scholarly journals Zinc-Based Metal-Organic Frameworks in Drug Delivery, Cell Imaging, and Sensing

Molecules ◽  
2021 ◽  
Vol 27 (1) ◽  
pp. 100
Author(s):  
Rashda Safdar Ali ◽  
Hongmin Meng ◽  
Zhaohui Li
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Cell Imaging ◽  
Metal Organic Frameworks ◽  
Drug Carriers ◽  
Metal Centers ◽  
Early Cancer Diagnosis ◽  
Efficient Detection ◽  
Metal Organic ◽  
Targeted Drug

The design and structural frameworks for targeted drug delivery of medicinal compounds and improved cell imaging have been developed with several advantages. However, metal-organic frameworks (MOFs) are supplemented tremendously for medical uses with efficient efficacy. These MOFs are considered as an absolutely new class of porous materials, extensively used in drug delivery systems, cell imaging, and detecting the analytes, especially for cancer biomarkers, due to their excellent biocompatibility, easy functionalization, high storage capacity, and excellent biodegradability. While Zn-metal centers in MOFs have been found by enhanced efficient detection and improved drug delivery, these Zn-based MOFs have appeared to be safe as elucidated by different cytotoxicity assays for targeted drug delivery. On the other hand, the MOF-based heterogeneous catalyst is durable and can regenerate multiple times without losing activity. Therefore, as functional carriers for drug delivery, cell imaging, and chemosensory, MOFs’ chemical composition and flexible porous structure allowed engineering to improve their medical formulation and functionality. This review summarizes the methodology for fabricating ultrasensitive and selective Zn-MOF-based sensors, as well as their application in early cancer diagnosis and therapy. This review also offers a systematic approach to understanding the development of MOFs as efficient drug carriers and provides new insights on their applications and limitations in utility with possible solutions.

Folic Acid Functionalized Zirconium‐Based Metal–Organic Frameworks as Drug Carriers for Active Tumor‐Targeted Drug Delivery

2018 ◽  
Vol 24 (64) ◽  
pp. 17148-17154 ◽  
Author(s):  
Hong Dong ◽  
Gui‐Xin Yang ◽  
Xin Zhang ◽  
Xiang‐Bin Meng ◽  
Jing‐Li Sheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Targeted Drug Delivery ◽  
Metal Organic Frameworks ◽  
Drug Carriers ◽  
Metal Organic ◽  
Targeted Drug

Drug-internalized bacterial swimmers for magnetically manipulable tumor-targeted drug delivery

Nanoscale ◽  
2020 ◽  
Vol 12 (25) ◽  
pp. 13513-13522
Author(s):  
Zhichu Xiang ◽  
Gexuan Jiang ◽  
Di Fan ◽  
Jiesheng Tian ◽  
Zhiyuan Hu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Tumor Therapy ◽  
Drug Carriers ◽  
Targeted Drug

Tumor-targeted drug carriers are becoming attractive for precise drug delivery in anti-tumor therapy.

scholarly journals Multifunctional NaLnF4@MOF-Ln Nanocomposites with Dual-Mode Luminescence for Drug Delivery and Cell Imaging

Nanomaterials ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 1274 ◽  
Author(s):  
Wang ◽  
Zhao ◽  
Gao ◽  
Xu ◽  
Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Imaging ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Water Soluble ◽  
Dual Mode ◽  
Metal Organic ◽  
Lanthanide Metal ◽  
Good Biocompatibility ◽  
Anti Stokes

Multifunctional nanomaterials for bioprobe and drug carrier have drawn great attention for their applications in the early monitoring the progression and treatment of cancers. In this work, we have developed new multifunctional water-soluble NaLnF4@MOF-Ln nanocomposites with dual-mode luminescence, which is based on stokes luminescent mesoporous lanthanide metal–organic frameworks (MOFs-Y:Eu3+) and anti-stokes luminescent NaYF4:Tm3+/Yb3+ nanoparticles. The fluorescence mechanism and dynamics are investigated and the applications of these nanocomposites as bioprobes and drug carriers in the cancer imaging and treatment are explored. Our results demonstrate that these nanocomposites with the excellent two-color emission show great potential in drug delivery, cancer cell imaging, and treatment, which are attributed to the unique spatial structure and good biocompatibility characteristics of NaLnF4@MOF-Ln nanocomposites.

scholarly journals Mini Review: Nano-Technology based Drug Deliveries

2018 ◽  
Vol 8 (6) ◽  
pp. 268-271
Author(s):  
Kuilong Wang
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Targeted Drug Delivery ◽  
Research Work ◽  
Drug Carriers ◽  
Nano Technology ◽  
Treatment Conditions ◽  
Nanoparticle Formulation ◽  
Targeted Drug

Targeted drug delivery with nano-technology has been researched and identified as being efficient across many treatment conditions. This review assesses some of the existing research work and evidence practice in using nano-technology based drug carriers. Keywords: Nano-technology, drug delivery, nanoparticle formulation, nano-technology carriers, drug resistance

scholarly journals The new frontiers of the targeted interventions in the pulmonary vasculature: precision and safety (2017 Grover Conference Series)

2017 ◽  
Vol 8 (1) ◽  
pp. 204589321775232 ◽  
Author(s):  
Jacob S. Brenner ◽  
Raisa Yu. Kiseleva ◽  
Patrick M. Glassman ◽  
Hamideh Parhiz ◽  
Colin F. Greineder ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Drug Carriers ◽  
Pulmonary Vasculature ◽  
Pulmonary Endothelium ◽  
Targeted Interventions ◽  
Safety Parameters ◽  
Specific Affinity ◽  
Targeted Drug ◽  
High Doses

The pulmonary vasculature plays an important role in many lung pathologies, such as pulmonary arterial hypertension, primary graft dysfunction of lung transplant, and acute respiratory distress syndrome. Therapy for these diseases is quite limited, largely due to dose-limiting side effects of numerous drugs that have been trialed or approved. High doses of drugs targeting the pulmonary vasculature are needed due to the lack of specific affinity of therapeutic compounds to the vasculature. To overcome this problem, the field of targeted drug delivery aims to target drugs to the pulmonary endothelial cells, especially those in pathological regions. The field uses a variety of drug delivery systems (DDSs), ranging from nano-scale drug carriers, such as liposomes, to methods of conjugating drugs to affinity moieites, such as antibodies. These DDSs can deliver small molecule drugs, protein therapeutics, and imaging agents. Here we review targeted drug delivery to the pulmonary endothelium for the treatment of pulmonary diseases. Cautionary notes are made of the risk–benefit ratio and safety—parameters one should keep in mind when developing a translational therapeutic.

Role of size of drug delivery carriers for pulmonary and intravenous administration with emphasis on cancer therapeutics and lung-targeted drug delivery

RSC Advances ◽  
2014 ◽  
Vol 4 (62) ◽  
pp. 32673-32689 ◽  
Author(s):  
Chetna Dhand ◽  
Molamma P. Prabhakaran ◽  
Roger W. Beuerman ◽  
R. Lakshminarayanan ◽  
Neeraj Dwivedi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Intravenous Administration ◽  
Targeted Drug Delivery ◽  
Cancer Therapeutics ◽  
Drug Carriers ◽  
Design Parameters ◽  
Targeted Drug

The design of a drug delivery system and the fabrication of efficient, successful, and targeted drug carriers are two separate issues that require slightly different design parameters.

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