scholarly journals Dose–Response Relationships between Levels of Alcohol Use and Risks of Mortality or Disease, for All People, by Age, Sex and Specific Risk Factors

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2652
Author(s):  
Jürgen Rehm ◽  
Pol Rovira ◽  
Laura Llamosas-Falcón ◽  
Kevin D. Shield
Keyword(s):  
Risk Factors ◽  
Alcohol Use ◽  
Dose Response ◽  
Injury Risk ◽  
Reference Group ◽  
Alcohol Policy ◽  
Curvilinear Relationship ◽  
Genetic Constitution ◽  
Response Curves ◽  
The Impact

Alcohol use has been causally linked to more than 200 disease and injury conditions, as defined by three-digit ICD-10 codes. The understanding of how alcohol use is related to these conditions is essential to public health and policy research. Accordingly, this study presents a narrative review of different dose–response relationships for alcohol use. Relative-risk (RR) functions were obtained from various comparative risk assessments. Two main dimensions of alcohol consumption are used to assess disease and injury risk: (1) volume of consumption, and (2) patterns of drinking, operationalized via frequency of heavy drinking occasions. Lifetime abstention was used as the reference group. Most dose–response relationships between alcohol and outcomes are monotonic, but for diabetes type 2 and ischemic diseases, there are indications of a curvilinear relationship, where light to moderate drinking is associated with lower risk compared with not drinking (i.e., RR < 1). In general, women experience a greater increase in RR per gram of alcohol consumed than men. The RR per gram of alcohol consumed was lower for people of older ages. RRs indicated that alcohol use may interact synergistically with other risk factors, in particular with socioeconomic status and other behavioural risk factors, such as smoking, obesity, or physical inactivity. The literature on the impact of genetic constitution on dose–response curves is underdeveloped, but certain genetic variants are linked to an increased RR per gram of alcohol consumed for some diseases. When developing alcohol policy measures, including low-risk drinking guidelines, dose–response relationships must be taken into consideration.

scholarly journals Atherosclerotic Risk Factors in Children with Celiac Disease

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Anna Rybak ◽  
Aldona Wierzbicka ◽  
Piotr Socha ◽  
Anna Stolarczyk ◽  
Bożena Cukrowska ◽  
...  
Keyword(s):  
Risk Factors ◽  
Celiac Disease ◽  
Folic Acid ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Reference Group ◽  
Autoimmune Disorder ◽  
Healthy Children ◽  
Positive Correlation ◽  
The Impact

Introduction and Objectives. Celiac disease (CD) is a complex autoimmune disorder occurring in genetically susceptible individuals. There is limited data on the impact of gluten-free diet (GFD) on the risk of developing cardiovascular diseases. Hereby, we present our study regarding the impact of treatment with GFD on the biochemical risk factors of atherosclerosis. Material and Methods. 277 patients with CD from 7 Polish clinics were enrolled in the study (210 children treated for at least 5 years and 67 children included in the study on the day of CD diagnosis and observed for 1 year on a GFD). We obtained selected clinical data, and we assessed lipid profile, apolipoproteins (A1, B, and E), lipoprotein (a), homocysteine, as well as antioxidants (folic and uric acid), and high-sensitivity CRP (hsCRP) for all patients. The compliance to GFD was verified using anti-transglutaminase antibodies and deamidated gliadin peptide antibodies. As a reference group, the data of 95 healthy children recruited for another project was used, for which we had the results of selected parameters. Results. We found significantly lower concentrations of total cholesterol, lipoprotein LDL-C, apolipoproteins A1 and B, as well as hCRP in all children with CD. We showed decreased level (<5 ng/mL) of folic acid among 46% of children treated for >5 years. Moreover, we showed significant decrease of folic acid level already after 1 year of a GFD (12 vs. 5.6 ng/mL; p<0.001). We also found significant negative correlation of z-score body mass index (BMI) with HDL and APOA1 level (r=−0.33; p=0.015 and r=−0.28; p=0.038, respectively) and modest positive correlation of z-score BMI with atherogenic factor of total cholesterol-HDL ratio and LDL-HDL ratio (r=0.40; p=0.002 and r=0.36; p=0.006, respectively). Analysis of physical activity showed an increase in the insulin levels with inactivity (r=0.36; p=0.0025). We also found positive correlation of the sleep duration with the adiponectin level (r=0.41; p=0.011). Conclusions. In children with CD treated with a GFD, decreased level of folic acid together with increased BMI, sedentary behavior, and an improper lipid profile may predispose them to atherosclerosis in the long run. This data suggests the need of further studies to determine the need for metabolic cardiovascular risk screening in children with CD.

Does caloric restriction induce hormesis?

2000 ◽  
Vol 19 (6) ◽  
pp. 320-329 ◽  
Author(s):  
A Turturro ◽  
B S Hass ◽  
R W Hart
Keyword(s):  
Caloric Restriction ◽  
Dose Response ◽  
Nonhuman Primates ◽  
Proliferative Potential ◽  
Response Curves ◽  
Aging Research ◽  
The Impact ◽  
Higher Doses ◽  
Hormetic Response ◽  
Selection Of

The question of whether caloric restriction (CR) is hormetic is addressed in terms of two common defini-tions of the term. In terms of the older definition, i.e., a growth-stimulatory effect when lower doses of a compound which resulted in growth inhibition at higher doses, CR is better characterized as a co-hormetic (i.e., a paradigm which at relatively “low doses,” in combina-tion with some stimulus, will evince increased growth (proliferation) and at higher “doses” will inhibit this increased proliferation) rather than a hormetic agent. Mechanisms such as cellular selection of cellular subpopulations, increases in receptor efficiency, and preservation of cellular proliferative potential can inter-act with agents and produce increased growth as long as the CR is not too severe. In terms of a broader definition, i.e., nonmonotonic dose-response behavior of a compound for any adverse response, CR appears to be hormetic, both as a result of body weight (BW) loss and other potential mechanisms. The impact of changes in BW, or frank CR, can be considered a component of every test for hormesis, and is thus capable for interaction with any other agent. The changes that BW loss (or CR) induce are so profound that any aspect of an agent's action-metabolism, pharmacokinetics, pharmacodynamics-can modulate the response of an organism to an agent. Similarly, other effects of a chemical that induce BW loss, e.g., physical activity or temperature dysregulation, can also induce dose-response curves that appear hormetic. The interaction of the hormetic agents of BW loss and CR can influence agent tests. Controlling these factors may make it possible to dissect the key components of a hormetic response. In addition, the effects of CR or BW loss appear to extrapolate well across species [Colman R, Kemnitz JW. Aging experi-ments using nonhuman primates. In: Yu BP (Ed), Methods in Aging Research. CRC Press, Boca Raton, FL, 1999, pp. 249-267]. Thus there is some reason to believe that these hormetic factors may be important for humans, and may already be a factor for tests of potentially adverse agents already conducted in humans.

Relationships and Mechanisms Between Occupational Risk Factors and Distal Upper Extremity Disorders

2019 ◽  
pp. 001872081986068 ◽  
Author(s):  
Peter J. Keir ◽  
Amanda Farias Zuniga ◽  
Daanish M. Mulla ◽  
Kumara G. Somasundram
Keyword(s):  
Risk Factors ◽  
Upper Extremity ◽  
Dose Response ◽  
Injury Risk ◽  
Epidemiological Studies ◽  
Task Demands ◽  
Laboratory Studies ◽  
Occupational Risk Factors ◽  
Upper Extremity Disorders ◽  
Extremity Injuries

Objective:The relationships between workplace risk factors and upper extremity injuries from epidemiological and laboratory studies were examined.Background:Epidemiological studies are associated with several limitations, affecting the strength of association between risk factors and the development of injuries.Method:In this narrative review, we identified epidemiological and laboratory studies (published primarily since 1997) investigating exposure to workplace risk factors (force, repetition, posture, vibration) and risk of hand/wrist tendon–related disorders, epicondylitis, and carpal tunnel syndrome (CTS).Results:Forceful exertions are strongly associated with hand/wrist tendon–related disorders, epicondylitis, and CTS. Dose–response relationships were found for epicondylitis (repetition) and CTS (posture). Interactions demonstrate multiplicative effects of risk factors for injury risk. Laboratory studies display clear associations between task demands and biomechanical measures linked to mechanisms for upper extremity injuries with animal models providing further evidence of a dose–response between risk factors and injury.Conclusion:Forceful, repetitive work requiring non-neutral postures are associated with increasing risk of hand/wrist tendon–related disorders, epicondylitis, and CTS as evidenced by epidemiology studies and laboratory-based investigations of humans and animals.Application:Understanding the relationship between exposure levels of workplace risk factors and upper extremity disorders can improve injury prevention and rehabilitation strategies.

scholarly journals The Development of a Tympanic Membrane Model and Probabilistic Dose-Response Risk Assessment of Rupture Because of Blast

2020 ◽  
Vol 185 (Supplement_1) ◽  
pp. 234-242
Author(s):  
Anthony E Iyoho ◽  
Kevin Ho ◽  
Philemon Chan
Keyword(s):  
Tympanic Membrane ◽  
Dose Response ◽  
Injury Risk ◽  
Element Model ◽  
Lumped Parameter Model ◽  
Unintended Effects ◽  
Response Curves ◽  
Membrane Rupture ◽  
Lumped Parameter ◽  
Dose Response Curves

ABSTRACT Introduction There is no dose-response model available for the assessment of the risk of tympanic membrane rupture (TMR), commonly known as eardrum rupture, from exposures to blast from nonlethal flashbangs, which can occur concurrently with temporary threshold shift. Therefore, the objective of this work was to develop a fast-running, lumped parameter model of the tympanic membrane (TM) with probabilistic dose-dependent prediction of injury risk. Materials and Methods The lumped parameter model was first benchmarked with a finite element model of the middle ear. To develop the dose-response curves, TMR data from a historic cadaver study were utilized. From these data, the binary probability response was constructed and logistic regression was applied to generate the respective dose-response curves at moderate and severe eardrum rupture severity. Results Hosmer-Lemeshow statistical and receiver operation characteristic analyses showed that maximum stored TM energy was the overall best dose metric or injury correlate when compared with total work and peak TM pressure. Conclusions Dose-response curves are needed for probabilistic risk assessments of unintended effects like TMR. For increased functionality, the lumped parameter model was packaged as a software library that predicts eardrum rupture for a given blast loading condition.

scholarly journals Evaluation of community coalition training effects on youth hospital-admitted injury incidence in Victoria, Australia: 2001–2017

2019 ◽  
Vol 26 (5) ◽  
pp. 463-470 ◽  
Author(s):  
Janneke Berecki-Gisolf ◽  
Bosco Rowland ◽  
Nicola Reavley ◽  
Barbara Minuzzo ◽  
John Toumbourou
Keyword(s):  
Risk Factors ◽  
Injury Risk ◽  
Negative Binomial ◽  
Hospital Admissions ◽  
Intervention Strategy ◽  
Age Groups ◽  
Negative Binomial Regression ◽  
Population Based ◽  
Injury Incidence ◽  
The Impact

BackgroundInjuries are one of the three leading causes of morbidity and mortality for young people internationally. Although community risk factors are modifiable causes of youth injury, there has been limited evaluation of community interventions. Communities That Care (CTC) offers a coalition training process to increase evidence-based practices that reduce youth injury risk factors.MethodUsing a non-experimental design, this study made use of population-based hospital admissions data to evaluate the impact on injuries for 15 communities that implemented CTC between 2001 and 2017 in Victoria, Australia. Negative binomial regression models evaluated trends in injury admissions (all, unintentional and transport), comparing CTC and non-CTC communities across different age groups.ResultsStatistically significant relative reductions in all hospital injury admissions in 0–4 year olds were associated with communities completing the CTC process and in 0–19 year olds when communities began their second cycle of CTC. When analysed by subgroup, a similar pattern was observed with unintentional injuries but not with transport injuries.ConclusionThe findings support CTC coalition training as an intervention strategy for preventing youth hospital injury admissions. However, future studies should consider stronger research designs, confirm findings in different community contexts, use other data sources and evaluate intervention mechanisms.

scholarly journals Time-dependent and force-dependent vasoreactivity of isolated human umbilical arteries

2020 ◽  
Vol 51 (3) ◽  
pp. 134-140
Author(s):  
Đorđe Đukanović ◽  
Milica Gajić ◽  
Ranko Škrbić
Keyword(s):  
Incubation Period ◽  
Cold Storage ◽  
Dose Response ◽  
In Vitro Studies ◽  
Time Dependent ◽  
Response Curves ◽  
Experimental Conditions ◽  
Umbilical Arteries ◽  
The Impact

Background/Aim: There have been different experimental conditions for in vitro studies on human umbilical arteries (HUA) in tissue bath system. This diversity was mainly reflected in variables such as stretching tension, incubation period and initial constriction challenging with potassium (KCl). The aim of the study was to establish optimal experimental conditions which will provide better responsiveness of HUA preparations, as well as to examine the impact of 24 h cold storage on viability and responsiveness of HUA to KCl and serotonin. Methods: The KCl-induced constrictions at different stretching tensions (0.5 g, 1.0 g, 2.0 g, 4.0 g), incubation times (30 min, 60 min, 120 min), and after multiple initial constriction challenging were compared. Dose response curves for serotonin were obtained under different conditions (1.0 g and 60 min vs. 2.0 g and 120 min). The influence of 24 h cold storage on KCland serotonininduced vasoconstriction of HUA preparations was examined as well. Results: The strongest constrictions induced by serotonin or KCl were obtained when preparations were adjusted at 2.0 g and incubated for 120 min. The KCl-induced constrictions observed after 120 min were statistically higher (p < 0.05) when preparations were challenged three times (30 min, 60 min, 120 min), compared to those challenged only once. The preparations that were stored at 4 ⁰C for 24 h showed significantly stronger serotonin-induced constrictions (p < 0.01). The cold storage had no influence on KCl-induced constriction. Conclusion: For performing in vitro studies on HUA preparations in tissue bath, we propose stretching tension of 2.0 g, incubation period of 120 min and multiple initial constriction challenging with KCl as optimal experimental condition. We also showed that HUA preparations retained functional viability even after 24 h of cold storage.

scholarly journals Dos mundos conectados: Cómo la exposición al estrés social nos hace más vulnerables al consumo de drogas

2021 ◽  
Author(s):  
Sandra Montagud-Romero ◽  
Marina D. Reguilón ◽  
Marta Rodriguez-Arias
Keyword(s):  
Risk Factors ◽  
Social Interaction ◽  
Alcohol Use ◽  
Animal Models ◽  
Drug Use ◽  
Powerful Effect ◽  
Close Relationship ◽  
The Impact ◽  
The Brain

Stress is one of the main risk factors that can induce humans to develop disorders such as depression, anxiety, or drug use. One of the main sources of stress is social interaction, which can lead to situations such as bullying at school or at work. In this article we will review the close relationship between exposure to stressful situations and increased cocaine or alcohol use. We will present the main results obtained with animal models, which allow us to study the brain mechanisms involved in the impact of stress on drug use. To conclude, we will detail the main mechanisms that explain the powerful effect of stress on drug use.

Cardio-vascular risk factors according to different profiles of night work and shift work

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
Y Esquirol ◽  
E Bourgkard ◽  
M Dziurlac ◽  
J Ferrieres ◽  
C Ribet ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Shift Work ◽  
Sleep Disturbances ◽  
Reference Group ◽  
Night Shift ◽  
Night Work ◽  
Funding Source ◽  
Work History ◽  
The Impact

Abstract Background The shift-night work concerns around 17% workers in our modern society with evident need of this type of organisation for productivity and economic reasons for the companies. if the impact of this global organisation pattern on cardiovascular disease or risk factors is more and more documented, it remains unclear which types of rotating or night work are really involved and which are the impact on cardiovascular risk of being exposed currently or in the past to these different types of shift-night work. Purpose To study possible relationships between arterial blood pressure, anthropometric markers, fasting biomarkers, and sleep disturbances, and different exposure profiles of night work and/or shift work. Methods A cross-sectional study was conducted among 65.126 workers aged 18–70 at baseline in the French random population-based Constances cohort. Four exposure groups were defined: (1) workers with current permanent night work, (2) current night shift workers 3x8, (3) day workers with past night and/or shift work, (4) day workers without night and/or shift work during their work history (reference group). Logistic regression models adjusted for age, sex, socio-economic position, and personal history of ischemic cardiovascular disease (CVD) were performed to assess associations between clinical risk markers for CVD at baseline and these exposure groups. Results Compared with the reference group, current and past night workers had a significant higher risk of obesity (Body Mass Index≥30). Permanent night workers had a significant higher risk of metabolic syndrome, mostly due to abdominal obesity, hypertriglyceridemia (&gt;1.7 mmol/l) and low level of high density lipoprotein. Even if day workers with past night/shift work had no statistically significant over-risk of metabolic syndrome, they presented significantly higher risks for the same three criteria as observed for the permanent night workers. However, only hypertriglyceridemia was significantly more frequent among 3x8 workers. Among current night workers, 3x8 had a higher risk of sleep disturbances while permanent had not. Sleep disturbances over-risk was also observed among day workers with past night/shift work. No over-risk of hypertension, hypercholesterolemia, hyperglycemia, and elevated levels of gamma-glutamyl-transferase was observed among the three groups. Conclusion The results support the need for enhanced cardiovascular follow-up of workers exposed to night and/or shift work. However, it is also necessary to follow regularly and specifically current day workers with a past night and/or shift work history. Funding Acknowledgement Type of funding source: Public Institution(s). Main funding source(s): INRS: institut National de Recherche et de Sécurité

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