scholarly journals Anti-Diabetic Potential of Plant-Based Pentacyclic Triterpene Derivatives: Progress Made to Improve Efficacy and Bioavailability

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7243
Author(s):  
Michael Oboh ◽  
Laurencia Govender ◽  
Muthulisi Siwela ◽  
Blessing Nkazimulo Mkhwanazi
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Cellular Response ◽  
Efficacy And Safety ◽  
Pentacyclic Triterpene ◽  
Control Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Current Review ◽  
Oral Hypoglycemic Drugs

Diabetes mellitus (DM) results from the inability of the pancreas to produce sufficient insulin or weakened cellular response to the insulin produced, which leads to hyperglycemia. Current treatments of DM focus on the use of oral hypoglycemic drugs such as acarbose, alpha-glucose inhibitors, sulphonylureas, thiazolidinediones, and biguanides to control blood glucose levels. However, these medications are known to have various side effects in addition to their bioavailability, efficacy, and safety concerns. These drawbacks have increased interest in the anti-diabetic potential of plant-derived bioactive compounds such as oleanolic and maslinic acids. Although their efficacy in ameliorating blood glucose levels has been reported in several studies, their bioavailability and efficacy remain of concern. The current review examines the anti-diabetic effects of oleanolic, maslinic, asiatic, ursolic, and corosolic acids and their derivatives, as well as the progress made thus far to enhance their bioavailability and efficacy. The literature for the current review was gathered from leading academic databases—including Google Scholar and PubMed—the key words listed below were used. The literature was searched as widely and comprehensively as possible without a defined range of dates.

scholarly journals Correlation Between Blood Glucose Control And Decrease Of Peripheral Vascularization In Diabetes Mellitus Patient

2018 ◽  
Vol 4 (1) ◽  
pp. 18
Author(s):  
Fitria Endah Janitra ◽  
Dinda Sandika
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Glucose Control ◽  
Diabetes Management ◽  
Blood Glucose Control ◽  
Nursing Intervention ◽  
Tissue Ischemia ◽  
Control Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels

Introduction: Diabetes mellitus (DM) is a metabolic disorder characterized by elevated blood glucose levels. Chronic complications of DM affect coronary circulation, peripheral vascularization, and blood vessels of the brain. Decrease in peripheral vascularization increases the risk of tissue ischemia and weakens functional status, therefore it is necessary to control blood glucose levels. Islam teaches to its believers to control their diet, where diet is one of the four pillars of diabetes management. Methodology: this is analytic descriptive research with cross sectional methods in 67 respondents taken by consecutive sampling technique. Results: There was a significant correlation within blood glucose control and decreased peripheral vascularization in DM patients (p-value 0.010). Discussion: need further research regarding nursing intervention to control blood glucose.

Ankle Brachial Indeks (ABI), Kadar Glukosa Darah dan Nutrisi Pada Ulkus Diabetikum

2019 ◽  
Vol 4 (3) ◽  
pp. 449
Author(s):  
Riwanti Silaban ◽  
Pina Lestari ◽  
May Daryeti ◽  
Diah Merdekawati
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Sampling Technique ◽  
P Value ◽  
Cross Sectional ◽  
Diabetic Ulcer ◽  
Control Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
And Control

<p><em>The increasing number of people with diabetes mellitus each year, the client has also experienced one of the complications, namely ulcers. During this time, the concern of nurses at Raden Mattaher Jambi Hospital is only an ulcer on the client, but no intervention has been made to determine the factors causing the duration of the client's ulcer resolved. The kind of is a cross-sectional. The sample in this study was 27 respondents who had criteria by what was to be studied. The sampling technique is done by accidental sampling that is taking samples by taking cases or respondents who happen to be available or available. Analysis of the data in this study was Univariate and Bivariate. It was held on April 29th until June 29th 2019 with uses observation sheets and questionnaires as aids in data collection. Statistical test results obtained p-value &lt;0.05, meaning that there is a relationship between ABI values, blood glucose levels and nutrients with the area of diabetic ulcer. It can be concluded that the ABI value, blood glucose level and nutrition affect the area of diabetic ulcer. It is expected that Raden Mattaher Jambi Hospital can make ABI examination a Standard Operational Procedure and control blood glucose and nutrition levels as a factor in accelerating wound healing.</em></p><p> </p><p><em>Semakin meningkatnya angka penderita diabetes mellitus tiap tahunnya, maka semakin meningkat pula klien mengalami salah satu komplikasinya yaitu ulkus. Selama ini, yang menjadi perhatian perawat di RSUD Raden Mattaher Jambi hanya ulkus pada klien, namun belum ada intervensi yang dilakukan guna mengetahui faktor penyebab lamanya ulkus klien teratasi. Jenis penelitian ini adalah penelitian cros sectional. Sampel dalam penelitian ini 27 responden yang memiliki kriteria sesuai dengan yang akan diteliti. Teknik pengambilan sampel dilakukan dengan cara accidental sampling yaitu pengambilan sampel dilakukan dengan mengambil kasus atau responden yang kebetulan ada atau tersedia. Analisa data dalam penelitian ini secarra Univariat dan Bivariat. Penelitian ini dilaksanakan dari 29 April-29 Juni 2019 dengan menggunakan lembar observasi dan kuesioner sebagai alat bantu dalam pengumpulan data. Hasil uji statistik diperoleh nilai p-value &lt; 0,05, artinya ada hubungan antara nilai ABI, kadar glukosa darah dan nutrisi dengan luas ulkus diabetikum. Dapat disimpulkan bahwa nilai ABI, kadar glukosa darah dan nutrisi mempengaruhi luas ulkus diabetikum. Diharapkan kepada pihak RSUD Raden Mattaher Jambi dapat menjadikan pemeriksaan ABI sebagai Standar Prosedur Operasional dan melakukan pengontrolan kadar glukosa darah serta nutrisi sebagai faktor mempercepat penyembuhan luka.</em></p>

scholarly journals MENGENDALIKAN KADAR GLUKOSA DARAH PASIEN DIABETES MELITUS TIPE 2 DENGAN OLAH SEHAT LAFIDZI 21

2018 ◽  
Vol 2 (1) ◽  
pp. 1
Author(s):  
Sulastri S ◽  
Tety Mulyati Arofi
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Control Group ◽  
Control Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Quasi Experimental ◽  
Diabetes Patients

Pendahuluan: Diabetes Mellitus merupakan suatu sindroma klinis kelainan metabolik yang ditandai oleh adanya hiperglikemia yang terjadi karena kelainan sekresi insulin, kerja insulin atau kedua-duanya. Perawatan pasien Diabetes bertujuan mengendalikan kadar glukosa darah sehingga tidak menimbulkan komplikasi yang dapat mengganggu kehidupan normal pasien. Berbagai penatalaksanaan untuk mengendalikan kadar glukosa darah dapat dilakukan, di antaranya olah sehat Lafidzi 21. Penelitian ini bertujuan untuk mengetahui pengaruh Olah Sehat Lafidzi 21 terhadap kadar glukosa darah pasien Diabetes tipe 2 di Klub Diabetes Rumah Sakit Islam Jakarta Cempaka Putih. Metode: Penelitian ini merupakan penelitian kuantitatif dengan rancangan quasi-experimental dengan kelompok kontrol. Olah Sehat Lafidzi 21 dilakukan oleh penderita Diabetes setiap hari selama 14 hari. Hasil: penelitian menunjukkan penurunan kadar glukosa darah puasa yang signifikan pada kelompok intervensi setelah melakukan Olah Sehat Lafidzi 21 (p =0,00). Simpulan: Olah Sehat Lafidzi 21 mampu menurunkan kadar glukosa darah secara signifikan pada penderita diabetes tipe 2 di Diabetes Klub Jakarta Islamic Hospital Cempaka Putih. Kata kunci: Olah Sehat Lafidzi 21, kadar gula darah, diabetes mellitus tipe 2.AbstractIntroduction: Diabetes Mellitus is a clinical syndrome of metabolic abnormalities characterized by the presence of hyperglycemia that occurs due to insulin secretion abnormalities, insulin work or both. Treatment of Diabetes patients aims to control blood glucose levels so as not to cause complications that can interfere with the patient's normal life. Various management to control blood glucose levels can be done, including healthy Lafidzi 21. This study aims to determine the influence of Healthy Lafidzi 21 on blood glucose level of Type 2 Diabetes patients at Diabetes Club Jakarta Islamic Hospital Cempaka Putih. Methods: This was a quantitative study with a quasi-experimental design with a control group. Healthy Lafidzi 21 is done by diabetics every day for 14 days. Results: the study showed a significant decrease in fasting blood glucose levels in the intervention group after performing Healthy Lafidzi 21 (p = 0.00). Conclusion: Healthy Lafidzi 21 is able to lower blood glucose levels significantly in people with type 2 diabetes in Diabetes Club Jakarta Islamic Hospital Cempaka Putih. Keywords: Healthy Lafidzi 21, blood sugar level, diabetes mellitus type 2.

scholarly journals A prospective comparative study to evaluate the effect of Myo-inositol plus diet vs diet alone in patients with gestational diabetes mellitus

2021 ◽  
Vol 14 (03) ◽  
pp. 197-201
Author(s):  
B Swathi ◽  
A Deepthi ◽  
B Sravani ◽  
Rekha ◽  
S Namratha ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Prospective Study ◽  
Control Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Number Of Patients ◽  
Prospective Comparative Study

Aim: The aim of this study was to compare the effect of Myo-inositol plus diet and diet alone in patients with gestational diabetes mellitus. Materials and methods: A Randomized Prospective study was carried out in Gestational Diabetes Mellitus patients to evaluate the efficacy of Myoinositol+diet vs Diet alone in the department of Gynaecology, Durgabhai Deshmukh Hospital, a 300 bedded multispecialty hospital from September 2018-April 2019.OGTT test was conducted to measure blood glucose levels. Results: Among the total number of patients (60), Myoinositol + diet is given in 50% and diet is given in 50% of the patients. Among 30 patients on diet, 19 patients couldn’t control rising blood glucose levels and were prescribed insulin for reduction of blood glucose levels. Among 30 patients on myoinositol+ diet, 4 patients couldn’t control 1 hr blood glucose levels and were prescribed insulin to control blood glucose levels. Conclusion: This study showed that Myoinositol + diet is effective than only diet with respect to decrease in blood glucose levels and safety among patients with Gestational Diabetes Mellitus. Therefore, we conclude that myoinositol + diet is safe and effective in reducing fasting and 2hr blood glucose levels.

Efeitos dos Programas de Treinamento Aeróbio, de Força e Combinado na Glicose Sanguínea em Diabéticos do Tipo 2: uma Revisão Sistemática/ Effects of Aerobic, Strength and Combined Programs Training on Blood Glucose in Type 2 Diabetic: a Systematic Review.

1970 ◽  
Vol 5 (1) ◽  
pp. 61-74 ◽  
Author(s):  
Alexandre de Souza E Silva ◽  
Maria Paula Gonçalves Mota
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Training Program ◽  
Aerobic Training ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Pubmed Database

O trabalho tem como objetivo analisar os estudos que avaliaram os efeitos dos programas de treinamento aeróbio, força e combinado nos níveis de glicose sanguínea em indivíduos com diabetes do tipo 2. Foi utilizado o método de revisão sistemática, sendo utilizada a base de dados PubMed. As palavras chaves utilizadas para pesquisa foram training and diabetes. Foram identificados 484 artigos originais. Apenas 17 estudos respeitaram os critérios de inclusão. Os resultados evidenciam que os programas de treinamento aeróbio diminuíram os níveis de glicose. O programa de treinamento de força também foi favorável à diminuição dos níveis de glicose sanguínea. Já o programa de treinamento combinado não demonstrou efeitos favoráveis no controle da glicose sanguínea. Conclui-se que o programa de treinamento aeróbio e de força ajudam a controlar os níveis de glicose sanguínea em indivíduos com diabetes do tipo 2. Palavras-chave: diabetes mellitus, treinamento, glicose.ABSTRACTThe study aims to analyze the studies that evaluated the effects of aerobic, strength and combined programs training in blood glucose levels in people with type 2 diabetes. We used a systematic review method and is used to PubMed database. The key words used for searching were training and diabetes. We identified 484 original articles. Only 17 studies complied with the inclusion criteria. The results show that aerobic training programs decreased glucose levels. The strength training program was also favorable to decrease in blood glucose levels. But the combined training program has not shown favorable effects on blood glucose control. We conclude that the aerobic training and strength helps control blood glucose levels in individuals with type 2 diabetes. Keywords: diabetes mellitus, training, glucose.

scholarly journals Pharmaceutical hit of anti type 2 Diabetes mellitus on the phenolic extract of Malaka (Phyllanthus emblica L.) flesh

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Musri Musman ◽  
Mauli Zakia ◽  
Ratu Fazlia Inda Rahmayani ◽  
Erlidawati Erlidawati ◽  
Safrida Safrida
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Body Weight ◽  
Blood Glucose ◽  
Phyllanthus Emblica ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Phenolic Extract

Abstract Background Ethnobotany knowledge in a community has shaped local wisdom in utilizing plants to treat diseases, such as the use of Malaka (Phyllanthus emblica) flesh to treat type 2 diabetes. This study presented evidence that the phenolic extract of the Malaka flesh could reduce blood sugar levels in the diabetic induced rats. Methods The phenolic extract of the P. emblica was administrated to the glucose-induced rats of the Wistar strain Rattus norvegicus for 14 days of treatment where the Metformin was used as a positive control. The data generated were analyzed by the two-way ANOVA Software related to the blood glucose level and by SAS Software related to the histopathological studies at a significant 95% confidence. Results The phenolic extract with concentrations of 100 and 200 mg/kg body weight could reduce blood glucose levels in diabetic rats. The post hoc Dunnet test showed that the administration of the extract to the rats with a concentration of 100 mg/kg body weight demonstrated a very significant decrease in blood glucose levels and repaired damaged cells better than administering the extract at a concentration of 200 mg/kg weight body. Conclusion The evidence indicated that the phenolic extract of the Malaka flesh can be utilized as anti type 2 Diabetes mellitus without damaging other organs.

Searching for Utopia, the Challenge of Standardized Medical Nutrition Therapy Prescription in Gestational Diabetes Mellitus Management: A Critical Review

2021 ◽  
Author(s):  
Nina Meloncelli ◽  
Shelley A. Wilkinson ◽  
Susan de Jersey
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Lifestyle Modification ◽  
Nutrition Therapy ◽  
Medical Nutrition Therapy ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Medical Nutrition

AbstractGestational diabetes mellitus (GDM) is a common pregnancy disorder and the incidence is increasing worldwide. GDM is associated with adverse maternal outcomes which may be reduced with proper management. Lifestyle modification in the form of medical nutrition therapy and physical activity, as well as self-monitoring of blood glucose levels, is the cornerstone of GDM management. Inevitably, the search for the “ultimate” diet prescription has been ongoing. Identifying the amount and type of carbohydrate to maintain blood glucose levels below targets while balancing the nutritional requirements of pregnancy and achieving gestational weight gain within recommendations is challenging. Recent developments in the area of the gut microbiota and its impact on glycemic response add another layer of complexity to the success of medical nutrition therapy. This review critically explores the challenges to dietary prescription for GDM and why utopia may never be found.

scholarly journals Degradation of Incretins and Modulation of Blood Glucose Levels by Periodontopathic Bacterial Dipeptidyl Peptidase 4

2017 ◽  
Vol 85 (9) ◽  
Author(s):  
Yuko Ohara-Nemoto ◽  
Manami Nakasato ◽  
Yu Shimoyama ◽  
Tomomi T. Baba ◽  
Takeshi Kobayakawa ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Dipeptidyl Peptidase ◽  
Oral Glucose ◽  
Content Type ◽  
Dipeptidyl Peptidase 4 ◽  
Glucose Levels ◽  
Flight Mass Spectrometry ◽  
Blood Glucose Levels ◽  
Molecular Events

ABSTRACT Severe periodontitis is known to aggravate diabetes mellitus, though molecular events related to that link have not been fully elucidated. Porphyromonas gingivalis, a major pathogen of periodontitis, expresses dipeptidyl peptidase 4 (DPP4), which is involved in regulation of blood glucose levels by cleaving incretins in humans. We examined the enzymatic characteristics of DPP4 from P. gingivalis as well as two other periodontopathic bacteria, Tannerella forsythia and Prevotella intermedia, and determined whether it is capable of regulating blood glucose levels. Cell-associated DPP4 activity was found in those microorganisms, which was effectively suppressed by inhibitors of human DPP4, and molecules sized 73 kDa in P. gingivalis, and 71 kDa in T. forsythia and P. intermedia were immunologically detected. The k cat/Km values of recombinant DPP4s ranged from 721 ± 55 to 1,283 ± 23 μM−1s−1 toward Gly-Pro-4-methylcoumaryl-7-amide (MCA), while those were much lower for His-Ala-MCA. Matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) analysis showed His/Tyr-Ala dipeptide release from the N termini of incretins, glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide, respectively, with the action of microbial DPP4. Moreover, intravenous injection of DPP4 into mice decreased plasma active GLP-1 and insulin levels, accompanied by a substantial elevation in blood glucose over the control after oral glucose administration. These results are the first to show that periodontopathic bacterial DPP4 is capable of modulating blood glucose levels the same as mammalian DPP4; thus, the incidence of periodontopathic bacteremia may exacerbate diabetes mellitus via molecular events of bacterial DPP4 activities.

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