scholarly journals The Role of Bioactive Compounds of Nigella sativa in Rheumatoid Arthritis Therapy—Current Reports

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3369
Author(s):  
Magdalena Zielińska ◽  
Katarzyna Dereń ◽  
Ewelina Polak-Szczybyło ◽  
Agnieszka Ewa Stępień
Keyword(s):  
Rheumatoid Arthritis ◽  
Bioactive Compounds ◽  
Nigella Sativa ◽  
Therapeutic Effects ◽  
Scientific Publications ◽  
Black Cumin ◽  
Health Promoting ◽  
Bioactive Ingredients ◽  
Current Article

Black cumin (Nigella sativa, NS) is included in the Ranunculaceae family and is classified as a medicinal plant due to very high levels of various bioactive compounds. They determine its therapeutic effects, including anti-inflammatory, anti-allergic, anti-cancer, hypoglycemic, antioxidant, hypotensive, hypolipidemic, and immunomodulating properties. The results of scientific studies indicate a supporting role of black cumin in the treatment of autoimmune diseases, including rheumatoid arthritis, due to the health-promoting properties of its bioactive ingredients. The aim of the current article is to analyze the results of scientific publications on the role of bioactive ingredients contained in black cumin in the treatment of rheumatoid arthritis.

The protective effect of Nigella Sativa oil extract against neurotoxicity induced by Valproic acid

2017 ◽  
Vol 6 (9) ◽  
pp. 5474 ◽  
Author(s):  
Basant Mahmoud Morsy ◽  
Ghada Mohamed Safwat ◽  
Doaa Ahmed Hussein ◽  
Reem Mohamed Samy
Keyword(s):  
Valproic Acid ◽  
Nigella Sativa ◽  
Liver Lipid ◽  
Black Cumin ◽  
Enzymatic Antioxidant ◽  
Nigella Sativa Oil ◽  
Active Chemical ◽  
Oil Extract ◽  
Liver Lipid Peroxidation

Nigella sativa (NS), commonly known as black cumin, has been used for medicinal purposes. Traditionally the seeds and its oil are used in several diseases. The greatest part of the remedial properties of this plant is due to the presence of thymoquinone (TQ) which is a major active chemical component of the essential oil. The current study performed to evaluate the effect of Nigella sativa Oil (NSO) extract on the neurotoxic and hepatotoxic potentials from Valproic acid (VPA) administration. Also we summarize recent findings emphasizing the role of main neurotoxic and hepatotoxic markers and oxidative stress in study’s case. Neurotoxicity was induced by VPA at dose of (500 mg/kg b.wt) by gastric intubation daily for 30 day. These rats received NSO extract was given orally at dose of (0.5 ml/kg b.wt) daily for 30 days after VPA administration. The current results revealed that NSO extract treatment ameliorated significantly the elevated levels of the neurotoxic and hepatotoxic biomarkers which elevated as a result to VPA administration. Moreover, NSO extract treatment ameliorated the non-enzymatic antioxidant, brain and liver lipid peroxidation (LPO) and glutathione (GSH) concentration and the enzymatic antioxidant, brain and liver catalase(CAT) activity.

scholarly journals The bioactive ingredients and therapeutic effects of Marrubium vulgare - A review

2021 ◽  
Vol 1 (2) ◽  
pp. 09-021
Author(s):  
Ali Esmail Al-Snafi ◽  
Hussein Ali Al-Saedy ◽  
Tayseer Ali Talab ◽  
Wajdi Jabbar Majid ◽  
Gaber El-Saber Batiha ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Night Blindness ◽  
Biological Effects ◽  
Phytochemical Analysis ◽  
Therapeutic Effects ◽  
Pulmonary Infections ◽  
Pharmacological Activities ◽  
Marrubium Vulgare ◽  
Bioactive Ingredients ◽  
Loss Of Appetite

Marrubium vulgare (Family: Lamiaceae) was used traditionally in the treatment of dyspeptic complains, pulmonary infections, cough, rheumatoid arthritis, night blindness, loss of appetite, as cholagogue, purgative, diuretic, bitter tonic, carminative and appetizer. The phytochemical analysis revealed that the plant contained alkaloids, sterols, steroids, terpenoids (diterpene), saponins, flavonoid, catecholic tannins, anthocyans, phenolic compounds and many other bioactive ingredients. The pharmacological investigations showed that the plant exerted anti-inflammatory, antiedematogenic, analgesic, antioxidant, antimicrobial, antidiabetic, cardiovascular hypolipidemic, antispasmodic and many other biological effects. This review discussed the bioactive contents and pharmacological activities of Marrubium vulgare.

scholarly journals Therapeutic Effects of Nigella Sativa Linn (Black Cumin) on Candida albicans Vaginitis

2015 ◽  
Vol 10 (1) ◽  
Author(s):  
Farzaneh Adiban Fard ◽  
Shahnaz Tork Zahrani ◽  
Alireza Akbarzadeh Bagheban ◽  
Faraz Mojab
Keyword(s):  
Candida Albicans ◽  
Nigella Sativa ◽  
Therapeutic Effects ◽  
Black Cumin

scholarly journals PHARMACEUTICAL SIGNIFICANCE OF NIGELLA SATIVA L., A WONDER HERB

2021 ◽  
Vol 3 (4) ◽  
pp. 04-13
Author(s):  
Irfat Ara ◽  
Mudasir Maqbool ◽  
Ginenus Fekadu ◽  
Tawseef Ahmad Hajam ◽  
Mohmad Amin Dar
Keyword(s):  
Chronic Headache ◽  
Nigella Sativa ◽  
Therapeutic Effects ◽  
Hepatic Toxicity ◽  
Gangetic Plains ◽  
Traditional System ◽  
Black Cumin ◽  
Traditional Remedies ◽  
Gastrointestinal Problems ◽  
Annual Herb

Nigella sativa L. (Family: Ranunculaceae; commonly known as black cumin) is an annual herb. N. sativa is cultivated and distributed all over India, especially in Punjab, Himachal Pradesh, Gangetic plains, Bihar, Bengal, Assam and Maharashtra. Among the traditional remedies, prescriptions of Nigella sativa for the treatment of various diseases are well-known since the prehistoric era. Therapeutic effects of Nigella sativa are thought to be due to nigellone and thymoquinone contents. The reported pharmacological properties include protection against disease and chemical-induced renal and hepatic toxicity, anti-inflammatory, analgesic, antipyretic, anti-microbial and antineoplastic activities. The oil decreases blood pressure, cholesterol, triglycerides, and glucose and increases respiration, hemoglobin and packed cell volume. In the traditional system of medicine, black cumin seeds are effective against cough, bronchitis, asthma, chronic headache, migraine, dizziness, chest congestion, dysmenorrheal, obesity, diabetes, paralysis, hemiplegia, back pain, infection, inflammation, rheumatism, hypertension and gastrointestinal problems such as dyspepsia, flatulence, dysentery, and diarrhea. In this review, we will elaborate about this wonder herb having miraculous effects.

scholarly journals A SIMPLIFIED LITERATURE-BASED REVIEW: PHYTOCHEMISTRY, PHARMACOLOGY, SAFETY PROFILE, NUTRITIONAL VALUE AND TRADITIONAL THERAPEUTIC EFFECTS OF NIGELLA SATIVA L. IN UNANI SYSTEM OF MEDICINE

2021 ◽  
Vol 14 (2) ◽  
Author(s):  
Shaheen Akhlaq ◽  
Shabnam Anjum Ara ◽  
Mohammad Fazil ◽  
Usama Akram ◽  
Bilal Ahmad ◽  
...  
Keyword(s):  
Safety Profile ◽  
Nigella Sativa ◽  
Chemical Compositions ◽  
Therapeutic Effects ◽  
Gulf Region ◽  
Black Cumin ◽  
Black Cumin Seed ◽  
Cumin Seed

Background: Nigella sativa L. or black cumin, belong to the family Ranunculaceae, has long been used traditionally, for food purposes and in traditional Unani medicines and is a native of the Arabian Gulf region, East Asia, Africa and Europe. It is a rich medicinal plant in bioactive compounds. Aim of the study: The aim of this review is to develop an overview of black cumin seed in the context of the status traditional Unani medicine ideology with the incorporation of ethno pharmacological uses, chemical compositions, pharmacological activities, safety profile with evidence-based approach. Materials and Methods: Information on Nigella sativa L. was obtained from published materials, including medicinal plants monographs, ancient and modern recorded classical texts, Unani pharmacopoeias and electronic databases such as Pub Med, Web of Science, Science Direct and Google Scholar. Results: Black cumin seed has been used in Unani traditional medical systems throughout history. The presence of thymoquinone is mainly responsible for its most of the medicinal properties. Moreover, the presence of vitamins, myristic acid, proteins, fats, fiber, amino acids and some trace metals are also reported in the seeds particularly used as a nutraceutical. Numerous in vivo and in vitro studies on pharmacological effects of Nigella sativa L. viz. antioxidant, anticancer, immuno-modulatory, antimicrobial, neuroprotective, cardio protective, gastro protective, anti-hypertensive, nephroprotective, hepatoprotective and anti-diabetic properties demonstrated positive effect against diabetes, hypertension, hypercholesterolemia, bronchitis, asthma, rheumatism, back pain, cancer, gastrointestinal disorders, and eczema etc. Conclusion: Contemporary researches on Nigella sativa L. support the views of Unani physicians for its use as a food and medicinal herb. Black cumin-based potential therapeutic agents need to be applied for a variety of diseases and the formulation of accepted functional foods with the aim to promote optimum health and lessen the risk of chronic diseases.

scholarly journals Use of low-cost chemotherapeutic and medicinal plants against Thai silver barb (Barbonymus gonionotus)

2013 ◽  
Vol 10 (2) ◽  
pp. 385-390 ◽  
Author(s):  
MBR Chowdhury ◽  
T Rahman
Keyword(s):  
Medicinal Plants ◽  
Field Condition ◽  
Nigella Sativa ◽  
Curcuma Longa ◽  
Low Cost ◽  
Fungal Disease ◽  
Bacterial Disease ◽  
Therapeutic Effects ◽  
Black Cumin ◽  
Highly Efficient

Studies were conducted to select and apply the effective low-cost chemotherapeutic and medicinal plants against diseased fish under laboratory and field condition. Thai silver barbs (Barbonymus gonionotus) weighing 20-25 gm were experimentally infected with a virulent bacterial pathogen (Aeromonas hydrophila) and a fungal pathogen (Aphanomyces invadans). Based on the previous studies, four chemotherapeutics, viz., salt + lime, alum, doxycycline and oxytetracycline were selected and applied to observe the therapeutic effects under laboratory and field condition. In the case of medicinal plants, leaves/ bulb / seeds/ rhizome of neem (Azadirachta indica), akand (Calotropis gigantea), garlic (Allium sativum), turmeric (Curcuma longa), shoti (Curcuma zedoaria), Indian sorrel (Oxalis corniculata), guava (Psidum guajava) and kalijira (Nigella sativa) were screened out and applied to the infected fish in laboratory and field condition to determine their efficacies. The antibiotics, both oxytetracycline and doxycycline were found to be very efficient followed by salt + lime and alum. For fungal infection, alum was excellent followed by salt + lime both under laboratory and field condition. Even in the pond trial, alum and salt + lime successfully checked the occurrence of epizootic ulcerative syndrome (EUS) and similar diseases. In the case of medicinal plants, neem and akand together reduced the occurrence bacterial and fungal disease. Garlic was very efficient to check bacterial infection but weak against fungal disease. Turmeric and arrowroot were found to be highly effective against fungal disease but moderately effective against bacterial disease. Field trial revealed that Indian sorrel and guava were highly efficient against bacterial disease but poorly efficient against fungal disease. On the other hand, arrowroot and black cumin were highly efficient against fungal disease but moderately efficient against bacterial disease. The results would be useful to the all concerned for proper health management of cultured fishes.DOI: http://dx.doi.org/10.3329/jbau.v10i2.14932 J. Bangladesh Agril. Univ. 10(2): 385-390, 2012

scholarly journals What Have We Learned about the Pathogenesis of Rheumatoid Arthritis from TNF-Targeted Therapy?

2012 ◽  
Vol 2012 ◽  
pp. 1-15 ◽  
Author(s):  
Richard O. Williams
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Susceptibility ◽  
Therapeutic Effects ◽  
Collagen Induced Arthritis ◽  
Inflammatory Bowel ◽  
Genetic And Environmental Factors ◽  
The Impact ◽  
Anti Inflammatory Cytokine ◽  
Pro Inflammatory Cytokines

Studies of cytokine regulation in rheumatoid arthritis led to the development of TNFα inhibitors which are now used for a number of indications, including rheumatoid arthritis, inflammatory bowel disease, psoriasis, psoriatic arthritis, and ankylosing spondylitis. The widespread use of biologics in the clinic offers unique opportunities for probing disease pathogenesis and this paper provides an overview of rheumatoid arthritis, with a particular emphasis on the impact of anti-TNFα therapy on pathogenetic mechanisms. An overview is also provided on the most commonly used animal models that mimic RA, including adjuvant-induced arthritis, collagen-induced arthritis, TNFα-transgenic mice, and the K/BxN and SKG models. These models have led to significant discoveries relating to the importance of pro-inflammatory cytokines in the pathogenesis of rheumatoid arthritis, resulting from disregulation of the normally finely tuned balance of pro- and anti-inflammatory cytokine signalling. In addition, experimental evidence is discussed suggesting how genetic and environmental factors can contribute to disease susceptibility. The role of effector and regulatory T cells is discussed in the light of the relatively disappointing therapeutic effects of T cell modifying agents such as anti-CD4 antibody and cyclosporin. It is concluded that comprehensive analyses of mechanisms of action of biologics and other drugs entering the clinic will be essential to optimise therapy, with the ultimate aim of providing a cure.

Sign in / Sign up

Export Citation Format

Share Document