scholarly journals Multifunctional NaLnF4@MOF-Ln Nanocomposites with Dual-Mode Luminescence for Drug Delivery and Cell Imaging

Nanomaterials ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 1274 ◽  
Author(s):  
Wang ◽  
Zhao ◽  
Gao ◽  
Xu ◽  
Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Imaging ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Water Soluble ◽  
Dual Mode ◽  
Metal Organic ◽  
Lanthanide Metal ◽  
Good Biocompatibility ◽  
Anti Stokes

Multifunctional nanomaterials for bioprobe and drug carrier have drawn great attention for their applications in the early monitoring the progression and treatment of cancers. In this work, we have developed new multifunctional water-soluble NaLnF4@MOF-Ln nanocomposites with dual-mode luminescence, which is based on stokes luminescent mesoporous lanthanide metal–organic frameworks (MOFs-Y:Eu3+) and anti-stokes luminescent NaYF4:Tm3+/Yb3+ nanoparticles. The fluorescence mechanism and dynamics are investigated and the applications of these nanocomposites as bioprobes and drug carriers in the cancer imaging and treatment are explored. Our results demonstrate that these nanocomposites with the excellent two-color emission show great potential in drug delivery, cancer cell imaging, and treatment, which are attributed to the unique spatial structure and good biocompatibility characteristics of NaLnF4@MOF-Ln nanocomposites.

Multifunctional drug carrier on the basis of 3d–4f Fe/La-MOFs for drug delivery and dual-mode imaging

2019 ◽  
Vol 7 (42) ◽  
pp. 6612-6622 ◽  
Author(s):  
Caixue Lin ◽  
Bin Chi ◽  
Chen Xu ◽  
Cheng Zhang ◽  
Feng Tian ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Dual Mode ◽  
Simultaneous Imaging

Multifunctional drug carriers for simultaneous imaging and drug delivery have emerged as an important new direction for the treatment of cancer.

scholarly journals Zinc-Based Metal-Organic Frameworks in Drug Delivery, Cell Imaging, and Sensing

Molecules ◽  
2021 ◽  
Vol 27 (1) ◽  
pp. 100
Author(s):  
Rashda Safdar Ali ◽  
Hongmin Meng ◽  
Zhaohui Li
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Cell Imaging ◽  
Metal Organic Frameworks ◽  
Drug Carriers ◽  
Metal Centers ◽  
Early Cancer Diagnosis ◽  
Efficient Detection ◽  
Metal Organic ◽  
Targeted Drug

The design and structural frameworks for targeted drug delivery of medicinal compounds and improved cell imaging have been developed with several advantages. However, metal-organic frameworks (MOFs) are supplemented tremendously for medical uses with efficient efficacy. These MOFs are considered as an absolutely new class of porous materials, extensively used in drug delivery systems, cell imaging, and detecting the analytes, especially for cancer biomarkers, due to their excellent biocompatibility, easy functionalization, high storage capacity, and excellent biodegradability. While Zn-metal centers in MOFs have been found by enhanced efficient detection and improved drug delivery, these Zn-based MOFs have appeared to be safe as elucidated by different cytotoxicity assays for targeted drug delivery. On the other hand, the MOF-based heterogeneous catalyst is durable and can regenerate multiple times without losing activity. Therefore, as functional carriers for drug delivery, cell imaging, and chemosensory, MOFs’ chemical composition and flexible porous structure allowed engineering to improve their medical formulation and functionality. This review summarizes the methodology for fabricating ultrasensitive and selective Zn-MOF-based sensors, as well as their application in early cancer diagnosis and therapy. This review also offers a systematic approach to understanding the development of MOFs as efficient drug carriers and provides new insights on their applications and limitations in utility with possible solutions.

scholarly journals Biomaterials for Drug Delivery: Sources, Classification, Synthesis, Processing, and Applications

2020 ◽  
Author(s):  
Samson O. Adeosun ◽  
Margaret O. Ilomuanya ◽  
Oluwashina P. Gbenebor ◽  
Modupeola O. Dada ◽  
Cletus C. Odili
Keyword(s):  
Drug Delivery ◽  
Target Cell ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Rehabilitation Process ◽  
Essential Components ◽  
Suitable Target ◽  
Health Related ◽  
Health Rehabilitation ◽  
And Performance

A way to avoid or minimize the side effect that could result in drug delivery to cells with increased efficiency and performance in the health rehabilitation process is to use biocompatible and biodegradable drug carriers. These are essentially biomaterials that are metallic, ceramic, or polymeric in nature. The sources of these materials must be biological in its entire ramification. The classification, synthesis, processing, and the applications to which these materials are put are the essential components of having suitable target cell drug carriers. This chapter will be devoted to discussing biomaterials suitable as drug carrier for use in the health-related matters of rehabilitation.

scholarly journals Functionalization of MOF-5 with mono-substituents: effects on drug delivery behavior

RSC Advances ◽  
2020 ◽  
Vol 10 (60) ◽  
pp. 36862-36872
Author(s):  
Mengru Cai ◽  
Liuying Qin ◽  
Longtai You ◽  
Yu Yao ◽  
Huimin Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Carrier ◽  
Metal Organic Frameworks ◽  
Metal Organic

Metal organic frameworks (MOFs) are widely used in drug carrier research due to their tunability.

scholarly journals Design, Synthesis and Characterization of a Novel Type of Thermo-Responsible Phospholipid Microcapsule–Alginate Composite Hydrogel for Drug Delivery

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 694 ◽  
Author(s):  
Liang Ding ◽  
Xinxia Cui ◽  
Rui Jiang ◽  
Keya Zhou ◽  
Yalei Wen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Laser Scanning ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Laser Scanning Confocal Microscopy ◽  
Composite Hydrogel ◽  
Design Synthesis ◽  
Liposome Membrane ◽  
Scanning Confocal Microscopy ◽  
Drug Carrier System

Liposomes are extensively used in drug delivery, while alginates are widely used in tissue engineering. However, liposomes are usually thermally unstable and drug-leaking when in liquids, while the drug carriers made of alginates show low loading capacities when used for drug delivery. Herein, we developed a type of thermo-responsible liposome–alginate composite hydrogel (TSPMAH) by grafting thermo-responsive liposomes onto alginates by using Ca2+ mediated bonding between the phosphatidic serine (PS) in the liposome membrane and the alginate. The temperature-sensitivity of the liposomes was actualized by using phospholipids comprising dipalmitoylphosphatidylcholine (DPPC) and PS and the liposomes were prepared by a thin-film dispersion method. The TSPMAH was then successfully prepared by bridge-linking the microcapsules onto the alginate hydrogel via PS-Ca2+-Carboxyl-alginate interaction. Characterizations of the TSPMAH were carried out using scanning electron microscopy, transform infrared spectroscopy, and laser scanning confocal microscopy, respectively. Their rheological property was also characterized by using a rheometer. Cytotoxicity evaluations of the TSPMAH showed that the composite hydrogel was biocompatible, safe, and non-toxic. Further, loading and thermos-inducible release of model drugs encapsulated by the TSPMAH as a drug carrier system was also studied by making protamine–siRNA complex-carrying TSPMAH drug carriers. Our results indicated that the TSPMAH described herein has great potentials to be further developed into an intelligent drug delivery system.

One-Step Synthesis of Small-Sized and Water-Soluble NaREF4Upconversion Nanoparticles for In Vitro Cell Imaging and Drug Delivery

2013 ◽  
Vol 19 (8) ◽  
pp. 2685-2694 ◽  
Author(s):  
Dongmei Yang ◽  
Yunlu Dai ◽  
Pingan Ma ◽  
Xiaojiao Kang ◽  
Ziyong Cheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Imaging ◽  
Water Soluble ◽  
One Step

Facile synthesis of water-soluble and biocompatible fluorescent nitrogen-doped carbon dots for cell imaging

The Analyst ◽  
2014 ◽  
Vol 139 (7) ◽  
pp. 1692-1696 ◽  
Author(s):  
Weiping Wang ◽  
Ya-Chun Lu ◽  
Hong Huang ◽  
Jiu-Ju Feng ◽  
Jian-Rong Chen ◽  
...  
Keyword(s):  
Carbon Dots ◽  
Cell Imaging ◽  
Water Soluble ◽  
Soluble Nitrogen ◽  
Facile Synthesis ◽  
Nitrogen Doped ◽  
Low Toxicity ◽  
Good Biocompatibility ◽  
Doped Carbon Dots ◽  
Nitrogen Doped Carbon

A simple and green hydrothermal method was developed for preparation of water-soluble nitrogen-doped carbon dots (N-CDs) from streptomycin. The prepared N-CDs reveal low toxicity, high stability and good biocompatibility, which can be used as fluorescent probes for cell imaging.

scholarly journals Resealed Erythrocytes as Drug Carriers and Its Therapeutic Applications

2017 ◽  
pp. 459-485
Author(s):  
Prabhakar Singh ◽  
Sudhakar Singh ◽  
Rajesh Kumar Kesharwani
Keyword(s):  
Drug Delivery ◽  
Blood Cells ◽  
Drug Delivery Systems ◽  
Release Kinetics ◽  
Drug Carrier ◽  
Drug Loading ◽  
Drug Carriers ◽  
Delivery Systems ◽  
The Body ◽  
Body Ideal

In this pharma innovative world, there are more than 30 drug delivery systems. Today's due to lacking the target specificity, the present scenario about drug delivery is emphasizing towards targeted drug delivery systems. Erythrocytes are the most common type of blood cells travel thousands of miles from wide to narrow pathways to deliver oxygen, drugs and nutrient during their lifetime. Red blood cells have strong and targeted potential carrier capabilities for varieties of drugs. Drug-loaded carrier erythrocytes or resealed erythrocytes are promising for various passive and active targeting. Resealed erythrocyte have advantage over several drug carrier models like biocompatibility, biodegradability without toxic products, inert intracellular environment, entrapping potential for a variety of chemicals, protection of the organism against toxic effects of the drug, able to circulate throughout the body, ideal zero-order drug-release kinetics, no undesired immune response against encapsulated drug etc. Resealed erythrocytes are rapidly taken up by macrophages of the Reticuloendothelial System (RES) of the liver, lung, and spleen of the body and hence drugs also. Resealed erythrocytes method of drugs delivery is secure and effective for drugs targeting specially for a longer period of time. This chapter will explain the different method of drug loading for resealed erythrocytes, their characterization, and applications in various therapies and associated health benefits.

scholarly journals Optical Detection of Charged Biomolecules: Towards Novel Drug Delivery Systems

10.14311/1450 ◽  
2011 ◽  
Vol 51 (5) ◽  
Author(s):  
V. Petráková
Keyword(s):  
Drug Delivery ◽  
Cell Imaging ◽  
Drug Carrier ◽  
Electrical Potential ◽  
Diamond Surface ◽  
Attractive Alternative ◽  
Covalent Bonds ◽  
Detection Tool ◽  
Novel Drug ◽  
Work Done

This paper presents work done on developing optically-traceable intracellular nanodiamond sensors, where the photoluminescence can be changed by a biomolecular attachment/delivery event. Their high biocompatibility, small size and stable luminescence from their color centers make nanodiamond (ND) particles an attractive alternative to molecular dyes for drug-delivery and cell-imaging applications. In our work, we study how surface modification of ND can change the color of ND luminescence (PL). This method can be used as a novel detection tool for remote monitoring of chemical processes in biological systems. Recently, we showed that PL can be driven by atomic functionalization, leading to a change in the color of ND luminescence from red (oxidized ND) to orange (hydrogenated ND). In this work, we show how PL of ND changes similarly when interacting with positively and negatively charged molecules. The effect is demonstrated on fluorinated ND, where the high dipole moment of the C-F bond is favorable for the formation of non-covalent bonds with charged molecules. We model this effect using electrical potential changes at the diamond surface. The final aim of the work is to develop a “smart” optically traceable drug carrier, where the delivery event is optically detectable.

scholarly journals Ratiometric Polymer Probe for Detection of Peroxynitrite and the Application for Live-Cell Imaging

Molecules ◽  
2019 ◽  
Vol 24 (19) ◽  
pp. 3465
Author(s):  
Hio Kuan Lao ◽  
Jingyun Tan ◽  
Chunfei Wang ◽  
Xuanjun Zhang
Keyword(s):  
Live Cell Imaging ◽  
Cell Imaging ◽  
In Vitro Study ◽  
Water Soluble ◽  
Fluorescence Intensity Ratio ◽  
Oxidation Stress ◽  
Promising Tool ◽  
Good Biocompatibility

Peroxynitrite (ONOO−) is one of the sources of oxidation stress involved in many biological signaling pathways. The role of ONOO− being a double-edged sword in biological systems drives the development of effective detection tools. In this work, a boronate-based polymeric fluorescent probe PB-PVA was synthesized and the probe performance was evaluated. The probe exhibits ratiometric sensing of ONOO− in a range of 0–6 µM. There is good linear relationship between the probe fluorescence intensity ratio and ONOO− concentration. The probe also displays moderate selectivity towards ONOO− over other ROS. Moreover, it is water-soluble and possesses good biocompatibility which aids the imaging of ONOO− in living cells. These properties could make the probe a promising tool in in vitro study related to ONOO−.

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