Effects of Olive Oil on Markers of Inflammation and Endothelial Function—A Systematic Review and Meta-Analysis

ObjectivesTo examine the effect of nut consumption on inflammatory biomarkers and endothelial function.DesignA systematic review and meta-analysis.Data sourcesMEDLINE, PubMed, Cumulative Index to Nursing and Allied Health Literature and Cochrane Central Register of Controlled Trials (all years to 13 January 2017).Eligibility criteriaRandomised controlled trials (with a duration of 3 weeks or more) or prospective cohort designs conducted in adults; studies assessing the effect of consumption of tree nuts or peanuts on C-reactive protein (CRP), adiponectin, tumour necrosis factor alpha, interleukin-6, intercellular adhesion molecule 1, vascular cell adhesion protein 1 and flow-mediated dilation (FMD).Data extraction and analysisRelevant data were extracted for summary tables and analyses by two independent researchers. Random effects meta-analyses were conducted to explore weighted mean differences (WMD) in change or final mean values for each outcome.ResultsA total of 32 studies (all randomised controlled trials) were included in the review. The effect of nut consumption on FMD was explored in nine strata from eight studies (involving 652 participants), with consumption of nuts resulting in significant improvements in FMD (WMD: 0.79%(95% CI 0.35 to 1.23)). Nut consumption resulted in small, non-significant differences in CRP (WMD: −0.01 mg/L (95% CI −0.06 to 0.03)) (26 strata from 25 studies), although sensitivity analyses suggest results for CRP may have been influenced by two individual studies. Small, non-significant differences were also found for other biomarkers of inflammation.ConclusionsThis systematic review and meta-analysis of the effects of nut consumption on inflammation and endothelial function found evidence for favourable effects on FMD, a measure of endothelial function. Non-significant changes in other biomarkers indicate a lack of consistent evidence for effects of nut consumption on inflammation. The findings of this analysis suggest a need for more research in this area, with a particular focus on randomised controlled trials.PROSPERO registration numberCRD42016045424.

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Response to commentary on 'zinc supplementation is associated with a reduction in serum markers of inflammation and oxidative stress in adults: A systematic review and meta-analysis of randomized controlled trials'

Cytokine ◽

10.1016/j.cyto.2021.155460 ◽

2021 ◽

Vol 141 ◽

pp. 155460

Author(s):

Razieh Hosseini ◽

Gordon A. Ferns ◽

Amirhossein Sahebkar ◽

Mohammad Ali Mirshekar ◽

Mohammad Jalali

Keyword(s):

Oxidative Stress ◽

Systematic Review ◽

Randomized Controlled Trials ◽

Zinc Supplementation ◽

Meta Analysis ◽

Serum Markers ◽

Controlled Trials ◽

Randomized Controlled ◽

Markers Of Inflammation ◽

And Oxidative Stress

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Effect of exercise training on endothelial function in heart failure patients: A systematic review meta-analysis

International Journal of Cardiology ◽

10.1016/j.ijcard.2016.12.145 ◽

2017 ◽

Vol 231 ◽

pp. 234-243 ◽

Cited By ~ 32

Author(s):

M.J. Pearson ◽

N.A. Smart

Keyword(s):

Heart Failure ◽

Systematic Review ◽

Exercise Training ◽

Endothelial Function ◽

Meta Analysis ◽

Heart Failure Patients

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Beneficial effects of dietary supplementation with olive oil, oleic acid, or hydroxytyrosol in metabolic syndrome: systematic review and meta-analysis

Free Radical Biology and Medicine ◽

10.1016/j.freeradbiomed.2021.06.017 ◽

2021 ◽

Author(s):

Rosario Pastor ◽

Cristina Bouzas ◽

Josep A. Tur

Keyword(s):

Systematic Review ◽

Metabolic Syndrome ◽

Oleic Acid ◽

Olive Oil ◽

Meta Analysis ◽

Dietary Supplementation ◽

Beneficial Effects

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Effectiveness of Exercise Training on Male Factor Infertility: A Systematic Review and Network Meta-analysis

Sports Health A Multidisciplinary Approach ◽

10.1177/19417381211055399 ◽

2021 ◽

pp. 194173812110553

Author(s):

Behzad Hajizadeh Maleki ◽

Bakhtyar Tartibian ◽

Mohammad Chehrazi

Keyword(s):

Systematic Review ◽

Resistance Training ◽

Meta Analysis ◽

Reproductive Function ◽

Controlled Trials ◽

Male Factor Infertility ◽

Continuous Training ◽

Male Factor ◽

Male Reproductive Function ◽

Markers Of Inflammation

Context: Mounting evidence from the literature suggests that different types of training interventions can be successful at improving several aspects of male reproductive function in both fertile and infertile populations. Objective: The aim of this study was to evaluate the effectiveness of exercise training on male factor infertility and seminal markers of inflammation. Data Sources: We searched PubMed, CISCOM, Springer, Elsevier Science, Cochrane Central Register of Controlled Trials, Scopus, PEDro, Ovid (Medline, EMBASE, PsycINFO), Sport Discus, Orbis, CINAHL, Web of Science, ProQuest, and the ClinicalTrials.gov registry for randomized controlled trials (RCTs) that analyzed the impacts of selected types of exercise interventions on markers of male reproductive function and reproductive performance. Study Selection: A total of 336 records were identified, of which we included 7 trials reporting on 2641 fertile and infertile men in the systematic review and network meta-analysis. Level of Evidence: Level 1 (because this is a systematic review of RCTs). Data Extraction: The data included the study design, participant characteristics, inclusion and exclusion, intervention characteristics, outcome measures, and the main results of the study. Results: The results of network meta-analysis showed that, compared with a nonintervention control group, the top-ranking interventions for pregnancy rate were for combined aerobic and resistance training (CET) (relative risk [RR] = 27.81), moderate-intensity continuous training (MICT) (RR = 26.67), resistance training (RT) (RR = 12.54), high-intensity continuous training (HICT) (RR = 5.55), and high-intensity interval training (HIIT) (RR = 4.63). While the top-ranking interventions for live birth rate were for MICT (RR = 10.05), RT (RR = 4.92), HIIT (RR = 4.38), CET (RR = 2.20), and HICT (RR = 1.55). Also, with the following order of effectiveness, 5 training strategies were significantly better at improving semen quality parameters (CET > MICT > HICT > RT > HIIT), seminal markers of oxidative stress (CET > MICT > HIIT > HICT > RT), seminal markers of inflammation (CET > MICT > HIIT > RT > HICT), as well as measures of body composition and VO2max (CET > HICT > MICT > HIIT > RT). Conclusion: The review recommends that the intervention with the highest probability of being the best approach out of all available options for improving the male factor infertility was for CET.

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