scholarly journals Habitual Dietary Intake Affects the Altered Pattern of Gut Microbiome by Acarbose in Patients with Type 2 Diabetes

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2107
Author(s):  
Fumie Takewaki ◽  
Hanako Nakajima ◽  
Daiki Takewaki ◽  
Yoshitaka Hashimoto ◽  
Saori Majima ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gut Microbiota ◽  
Dietary Intake ◽  
Hierarchical Clustering ◽  
Gut Microbiome ◽  
Japanese Patients ◽  
Carbohydrate Intake ◽  
Fat Intake ◽  
Lower Abundance

The aim of this research was to reveal the characteristics of gut microbiome altered by acarbose intervention in Japanese patients with type 2 diabetes (T2D) and its possible association with habitual dietary intake. Eighteen patients with T2D were administered acarbose for four weeks. The abundances of two major phyla, namely Actinobacteria and Bacteroidetes, were reciprocally changed accompanied by the acarbose intervention. There were also significant changes in the abundances of ten genera, including the greater abundance of Bifidobacterium, Eubacterium, and Lactobacillus and the lower abundance of Bacteroides in the group after the intervention than that before the intervention. Hierarchical clustering of habitual dietary intake was performed based on the pattern of changes in the gut microbiota and were classified into distinct three clusters. Cluster I consisted of sucrose, cluster II mainly included fat intake, and cluster III mainly included carbohydrate intake. Moreover, the amount of change in Faecalibacterium was positively correlated with the intake of rice, but negatively correlated with the intake of bread. The intake of potato was negatively correlated with the amount of change in Akkermansia and Subdoligranulum. Acarbose altered the composition of gut microbiome in Japanese patients with T2D, which might be linked to the habitual dietary intake.

An alcohol-free beer enriched with isomaltulose and a resistant dextrin modulates gut microbiome in subjects with type 2 diabetes mellitus and overweight or obesity: a pilot study

2021 ◽  
Author(s):  
Rocío Mateo-Gallego ◽  
Isabel Moreno-Indias ◽  
Ana M. Bea ◽  
Lidia Sánchez-Alcoholado ◽  
Antonio J. Fumanal ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Pilot Study ◽  
Gut Microbiota ◽  
Gut Microbiome ◽  
Low Doses ◽  
Resistant Dextrin ◽  
Overweight Or Obesity

An alcohol-free beer including the substitution of regular carbohydrates for low doses of isomaltulose and maltodextrin within meals significantly impacts gut microbiota in diabetic subjects with overweight or obesity.

scholarly journals Dietary Macronutrient Intakes and Mortality among Patients with Type 2 Diabetes

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1665 ◽  
Author(s):  
Cheng-Chieh Lin ◽  
Chiu-Shong Liu ◽  
Chia-Ing Li ◽  
Chih-Hsueh Lin ◽  
Wen-Yuan Lin ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dietary Intake ◽  
Total Energy ◽  
Energy Intake ◽  
Total Energy Intake ◽  
Diabetic Patients ◽  
Fat Intake ◽  
Food Diary ◽  
Cvd Mortality

The best macronutrient percentages of dietary intake supporting longevity remains unclear. The strength of association between dietary intake and mortality in patients with type 2 diabetes (T2DM) should be quantified as a basis for dietary recommendations. Our study cohort consisted of 15,289 type 2 diabetic patients aged 30 years and older in Taiwan during 2001–2014 and was followed up through 2016. Percentages of macronutrient intakes were calculated as dietary energy intake contributed by carbohydrate, protein, and fat, divided by the total energy intake using a 24 h food diary recall approach. Cox proportional hazard models were applied to examine the temporal relation of macronutrient intakes with all-cause and cause-specific mortality. The average follow-up time was 7.4 years, during which 2784 adults with T2DM died. After multivariable adjustment, people with fourth and fifth quintiles of total energy, second and third quintiles of carbohydrate, and fourth quintiles of protein intakes were likely to have lower risks of all-cause and expanded cardiovascular disease (CVD) mortality. People with fifth quintiles of total energy intake were likely to have decreased non-expanded CVD mortality. We found a significant interaction between gender and fat intake on all-cause and expanded CVD mortality. Fat intake was associated with all-cause, expanded and non-expanded CVD mortality among males with T2DM. Total energy, carbohydrate, and protein intakes were associated with lower risks of all-cause and expanded CVD mortality, with minimal risks observed at ≥1673 Kcal total energy, 43–52% carbohydrate intake, and 15–16% protein intake among people with T2DM.

scholarly journals Dietary intake in Japanese patients with type 2 diabetes: Analysis from Japan Diabetes Complications Study

2013 ◽  
Vol 5 (2) ◽  
pp. 176-187 ◽  
Author(s):  
Chika Horikawa ◽  
Yukio Yoshimura ◽  
Chiemi Kamada ◽  
Shiro Tanaka ◽  
Sachiko Tanaka ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dietary Intake ◽  
Diabetes Complications ◽  
Japanese Patients

scholarly journals Analyzing Type 2 Diabetes Associations with the Gut Microbiome in Individuals from Two Ethnic Backgrounds Living in the Same Geographic Area

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 3289
Author(s):  
Manon Balvers ◽  
Mélanie Deschasaux ◽  
Bert-Jan van den Born ◽  
Koos Zwinderman ◽  
Max Nieuwdorp ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gut Microbiota ◽  
South Asian ◽  
Gut Microbiome ◽  
Geographical Area ◽  
Microbiota Composition ◽  
Α Diversity ◽  
Functional Pathways ◽  
Gut Microbiota Composition

It is currently unknown whether associations between gut microbiota composition and type 2 diabetes (T2D) differ according to the ethnic background of individuals. Thus, we studied these associations in participants from two ethnicities characterized by a high T2D prevalence and living in the same geographical area, using the Healthy Life In Urban Settings (HELIUS) study. We included 111 and 128 T2D participants on metformin (Met-T2D), 78 and 49 treatment-naïve T2D (TN-T2D) participants, as well as a 1:1 matched group of healthy controls from, respectively, African Surinamese and South-Asian Surinamese descent. Fecal microbiome profiles were obtained through 16S rRNA gene sequencing. Univariate and machine learning analyses were used to explore the associations between T2D and the composition and function of the gut microbiome in both ethnicities, comparing Met-T2D and TN-T2D participants to their respective healthy control. We found a lower α-diversity for South-Asian Surinamese TN-T2D participants but no significant associations between TN-T2D status and the abundance of bacterial taxa or functional pathways. In African Surinamese participants, we did not find any association between TN-T2D status and the gut microbiome. With respect to Met-T2D participants, we identified several bacterial taxa and functional pathways with a significantly altered abundance in both ethnicities. More alterations were observed in South-Asian Surinamese. Some altered taxa and pathways observed in both ethnicities were previously related to metformin use. This included a strong negative association between the abundance of Romboutsia and Met-T2D status. Other bacterial taxa were consistent with previous observations in T2D, including reduced butyrate producers such as Anaerostipes hadrus. Hence, our results highlighted both shared and unique gut microbial biomarkers of Met-T2D in individuals from different ethnicities but living in the same geographical area. Future research using higher-resolution shotgun sequencing is needed to clarify the role of ethnicity in the association between T2D and gut microbiota composition.

767-P: Family Support for Medical Nutritional Therapy and Dietary Intake among Japanese Patients with Type 2 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 767-P
Author(s):  
CHIKA HORIKAWA ◽  
YASUNAGA TAKEDA ◽  
MARIKO HATTA ◽  
DAI ISHII ◽  
SAKIKO Y. MORIKAWA ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dietary Intake ◽  
Family Support ◽  
Japanese Patients ◽  
Nutritional Therapy

Higher Dietary Intake of Vitamin D Is Associated with Lower Incidence of Diabetic Nephropathy in Japanese Patients with Type 2 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1561-P ◽  
Author(s):  
CHIKA HORIKAWA ◽  
REI AIDA ◽  
SHIRO TANAKA ◽  
SACHIKO TANAKA ◽  
CHIEMI KAMADA ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Diabetic Nephropathy ◽  
Dietary Intake ◽  
Lower Incidence ◽  
Japanese Patients

Impact of Carbohydrate Intake on Obesity in Japanese Patients with Type 2 Diabetes—An Analysis of the JDCP Registry

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 787-P
Author(s):  
SATOSHI MATSUNAGA ◽  
HIROHITO SONE ◽  
KINSUKE TSUDA ◽  
YOSHIHARU OSHIDA ◽  
SATOSHI SASAKI ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Japanese Patients ◽  
Carbohydrate Intake

scholarly journals The Association of Dietary Intakes and Gut Microbiota in Korean Lean and Obese Patients with Type 2 Diabetes

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1550-1550
Author(s):  
Ha-Neul Choi ◽  
Jung-Eun Yim
Keyword(s):  
Type 2 Diabetes ◽  
Body Weight ◽  
Gut Microbiota ◽  
Dietary Intake ◽  
Body Fat ◽  
Blood Parameters ◽  
The Body ◽  
Proper Function ◽  
The Difference

Abstract Objectives Several studies have reported that dysbiosis of the gut microbiota as a key role in rapid progression of insulin resistance and type 2 diabetes mellitus (T2DM). The diet can affect the composition and proper function of the gut microbiota. However, the association of diets, blood parameters, and gut microbiota studies have not been fully investigated in Korean subjects. Thus, the aim of this study was to characterize and compare the dietary intake, blood parameters, and gut microbiota in Korean lean and obese T2DM patients. Methods T2DM patients were recruited. We are classified as obese group (ODM; body mass index (BMI) ≥ 25 kg/m2) and lean group (LDM; BMI < 25 kg/m2). The anthropometric data, body composition, and blood parameters were measured. 3-day food record evaluation was used to analyze dietary intake using computer aided nutritional program (version. 5.0). The gut microbiota was investigated by quantitative real-time PCR. The collected data were analyzed statistically using SPSS statistics (version 25.0). Results Body weight, body fat mass, and % body fat of the ODM group were significantly higher than the LDM group. Compared with the ODM group, serum adropin and adiponectin of the LDM group were significant higher, whereas serum leptin of the LDM group was significant lower. The intakes of energy, fat, cholesterol, and protein in the ODM group tended to be higher in comparison the LDM group, although the difference was not significant. The difference of gut microbiota between the LDM and ODM groups was not found. However, the Firmicutes/Bacteroidetes ratio was significantly increased in accordance with BMI, the Prevotella was also positive correlated with PUFA intake. In ODM group, the consumption of vegetables was positively correlated with the Lactobacillus. Conclusions We found that the diet can affect the composition of gut microbiota and the effects of diet were different depending of the body weight in Korean T2DM patients. Funding Sources This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP).

scholarly journals Secular Trends in Dietary Intake over a 20-Year Period in People with Type 2 Diabetes in Japan: A Comparative Study of Two Nationwide Registries; Japan Diabetes Complications Study (JDCS) and Japan Diabetes Clinical Data Management Study (JDDM)

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3428
Author(s):  
Mizuki Takeuchi ◽  
Chika Horikawa ◽  
Mariko Hatta ◽  
Yasunaga Takeda ◽  
Rina Nedachi ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dietary Intake ◽  
Data Management ◽  
Clinical Data ◽  
Diabetes Complications ◽  
Japanese Patients ◽  
Food Groups ◽  
Management Study ◽  
Vegetables And Fruits

Background: In order to provide effective dietary guidance, it is necessary to consider dietary intake, which can change over time. This study analyzed changes in the diet of Japanese patients with type 2 diabetes over a 20-year period. Methods: We compared the results of two dietary surveys that used the food frequency questionnaire format. The first was conducted in 1996 by the Japan Diabetes Complications Study (JDCS) (n = 1509; males 53.3%), and the second in 2014–2018 by the Japan Diabetes Clinical Data Management Study (JDDM) (n = 1145; males 65.6%). Both are nationwide representative registries of outpatients with type 2 diabetes in Japan. Results: Over a 20-year period, both men and women with type 2 diabetes had a significant increase in body mass index (BMI). Nonetheless, there was only a small change in energy intake. Conversely, there was a significant increase in fat intake and thus in the fat-to-energy ratio. With regard to food groups, there was a significant increase in meat intake and a decrease in the intake of fish, soybeans/soy products, vegetables, and fruits, with a particularly significant decrease in vegetables. Conclusions: Even in Japan, an industrialized country with a stable socioeconomic environment, there were many significant changes in the dietary intake of patients with type 2 diabetes over the 20-year period.

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