scholarly journals A Nutraceutical Rich in Docosahexaenoic Acid Improves Portal Hypertension in a Preclinical Model of Advanced Chronic Liver Disease

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2358 ◽  
Author(s):  
Boyer-Diaz ◽  
Domingo ◽  
de Gregorio ◽  
Manicardi ◽  
Aristu-Zabalza ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Portal Hypertension ◽  
Liver Disease ◽  
Docosahexaenoic Acid ◽  
Chronic Liver Disease ◽  
Stellate Cell ◽  
Preclinical Study ◽  
Chronic Liver ◽  
Preclinical Model ◽  
And Oxidative Stress

Inflammation and oxidative stress play a key role in the pathophysiology of advanced chronic liver disease (ACLD) and portal hypertension (PH). Considering the current lack of effective treatments, we evaluated an anti-inflammatory and antioxidant nutraceutical rich in docosahexaenoic acid (DHA) as a possible therapy for ACLD. We investigated the effects of two-week DHA supplementation (500 mg/kg) on hepatic fatty acids, PH, oxidative stress, inflammation, and hepatic stellate cell (HSC) phenotype in rats with ACLD. Additionally, the effects of DHA were evaluated in murine macrophages and human HSC. In contrast to vehicle-treated animals, cirrhotic rats receiving DHA reestablished a healthy hepatic fatty acid profile, which was associated with an improvement in PH. The mechanisms underlying this hemodynamic improvement included a reduction in oxidative stress and inflammation, as well as a marked HSC deactivation, confirmed in human HSC. Experiments with cultured macrophages showed that treatment with DHA protects against pro-inflammatory insults. The present preclinical study demonstrates that a nutraceutical rich in DHA significantly improves PH in chronic liver disease mainly by suppressing inflammation and oxidative stress-driven HSC activation, encouraging its evaluation as a new treatment for PH and cirrhosis.

scholarly journals Oxidative Stress in Chronic Liver Disease and Portal Hypertension: Potential of DHA as Nutraceutical

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2627 ◽  
Author(s):  
Zoe Boyer-Diaz ◽  
Paloma Morata ◽  
Peio Aristu-Zabalza ◽  
Albert Gibert-Ramos ◽  
Jaime Bosch ◽  
...  
Keyword(s):  
Public Health ◽  
Oxidative Stress ◽  
Portal Hypertension ◽  
Liver Disease ◽  
Docosahexaenoic Acid ◽  
Chronic Liver Disease ◽  
Current Knowledge ◽  
Chronic Liver ◽  
Public Health Issue ◽  
Clinical Scenarios

Chronic liver disease constitutes a growing public health issue worldwide, with no safe and effective enough treatment clinical scenarios. The present review provides an overview of the current knowledge regarding advanced chronic liver disease (ACLD), focusing on the major contributors of its pathophysiology: inflammation, oxidative stress, fibrosis and portal hypertension. We present the benefits of supplementation with docosahexaenoic acid triglycerides (TG-DHA) in other health areas as demonstrated experimentally, and explore its potential as a novel nutraceutical approach for the treatment of ACLD and portal hypertension based on published pre-clinical data.

FRI-110-A nutraceutical supplement rich in docosahexaenoic acid improves portal hypertension in a pre-clinical model of chronic liver disease

2019 ◽  
Vol 70 (1) ◽  
pp. e435-e436
Author(s):  
Zoe Boyer-Diaz ◽  
Nicolo Manicardi ◽  
Peio Aristu ◽  
Laia Abad ◽  
Begoña Cordobilla ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Liver Disease ◽  
Docosahexaenoic Acid ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Clinical Model

scholarly journals Sarcopenia Induced by Chronic Liver Disease in Mice Requires the Expression of the Bile Acids Membrane Receptor TGR5

2020 ◽  
Vol 21 (21) ◽  
pp. 7922
Author(s):  
Johanna Abrigo ◽  
Fabián Campos ◽  
Francisco Gonzalez ◽  
Francisco Aguirre ◽  
Andrea Gonzalez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Bile Acids ◽  
Fiber Type ◽  
Ring Finger ◽  
Chronic Liver ◽  
Receptor Expression ◽  
Skeletal Muscle Atrophy ◽  
And Oxidative Stress

Sarcopenia is a condition of muscle dysfunction, commonly associated with chronic liver disease (CLD), characterized by a decline in muscle strength, the activation of the ubiquitin-proteasome system (UPS), and oxidative stress. We recently described a murine model of CLD-induced sarcopenia by intake of hepatotoxin 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC), which presents an increase in plasma bile acids (BA). BA induced skeletal muscle atrophy through a mechanism dependent on the Takeda G protein-coupled receptor 5 (TGR5) receptor. In the present study, we evaluated the role of TGR5 signaling in the development of sarcopenia using a model of DDC-induced CLD in C57BL6 wild-type (WT) mice and mice deficient in TGR5 expression (TGR5−/− mice). The results indicate that the decline in muscle function and contractibility induced by the DDC diet is dependent on TGR5 expression. TGR5 dependence was also observed for the decrease in fiber diameter and sarcomeric proteins, as well as for the fast-to-slow shift in muscle fiber type. UPS overactivation, indicated by increased atrogin-1/MAFbx (atrogin-1) and muscle RING-finger protein-1 (MuRF-1) protein levels and oxidative stress, was abolished in tibialis anterior muscles from TGR5−/− mice. Our results collectively suggest that all sarcopenia features induced by the DDC-supplemented diet in mice are dependent on TGR5 receptor expression.

Elemental Zinc Is Inversely Associated with C-Reactive Protein and Oxidative Stress in Chronic Liver Disease

2017 ◽  
Vol 178 (2) ◽  
pp. 189-193 ◽  
Author(s):  
Md. Giash Uddin ◽  
Mohammad Salim Hossain ◽  
Md. Atiqur Rahman ◽  
A. H. M. Mazbah Uddin ◽  
Md. Shafiullah Bhuiyan
Keyword(s):  
Oxidative Stress ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
And Oxidative Stress

scholarly journals Results of liver and spleen endoscopic ultrasonographic elastography predict portal hypertension secondary to chronic liver disease

2020 ◽  
Vol 08 (11) ◽  
pp. E1623-E1632
Author(s):  
Carlos Robles-Medranda ◽  
Roberto Oleas ◽  
Miguel Puga-Tejada ◽  
Manuel Valero ◽  
Raquel Del Valle ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Portal Hypertension ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Predictive Value ◽  
Strain Ratio ◽  
Chronic Liver ◽  
Spleen Stiffness ◽  
Eus Elastography ◽  
Sensitivity Specificity

Abstract Background and study aims Assessment of endoscopic ultrasonography (EUS)-elastography of the liver and spleen may identify patients with portal hypertension secondary to chronic liver disease. We aimed to evaluate use of EUS-elastography of the liver and spleen in identification of portal hypertension in patients with chronic liver disease. Patients and methods This was a single-center, diagnostic cohort study. Consecutive patients with liver cirrhosis and portal hypertension underwent EUS-elastography of the liver and spleen. Patients without a history of liver disease were enrolled as controls. The primary outcome was diagnostic yield of liver and spleen stiffness measurement via EUS-elastography in prediction of portal hypertension secondary to chronic liver cirrhosis. Cutoff values were defined through Youden’s index. Overall accuracy was calculated for parameters with an area under the receiver operating characteristic (AUROC) curve ≥ 80 %. Results Among the 61 patients included, 32 had cirrhosis of the liver. Liver and spleen stiffness was measured by the strain ratio and strain histogram, with sensitivity/(1 − specificity) AUROC values ≥ 80 %. For identification of patients with cirrhosis and portal hypertension, the liver strain ratio (SR) had a sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of 84.3 %, 82.8 %, 84.4 %, and 82.8 %, respectively; the liver strain histogram (SH) had values of 87.5 %, 69.0 %, 75.7 %, and 83.3 %, respectively. EUS elastography of the spleen via the SR reached a sensitivity, specificity, PPV, and NPV of 87.5 %, 69.0 %, 75.7 %, and 83.3 %, respectively, whereas the values of SH were 56.3 %, 89.7 %, 85.7 %, and 65.0 %, respectively. Conclusion Endoscopic ultrasonographic elastography of the liver and spleen is useful for diagnosis of portal hypertension in patients with cirrhosis.

scholarly journals Relationship between Tetrahydrobiopterin and Portal Hypertension in Patients with Chronic Liver Disease

2014 ◽  
Vol 29 (3) ◽  
pp. 392 ◽  
Author(s):  
Won Ki Hong ◽  
Kwang Yong Shim ◽  
Soon Koo Baik ◽  
Moon Young Kim ◽  
Mee Yon Cho ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Chronic Liver
Sign in / Sign up

Export Citation Format

Share Document