scholarly journals Evaluation of Laboratory Predictors for In-Hospital Mortality in Infective Endocarditis and Negative Blood Culture Pattern Characteristics

Pathogens ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 551
Author(s):  
Ana-Maria Buburuz ◽  
Antoniu Petris ◽  
Irina Iuliana Costache ◽  
Igor Jelihovschi ◽  
Catalina Arsenescu-Georgescu ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Blood Culture ◽  
Blood Cell ◽  
Hospital Mortality ◽  
Cell Count ◽  
Neutrophil Count ◽  
Hospital Death ◽  
Blood Cell Count ◽  
Positive Groups ◽  
Culture Negative

Objective: This study aimed to identify possible differences between blood culture-negative and blood culture-positive groups of infective endocarditis (IE), and explore the associations between biological parameters and in-hospital mortality. Methods: This was a retrospective study of patients hospitalized for IE between 2007 and 2017. Epidemiological, clinical and paraclinical characteristics, by blood culture-negative and positive groups, were collected. The best predictors of in-hospital mortality based on the receiver-operating characteristic (ROC) analysis and AUC (area under the curve) results were identified. Results: A total of 126 IE patients were included, 54% with negative blood cultures at admission. Overall, the in-hospital mortality was 28.6%, higher in the blood culture-negative than positive group (17.5% vs. 11.1%, p = 0.207). A significant increase in the Model for End-Stage Liver Disease Excluding International Normalized Ratio (MELD-XI) score was observed in the blood culture-negative group (p = 0.004), but no baseline characteristics differed between the groups. The best laboratory predictors of in-hospital death in the total study group were the neutrophil count (AUC = 0.824), white blood cell count (AUC = 0.724) and MELD-XI score (AUC = 0.700). Conclusion: Classic laboratory parameters, such as the white blood cell count and neutrophil count, were associated with in-hospital mortality in infective endocarditis. In addition, MELD-XI was a good predictor of in-hospital death.

Complete blood cell count risk score as a predictor of in-hospital mortality and morbidity among patients undergoing cardiac surgery with cardiopulmonary bypass

2015 ◽  
Vol 187 ◽  
pp. 60-62 ◽  
Author(s):  
Ana Paula Porto Rödel ◽  
Manuela Borges Sangoi ◽  
Larissa Garcia de Paiva ◽  
Jossana Parcianello ◽  
José Edson Paz da Silva ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Blood Cell ◽  
Hospital Mortality ◽  
Cell Count ◽  
Risk Score ◽  
Complete Blood Cell Count ◽  
Blood Cell Count ◽  
Mortality And Morbidity

Predictive value of white blood cell count on admission for in-hospital mortality in acute stroke patients

2004 ◽  
Vol 107 (1) ◽  
pp. 38-43 ◽  
Author(s):  
Radoslaw Kazmierski ◽  
Przemyslaw Guzik ◽  
Wojciech Ambrosius ◽  
Anna Ciesielska ◽  
Jakub Moskal ◽  
...  
Keyword(s):  
Blood Cell ◽  
Hospital Mortality ◽  
Acute Stroke ◽  
Cell Count ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Predictive Value ◽  
Blood Cell Count ◽  
Stroke Patients

PSII-14 Supplementation of Bacillus Amyloquefaciens on Systemic Immunity of Weaned Pigs Experimentally Infected with a Pathogenic E. coli

2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 168-169
Author(s):  
Cynthia Jinno ◽  
Braden T Wong ◽  
Martina Kluenemann ◽  
Xunde Li ◽  
Yanhong Liu
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Neutrophil Count ◽  
Complete Blood Count ◽  
Control Group ◽  
Blood Cell Count ◽  
Weaned Pigs ◽  
E Coli ◽  
Antibiotic Group ◽  
Wbc Count

Abstract The objective of this experiment was to investigate the effects of dietary supplementation of Bacillus amyloquefaciens on total and differential blood cell count in weaned pigs experimentally infected with a pathogenic E. coli. A total of 50 weaned pigs (7.41 ± 1.35 kg) were individually housed in disease containment rooms and randomly assigned to one of the 5 treatments: sham control (CON-), sham B. amyloquefaciens (BAM-), challenged control (CON+), challenged B. amyloquefaciens (BAM+) and challenged carbadox (CAR+). The experiment lasted 28 days with 7 days’ adaptation and 21 days after the first E. coli inoculation. The doses of F18 E. coli inoculum were 1010 CFU/3 mL oral dose daily for 3 consecutive days. Whole blood samples were collected from all pigs on d -7, and d 0, 7, 14, and 21 post infection (PI) to measure total and differential blood cell count by complete blood count (CBC) analysis. Supplementation of BAM or CAR increased (P < 0.05) either the percentage or the number of lymphocytes on d 0 before E. coli inoculation. E. coli challenge increased (P < 0.05) white blood cell (WBC) count on d 7 and 21 PI, while supplementation of BAM tended (P < 0.10) to have low WBC on d 7 PI and had lower (P < 0.05) WBC on d 21 PI compared with CON+. Pigs in BAM+ also had lower (P < 0.05) neutrophil count on d 14 PI, pigs fed with CAR had lower (P < 0.05) neutrophil count on d 14 and 21 PI, compared with pigs in CON+. No difference was observed in red blood cell profile among all treatments throughout the experiment. In conclusion, pigs fed with B. amyloquefaciens have similar systemic immune response to pigs in antibiotic group and have relatively lower systemic inflammation caused by E. coli compared with control group.

scholarly journals Clinical Characteristics and Prognosis of Patients with COVID-19 Combineded with or without Diabetes, Hypertension or Coronary

2020 ◽  
Author(s):  
Haoxiang Li ◽  
Jianguo Zhang ◽  
Jinhui Zhang ◽  
Ling Yang ◽  
Dong Wang ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Blood Cell ◽  
Cell Count ◽  
Chronic Diseases ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Neutrophil Count ◽  
Blood Cell Count ◽  
Neutrophil Percentage ◽  
D Dimer

Abstract Bcakground: This study was to investigate the clinical characteristics and prognosis of COVID-19 patients combined with or without major chronic diseases like diabetes, hypertension or coronary. Methods: We retrospectively analyzed 183 patients with COVID-19 diagnosed at First People's Hospital of Jiangxia District (FPHJD) in Wuhan, China attended by Affiliated Hospital of Jiangsu University supporting medical team from February 1, 2020 to March 15, 2020. Patients were divided into simple COVID-19 group(n=134), COVID-19 combined with diabetes, hypertension or coronary group(n=49). Besides, COVID-19 patients with diabetes, hypertension or coronary were further classified into severe pneumonia group(n=23) and common pneumonia group(n=26), death group(n=17) and survival group(n=32). The prognosis of COVID-19 patients was evaluated by analyzing the clinical data and the results of laboratory tests. Results: 183 patients were included in this study, of whom 166 were discharged and 16 died in hospital. 49 (26.92%) patients had a comorbidity, with hypertension being the most common [37 (20.33%) patients], followed by diabetes [25 (13.74%) patients] and coronary heart disease [4 (2.2%) patients]. Compared with simple COVID-19 group, the proportion of history of chronic respiratory system disease, age, D-dimer, procalcitonin, C-reactive protein, myoglobin, cardiac troponin I, creatine kinase MB, lactate dehydrogenase, white blood cell count, neutrophil count, neutrophil percentage, blood urea nitrogen, creatinine and mortality rate were significantly higher in COVID-19 combined with chronic diseases group, whereas lymphocyte count, lymphocyte percentage and alanine transferase were significantly lower in COVID-19 combined with chronic diseases group. Among COVID-19 patients with chronic diseases, D-dimer, procalcitonin, C-reactive protein, myoglobin, cardiac troponin I, lactate dehydrogenase, white blood cell count, neutrophil count, neutrophil percentage, blood urea nitrogen, death rate was significantly higher in severe pneumonia group than common pneumonia group. While lymphocyte count and lymphocyte percentage were significantly lower in severe pneumonia group than common pneumonia group. Besides, we found that the proportion of history of chronic respiratory system disease, D-dimer, procalcitonin, myoglobin, cardiac troponin I, creatine kinase MB, lactate dehydrogenase, neutrophil count, neutrophil percentage, blood urea nitrogen were significantly higher in death group compared with survival group, whereas lymphocyte count and lymphocyte percentage were significantly lower in survival group. In COVID-19 combined with chronic diseases group, univariate logistic regression showed that the risk for severe pneumonia were D-dimer, C-reactive protein, lactate dehydrogenase, white blood cell count, neutrophil count and neutrophil percentage. Univariate logistic regression also showed that the risk for death were D-dimer, lactate dehydrogenase, white blood cell count, neutrophil count, neutrophil percentage and blood urea nitrogen. Multivariate regression logistic showed that lactate dehydrogenase were independent risk factors for death among COVID-19 patients combined with chronic diseases. Cox regression analysis showed that compared with simple COVID-19 group, the RR(95% CI) in COVID-19 patients combined with diabetes, hypertension, and coronary were 2.187 (1.141~4.191) for death (P<0.05). Conclusion: Among COVID-19 patients combined with diabetes, hypertension or coronary, the risk factors for severe pneumonia were D-dimer, C-reactive protein, lactate dehydrogenase, white blood cell count, neutrophil count and neutrophil percentage, whereas the risk factors for death were D-dimer, lactate dehydrogenase, white blood cell count, neutrophil count, neutrophil percentage and blood urea nitrogen. Moreover, lactate dehydrogenase were independent risk factors for death. The mortality rate of COVID-19 patients combined with diabetes, hypertension or coronary was higher than that of simple COVID-19 patients.

Successful Treatment of Refractory Idiopathic Aplastic Anemia with Rituximab

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 4114-4114
Author(s):  
Sreedhar Katragadda ◽  
John C Nelson
Keyword(s):  
Bone Marrow ◽  
Platelet Count ◽  
Blood Cell ◽  
Aplastic Anemia ◽  
Cell Count ◽  
Absolute Neutrophil Count ◽  
Neutrophil Count ◽  
Red Blood Cell ◽  
Antithymocyte Globulin ◽  
Blood Cell Count

Abstract We report the first case of refractory idiopathic aplastic anemia who responded to Rituximab (anti-CD 20 monoclonal antibody). The patient is a 22 year old Hispanic male construction worker who presented with a two week history of weakness, dyspnea on exertion and gum bleeding was found to have a platelet count of 11 × 109/L, hemoglobin of 7.4 g/dL, and white blood cell count of 1.6 × 109/L with 30% neutrophils. A bone marrow biopsy showed hypocellular marrow with relative lymphocytosis of mixed B and T cells and a normal chromosome analysis. A paroxysmal nocturnal hemoglobinuria (PNH) panel was negative. Serological studies did not show any evidence of HBV, HCV, CMV or EBV infection, but did show previous infection with parvo B19. He was initially treated with horse antithymocyte globulin (ATG) at a dose of 40 mg/kg for four days and cyclosporine. After ten weeks of treatment he was still requiring weekly packed red blood cell and platelet transfusions and G-CSF support. At that time he was treated with rabbit antithymocyte globulin and cyclosporine was continued. He had a partial recovery with absolute neutrophil count remaining mostly above 1 × 109/L, but he was still requiring red blood cell and platelet transfusions with baseline hemoglobin of 6 gm/dL and platelet count of less than 20 × 109/L. A bone marrow biopsy done ten weeks after the rabbit ATG treatment showed hypocellular marrow (20% cellularity) with trilineage hematopoiesis, with no evidence of dysplasia. Due to his transfusion dependence after eight months from his rabbit ATG treatment, he received Rituximab at a dose of 375 mg/m2 weekly for four weeks. He had a dramatic improvement of hemoglobin to 11.5 gm/dL and white blood cell count to 3.5 × 109/L, with an absolute neutrophil count of 2 × 109/L, although his platelet count remained at 20 × 109/L. He remains transfusion independent for a follow-up period of 8 months after the Rituximab treatment. Review of literature showed partial to good responses with Rituximab in aplastic anemia patient who refused treatment with ATG and cyclosporine (Hansen PB et al), aplastic anemia associated with CLL (Bharwani L et al), severe aplastic anemia induced by fludarabine and cyclophosphamide in a patient with B-CLL (Castiglioni MG et al) and, refractory Diamond-Blackfan anemia (Morimoto A et al).

scholarly journals Factors Affecting Mortality in Patients with Blood-Culture Negative Infective Endocarditis

2020 ◽  
Vol 29 (01) ◽  
pp. 012-018
Author(s):  
Lira Firiana ◽  
Bambang Budi Siswanto ◽  
Emir Yonas ◽  
Radityo Prakoso ◽  
Raymond Pranata
Keyword(s):  
Heart Failure ◽  
Infective Endocarditis ◽  
Blood Culture ◽  
Risk Stratification ◽  
Hospital Mortality ◽  
Kidney Function ◽  
Functional Class ◽  
Class Iii ◽  
Nyha Functional Class ◽  
Culture Negative

AbstractInfective endocarditis retains high morbidity and mortality rates despite recent advances in diagnostics, pharmacotherapy, and surgical intervention. Risk stratification in endocarditis patients, including blood-culture negative endocarditis, is crucial in deciding the optimal management strategy; however, the studies investigating risk stratification in these patients were lacking despite the difference with blood-culture positive endocarditis. The aim of this study is to identify risk factors associated with in-hospital mortality in blood-culture negative infective endocarditis patients. A retrospective cohort study was conducted at National Cardiovascular Center Harapan Kita, Jakarta in blood-culture negative infective endocarditis patients from 2013 to 2015. Patient characteristics, clinical parameters, echocardiographic parameters, and clinical complications were collected from medical records and hospital information systems. There were 146 patients that satisfy the inclusion and exclusion criteria out of 162 patients with blood-culture infective endocarditis. The in-hospital mortality rate was 13.5%. On bivariate analyses, factors that were related to in-hospital mortality include New York Heart Association (NYHA) class III and IV heart failure (p = 0.007), history of hypertension (p = 0.021), stroke during hospitalization (p < 0.001), the decline in renal function (p < 0.001), and surgery (p = 0.028). Variables that were independently associated with mortality upon multivariate analysis were heart failure NYHA functional class III and IV (OR 7.56, p = 0.011), worsening kidney function (OR 10.23, p < 0.001), and stroke during hospitalization (OR 8.92, p = 0.001). Presence of heart failure with NYHA functional class III and IV, worsening kidney function, and stroke during hospitalization were independently associated with in-hospital mortality in blood-culture infective endocarditis patients.

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