scholarly journals The Oryx Antelope (Oryx gazella): An Unexpected Host for Porcine Circovirus-2 (PCV-2)

Pathogens ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1402
Author(s):  
Umberto Molini ◽  
Lauren Michelle Coetzee ◽  
Maria Yvonne Hemberger ◽  
Siegfried Khaiseb ◽  
Giovanni Cattoli ◽  
...  
Keyword(s):  
Control Measure ◽  
Porcine Circovirus ◽  
Effective Control ◽  
Economic Losses ◽  
Swine Industry ◽  
Animal Populations ◽  
New Variant ◽  
Two Samples ◽  
Porcine Circovirus 2 ◽  
The Impact

For several years after its discovery, Porcine circovirus 2 (PCV-2) represented a major threat to the swine industry through economic losses due to the associated clinical syndromes, decreased production performances in both symptomatic and asymptomatic animals and disease management costs. Widespread vaccination administration has largely reduced the impact of this infection and represents the most effective control measure. The efficacy of vaccination is threatened by the emergence of novel (or uncommon) PCV-2 genotypes. In addition to domestic pigs, PCV-2 has been detected in several other species, a fact which could have an impact on new variant emergence and maintenance. Considering this, the present study assessed the distribution of the minor PCV-2c genotype in non-Suidae ungulates in Namibia. Red hartebeests (Alcelaphus buselaphus caama) (n = 44), kudus (Tragelaphus strepsiceros) (n = 10) and oryxes (Oryx gazella) (n = 54), whose mediastinal lymph nodes were sampled after slaughtering during the period 2019–2021, were included in the study. Two oryxes (3.7%; 95% CI = 0.45–12.75%) were PCV-2-positive by PCR. Complete genome sequence was obtained for the two samples identifying them as PCV-2c genotype. The sequences were identical and shared a high percentage of identity (~99.9%) with those recently obtained from warthogs living in the same area. The present study confirms the presence of the PCV-2c genotype (previously considered extinct) in Namibian wild animal populations and demonstrates greater than expected PCV-2 host plasticity. Because of the role these niches can have in the maintenance and evolution of minor PCV-2 genotypes, more extensive and dedicated studies should be performed to prepare authorities to promptly react to potential emerging threats from these viruses.

Characterizing the effectiveness of COVID-19 mitigation measures: A data-centric approach (Preprint)

2020 ◽  
Author(s):  
Lukman Olagoke ◽  
Ahmet E. Topcu
Keyword(s):  
Control Measure ◽  
Control Measures ◽  
World Health ◽  
Mitigation Measures ◽  
Effective Control ◽  
The World ◽  
Decision Making Processes ◽  
And Performance ◽  
Health Organization ◽  
The Impact

BACKGROUND COVID-19 represents a serious threat to both national health and economic systems. To curb this pandemic, the World Health Organization (WHO) issued a series of COVID-19 public safety guidelines. Different countries around the world initiated different measures in line with the WHO guidelines to mitigate and investigate the spread of COVID-19 in their territories. OBJECTIVE The aim of this paper is to quantitatively evaluate the effectiveness of these control measures using a data-centric approach. METHODS We begin with a simple text analysis of coronavirus-related articles and show that reports on similar outbreaks in the past strongly proposed similar control measures. This reaffirms the fact that these control measures are in order. Subsequently, we propose a simple performance statistic that quantifies general performance and performance under the different measures that were initiated. A density based clustering of based on performance statistic was carried out to group countries based on performance. RESULTS The performance statistic helps evaluate quantitatively the impact of COVID-19 control measures. Countries tend show variability in performance under different control measures. The performance statistic has negative correlation with cases of death which is a useful characteristics for COVID-19 control measure performance analysis. A web-based time-line visualization that enables comparison of performances and cases across continents and subregions is presented. CONCLUSIONS The performance metric is relevant for the analysis of the impact of COVID-19 control measures. This can help caregivers and policymakers identify effective control measures and reduce cases of death due to COVID-19. The interactive web visualizer provides easily digested and quick feedback to augment decision-making processes in the COVID-19 response measures evaluation. CLINICALTRIAL Not Applicable

scholarly journals Generation of PCV2 in PK15 cells transfected with recombinant baculovirus containing a 1.1 copy of the PCV2 genome

2017 ◽  
Vol 65 (2) ◽  
pp. 278-290 ◽  
Author(s):  
Jie Cai ◽  
Xiaohong Xie ◽  
Yi Hu ◽  
Yang Zhan ◽  
Wanting Yu ◽  
...  
Keyword(s):  
Genomic Dna ◽  
Recombinant Baculovirus ◽  
Porcine Circovirus ◽  
Economic Losses ◽  
Loop Structure ◽  
Swine Industry ◽  
Stem Loop ◽  
Stem Loop Structure ◽  
Pcv2 Replication ◽  
Pcv2 Genome

Porcine circovirus associated diseases (PCVAD) caused by PCV2 are responsible for severe economic losses in the swine industry. The mechanism of PCV2 replication has not been fully elucidated yet. PCV2 may be successfully rescued by means of either an infectious DNA clone containing the full length of the viral genomic DNA, or from PCV2-infected clinical tissues in PK15 cell culture. However, viruses harvested by both methods have low titres. In this study, PCV2 was prepared with a higher titre from PK15 cells infected by recombinant baculoviruses containing 1PCV2 (one stem-loop structure) or 1.1PCV2 (two stem-loop structure) genomic DNA copy. In addition, infectious DNA clones containing two stem-loop structures in either plasmid or baculovirus backbones are capable of generating a higher virus titre than the DNA clones with only one copy of stem-loop structure.

scholarly journals Identifying causes and potential consequences of financial fraud

2019 ◽  
pp. 47-56
Author(s):  
Tetiana Kizyma ◽  
Andrii Kizyma
Keyword(s):  
Social Relations ◽  
Negative Impact ◽  
Research Literature ◽  
Effective Control ◽  
Economic Losses ◽  
Financial Fraud ◽  
Fraud Triangle ◽  
The Individual ◽  
Global Threat ◽  
The Impact

Introduction. The article claims that due to the rapid growth of financial relations, advancement of globalization processes, the impact of IT and the Internet on financial performance, the number of economic crimes in Ukraine has increased recently, especially financial fraud offences. The authors provide evidence that fraudulent schemes have targeted not only public and private finance, but all social relations. Purpose. Therefore, the aim of the paper is to address financial fraud as a global threat and identify its causes and potential consequences. Methods. For addressing the causes and effects of financial fraud, the following general research methods are used: analysis, synthesis, induction, deduction, abstraction and grouping. Results. It should be noted that the problem of financial fraud has not received sufficient attention in domestic research literature and practice. The paper presents the leading causes of financial fraud, which include economic, moral and psychological causes as well as regulatory, infrastructural and organizational ones. Financial fraud has a negative impact on the national economy and the welfare of citizens, and therefore leads to the multimillion losses. In order to identify consequences of financial fraud, a combination two types of evaluating such consequences is suggested: quantitative (involves the calculation of pecuniary damage, economic losses and lost economic profit due to fraud offences, and qualitative (logically explains circumstances of financial fraud, risks of losing corporate reputation, image and investment attractiveness). There are three major reasons why financial fraud occurs, which constitute the so-called fraud triangle: the opportunity to commit fraud; the pressure on the individual or the motivation behind the crime; the ability to rationalize the fraud. Therefore, the most important tasks for state bodies, economic entities and individuals include neutralizing the factors which lead to financial fraud and exercising effective control over the prevention of fraud offences in social and economic areas in general, and in financial area in particular. Discussion. Further studies should focus on a comprehensive analysis of the most common types of financial fraud, which take place in Ukraine. The authors argue that this will lead to establishing a set of policies aimed at reducing this negative phenomenon.

scholarly journals Potential Economic Impact of Laurel Wilt Disease on the Florida Avocado Industry

2010 ◽  
Vol 20 (1) ◽  
pp. 234-238 ◽  
Author(s):  
Edward A. Evans ◽  
Jonathan Crane ◽  
Alan Hodges ◽  
Jason L. Osborne
Keyword(s):  
Regional Economy ◽  
Impact Analysis ◽  
Control Measure ◽  
Wilt Disease ◽  
Persea Americana ◽  
Economic Losses ◽  
Laurel Wilt ◽  
Raffaelea Lauricola ◽  
Laurel Wilt Disease ◽  
The Impact

This article describes and provides preliminary estimates of the potential economic losses that could result from an incursion of the recently discovered exotic laurel wilt disease caused by Raffaelea lauricola, in the main avocado (Persea americana) growing area of Florida. Estimates are provided for the direct losses as well as the indirect or “spillover” losses that could occur across the rest of the regional economy. The Impact Analysis for Planning (IMPLAN) input-output multipliers were used in assessing the regional impacts. The results of the investigation indicate that the direct loss to the industry in terms of lost sales, property damage, and increased management costs could range from $356 million in a do-nothing situation to about $183 million if damage control measure were 50% effective. If increased management costs and decreased property values are ignored, the adverse impact on the regional economy could range from $54 million in a do-nothing situation to $27 million in a case in which the treatments result in only a 50% reduction in avocado production.

scholarly journals Free to Circulate: An Update on the Epidemiological Dynamics of Porcine Circovirus 2 (PCV-2) in Italy Reveals the Role of Local Spreading, Wild Populations, and Foreign Countries

Pathogens ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 221 ◽  
Author(s):  
Giovanni Franzo ◽  
Susanna Tinello ◽  
Laura Grassi ◽  
Claudia Maria Tucciarone ◽  
Matteo Legnardi ◽  
...  
Keyword(s):  
Haplotype Network ◽  
Porcine Circovirus ◽  
Wild Populations ◽  
Swine Industry ◽  
Wild Boars ◽  
Domestic Pigs ◽  
Detection Frequency ◽  
Foreign Countries ◽  
Porcine Circovirus 2 ◽  
Spread Dynamics

Porcine circovirus 2 (PCV-2) is one of the most impactful and widespread pathogens of the modern swine industry. Unlike other DNA viruses, PCV-2 is featured by a remarkable genetic variability, which has led to the emergence and recognition of different genotypes, some of which (PCV-2a, 2b, and 2d) have alternated over time. Currently, PCV-2d is considered the most prevalent genotype, and some evidence of differential virulence and vaccine efficacy have been reported. Despite the potential practical relevance, the data on PCV-2 epidemiology in Italy are quite outdated and do not quantify the actual circulation of this genotype in Italy. In the present study, 82 complete ORF2 sequences were obtained from domestic pigs and wild boars sampled in Northern Italy in the period 2013–2018 and merged with those previously obtained from Italy and other countries. A combination of phylogenetic, haplotype network, and phylodynamic analyses were used to genotype the collected strains and evaluate the temporal trend and the spatial and host spread dynamics. A rising number of PCV-2d detections was observed in domestic pigs, particularly since 2013, reaching a detection frequency comparable to PCV-2b. A similar picture was observed in wild boars, although a lower sequence number was available. Overall, the present study demonstrates the extreme complexity of PCV-2 molecular epidemiology in Italy, the significant spread across different regions, the recurrent introduction from foreign countries, and the frequent occurrence of recombination events. Although a higher viral flux occurred from domestic to wild populations than vice versa, wild boars seem to maintain PCV-2 infection and spread it over relatively long distances.

scholarly journals Field Efficacy of a Combination of Seed Treatment and Foliar Spray against Pest Complex in Green Gram

2021 ◽  
Author(s):  
V.K. Chaudhari ◽  
V.B. Patel ◽  
M.P. Patel ◽  
A.S. Bhanvadiya
Keyword(s):  
Seed Treatment ◽  
Insect Pests ◽  
Control Measure ◽  
Block Design ◽  
Foliar Spray ◽  
Green Gram ◽  
Effective Control ◽  
Economic Losses ◽  
Growth Stages ◽  
Larval Population

Background: Pulses constitute the major source of dietary protein; therefore, it has ability to fulfil required protein recommended dietary allowance for vegetarian population of India. Pulse crop attack more than 200 insect pests and inflicting heavy damages at different growth stages that lead to significant economic losses to the farmers. The studies were conducted on green gram to find out the effective control measure of different crop stages against insect pests complex in green gram. Methods: The field experiment was laid out in a randomized block design and the consist 12 treatments with seed treatment and foliar sprays of insecticides at 50 per cent flowering stages then these treatments were replicated thrice at both years 2017 and 2018. Result: The experiments concluded that the reduction of sucking pests population like thrips, jassid and whitefly and larval population of Maruca vitrata and Helicoverpa armigera was found in seed treated with imidacloprid 48 FS and spray of flubendiamide at 50 per cent flowering stage in green gram with Rs. 10,678 net profit and 1:1.42 cost-benefit ratio.

scholarly journals Seroprevalence of Porcine Circovirus-2 in Domestic Pigs (Sus Scrofa Domestica) in Latvia

2018 ◽  
Vol 72 (5) ◽  
pp. 285-289
Author(s):  
Inga Pigiņka-Vjačeslavova ◽  
Edīte Birģele ◽  
Žanete Šteingolde
Keyword(s):  
Postweaning Multisystemic Wasting Syndrome ◽  
Porcine Circovirus ◽  
Economic Losses ◽  
Housing Conditions ◽  
Domestic Pig ◽  
Wasting Syndrome ◽  
Porcine Circovirus 2 ◽  
Sus Scrofa Domestica ◽  
Different Levels ◽  
Primary Agent

Abstract Porcine circovirus-2 (PCV2) is the primary agent of Postweaning Multisystemic Wasting Syndrome (PMWS), and is associated with Porcine Circovirus Associated Disease, which causes great economic losses in pig breeding. PCV2 infection is distributed worldwide throughout the domestic pig population. There have not been any investigations on the distribution of PCV2 sero-prevalence in the population of pigs in Latvia. However PCV2 is one of main differential infections for many diseases, and therefore it is very variable in clinical presentation of PMWS and other diseases associated with PCV2. The objective of this study was to investigate the seroprevalence of PCV2 in pigs of different-scale farms located in different regions of Latvia. Blood samples of 963 pigs from 58 different-scale farms were examined for the PCV2 antibody from 2006 to 2016. It can be suggested that PCV2 is widespread within the territory of Latvia. Farms with pig number of up to 10 and farms with more than 5000 animals have different levels of biosafety, housing conditions and herd management. Nevertheless, the study showed that the number of PCV2-seropositive animals is similar in all farms (from 70.0% to 79.7%).

scholarly journals Genetic Diversity and Prevalence of Porcine Circovirus Type 2 in China During 2000-2019

2021 ◽  
Vol 8 ◽  
Author(s):  
Ning Li ◽  
Jing Liu ◽  
Jiali Qi ◽  
Feng Hao ◽  
Lei Xu ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Wide Distribution ◽  
Porcine Circovirus Type ◽  
Porcine Circovirus Type 2 ◽  
Amino Acid Sequences ◽  
Porcine Circovirus ◽  
Economic Losses ◽  
Swine Industry ◽  
Emerging Virus

As the major pathogen for porcine circovirus-associated disease (PCVAD), porcine circovirus type 2 (PCV2) is no longer treated as an emerging virus anymore. The wide distribution of PCV2 infection in China causes huge economic losses in the swine industry. Currently, it is generally believed that PCV2 has eight genotypes (PCV2a to PCV2h), with PCV2a, PCV2b, and PCV2d being widely distributed. To comprehensively explore the genetic diversity and prevalence of PCV2 in China, PCV-2 sequences submitted from China in the GenBank database were retrieved. With a total of 714 PCV2 strains were retrieved, we found that early-submitted PCV2 sequences were mainly collected from coastal provinces in the southeast part of China, which may indicate PCV2 was initially circulating in those regions. From 2002 to 2008, PCV2b was the dominant prevalent genotype in those retrieved sequences. From 2009, PCV2d became the dominant genotype in those sequences, dropping a hint that a potential shift of PCV2b to PCV2d might occur in 2009, which is similar to the patterns at the global level. In addition to the PCV2a, PCV2b, and PCV2d genotypes, novel strains were also characterized. We further revealed that the amino acid sequences consistency of PCV2a Cap is higher than those in other genotypes. Together, this study provided clues for the possible prevalent genotypes and dynamics of genetic diversity in China from 2000 to 2019.

scholarly journals A Slaughterhouse Survey for Porcine Circovirus Type 2 in Commercial Pigs in Ibadan, Southwest Nigeria

2018 ◽  
Vol 62 (2) ◽  
pp. 30-34 ◽  
Author(s):  
C. O. Aiki-Raji ◽  
A. I. Adebiyi ◽  
D. O. Oluwayelu
Keyword(s):  
Control Strategies ◽  
Porcine Circovirus Type ◽  
Porcine Circovirus Type 2 ◽  
Porcine Circovirus ◽  
Economic Losses ◽  
Carrier Status ◽  
Swine Industry ◽  
Southwest Nigeria ◽  
Swine Disease

Abstract Porcine circovirus type 2 (PCV2) is recognized as one of the most important agents of reproductive disorders in gilts and sows worldwide. It is associated with considerable economic losses in the swine industry due to the unthriftiness, and variable morbidity and mortality it causes in pigs. In spite of the devastation caused by this virus to the global pig industry, there is little or no report of its occurrence in Nigeria. Hence, a slaughterhouse based survey was conducted to determine the prevalence of PCV2 infections in pigs in Ibadan, southwest Nigeria. Using a commercial ELISA kit, 364 pig sera collected from a major abattoir were screened for IgG antibodies against PCV2. The overall prevalence of anti-PCV2 antibodies in the pigs was 1.4 % (5/364), with more female pigs (4/237, 1.7 %) being seropositive than males (1/127, 0.8 %). Since there is no routine vaccination against this swine disease in Nigeria, thus the antibodies detected in the pig sera indicated a natural exposure to the virus. The absence of clinical disease in the pigs also suggests the possibility of a carrier status for these animals and shows that they could serve as hosts for the perpetuation of the disease. These findings underscore the need for continuous surveillance for PCV2 among pigs in Nigeria in order to determine its contribution to production losses incurred in the Nigerian swine industry and aid the development of prevention and control strategies against the disease.

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