scholarly journals A SIMPLIFIED LITERATURE-BASED REVIEW: PHYTOCHEMISTRY, PHARMACOLOGY, SAFETY PROFILE, NUTRITIONAL VALUE AND TRADITIONAL THERAPEUTIC EFFECTS OF NIGELLA SATIVA L. IN UNANI SYSTEM OF MEDICINE

2021 ◽  
Vol 14 (2) ◽  
Author(s):  
Shaheen Akhlaq ◽  
Shabnam Anjum Ara ◽  
Mohammad Fazil ◽  
Usama Akram ◽  
Bilal Ahmad ◽  
...  
Keyword(s):  
Safety Profile ◽  
Nigella Sativa ◽  
Chemical Compositions ◽  
Therapeutic Effects ◽  
Gulf Region ◽  
Black Cumin ◽  
Black Cumin Seed ◽  
Cumin Seed

Background: Nigella sativa L. or black cumin, belong to the family Ranunculaceae, has long been used traditionally, for food purposes and in traditional Unani medicines and is a native of the Arabian Gulf region, East Asia, Africa and Europe. It is a rich medicinal plant in bioactive compounds. Aim of the study: The aim of this review is to develop an overview of black cumin seed in the context of the status traditional Unani medicine ideology with the incorporation of ethno pharmacological uses, chemical compositions, pharmacological activities, safety profile with evidence-based approach. Materials and Methods: Information on Nigella sativa L. was obtained from published materials, including medicinal plants monographs, ancient and modern recorded classical texts, Unani pharmacopoeias and electronic databases such as Pub Med, Web of Science, Science Direct and Google Scholar. Results: Black cumin seed has been used in Unani traditional medical systems throughout history. The presence of thymoquinone is mainly responsible for its most of the medicinal properties. Moreover, the presence of vitamins, myristic acid, proteins, fats, fiber, amino acids and some trace metals are also reported in the seeds particularly used as a nutraceutical. Numerous in vivo and in vitro studies on pharmacological effects of Nigella sativa L. viz. antioxidant, anticancer, immuno-modulatory, antimicrobial, neuroprotective, cardio protective, gastro protective, anti-hypertensive, nephroprotective, hepatoprotective and anti-diabetic properties demonstrated positive effect against diabetes, hypertension, hypercholesterolemia, bronchitis, asthma, rheumatism, back pain, cancer, gastrointestinal disorders, and eczema etc. Conclusion: Contemporary researches on Nigella sativa L. support the views of Unani physicians for its use as a food and medicinal herb. Black cumin-based potential therapeutic agents need to be applied for a variety of diseases and the formulation of accepted functional foods with the aim to promote optimum health and lessen the risk of chronic diseases.

scholarly journals Deodorant Activity of Black Cumin Seed Essential Oil against Garlic Organosulfur Compound

Biomolecules ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1874
Author(s):  
Yuri Yoshioka ◽  
Shinichi Matsumura ◽  
Masanori Morimoto
Keyword(s):  
Essential Oil ◽  
Nigella Sativa ◽  
Organosulfur Compound ◽  
Major Constituent ◽  
Organosulfur Compounds ◽  
Black Cumin ◽  
Allyl Mercaptan ◽  
Black Cumin Seed ◽  
Cumin Seed

The deodorant activity of black cumin (Nigella sativa L.) seed, a spice used to flavor curry and vegetable foods in Southwest Asia, against garlic (Allium sativum L.) organosulfur compounds related to human malodor was evaluated. Black cumin seed essential oil showed remarkable deodorant activity against garlic essential oil. The mode of action of this deodorant activity was presumed to be that black cumin seed essential oil covalently reacted with the organosulfur compounds in garlic. Therefore, thymoquinone, which is a major constituent in black cumin seed essential oil, and allyl mercaptan, which is one of the organosulfur compounds produced by cutting garlic, were reacted in vitro, and the products were purified and elucidated using spectroscopic data. As a result, these substances were identified as different allyl mercaptan adducts to dihydrothymoquinone. This chemical reaction was presumed to play a key role in the deodorant activity of black cumin seed essential oil.

In Vitro Antifungal Effect of Black Cumin Seed Quinones against Dairy Spoilage Yeasts at Different Acidity Levels

2010 ◽  
Vol 73 (12) ◽  
pp. 2291-2295 ◽  
Author(s):  
KATERINA HALAMOVA ◽  
LADISLAV KOKOSKA ◽  
JAROSLAV FLESAR ◽  
OLGA SKLENICKOVA ◽  
BLANKA SVOBODOVA ◽  
...  
Keyword(s):  
Nigella Sativa ◽  
Potassium Sorbate ◽  
Food Preservatives ◽  
Black Cumin ◽  
Spoilage Yeast ◽  
Spoilage Yeasts ◽  
Broth Microdilution Method ◽  
Black Cumin Seed ◽  
Cumin Seed

The antiyeast activity of the black cumin seed (Nigella sativa) quinones dithymoquinone, thymohydroquinone (THQ), and thymoquinone (TQ) were evaluated in vitro with a broth microdilution method against six dairy spoilage yeast species. Antifungal effects of the quinones were compared with those of preservatives commonly used in milk products (calcium propionate, natamycin, and potassium sorbate) at two pH levels (4.0 and 5.5). THQ and TQ possessed significant antiyeast activity and affected the growth of all strains tested at both pH levels, with MICs ranging from 8 to 128 μg/ml. With the exception of the antibiotic natamycin, the inhibitory effects of all food preservatives against the yeast strains tested in this study were strongly affected by differences in pH, with MICs of ≥16 and ≥512 μg/ml at pH 4.0 and 5.5, respectively. These findings suggest that HQ and TQ are effective antiyeast agents that could be used in the dairy industry as chemical preservatives of natural origin.

scholarly journals Assessment the Antioxidant and Hypolipidmic Effect of Black Cumin (Nigella sativa L.) Flavonoids in Induced Oxidative Stressed Male Rabbits

2012 ◽  
Vol 36 (2) ◽  
pp. 163-173
Author(s):  
Kahtan A. Al-Mzaien
Keyword(s):  
Oxidative Stress ◽  
Drinking Water ◽  
Nigella Sativa ◽  
Tap Water ◽  
Scavenging Activity ◽  
Black Cumin ◽  
Sugar Moiety ◽  
Black Cumin Seed ◽  
Cumin Seed

Qualitative and quantitative assessment of flavonoids, sugar moiety and antioxidant scavenging activity (in vitro and vivo) of black cumin seed ( Nigella sativa L.) as well as serum lipid profile inhydrogen peroxide (H2O2) induced oxidative stress and flavonoids treated adult male rabbits were the main aim of the current study. The results showed that black cumin seeds contained 4.50gmcrude flavonoids per kg crushed seeds and the high performance liquid chromatography indicated the existence of 22 flavonoids, only seven of which were identified flavonoids represented nearly 2.751gm/kg of the total flavonoids. The concentration of kaempferol was the highest whereas quercetin the lowest. Glucose, fructose and sucrose were the sugar moiety of flavonoids with an average concentration of 3.22, 2.21 and 3.31 g/kg crushed seeds respectively. Assessment the antioxidant scavenging activity of the extracted flavonoids and its effect on lipid profile in H2O2 treated rabbits were carried out as follows; eighteen adult male rabbits were randomly divided into three equal groups. Rabbits in the first group were received tap water and served as control (C), whereas animals in 2nd group received 0.5% H2O2 in drinking tap water (T1), animals in the 3rd group were received 0.5% H2O2 in drinking water with 27.5mg/kg B.W. of black cuminseeds flavonoids.Fasting blood samples were collected at 0, 4, 8 and 12 weeks of the experiment. The results clarified that 0.5% H2O2 in drinking water caused significant elevation in serum malondialdehyde (MDA) and reduction in glutathione (GSH) concentration of treated animals respectively.The incidence of antioxidant scavenging activity in vitro was more pronounced than that recorded in vivo particularly at the early stages of administration and extracted flavonoids ameliorate to a great extent the incidence of hydrogen peroxide induced oxidative stress in male rabbits. The results revealed that administration of 0.5% H2O2 in drinking water for 12 weeks to male rabbits caused significant p<0.05 elevation in TC, TAG, LDL-C and VLDL-C concentration, with significant p<0.05 reduction in serum HDL-C concentration as compared with the control where as Black Cumin seed flavonoids caused significant reduction in the serum concentration of TC, TAG, LDL-C, and VLDL-C and significantly p<0.05 elevation in HDL-C concentration comparing to H2O2 treated group.Conclusion: This study clarified the significant role of black cumin flavonoids in modulation of glutathion (GSH) content and malondialdehyde( MDA) equivalent and exhibited highly hypolipidmic effect.

scholarly journals A case study on in vitro investigations of the potent biological activities of wheat germ and black cumin seed oil

2015 ◽  
Vol 39 ◽  
pp. 801-812 ◽  
Author(s):  
Didem AĞ ŞELECİ ◽  
Zinar Pınar GÜMÜŞ ◽  
Murat YAVUZ ◽  
Muharrem ŞELECİ ◽  
Rebecca BONGARTZ ◽  
...  
Keyword(s):  
Wheat Germ ◽  
Seed Oil ◽  
Biological Activities ◽  
Black Cumin ◽  
Black Cumin Seed ◽  
Cumin Seed ◽  
Black Cumin Seed Oil

scholarly journals EFFECTIVENESS TEST OF BLACK CUMIN SEEDS (NIGELLA SATIVA) EXTRACT ON THE GROWTH OF KLEBSIELLA PNEUMONIAE AND PSEUDOMONAS AERUGINOSA BACTERIA

2021 ◽  
Vol 7 (2) ◽  
pp. 130-138
Author(s):  
Nadya Nazimuddin Putri ◽  
Linda Chiuman ◽  
Chrismis Novalinda Ginting ◽  
Ermi Girsang
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Klebsiella Pneumoniae ◽  
Nigella Sativa ◽  
Ethanol Extract ◽  
Inhibition Zone ◽  
Seed Extract ◽  
Diffusion Method ◽  
Black Cumin ◽  
Black Cumin Seed ◽  
Cumin Seed

Black cumin seeds are known to have beneficial contents as antibacterial. This study aimed to determine the effectiveness of black cumin seed extract (Nigella sativa) on the growth of Klebsiella pneumoniae and Pseudomonas aeruginosa. The method used was the disc diffusion method. The ethanol extract of black cumin seeds gain by maceration method and was made into various concentration (5, 7.5, 10, 12.5, and 15)%. For positive control, ciprofloxacin disc were used and negative control used distilled water. The research model used was in vitro experimental research. The results showed that ethanol extract of black cumin seeds have antibacterial activity against Klebsiella pneumoniae with inhibition zone diameters (4.5, 6.7, 10.1, 11, 12.8) mm, Pseudomonas aeruginosa with inhibition zone diameters (7.5, 12, 12.6, 13.4, 15.6) mm, positive controls respectively (24.3 and 20.7) mm and negative controls (0). It can be concluded that black cumin seed extract has an inhibiting effect on the growth of Klebsiella pneumoniae and Pseudomonas aeruginosa.

scholarly journals Ethanol Extract of Black Cumin Seed (Nigella Sativa) Reduces Expression Kidney iNOS in Mice Model Preeclampsia

2019 ◽  
Vol 5 (2) ◽  
pp. 88
Author(s):  
Rubiati Hipni
Keyword(s):  
Nigella Sativa ◽  
Ethanol Extract ◽  
Negative Control ◽  
Inos Expression ◽  
Control Group ◽  
Mice Model ◽  
Control Group Design ◽  
Black Cumin ◽  
Black Cumin Seed ◽  
Cumin Seed

This study aims to analyze the effect of ethanol extract of black cumin seeds (Nigella Sativa) on iNOS expression in the kidney of mice model preeclampsia. Design This study uses an experimental design with a posttest only control group design. Using a mice model preeclampsia. This study was divided into 6 groups: negative control, positive control (preeclampsia model), model + black cumin seed extract 500 mg/KgBB/day, 1000 mg/KgBB/day, 1500 mg/KgBB/day, and 2000 mg/KgBB/day days, after surgery on mice then examined iNOS Kidney expression by methods Immunohistochemical. Data from observations were analyzed by one way ANOVA test. The result there is an effect of ethanol extract of black cumin seeds on renal iNOS expression in mice model preeclampsia (p <0.05) at doses of 500mg, 1000mg, 1500mg, and 2000mg on decreasing renal iNOS expression. The conclusion Ethanol extract of black cumin seeds (Nigella sativa) can reduce iNOS Kidney expression in Mice Preeclampsia.

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