scholarly journals Effects of Drugs and Excipients on Hydration Status

Nutrients ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 669 ◽  
Author(s):  
Ana Puga ◽  
Sara Lopez-Oliva ◽  
Carmen Trives ◽  
Teresa Partearroyo ◽  
Gregorio Varela-Moreiras

Despite being the most essential nutrient, water is commonly forgotten in the fields of pharmacy and nutrition. Hydration status is determined by water balance (the difference between water input and output). Hypohydration or negative water balance is affected by numerous factors, either internal (i.e., a lack of thirst sensation) or external (e.g., polypharmacy or chronic consumption of certain drugs). However, to date, research on the interaction between hydration status and drugs/excipients has been scarce. Drugs may trigger the appearance of hypohydration by means of the increase of water elimination through either diarrhea, urine or sweat; a decrease in thirst sensation or appetite; or the alteration of central thermoregulation. On the other hand, pharmaceutical excipients induce alterations in hydration status by decreasing the gastrointestinal transit time or increasing the gastrointestinal tract rate or intestinal permeability. In the present review, we evaluate studies that focus on the effects of drugs/excipients on hydration status. These studies support the aim of monitoring the hydration status in patients, mainly in those population segments with a higher risk, to avoid complications and associated pathologies, which are key axes in both pharmaceutical care and the field of nutrition.

2019 ◽  
Vol 23 (5) ◽  
pp. 2339-2350 ◽  
Author(s):  
Vazken Andréassian ◽  
Tewfik Sari

Abstract. This Technical Note documents and analyzes the puzzling similarity of two widely used water balance formulas: Turc–Mezentsev and Tixeront–Fu. It details their history and their hydrological and mathematical properties, and discusses the mathematical reasoning behind their slight differences. Apart from the difference in their partial differential expressions, both formulas share the same hydrological properties, and it seems impossible to recommend one over the other as more “hydrologically founded”: hydrologists should feel free to choose the one they feel more comfortable with.


1980 ◽  
Vol 94 (3) ◽  
pp. 735-737 ◽  
Author(s):  
E. T. Clemens ◽  
C. E. Stevens

The efficiency of digestion and absorption is dependent upon the rate at which digesta moves through the gastrointestinal tract. The following report describes the gastrointestinal transit for digesta markers given to ten species of mammals fed the same diet.


2019 ◽  
Vol 20 (3) ◽  
pp. 65-70
Author(s):  
Dong-Hwan Lee ◽  
Joong-Hyun Song ◽  
DoHyeon Yu ◽  
Su-Jin An ◽  
Hee-Chun Lee ◽  
...  

2019 ◽  
Author(s):  
Vazken Andréassian ◽  
Tewfik Sari

Abstract. This Technical Note documents and analyzes the confounding similarity of two widely used water balance formulas: Turc-Mezentsev and Tixeront-Fu. It details their history, their hydrological and mathematical properties, and discusses the mathematical reasoning behind their slight differences. Apart from the difference identified in their partial differential expressions, both formulas share the same hydrological properties and it seems impossible to recommend one over the other as more hydrologically founded: hydrologists should feel free to choose the one they feel more comfortable with.


1973 ◽  
Vol 29 (02) ◽  
pp. 490-498 ◽  
Author(s):  
Hiroh Yamazaki ◽  
Itsuro Kobayashi ◽  
Tadahiro Sano ◽  
Takio Shimamoto

SummaryThe authors previously reported a transient decrease in adhesive platelet count and an enhancement of blood coagulability after administration of a small amount of adrenaline (0.1-1 µg per Kg, i. v.) in man and rabbit. In such circumstances, the sensitivity of platelets to aggregation induced by ADP was studied by an optical density method. Five minutes after i. v. injection of 1 µg per Kg of adrenaline in 10 rabbits, intensity of platelet aggregation increased to 115.1 ± 4.9% (mean ± S. E.) by 10∼5 molar, 121.8 ± 7.8% by 3 × 10-6 molar and 129.4 ± 12.8% of the value before the injection by 10”6 molar ADP. The difference was statistically significant (P<0.01-0.05). The above change was not observed in each group of rabbits injected with saline, 1 µg per Kg of 1-noradrenaline or 0.1 and 10 µg per Kg of adrenaline. Also, it was prevented by oral administration of 10 mg per Kg of phenoxybenzamine or propranolol or aspirin or pyridinolcarbamate 3 hours before the challenge. On the other hand, the enhancement of ADP-induced platelet aggregation was not observed in vitro, when 10-5 or 3 × 10-6 molar and 129.4 ± 12.8% of the value before 10∼6 molar ADP was added to citrated platelet rich plasma (CPRP) of rabbit after incubation at 37°C for 30 second with 0.01, 0.1, 1, 10 or 100 µg per ml of adrenaline or noradrenaline. These results suggest an important interaction between endothelial surface and platelets in connection with the enhancement of ADP-induced platelet aggregation by adrenaline in vivo.


Author(s):  
Philip Isett

This chapter presents the equations and calculations for energy approximation. It establishes the estimates (261) and (262) of the Main Lemma (10.1) for continuous solutions; these estimates state that we are able to accurately prescribe the energy that the correction adds to the solution, as well as bound the difference between the time derivatives of these two quantities. The chapter also introduces the proposition for prescribing energy, followed by the relevant computations. Each integral contributing to the other term can be estimated. Another proposition for estimating control over the rate of energy variation is given. Finally, the coarse scale material derivative is considered.


Metahumaniora ◽  
2017 ◽  
Vol 7 (3) ◽  
pp. 378
Author(s):  
Vincentia Tri Handayani

AbstrakFolklor yang menghasilkan tradisi lisan merupakan perwujudan budaya yang lahirdari pengalaman kelompok masyarakat. Salah satu bentuk tradisi lisan adalah ungkapan yangmengandung unsur budaya lokal dalam konstruksinya yang tidak dimiliki budaya lainnya.Ungkapan idiomatis memberikan warna pada bahasa melalui penggambaran mental. Dalambahasa Perancis, ungkapan dapat berupa locution dan expression. Perbedaan motif acuansuatu ungkapan dapat terlihat dari pengaruh budaya masyarakat pengguna bahasa. Sebuahleksem tidak selalu didefinisikan melalui unsur minimal, tidak juga melalui kata-kata,baik kata dasar atau kata kompleks, namun dapat melalui kata-kata beku yang maknanyatetap. Hubungan analogis dari makna tambahan yang ada pada suatu leksem muncul dariidentifikasi semem yang sama. Semem tersebut mengarah pada term yang diasosiasikan danyang diperkaya melalui konteks (dalam ungkapan berhubungan dengan konteks budaya).Kata kunci: folklor, ungkapan, struktur, makna idiomatis, kebudayaanAbstractFolklore which produces the oral tradition is a cultural manifestation born out theexperience of community groups. One form of the oral tradition is a phrase that containsthe elements of local culture in its construction that is not owned the other culture. Theidiomatic phrase gives the color to the language through the mental representation. InFrench, the expression can consist of locution and expression. The difference motivesreference of an expression can be seen from the influence of the cultural community thelanguage users. A lexeme is not always defined through a minimal element, nor throughwords, either basic or complex words, but can be through the frost words whose meaningsare fixed. The analogical connection of the additional meanings is on a lexeme arises fromthe identification of the same meaning. The meaning ‘semem’ leads to the associated termsand which are enriched through the context (in idiom related to the cultural context).Keywords : folklore, idioms, structure, idiom meaning, cultureI PENDAHULUAN


1994 ◽  
Vol 25 (5) ◽  
pp. 331-344 ◽  
Author(s):  
Peter M. Lafleur

Evapotranspiration (ET) and precipitation were measured during five summers (1989-1993 inclusive) at a subarctic forest site near Churchill, Manitoba, Canada. Mean daily ET varied from 2.14-3.18 mm d−1 during the five summers, while mean daily precipitation (P) ranged from 1.46-3.15 mm d−1. Yearly variability in summer ET was most influenced by availability of surface moisture, then by atmospheric conditions (i.e. temperature), and least of all by net radiation. In four of the five years total summer ET exceeded P resulting in significant soil water deficits and in the other year summer ET and P were similar in magnitude. The use of equilibrium evaporation (EE) as a predictor of ET was explored. Separate relationships between ET and EE were computed for all five years. Three statistically dissimilar groups of equations were found: 1989/1990, 1991/ 1992, and 1993. A single regression equation describing all years is presented.


Author(s):  
Michel Meyer

Rhetoric has always been torn between the rhetoric of figures and the rhetoric of conflicts or arguments, as if rhetoric were exclusively one or the other. This is a false dilemma. Both types of rhetoric hinge on the same structure. A common formula is provided in Chapter 3 which unifies rhetoric stricto sensu and rhetoric as argumentation as two distinct but related strategies adopted according to the level of problematicity of the questions at stake, thereby giving unity to the field called “Rhetoric.” Highly problematic questions require arguments to justify their answers; non-divisive ones can be treated rhetorically through their answers as if they were self-evident. Another classic problem is how to understand the difference between logic and rhetoric. The difference between the two is due to the presence of questions explicitly answered in the premises in logic and only suggested (or remaining indeterminate) in rhetoric.


Author(s):  
D. T. Gauld ◽  
J. E. G. Raymont

The respiratory rates of three species of planktonic copepods, Acartia clausi, Centropages hamatus and Temora longicornis, were measured at four different temperatures.The relationship between respiratory rate and temperature was found to be similar to that previously found for Calanus, although the slope of the curves differed in the different species.The observations on Centropages at 13 and 170 C. can be divided into two groups and it is suggested that the differences are due to the use of copepods from two different generations.The relationship between the respiratory rates and lengths of Acartia and Centropages agreed very well with that previously found for other species. That for Temora was rather different: the difference is probably due to the distinct difference in the shape of the body of Temora from those of the other species.The application of these measurements to estimates of the food requirements of the copepods is discussed.


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