scholarly journals PHARMACEUTICAL SIGNIFICANCE OF NIGELLA SATIVA L., A WONDER HERB

2021 ◽  
Vol 3 (4) ◽  
pp. 04-13
Author(s):  
Irfat Ara ◽  
Mudasir Maqbool ◽  
Ginenus Fekadu ◽  
Tawseef Ahmad Hajam ◽  
Mohmad Amin Dar

Nigella sativa L. (Family: Ranunculaceae; commonly known as black cumin) is an annual herb. N. sativa is cultivated and distributed all over India, especially in Punjab, Himachal Pradesh, Gangetic plains, Bihar, Bengal, Assam and Maharashtra. Among the traditional remedies, prescriptions of Nigella sativa for the treatment of various diseases are well-known since the prehistoric era. Therapeutic effects of Nigella sativa are thought to be due to nigellone and thymoquinone contents. The reported pharmacological properties include protection against disease and chemical-induced renal and hepatic toxicity, anti-inflammatory, analgesic, antipyretic, anti-microbial and antineoplastic activities. The oil decreases blood pressure, cholesterol, triglycerides, and glucose and increases respiration, hemoglobin and packed cell volume. In the traditional system of medicine, black cumin seeds are effective against cough, bronchitis, asthma, chronic headache, migraine, dizziness, chest congestion, dysmenorrheal, obesity, diabetes, paralysis, hemiplegia, back pain, infection, inflammation, rheumatism, hypertension and gastrointestinal problems such as dyspepsia, flatulence, dysentery, and diarrhea. In this review, we will elaborate about this wonder herb having miraculous effects.

Author(s):  
Farzaneh Adiban Fard ◽  
Shahnaz Tork Zahrani ◽  
Alireza Akbarzadeh Bagheban ◽  
Faraz Mojab

2021 ◽  
Vol 14 (2) ◽  
Author(s):  
Shaheen Akhlaq ◽  
Shabnam Anjum Ara ◽  
Mohammad Fazil ◽  
Usama Akram ◽  
Bilal Ahmad ◽  
...  

Background: Nigella sativa L. or black cumin, belong to the family Ranunculaceae, has long been used traditionally, for food purposes and in traditional Unani medicines and is a native of the Arabian Gulf region, East Asia, Africa and Europe. It is a rich medicinal plant in bioactive compounds. Aim of the study: The aim of this review is to develop an overview of black cumin seed in the context of the status traditional Unani medicine ideology with the incorporation of ethno pharmacological uses, chemical compositions, pharmacological activities, safety profile with evidence-based approach. Materials and Methods: Information on Nigella sativa L. was obtained from published materials, including medicinal plants monographs, ancient and modern recorded classical texts, Unani pharmacopoeias and electronic databases such as Pub Med, Web of Science, Science Direct and Google Scholar. Results: Black cumin seed has been used in Unani traditional medical systems throughout history. The presence of thymoquinone is mainly responsible for its most of the medicinal properties. Moreover, the presence of vitamins, myristic acid, proteins, fats, fiber, amino acids and some trace metals are also reported in the seeds particularly used as a nutraceutical. Numerous in vivo and in vitro studies on pharmacological effects of Nigella sativa L. viz. antioxidant, anticancer, immuno-modulatory, antimicrobial, neuroprotective, cardio protective, gastro protective, anti-hypertensive, nephroprotective, hepatoprotective and anti-diabetic properties demonstrated positive effect against diabetes, hypertension, hypercholesterolemia, bronchitis, asthma, rheumatism, back pain, cancer, gastrointestinal disorders, and eczema etc. Conclusion: Contemporary researches on Nigella sativa L. support the views of Unani physicians for its use as a food and medicinal herb. Black cumin-based potential therapeutic agents need to be applied for a variety of diseases and the formulation of accepted functional foods with the aim to promote optimum health and lessen the risk of chronic diseases.


2013 ◽  
Vol 10 (2) ◽  
pp. 385-390 ◽  
Author(s):  
MBR Chowdhury ◽  
T Rahman

Studies were conducted to select and apply the effective low-cost chemotherapeutic and medicinal plants against diseased fish under laboratory and field condition. Thai silver barbs (Barbonymus gonionotus) weighing 20-25 gm were experimentally infected with a virulent bacterial pathogen (Aeromonas hydrophila) and a fungal pathogen (Aphanomyces invadans). Based on the previous studies, four chemotherapeutics, viz., salt + lime, alum, doxycycline and oxytetracycline were selected and applied to observe the therapeutic effects under laboratory and field condition. In the case of medicinal plants, leaves/ bulb / seeds/ rhizome of neem (Azadirachta indica), akand (Calotropis gigantea), garlic (Allium sativum), turmeric (Curcuma longa), shoti (Curcuma zedoaria), Indian sorrel (Oxalis corniculata), guava (Psidum guajava) and kalijira (Nigella sativa) were screened out and applied to the infected fish in laboratory and field condition to determine their efficacies. The antibiotics, both oxytetracycline and doxycycline were found to be very efficient followed by salt + lime and alum. For fungal infection, alum was excellent followed by salt + lime both under laboratory and field condition. Even in the pond trial, alum and salt + lime successfully checked the occurrence of epizootic ulcerative syndrome (EUS) and similar diseases. In the case of medicinal plants, neem and akand together reduced the occurrence bacterial and fungal disease. Garlic was very efficient to check bacterial infection but weak against fungal disease. Turmeric and arrowroot were found to be highly effective against fungal disease but moderately effective against bacterial disease. Field trial revealed that Indian sorrel and guava were highly efficient against bacterial disease but poorly efficient against fungal disease. On the other hand, arrowroot and black cumin were highly efficient against fungal disease but moderately efficient against bacterial disease. The results would be useful to the all concerned for proper health management of cultured fishes.DOI: http://dx.doi.org/10.3329/jbau.v10i2.14932 J. Bangladesh Agril. Univ. 10(2): 385-390, 2012


Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3369
Author(s):  
Magdalena Zielińska ◽  
Katarzyna Dereń ◽  
Ewelina Polak-Szczybyło ◽  
Agnieszka Ewa Stępień

Black cumin (Nigella sativa, NS) is included in the Ranunculaceae family and is classified as a medicinal plant due to very high levels of various bioactive compounds. They determine its therapeutic effects, including anti-inflammatory, anti-allergic, anti-cancer, hypoglycemic, antioxidant, hypotensive, hypolipidemic, and immunomodulating properties. The results of scientific studies indicate a supporting role of black cumin in the treatment of autoimmune diseases, including rheumatoid arthritis, due to the health-promoting properties of its bioactive ingredients. The aim of the current article is to analyze the results of scientific publications on the role of bioactive ingredients contained in black cumin in the treatment of rheumatoid arthritis.


2020 ◽  
Vol 7 (1) ◽  
pp. 1-4
Author(s):  
Abdela Befa Kinki

Black cumin (Nigella sativa L.) is an annual herb of the Ranunculaceae family, which is growing in Mediterranean region and Ethiopia. In Ethiopia the most people are used as household spice preparation and medicinal purpose. In Ethiopia, black cumin varieties are now days released, but there is no as such work on their physiochemical properties avail. This work presents the investigation of the physicochemical properties of the three-black cumin (Nigella sativa L.) verities (Derbera, Dershaye, and Edan). The results of physicochemical properties Derbera is highest in essential oil content (0.7%) and Edane is lowest (0.3%) than other verities and Dershaye is highest in refractive index of essential oil(1.49), refractive index of oleoresin( 1.52%), moisture(8.0%),fat(24.0%),ash(10.45%), protein(20.61%) and lowest in fiber(16.7%) content than other varieties. From this result, Dershaye black cumin Variety, verities show the superior quality in physicochemical properties than the two black cumin verities (Derbera and Edane).


2017 ◽  
Vol 68 (2) ◽  
pp. 331-336
Author(s):  
Gabriela Isopencu ◽  
Mirela Marfa ◽  
Iuliana Jipa ◽  
Marta Stroescu ◽  
Anicuta Stoica Guzun ◽  
...  

Nigella sativa, also known as black cumin, an annual herbaceous plant growing especially in Mediterranean countries, has recently gained considerable interest not only for its use as spice and condiment but also for its healthy properties of the fixed and essential oil and its potential as a biofuel. Nigella sativa seeds fixed oil, due to its high content in linoleic acid followed by oleic and palmitic acid, could be beneficial to human health. The objective of this study is to determine the optimum conditions for the solvent extraction of Nigella sativa seeds fixed oil using a three-level, three-factor Box-Behnken design (BBD) under response surface methodology (RSM). The obtained experimental data, fitted by a second-order polynomial equation were analysed by Pareto analysis of variance (ANOVA). From a total of 10 coefficients of the statistical model only 5 are important. The obtained experimental values agreed with the predicted ones.


2017 ◽  
Vol 6 (9) ◽  
pp. 5474 ◽  
Author(s):  
Basant Mahmoud Morsy ◽  
Ghada Mohamed Safwat ◽  
Doaa Ahmed Hussein ◽  
Reem Mohamed Samy

Nigella sativa (NS), commonly known as black cumin, has been used for medicinal purposes. Traditionally the seeds and its oil are used in several diseases. The greatest part of the remedial properties of this plant is due to the presence of thymoquinone (TQ) which is a major active chemical component of the essential oil. The current study performed to evaluate the effect of Nigella sativa Oil (NSO) extract on the neurotoxic and hepatotoxic potentials from Valproic acid (VPA) administration. Also we summarize recent findings emphasizing the role of main neurotoxic and hepatotoxic markers and oxidative stress in study’s case. Neurotoxicity was induced by VPA at dose of (500 mg/kg b.wt) by gastric intubation daily for 30 day. These rats received NSO extract was given orally at dose of (0.5 ml/kg b.wt) daily for 30 days after VPA administration. The current results revealed that NSO extract treatment ameliorated significantly the elevated levels of the neurotoxic and hepatotoxic biomarkers which elevated as a result to VPA administration. Moreover, NSO extract treatment ameliorated the non-enzymatic antioxidant, brain and liver lipid peroxidation (LPO) and glutathione (GSH) concentration and the enzymatic antioxidant, brain and liver catalase(CAT) activity.


2021 ◽  
Author(s):  
Chandan Sarkar ◽  
Sarmin Jamaddar ◽  
Tawhida Islam ◽  
Milon Mondal ◽  
Muhammad Torequl Islam ◽  
...  

The dietary phytochemical thymoquinone, obtained from the black and angular seeds of Nigella sativa, is a promising monoterpenoid hydrocarbons, which has been receiving massive attention for its therapeutic potential and pharmacological properties.


2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Abebe Birara Dessie ◽  
Tadie Mirie Abate ◽  
Betelhem Tsedalu Adane ◽  
Tiru Tesfa ◽  
Shegaw Getu

Abstract Ethiopia is one of the east African countries which produce and exports various spices to other countries. Black cumin (Nigella sativa L.) is an important stiff annual flowering plant which mainly grows by producers for its seeds. An increasing demand of black cumin seed and oil in local, national and international market for medicinal, consumption and commercial purpose makes the best alternative crop for small holder farmers in Ethiopia. In spite of its importance, not much has been done to improve its production and productivity in Ethiopia. Therefore, this research was designed to examining efficiency variations and factors influencing technical inefficiency levels of producers on black cumin production in northwest Ethiopia. Primary data were collected using a semi-structured questionnaire administered on 188 black cumin producers selected using systematic random sampling technique. Moreover, various data analysis methods such as descriptive statistics and stochastic frontier model were used for analyzing the data. The empirical result obtained by applying maximum likelihood estimate of stochastic frontier model revealed that seed (p < 0.01) labor (p < 0.05), chemical (p < 0.01) and land (p < 0.05) were significant input variables in determining black cumin production. The mean technical efficiency level of black cumin producer was generally low, about 53.1%. The mean value of actual yield, potential yield and yield gap was 3.131, 5.832 and 2.701 quintals, respectively. Moreover, the result of stochastic frontier model together with the inefficiency parameters revealed that market price of black cumin (p < 0.01) and access of extension service (p < 0.1) were significant variables and positively influenced the efficiency levels of black cumin producers. Whereas age of producers (p < 0.05) and distance to farm plot (p < 0.01) negatively influenced the technical efficiency levels of black cumin producers. Therefore, the study recommends that adoption of latest agricultural technologies; development of institutions, agricultural extension services and infrastructure are advisable to improve the efficiency and commercial value of black cumin production.


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