scholarly journals Impact of Body Mass Index on the Age of Relapsing-Remitting Multiple Sclerosis Onset: A Retrospective Study

2021 ◽  
Vol 13 (4) ◽  
pp. 517-526
Author(s):  
Vasileios Siokas ◽  
Konstantinos Katsiardanis ◽  
Athina-Maria Aloizou ◽  
Christos Bakirtzis ◽  
Ioannis Liampas ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Body Mass Index ◽  
Linear Regression ◽  
Body Mass ◽  
Linear Regression Analysis ◽  
Disease Onset ◽  
Demographic Characteristics ◽  
Categorical Variables ◽  
Relapsing Remitting ◽  
The Impact

A BACKROUND: Multiple sclerosis (MS) is a complex chronic disease of the central nervous system (CNS). Body mass index (BMI), a component of metabolic syndrome (MetS), is considered among the risk factors for MS. However, its role in MS remains ambiguous. OBJECTIVE: To examine the impact of BMI on the age of onset in patients with relapsing-remitting MS (RRMS) in a Greek cohort. METHODS: Data from 821 Greek patients with RRMS were collected. The BMI values were considered as quartiles. Comparisons for the demographic characteristics between the quartiles were made by Pearson’s chi-square test for the categorical variables and by ANOVA for the continuous variables. An overall p-value was calculated corresponding to trend for association. In case of significant association, further post-hoc analysis was performed in order to identify differences in demographic characteristics between specific BMI quartiles groups. Linear regression analyses were used to assess the relationship between BMI and age at onset of MS. RESULTS: Comparisons of participant characteristics by quartiles of BMI revealed that participants with the highest BMI had an older age of disease onset. Results from linear regression analysis showed that with each increase of 1 BMI unit, the age of RRMS onset increases by 0.255 (95% CI 0.136 to 0.374) years, p < 0.001. CONCLUSIONS: Patients with higher BMI, as a parameter of MetS, exhibit increased age of RRMS onset. Our results may present an alternative personalized approach for diagnosis, prognosis, and/or prevention of RRMS.

scholarly journals The Effect of Body Mass Index on Brain Volume and Cognitive Function in Relapsing–Remitting Multiple sclerosis: A CombiRx Secondary Analysis

2021 ◽  
Vol 13 ◽  
pp. 117957352110421
Author(s):  
Aliza Bitton Ben-Zacharia ◽  
Malvin N. Janal ◽  
Abraham A. Brody ◽  
Jerry Wolinsky ◽  
Fred Lublin ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Body Mass Index ◽  
Cognitive Function ◽  
Body Mass ◽  
Multivariate Regression ◽  
Mixed Model ◽  
Brain Volume ◽  
Relapsing Remitting ◽  
The Mean ◽  
The Impact

Background Multiple sclerosis (MS) is an autoimmune disease leading to physical, emotional and cognitive disability. High body mass index (BMI) may impact cognitive function and brain volume in MS. Yet, there is paucity of evidence addressing the impact of BMI on cognitive function and brain volume in MS. Objectives The purpose of this study was to examine the effects of BMI on normal appearing brain volume and cognitive function in patients with relapsing–remitting MS. Methods A secondary data analysis of the NIH CombiRx study was conducted. Multivariate regression and mixed model analyses were executed to analyze the effect of BMI on brain volume and cognitive function. Results The mean baseline age of the 768 participants was 38.2(SD = 9.4) years. 73% were female and 88.8% were Caucasian. The mean BMI was 28.8 kg/m2(SD = 6.7). The multivariate regression and mixed model analyses failed to show a clinical effect of BMI on brain volume and cognitive function. Conclusion BMI did not show an effect on cognitive function and brain volume among MS patients. Although there is increased interest in the effects of modifiable factors on the course of MS, the effects of BMI on brain volume and cognitive function are debatable and warrant further research. ClinicalTrials.gov NCT00211887

scholarly journals Symptom Co-occurrences Associated with Smoking in Individuals with Relapsing-Remitting Multiple Sclerosis

2016 ◽  
Vol 18 (4) ◽  
pp. 163-168 ◽  
Author(s):  
Pamela Newland ◽  
Louise Flick ◽  
Hong Xian ◽  
Florian P. Thomas
Keyword(s):  
Multiple Sclerosis ◽  
Factor Analysis ◽  
Linear Regression ◽  
Tobacco Use ◽  
Linear Regression Analysis ◽  
Disease Process ◽  
Behavioral Risk ◽  
Cross Sectional ◽  
Relapsing Remitting ◽  
The Impact

Background: The impact of tobacco on the multiple sclerosis (MS) disease process and symptoms is complex and not clearly understood. Tobacco may be used to self-treat some symptoms but also seems to intensify others. Studies to date have not characterized co-occurring symptoms (symptom patterns) and their association with tobacco use. Methods: This study describes tobacco use in patients with relapsing-remitting MS and associated symptoms and symptom co-occurrences. In this cross-sectional study, 101 participants with an average age of 43 years completed a survey adapted from the Behavioral Risk Factor Surveillance System and the revised MS-Related Symptom Checklist. Data reduction was performed using factor analysis on the 43 items of the checklist, and linear regression was used to detect associations between symptom clusters (factors) and smoking. Results: Using the factor analysis result, the linear regression analysis found that tobacco use is positively associated with co-occurring symptoms and symptoms of factor 1: Mental/Emotional (anxiety, loneliness, depression, and difficulty sleeping) and factor 4: Neuro/Autonomic (urinary). Conclusions: Smoking is associated with patterns of symptoms. The study of MS and tobacco use over time will allow determination of the temporal pattern of tobacco use and MS symptoms.

scholarly journals Left Atrial Deformation And Risk of Transient Ischemic Attack And Stroke In Paroxysmal Atrial Fibrillation

2021 ◽  
Author(s):  
Jian Chen ◽  
Ying Zhao ◽  
Changsheng Ma ◽  
Xin Du ◽  
Yihua He
Keyword(s):  
Atrial Fibrillation ◽  
Body Mass Index ◽  
Regression Analysis ◽  
Linear Regression ◽  
Body Mass ◽  
Left Atrial ◽  
Speckle Tracking ◽  
Linear Regression Analysis ◽  
Volume Index ◽  
Chamber View

Abstract Left atrial (LA) remodeling is closely related to cerebral stroke, but the relationship between impaired deformability of LA in early stages and stroke/TIA is not clear. The aim of this study was to evaluate the changes of LA deformability and its relationship with stroke/TIA events by using Speckle Tracking echocardiography. In 365 patients with paroxysmal atrial fibrillation (AF) (318, Non stroke/TIA; 47, stroke/TIA), comprehensive echocardiography was performed by using speckle tracking imaging to calculate mean LA longitudinal strain and strain rate values from apical four chamber view, apical two chamber view and apical three cavity view. The patients in stroke/TIA group had greater ages, a greater proportion of men and lower LA strain rate during left ventricular (LV) early diastole (SRE), and the difference was statistically significant(p<0.05). In the univariate linear regression analysis, the following clinical and conventional echocardiographic parameters each had a significant linear correlation with SRE(p<0.001), they were E/A ratio, LA volume index, body mass index, mean E/e′, LV ejection fraction, age, proportion of hypertension. Through a multiple linear regression analysis, the results show that there is a linear dependence between SRE and E/A ratio, LA volume index and Body mass index. The regression equation is y=-1.430-0.394X1+0.012X2+0.019X3(p<0.001) (y,SRE; X1,E/A ratio; X2,LA volume index; X3,Body mass index).In the multivariate logistic regression analyses, SRE and Sex ratio were independently risk factors stroke/TIA. (SRE, OR 2.945, 95% CI 1.092-7.943, p= 0.033; Sex, OR 0.462, 95% CI 0.230-0.930, p = 0.031)In patients with paroxysmal AF, SRE could reflect the impaired deformability of LA in early stages, and it was associated with the risk of stroke/TIA.

Serum myonectin is increased after laparoscopic sleeve gastrectomy

2020 ◽  
Vol 57 (5) ◽  
pp. 360-364
Author(s):  
Lei Li ◽  
Qianqian Wang ◽  
Chengkun Qin
Keyword(s):  
Body Mass Index ◽  
Regression Analysis ◽  
Sleeve Gastrectomy ◽  
Linear Regression ◽  
Laparoscopic Sleeve Gastrectomy ◽  
Body Mass ◽  
Linear Regression Analysis ◽  
Acid Uptake ◽  
Model Assessment ◽  
Obese Patients

Objective Myonectin, a newly discovered myokine, enhances fatty acid uptake in cultured adipocytes and hepatocytes and suppresses circulating levels of free fatty acids in mice. Recent studies showed that serum myonectin concentration is negatively correlated with obesity. This study was undertaken to evaluate the change of serum myonectin in obese patients after laparoscopic sleeve gastrectomy. Methods This study was performed in a population of 42 obese and 58 control subjects from April of 2018 to December of 2019. All obese subjects underwent laparoscopic sleeve gastrectomy. Anthropometric measurements, lipid profiles, HbA1c and serum myonectin were assessed at baseline and six months after laparoscopic sleeve gastrectomy. Results Serum myonectin concentrations were significantly lower in the obese patients than in the controls. Serum myonectin concentrations were increased at six months after laparoscopic sleeve gastrectomy. Simple linear regression analysis indicated that serum myonectin was negatively correlated with weight, waist circumference, hip circumference, body mass index, fasting plasma glucose, homeostasis model assessment of insulin resistance and HbA1c. Only body mass index was still inversely correlated with serum myonectin after multiple linear regression analysis. Conclusion Serum myonectin is correlated with obesity and increased after laparoscopic sleeve gastrectomy.

scholarly journals Multiple Sclerosis Wellness Shared Medical Appointment Model: A Pilot Study

2021 ◽  
Author(s):  
Justin R. Abbatemarco ◽  
Jeffrey A. Cohen ◽  
Belinda L. Udeh ◽  
Sunakshi Bassi ◽  
Mary R. Rensel
Keyword(s):  
Multiple Sclerosis ◽  
Health Care ◽  
Body Mass Index ◽  
Health Care Utilization ◽  
Body Mass ◽  
Private Insurance ◽  
Emergency Department Visits ◽  
Care Utilization ◽  
Patient Reported ◽  
The Impact

Abstract Background: Shared medical appointments (SMAs) are group medical visits combining medical care and patient education. We examined the impact of a wellness-focused pilot SMA in a large multiple sclerosis (MS) clinic. Methods: We reviewed data on all patients who participated in the SMA from January 2016 through June 2019. Data were collected 12 months pre/post SMA; included demographics, body mass index, patient-reported outcomes, and health care utilization; and were compared using Wilcoxon rank sum test. Results: Fifty adult patients (mean ± SD age, 50.1 ± 12.3 years) attended at least one MS wellness SMA. Most patients had private insurance (50%), and 26% had Medicaid coverage. The most common comorbidity was depression/anxiety (44%). Pre/post SMA outcomes showed a small but significant reduction in body mass index (30.2 ± 7.3 vs 28.8 ± 7.1, P = .03), and Patient Health Questionnaire-9 scores decreased from 7.3 ± 5.5 to 5.1 ± 5.6 (P = .001). The number of emergency department visits decreased from 13 to two (P = .0005), whereas follow-up visits increased with an attendees’ primary care provider from 19 to 41 (P &lt; .001), physical therapist from 15 to 27 (P = .004), and psychologist from six to 19 (P = .003). Conclusions: This pilot MS wellness SMA was associated with improved physical and psychological outcomes. There was increased, lower-cost health care utilization with reduced acute, high-cost health care utilization, suggesting that SMAs may be a cost-effective and beneficial method in caring for patients with MS.

Risk factors for development of obesity in an ethnically diverse CHD population

2019 ◽  
Vol 29 (2) ◽  
pp. 123-127
Author(s):  
Scott J. Weinreb ◽  
Abigail J. Pianelli ◽  
Sreyans R. Tanga ◽  
Ira A. Parness ◽  
Rajesh U. Shenoy
Keyword(s):  
Body Mass Index ◽  
Regression Analysis ◽  
Linear Regression ◽  
Longitudinal Data ◽  
Body Mass ◽  
Linear Regression Analysis ◽  
Paediatric Population ◽  
Post Surgery ◽  
Significant Difference ◽  
Age Cohort

AbstractObjectivesPrevious cross-sectional studies have demonstrated obesity rates in children with CHD and the general paediatric population. We reviewed longitudinal data to identify factors predisposing to the development of obesity in children, hypothesising that age may be an important risk factor for body mass index growth.Study designRetrospective electronic health records were reviewed in all 5–20-year-old CHD patients seen between 2011 and 2015, and in age-, sex-, and race/ethnicity-matched controls. Subjects were stratified into aged cohorts of 5–10, 11–15, and 15–20. Annualised change in body mass index percentile (BMI%) over this period was compared using paired Student’s t-test. Linear regression analysis was performed with the CHD population.ResultsA total of 223 CHD and 223 matched controls met the inclusion criteria for analysis. Prevalence of combined overweight/obesity did not differ significantly between the CHD cohort (24.6–25.8%) and matched controls (23.3–29.1%). Univariate analysis demonstrated a significant difference of BMI% change in the age cohort of 5–10 (CHD +4.1%/year, control +1.7%/year, p=0.04), in male sex (CHD +1.8%/year, control −0.3%/year, p=0.01), and status-post surgery (CHD 2.03%/year versus control 0.37%, p=0.02). Linear regression analysis within the CHD subgroup demonstrated that age 5–10 years (+4.80%/year, p<0.001) and status-post surgery (+3.11%/year, p=0.013) were associated with increased BMI% growth.ConclusionsPrevalence rates of overweight/obesity did not differ between children with CHD and general paediatric population over a 5-year period. Longitudinal data suggest that CHD patients in the age cohort 5–10 and status-post surgery may be at increased risk of BMI% growth relative to peers with structurally normal hearts.

scholarly journals Body Mass Index in Multiple Sclerosis: Associations with CSF Neurotransmitter Metabolite Levels

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Manolis Markianos ◽  
Maria-Eleftheria Evangelopoulos ◽  
Georgios Koutsis ◽  
Panagiota Davaki ◽  
Constantinos Sfagos
Keyword(s):  
Multiple Sclerosis ◽  
Body Mass Index ◽  
Body Mass ◽  
Body Height ◽  
Disease Process ◽  
Disability Score ◽  
Duration Of Illness ◽  
Relapsing Remitting ◽  
Relapsing Remitting Multiple Sclerosis ◽  
Age Range

Body weight and height of patients with relapsing-remitting multiple sclerosis (RRMS) or clinically isolated syndrome suggesting MS (CIS) in the age range 18 to 60 years (154 males and 315 females) were compared with those of subjects (146 males and 212 females) free of any major neurological disease. In drug-free patients, CSF levels of the metabolites of noradrenaline (MHPG), serotonin (5-HIAA), and dopamine (HVA), neurotransmitters involved in eating behavior, were estimated in searching for associations with body mass index (BMI). Statistical evaluations were done separately for males and females. Lower BMI was found in female MS patients compared to female controls, more pronounced in RRMS. BMI was not associated with duration of illness, smoking, present or previous drug treatment, or disability score. Body height showed a shift towards greater values in MS patients compared to controls. Patients in the lower BMI quartile (limits defined from control subjects) had lower 5-HIAA and HVA compared to patients in the upper quartile. The results provide evidence for weight reduction during disease process in MS, possibly related to deficits in serotoninergic and dopaminergic activities that develop during disease course, resulting in impairments in food reward capacity and in motivation to eat.

scholarly journals Predictors of Hypertension among Nonpregnant Females Attending Health Promotion Clinic with Special Emphasis on Smokeless Tobacco: A Cross-Sectional Study

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Devika Bhatt ◽  
Shashi Sharma ◽  
Ruchika Gupta ◽  
Dhirendra N. Sinha ◽  
Ravi Mehrotra
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Health Promotion ◽  
Regression Analysis ◽  
Linear Regression ◽  
Body Mass ◽  
Smokeless Tobacco ◽  
Linear Regression Analysis ◽  
High Body Mass Index ◽  
Cross Sectional

Aim. To determine the predictors of hypertension among nonpregnant females attending a health promotion clinic. Design and Setting. A cross-sectional study was conducted during March to June 2016, at the National Institute of Cancer Prevention and Research, India. Methods. The study included 319 nonpregnant females of age 20–70 years. Demographics such as age, literacy, and income were noted. History regarding use, frequency, and quantity of smokeless tobacco was taken. Height, weight, and blood pressure were measured and body mass index was calculated. Statistical Analysis. Pearson’s product-moment correlation coefficient was calculated between each of the variables of age, smokeless tobacco consumption, and body mass index versus systolic and diastolic blood pressure, respectively. The linear as well as multiple linear regression analysis was employed to identify the risk factors for hypertension. Results. A univariate linear regression analysis showed that age, smokeless tobacco consumption, and body mass index were associated with systolic blood pressure (P value < 0.001 for each). For diastolic blood pressure, high body mass index was a predictor. Multiple linear regression analysis showed that both systolic and diastolic hypertension were associated with high body mass index and low level of education. Moreover, the systolic hypertension was associated with higher age and smokeless tobacco use. Conclusion. Health promotion requires control of body mass index and smokeless tobacco cessation for preventing hypertension and its complications.

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