scholarly journals Scar-Free Healing: Current Concepts and Future Perspectives

Nanomaterials ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 2179
Author(s):  
Alexandra Elena Stoica ◽  
Alexandru Mihai Grumezescu ◽  
Anca Oana Hermenean ◽  
Ecaterina Andronescu ◽  
Bogdan Stefan Vasile
Keyword(s):  
Wound Healing ◽  
Trauma Surgery ◽  
Cell Types ◽  
Healing Time ◽  
Scar Formation ◽  
Skin Damage ◽  
Future Perspectives ◽  
Damage Cell ◽  
The Difference ◽  
Fetal Wound

Every year, millions of people develop scars due to skin injuries after trauma, surgery, or skin burns. From the beginning of wound healing development, scar hyperplasia, and prolonged healing time in wound healing have been severe problems. Based on the difference between adult and fetal wound healing processes, many promising therapies have been developed to decrease scar formation in skin wounds. Currently, there is no good or reliable therapy to cure or prevent scar formation. This work briefly reviews the engineering methods of scarless wound healing, focusing on regenerative biomaterials and different cytokines, growth factors, and extracellular components in regenerative wound healing to minimize skin damage cell types, and scar formation.

Rapid epithelialisation of fetal wounds is associated with the early deposition of tenascin

1991 ◽  
Vol 99 (3) ◽  
pp. 583-586 ◽  
Author(s):  
D.J. Whitby ◽  
M.T. Longaker ◽  
M.R. Harrison ◽  
N.S. Adzick ◽  
M.W. Ferguson
Keyword(s):  
Wound Healing ◽  
Cell Migration ◽  
Temporal Distribution ◽  
Cell Types ◽  
Skin Wound ◽  
Skin Wound Healing ◽  
Early Appearance ◽  
Complex Process ◽  
Healing Wounds ◽  
Fetal Wound

Wound healing is a complex process involving the interaction of many cell types with the extracellular matrix (ECM). Fetal skin wound healing differs from that in the adult in that it occurs rapidly and without scar formation. The mechanisms underlying these differing processes may be related to the fetal environment, the stage of differentiation of the fetal cells or the ECM deposited in the wound. The spatial and temporal distribution of two components of the ECM, fibronectin and tenascin, were studied by immunostaining of cryosections from trunk wounds of fetal and adult sheep. Epithelialisation was complete earlier in the fetal wound than in the adult. The distribution of fibronectin was similar in fetal and adult wounds but tenascin was present earlier in the fetal wound. Fibronectin has several roles in wound healing including acting as a substratum for cell migration and as a mediator of cell adhesion through cell surface integrins. The attachment of fibroblasts to fibronectin is inhibited by tenascin and during development the appearance of tenascin in the ECM of migratory pathways correlates with the initiation of cell migration. Similarly, the appearance of tenascin in healing wounds may initiate cell migration. Tenascin was present in these wounds prior to cell migration and the rapid epithelialisation of fetal wounds may be due to the early appearance of tenascin in the wound.

scholarly journals Resveratrol-loaded peptide-hydrogels inhibit scar formation in wound healing through suppressing inflammation

2019 ◽  
Author(s):  
Chen-Chen Zhao ◽  
Lian Zhu ◽  
Zheng Wu ◽  
Rui Yang ◽  
Na Xu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Damage Model ◽  
Skin Wound ◽  
Scar Formation ◽  
Wound Dressings ◽  
Skin Damage ◽  
Skin Wound Healing ◽  
Accelerate Wound Healing ◽  
Peptide Hydrogels

Abstract Scar formation seriously affects the repair of damaged skin especially in adults and the excessive inflammation has been considered as the reason. The self-assembled peptide-hydrogels are ideal biomaterials for skin wound healing due to their similar nanostructure to natural extracellular matrix, hydration environment and serving as drug delivery systems. In our study, resveratrol, a polyphenol compound with anti-inflammatory effect, is loaded into peptide-hydrogel (Fmoc-FFGGRGD) to form a wound dressing (Pep/RES). Resveratrol is slowly released from the hydrogel in situ, and the release amount is controlled by the loading amount. The in vitro cell experiments demonstrate that the Pep/RES has no cytotoxicity and can inhibit the production of pro-inflammatory cytokines of macrophages. The Pep/RES hydrogels are used as wound dressings in rat skin damage model. The results suggest that the Pep/RES dressing can accelerate wound healing rate, exhibit well-organized collagen deposition, reduce inflammation and eventually prevent scar formation. The Pep/RES hydrogels supply a potential product to develop new skin wound dressings for the therapy of skin damage.

scholarly journals Scar-Free Embryonic Wound Healing and the Prevention of Scarring Following Wound Healing in the Adult

1997 ◽  
Vol 1 (1) ◽  
pp. 1-11 ◽  
Author(s):  
R. L. McCallion ◽  
M. W. J. Ferguson
Keyword(s):  
Wound Healing ◽  
Clinical Problem ◽  
Scar Formation ◽  
Accidental Injury ◽  
Matrix Deposition ◽  
Disease States ◽  
Important Clinical Problem ◽  
Extracellular Matrix Deposition ◽  
And Function ◽  
Fetal Wound

The development of scarring following accidental injury or surgery is an important clinical problem, often resulting in adverse effects on frowth and function, as well as an undersirable cosmetic appearance. Adult wound healing and scar formation are characterised by acute inflammation, wound contraction and disordered collagen deposition. Similar processes may also be involved in the progression of fibrotic disease states such as pulmonary fibrosis and hepatic cirrhosis. A major clinical objective is therefore, the reduction, and ideally the prevention, of scarring. The embryo and early fetus respond to injury in a way that is fundamentally different from the adult. In general, the early fetus heals rapidly, without scar formation. Extracellular matrix deposition in the fetal wound is rapid and organised in its structure, much more similar in appearance to unwounded skin, whilst, in the adult, matrix deposition is disordered. The inflammatory response, charasterisitic of the early phase of adult wound healing, is absent, or highly limited, in the fetus and the levels of cytokines are generally greatly reduced. Research into fundamental cellular and molecular differences between adult and fetal wound healing have revealed a number o targets in the adult wound which can be manipulated to more closely resemble the fetal wound environment and hence result in the reduction of adult scarring.

Studies in fetal wound healing VI. Second and early third trimester fetal wounds demonstrate rapid collagen deposition without scar formation

1990 ◽  
Vol 25 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Michael T. Longaker ◽  
David J. Whitby ◽  
N. Scott Adzick ◽  
Timothy M. Crombleholme ◽  
Jacob C. Langer ◽  
...  
Keyword(s):  
Wound Healing ◽  
Scar Formation ◽  
Collagen Deposition ◽  
Third Trimester ◽  
Fetal Wound Healing ◽  
Fetal Wound

scholarly journals The application of moist dressing in treating burn wound

Open Medicine ◽  
2015 ◽  
Vol 10 (1) ◽  
Author(s):  
Liu Wei
Keyword(s):  
Wound Healing ◽  
Treatment Group ◽  
Healing Time ◽  
Control Group ◽  
Burn Wound ◽  
Burn Wounds ◽  
Wound Pain ◽  
The Difference ◽  
And Control ◽  
The Impact

AbstractBasic experiments have demonstrated that the effect of wound healing in moist environments is better than that in dry environments; therefore, research on moist dressing is the focus of wound healing research. 42 burn patients receiving treatment in Jiangsu Provincial People’s Hospital were selected as experimental cases. Wound surface is divided into treatment group and control group using a self-contrasted method. The treatment group received a moist dressing in the treatment of burn wounds and the control group adopted iodine gauze or Vaseline gauze coverage. Wound healing effect and the impact on the degree of pain of in the two different treatment methods were observed after treatment. The results of 42 patients were included in the analysis. The average healing time of patients’ burn wounds in treatment group is (10.9 3.3) d, and the average healing time in control group is (13.8 3.6) d, so, the difference is significant (P<0.01). Wound pain in the treatment group is significantly lower than that in the control group (P<0.01). Using moist dressing (Mepitel and Mepilex, etc.) in the treatment of burn wounds, woundhealing time can be shortened and wound pain can be reduced significantly.

scholarly journals Mast Cells Contribute to Scar Formation during Fetal Wound Healing

2012 ◽  
Vol 132 (2) ◽  
pp. 458-465 ◽  
Author(s):  
Brian C. Wulff ◽  
Allison E. Parent ◽  
Melissa A. Meleski ◽  
Luisa A. DiPietro ◽  
Megan E. Schrementi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Mast Cells ◽  
Scar Formation ◽  
Fetal Wound Healing ◽  
Fetal Wound

scholarly journals Fetal Wound Healing The Ontogeny of Scar Formation in the Non-Human Primate

1993 ◽  
Vol 217 (4) ◽  
pp. 391-396 ◽  
Author(s):  
H. Peter Lorenz ◽  
David J. Whitby ◽  
Michael T. Longaker ◽  
N. Scott Adzick
Keyword(s):  
Wound Healing ◽  
Scar Formation ◽  
Fetal Wound Healing ◽  
Fetal Wound ◽  
Human Primate

PENGGUNAAN SELAPUT AMNION SEGAR PADA INSISI LUKA OPERASI SEKSIO SESAREA

2019 ◽  
Vol 1 (2) ◽  
pp. 47-55
Author(s):  
Syahredi Syaiful Adnani ◽  
Hafni Bachtiar
Keyword(s):  
Wound Healing ◽  
Caesarean Section ◽  
Amniotic Membrane ◽  
Healing Time ◽  
Cost Of Care ◽  
Control Group ◽  
P Value ◽  
Control Groups ◽  
And Control ◽  
Wound Healing Time

In the last few decades, the incidence of caesarean section is increasing in the world, especially in Indonesia. One of the way to treat tissue scar is through biologic and synthetic dressing where nowadays, amnion has been used as biologic dressing frequently. This study was conducted to determine the effect of the use of fresh amniotic membrane on wound incision Caesarean section compared with Caesarean section incision wound covered using regular gauze bandages and fixated with plaster in RS. Dr. Reksodiwiryo Padang. The design of this study is an experimen-tal study with Post test design with control group design. Sampling was done using a formula consecutive sampling two different test samples obtained an average of 72 people for each group. The analysis used include univariate and bivariate analyzes. The average wound healing time the difference was statistically significant (p value <0.05) in the treatment and control groups. There was highly significant difference in the proportion of local infection on day 3 between the treatment and control groups (p value <0.05). There were very significant differences in the proportion of local allergic reactions at day 3, and 5 between the treatment and control group (p <0.05). There are significant differences in terms of the cost of care per day between treatment and control groups (p <0.05). From this study, the average wound healing time has a very significant difference.Keywords: Fresh Amniotic Membrane, Wound Cesarean Section, Wound Healing

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