
Three Dimensional ◽  
Delivery Systems ◽  
Diatom Frustule ◽  
Artificial Environment

Diatom microalgae are the most outstanding natural source of porous silica. The diatom cell is enclosed in a three-dimensional (3-D) ordered nanopatterned silica cell wall, called frustule. The unique properties of the diatom frustule, including high specific surface area, thermal stability, biocompatibility, and tailorable surface chemistry, make diatoms really promising for biomedical applications. Moreover, they are easy to cultivate in an artificial environment and there is a large availability of diatom frustules as fossil material (diatomite) in several areas of the world. For all these reasons, diatoms are an intriguing alternative to synthetic materials for the development of low-cost drug delivery systems. This review article focuses on the possible use of diatom-derived silica as drug carrier systems. The functionalization strategies of diatom micro/nanoparticles for improving their biophysical properties, such as cellular internalization and drug loading/release kinetics, are described. In addition, the realization of hybrid diatom-based devices with advanced properties for theranostics and targeted or augmented drug delivery applications is also discussed.

scholarly journals MUCOADHESIVE BUCCAL DRUG DELIVERY SYSTEMS CONTAINING POLYSACCHARIDES

2020 ◽  
Vol 54 (9-10) ◽  
pp. 889-902
Author(s):  
IRINA M. PELIN ◽  
DANA M. SUFLET
Keyword(s):  
Drug Delivery ◽  
Drug Administration ◽  
Drug Delivery Systems ◽  
Enzymatic Degradation ◽  
Low Cost ◽  
Hepatic Metabolism ◽  
Drug Action ◽  
Delivery Systems ◽  
Buccal Drug Delivery ◽  
Systemic Drug

The buccal mucosa is an attractive site for drug administration as it allows avoiding the enzymatic degradation of the drug in the gastrointestinal tract and its hepatic metabolism. For buccal administration, different drug delivery systems with controlled mucoadhesion have been developed and some of them are available on the market. Mucoadhesion makes it possible to obtain prolonged, local or systemic drug action, and this process is highly influenced by several factors, among which, the reactivity of macromolecules from the formulations is very important. Polysaccharides are increasingly studied due to their abundance in natural resources, low-cost availability and easy chemical modification, but also due to their biocompatibility, biodegradability and non-toxicity properties. This review briefly describes the advantages of using the buccal route of drug administration, the influencing factors that are taken into account for obtaining mucoadhesive dosage forms, and the main polysaccharides and their derivatives used for fabrication of buccal drug delivery systems.

Polymer nanofibers for biomedical applications: advances by electrospinning

2021 ◽  
Vol 04 ◽  
Author(s):  
Anna L.M.M. Toledo ◽  
Talita N. da Silva ◽  
Arianne C. dos S. Vaucher ◽  
Arthur H. V. Miranda ◽  
Gabriela C. C. Silva de Miranda ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
New Technologies ◽  
Low Cost ◽  
Electrospun Nanofibers ◽  
Delivery Systems ◽  
Electrospun Fibers ◽  
Sustained Delivery ◽  
Biomedical Devices ◽  
Ultrathin Fibers

Background: The demand for novel biomaterials has been exponentially rising in the last years as well as the searching for new technologies able to produce more efficient products in both drug delivery systems and regenerative medicine. Objective: The technique that can pretty well encompass the needs for novel and high-end materials with a relatively low-cost and easy operation is the electrospinning of polymer solutions. Methods: Electrospinning usually produces ultrathin fibers that can be applied in a myriad of biomedical devices including sustained delivery systems for drugs, proteins, biomolecules, hormones, etc that can be applied in a broad spectrum of applications, from transdermal patches to cancer-related drugs. Results: Electrospun fibers can be produced to mimic certain tissues of the human body, being an option to create new scaffolds for implants with several advantages. Conclusions: In this review, we aimed to encompass the use of electrospun fibers in the field of biomedical devices, more specifically in the use of electrospun nanofibers applications toward the production of drug delivery systems and scaffolds for tissue regeneration.

scholarly journals Review on Transferosomes and Transferosomal Gels

2021 ◽  
pp. 114-126
Author(s):  
P. Kranthi Kumar ◽  
R. Santosh Kumar
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
First Generation ◽  
Delivery Systems ◽  
Non Invasive ◽  
Transdermal Drug Delivery Systems ◽  
First Pass Metabolism ◽  
Pharmaceutical Uses ◽  
Pass Metabolism

Transdermal drug delivery systems (TDDS), which are self-administrable and non-invasive, can improve bioavailability and patient compliance by bypassing first-pass metabolism. Vesicular-based TDDS have attracted a lot of attention in recent years because they're designed for controlled, efficient, and targeted drug delivery. One of these delivery technologies, transferosomal-based formulations, has grown in popularity due to its ability to achieve all of the desired criteria and quality qualities. Transferosomes combine the characteristics of liposomes and niosomes because they contain both liposomes (phospholipids and cholesterols) and niosomes as components (nonionic surfactants; edge activators). as a result, they are referred to as the first generation of elastic liposomes. However transdermal drug delivery is difficult due to the presence of the skin's protective barrier, transferosomal drug delivery overcomes all obstacles due to its unique characteristics, such as its ultradeformable vesicular nature. The benefits, limitations, modes of penetration, formulations, production and assessment methodologies, and pharmaceutical uses of transferosomal drug delivery systems are discussed in this paper. Conclusion: Transferosomes have several importance over other vesicular systems, including greater deformability, greater penetration power across skin, the ability to deliver systemic drugs, and higher stability.

Raman spectroscopy in pharmaceutical research and industry

2018 ◽  
Vol 3 (8) ◽  
Author(s):  
Nathalie Jung ◽  
Maike Windbergs
Keyword(s):  
Drug Delivery ◽  
Raman Spectroscopy ◽  
Quality Control ◽  
Drug Delivery Systems ◽  
Large Scale ◽  
Pharmaceutical Research ◽  
Delivery Systems ◽  
Scale Production ◽  
Non Invasive ◽  
Large Scale Production

Abstract In the fast-developing fields of pharmaceutical research and industry, the implementation of Raman spectroscopy and related technologies has been very well received due to the combination of chemical selectivity and the option for non-invasive analysis of samples. This chapter explores established and potential applications of Raman spectroscopy, confocal Raman microscopy and related techniques from the early stages of drug development research up to the implementation of these techniques in process analytical technology (PAT) concepts for large-scale production in the pharmaceutical industry. Within this chapter, the implementation of Raman spectroscopy in the process of selection and optimisation of active pharmaceutical ingredients (APIs) and investigation of the interaction with excipients is described. Going beyond the scope of early drug development, the reader is introduced to the use of Raman techniques for the characterization of complex drug delivery systems, highlighting the technical requirements and describing the analysis of qualitative and quantitative composition as well as spatial component distribution within these pharmaceutical systems. Further, the reader is introduced to the application of Raman techniques for performance testing of drug delivery systems addressing drug release kinetics and interactions with biological systems ranging from single cells up to complex tissues. In the last part of this chapter, the advantages and recent developments of integrating Raman technologies into PAT processes for solid drug delivery systems and biologically derived pharmaceutics are discussed, demonstrating the impact of the technique on current quality control standards in industrial production and providing good prospects for future developments in the field of quality control at the terminal part of the supply chain and various other fields like individualized medicine. On the way from the active drug molecule (API) in the research laboratory to the marketed medicine in the pharmacy, therapeutic efficacy of the active molecule and safety of the final medicine for the patient are of utmost importance. For each step, strict regulatory requirements apply which demand for suitable analytical techniques to acquire robust data to understand and control design, manufacturing and industrial large-scale production of medicines. In this context, Raman spectroscopy has come to the fore due to the combination of chemical selectivity and the option for non-invasive analysis of samples. Following the technical advancements in Raman equipment and analysis software, Raman spectroscopy and microscopy proofed to be valuable methods with versatile applications in pharmaceutical research and industry, starting from the analysis of single drug molecules as well as complex multi-component formulations up to automatized quality control during industrial production.

Recent Advances on Cellulose-Based Nano-Drug Delivery Systems: Design of Prodrugs and Nanoparticles

2019 ◽  
Vol 26 (14) ◽  
pp. 2410-2429 ◽  
Author(s):  
Lin Dai ◽  
Chuanling Si
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Low Cost ◽  
Drug Loading ◽  
Scale Up ◽  
Physicochemical Characterization ◽  
Systems Design ◽  
Delivery Systems ◽  
Recent Advances ◽  
Nano Drug Delivery

Background:Cellulose being the first abundant biopolymers in nature has many fascinating properties, including low-cost, good biodegradability, and excellent biocompatibility, which made cellulose a real potential material to create nano-drug delivery systems (nano-DDS). This review aims to present and discuss some remarkable recent advances on the drug delivery applications of cellulosebased prodrugs and nanoparticles.Methods:By searching the research literatures over last decade, a variety featured studies on cellulosebased nano-DDS were summarized and divided into prodrugs, prodrug nanoparticles, solid or derivative nanopartilces, amphiphilic copolymer nanoparticles, and polyelectrolyte complex nanoparticles. Various methods employed for the functionalization, pharmacodynamic actions and applications were described and discussed.Results:Many types of cellulose-based nano-DDS can ensure efficient encapsulation of various drugs and then overcome the free drug molecule shortcomings. Among all the method described, cellulosebased amphiphilic nanoparticles are most frequently used. These formulations have the higher drug loading capability, a simple and flexible way to achieve multi-functional. Apart from hydrophilic or hydrophobic modification, cellulose or its derivatives can form nanoparticles with different small molecules and macromolecules, leading to a large spectrum of cellulose-based nano-DDS and providing some unexpected advantages.Conclusion:Thorough physicochemical characterization and profound understanding of interactions of the cellulose-based nano-DDS with cells and tissues is indispensable. Moreover, studies toward technics parameter optimization and scale up from the laboratory to production level should be undertaken. The development of intravenous and orally applicable cellulose-based nano-DDS will be an important research area, and these systems will have more commercial status in the market.

A Review on Chitosan in Drug Delivery for the Treatment of Neurological and Psychiatric Disorders

2021 ◽  
Vol 22 ◽  
Author(s):  
Mehran Shayganfard
Keyword(s):  
Drug Delivery ◽  
Spinal Cord ◽  
Drug Delivery Systems ◽  
Neurological Diseases ◽  
Delivery Systems ◽  
Psychiatric Diseases ◽  
Non Invasive ◽  
Hypoxic Ischemia ◽  
Number Of Patients ◽  
Cord Injury

: Neurological diseases are known as global health problems with a growing number of patients annually. Neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease as well as spinal cord injury, hypoxic ischemia injury, epilepsy, depression etc., are some examples of neurological diseases. One of the main problems in the treatment of these diseases is the delivery of drugs across the blood-brain barrier (BBB). These days, researchers have tended to find non-invasive and non-toxic strategies for solving this problem. As a non-toxic, safe, and potential agent, chitosan has attracted attention for use in drug delivery systems. Recently, numerous studies have designed drug delivery systems by using chitosan for the treatment of various neurological diseases. In this paper, the latest developments of chitosan and its derivatives and their utilization in the drug delivery systems for the treatment of different neurological and psychiatric diseases were reviewed.

Recent Advances in Colon Drug Delivery Technology.

2021 ◽  
Vol 11 ◽  
Author(s):  
Rakesh Pahwa ◽  
Ridhi Bajaj ◽  
Pankaj Bhateja ◽  
Mona Piplani
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Release Kinetics ◽  
Delivery Systems ◽  
Structure Property ◽  
Colonic Delivery ◽  
Colon Drug Delivery ◽  
Targeted Drug ◽  
Delivery Technology

: Colon targeted drug delivery technology; an approach of immense potential has acquired tremendous significance for managing a number of ailments particularly of colon and for delivering therapeutic proteins and peptides systemically. The major hurdles for delivering drug in colonic region include absorption and degradation pathways in the upper gastrointestinal tract (GIT). To achieve a triumphant colonic delivery, therapeutic agent must be sheltered from getting absorbed in the preliminary region of GIT, in addition, ensure its release in proximal colon in a controlled way. The principle approaches for instance prodrug approach, pH sensitivity, time-dependency (lag time), degradation by microbes etc. have been effectively applied for obtaining colon targeted drug delivery. These approaches have accomplished immense relevance. Therefore, incessant attempts have been mainly focused on the design of colon targeted drug delivery systems having enhanced site specificity along with study of its versatile drug release kinetics to achieve diverse therapeutic requirements. The current manuscript illustrates significance of different colon drug delivery systems and general considerations for designing colon targeting systems including primary as well as novel approaches. Recent investigational studies carried out by scientific communities worldwide for the designing and preparation of various colon targeted formulations along with their significant insights have been described. Recent patents, structure property relationship and dissolution aspects pertaining to the colon specific drug delivery have also been depicted.

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