scholarly journals Comprehensive Preterm Breast Milk Metabotype Associated with Optimal Infant Early Growth Pattern

Nutrients ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 528 ◽  
Author(s):  
Marie-Cécile Alexandre-Gouabau ◽  
Thomas Moyon ◽  
Agnès David-Sochard ◽  
François Fenaille ◽  
Sophie Cholet ◽  
...  
Keyword(s):  
Breast Milk ◽  
Preterm Infants ◽  
Growth Pattern ◽  
Critical Role ◽  
Holistic Approach ◽  
Early Growth ◽  
Energy Utilization ◽  
Study Population ◽  
Branched Chain

Early nutrition impacts preterm infant early growth rate and brain development but can have long lasting effects as well. Although human milk is the gold standard for feeding new born full-term and preterm infants, little is known about the effects of its bioactive compounds on breastfed preterm infants’ growth outcomes. This study aims to determine whether breast milk metabolome, glycome, lipidome, and free-amino acids profiles analyzed by liquid chromatography-mass spectrometry had any impact on the early growth pattern of preterm infants. The study population consisted of the top tercile-Z score change in their weight between birth and hospital discharge (“faster grow”, n = 11) and lowest tercile (“slower grow”, n = 15) from a cohort of 138 premature infants (27–34 weeks gestation). This holistic approach combined with stringent clustering or classification statistical methods aims to discriminate groups of milks phenotype and identify specific metabolites associated with early growth of preterm infants. Their predictive reliability as biomarkers of infant growth was assessed using multiple linear regression and taking into account confounding clinical factors. Breast-milk associated with fast growth contained more branched-chain and insulino-trophic amino acid, lacto-N-fucopentaose, choline, and hydroxybutyrate, pointing to the critical role of energy utilization, protein synthesis, oxidative status, and gut epithelial cell maturity in prematurity.

scholarly journals The Revolution of Breast Milk: The Multiple Role of Human Milk Banking between Evidence and Experience—A Narrative Review

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Pasqua Anna Quitadamo ◽  
Giuseppina Palumbo ◽  
Liliana Cianti ◽  
Paola Lurdo ◽  
Maria Assunta Gentile ◽  
...  
Keyword(s):  
Breast Milk ◽  
Human Milk ◽  
Preterm Infants ◽  
Multiple Role ◽  
Life Saving ◽  
The World ◽  
Human Milk Banking ◽  
Milk Banking ◽  
Main Component

The review recalls the importance of breast milk and deepens the theme of human milk banking, a virtuous reality that is expanding all over the world but is still little known. In the last 15 years, modern biological technologies have crystallized the concept of uniqueness and irreproducibility of human milk, by establishing three new principles: first: human milk: a “life-saving” drug; second: human milk: the best food for preterm infants; and third: human milk: the main component of premature infant care. Our experience teaches us that human milk banking plays many roles that need to be known and shared.

scholarly journals The role of breast milk fortifier in the post-discharge nutrition of preterm infants

2021 ◽  
pp. 42-48
Author(s):  
Kenny McCormick ◽  
Caroline King ◽  
Sara Clarke ◽  
Chris Jarvis ◽  
Mark Johnson ◽  
...  
Keyword(s):  
Breast Milk ◽  
Preterm Infants ◽  
Best Practice ◽  
Optimal Growth ◽  
Post Discharge ◽  
Term Infants ◽  
Community Healthcare ◽  
Fortified Milk ◽  
Bone Mineralisation

Infants born prematurely are often discharged from hospital before 37 weeks post-menstrual age. While breastfeeding will meet all the nutritional requirements of full-term infants, these preterm infants may need enhanced levels of protein, minerals and possibly energy to ensure optimum growth, bone mineralisation and neurological development. To meet these additional nutrient needs in the neonatal unit, it is currently recommended that multinutrient breast milk fortifier is added to maternal breast milk. There may also be benefits in continuing to provide fortified milk after discharge, potentially including improved growth and preserving breastfeeding, and this is increasingly becoming a recognised practice in some neonatal units. This article presents the discussion and consensus of a multidisciplinary panel of neonatologists, neonatal dietitians, a GP and a neonatal outreach sister. The aim is to develop guidance on providing safe and effective nutritional supplementation for preterm infants after discharge in order to maintain optimal growth. This guidance is aimed at community healthcare staff and is based on the limited evidence available, using shared best practice and expertise.

The role of metal oxide interactions: revisiting Pt growth on the TiO2 surface in the process of impregnation method

Nanoscale ◽  
2017 ◽  
Vol 9 (37) ◽  
pp. 14272-14279 ◽  
Author(s):  
Zhi Jiang ◽  
Zhongti Sun ◽  
Yuqi Yang ◽  
Siyu Chen ◽  
Wenfeng Shangguan ◽  
...  
Keyword(s):  
Metal Oxide ◽  
Growth Pattern ◽  
First Principles ◽  
Critical Role ◽  
Impregnation Method ◽  
Tio2 Surface ◽  
First Principles Calculations ◽  
Titania Surface

First-principles calculations and experiments illustrated that the metal oxide interaction introduced by calcinations process plays a critical role in controlling the PtOx dispersion over titania, which will further influence the growth pattern of Pt on the titania surface.

scholarly journals Dietary Energy Partition: The Central Role of Glucose

2020 ◽  
Vol 21 (20) ◽  
pp. 7729
Author(s):  
Xavier Remesar ◽  
Marià Alemany
Keyword(s):  
Nutrient Dynamics ◽  
Cell Metabolism ◽  
Critical Role ◽  
Amino Nitrogen ◽  
Energy Utilization ◽  
Basic Knowledge ◽  
Tissue Cell ◽  
Factors Affecting ◽  
The Metabolic Syndrome

Humans have developed effective survival mechanisms under conditions of nutrient (and energy) scarcity. Nevertheless, today, most humans face a quite different situation: excess of nutrients, especially those high in amino-nitrogen and energy (largely fat). The lack of mechanisms to prevent energy overload and the effective persistence of the mechanisms hoarding key nutrients such as amino acids has resulted in deep disorders of substrate handling. There is too often a massive untreatable accumulation of body fat in the presence of severe metabolic disorders of energy utilization and disposal, which become chronic and go much beyond the most obvious problems: diabetes, circulatory, renal and nervous disorders included loosely within the metabolic syndrome. We lack basic knowledge on diet nutrient dynamics at the tissue-cell metabolism level, and this adds to widely used medical procedures lacking sufficient scientific support, with limited or nil success. In the present longitudinal analysis of the fate of dietary nutrients, we have focused on glucose as an example of a largely unknown entity. Even most studies on hyper-energetic diets or their later consequences tend to ignore the critical role of carbohydrate (and nitrogen disposal) as (probably) the two main factors affecting the substrate partition and metabolism.

scholarly journals Breast Milk Lipidome Is Associated with Early Growth Trajectory in Preterm Infants

Nutrients ◽  
2018 ◽  
Vol 10 (2) ◽  
pp. 164 ◽  
Author(s):  
Marie-Cécile Alexandre-Gouabau ◽  
Thomas Moyon ◽  
Véronique Cariou ◽  
Jean-Philippe Antignac ◽  
El Qannari ◽  
...  
Keyword(s):  
Breast Milk ◽  
Preterm Infants ◽  
Early Growth ◽  
Growth Trajectory

scholarly journals Correction: Alexandre-Gouabau et al. “Comprehensive Preterm Breast Milk Metabotype Associated with Optimal Infant Early Growth Pattern”, Nutrients, 2019, 11, 528

Nutrients ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 162
Author(s):  
Marie-Cécile Alexandre-Gouabau ◽  
Thomas Moyon ◽  
Agnès David-Sochard ◽  
François Fenaille ◽  
Sophie Cholet ◽  
...  
Keyword(s):  
Breast Milk ◽  
Growth Pattern ◽  
Early Growth

The authors wish to make a correction to Section 2 [...]

scholarly journals Bioactive Factors in Human Breast Milk Attenuate Intestinal Inflammation during Early Life

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 581 ◽  
Author(s):  
Julie D. Thai ◽  
Katherine E. Gregory
Keyword(s):  
Breast Milk ◽  
Preterm Infants ◽  
Early Life ◽  
Protective Factor ◽  
Intestinal Inflammation ◽  
Critical Role ◽  
High Morbidity ◽  
Human Breast Milk ◽  
Bioactive Components ◽  
Human Breast

Human breast milk is well known as the ideal source of nutrition during early life, ensuring optimal growth during infancy and early childhood. Breast milk is also the source of many unique and dynamic bioactive components that play a key role in the development of the immune system. These bioactive components include essential microbes, human milk oligosaccharides (HMOs), immunoglobulins, lactoferrin and dietary polyunsaturated fatty acids. These factors all interact with intestinal commensal bacteria and/or immune cells, playing a critical role in establishment of the intestinal microbiome and ultimately influencing intestinal inflammation and gut health during early life. Exposure to breast milk has been associated with a decreased incidence and severity of necrotizing enterocolitis (NEC), a devastating disease characterized by overwhelming intestinal inflammation and high morbidity among preterm infants. For this reason, breast milk is considered a protective factor against NEC and aberrant intestinal inflammation common in preterm infants. In this review, we will describe the key microbial, immunological, and metabolic components of breast milk that have been shown to play a role in the mechanisms of intestinal inflammation and/or NEC prevention.

scholarly journals Breast Milk Lipidome Is Associated with Early Growth Trajectory in Preterm Infants

2017 ◽  
Author(s):  
Marie-Cécile Alexandre-Gouabau ◽  
Thomas Moyon ◽  
Véronique Cariou ◽  
Jean-Philippe Antignac ◽  
El Mostafa Qannari ◽  
...  
Keyword(s):  
Growth Rate ◽  
Breast Milk ◽  
Preterm Infants ◽  
High Resolution Mass Spectrometry ◽  
Early Growth ◽  
Milk Lipid ◽  
Initial Growth ◽  
Z Score ◽  
Very Preterm Infants ◽  
Lipid Species

Human milk is recommended for feeding preterm infant. Yet the potential impact of specific breast-milk lipid components on the initial growth rate of very-preterm infants has received scant attention. The current pilot study aims to determine whether breast-milk lipidome had any impact on the early growth pattern of preterm infants fed their own mother’s milk. A prospective monocentric observational birth cohort was established, enrolling 147 preterm infants, who received their own mother’s breast-milk throughout hospital stay. Among that cohort, infants who experienced slow (n=15) or fast (n=11) growth were selected, based on the change in their weight Z-score between birth and hospital discharge (-1.54± 0.42 and -0.48± 0.19 Z-score, respectively). Liquid chromatography-high resolution-mass spectrometry was used to obtain lipidomic signatures in breast-milk. Multivariate analyses made it possible to identify breast-milk lipid species that allowed clear-cut discrimination between the 2 infants’ groups. Validation of the selected biomarkers was performed by means of various multidimensional statistical techniques, false-discovery rate and ROC curve computation. Breast-milk associated with fast growth contained more medium chain-saturated fatty acid and -sphingomyelin, dihomo-γ-linolenic acid (DGLA)-containing phosphethanolamine, and less oleic acid-containing triglyceride and DGLA-oxylipin. Their predictive ability of preterm early-growth rate was validated in presence of confounding clinical factors. 

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