scholarly journals Inulin and Its Application in Drug Delivery

2021 ◽  
Vol 14 (9) ◽  
pp. 855
Author(s):  
Franklin Afinjuomo ◽  
Sadikalmahdi Abdella ◽  
Souha H. Youssef ◽  
Yunmei Song ◽  
Sanjay Garg
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Flexible Structure ◽  
Hydroxyl Groups ◽  
Protective Effects ◽  
Drug Delivery Carrier ◽  
Targeting Ability ◽  
Organ Targeting ◽  
Structure Stabilization

Inulin’s unique and flexible structure, stabilization/protective effects, and organ targeting ability make it an excellent drug delivery carrier compared to other biodegradable polysaccharides. The three hydroxyl groups attached to each fructose unit serve as an anchor for chemical modification. This, in turn, helps in increasing bioavailability, improving cellular uptake, and achieving targeted, sustained, and controlled release of drugs and biomolecules. This review focuses on the various types of inulin drug delivery systems such as hydrogel, conjugates, nanoparticles, microparticles, micelles, liposomes, complexes, prodrugs, and solid dispersion. The preparation and applications of the different inulin drug delivery systems are further discussed. This work highlights the fact that modification of inulin allows the use of this polymer as multifunctional scaffolds for different drug delivery systems.

scholarly journals Application of fibrin in drug technology: Achievements and perspectives

2020 ◽  
Vol 74 ◽  
pp. 322-330
Author(s):  
Jakub Rech ◽  
Justyna Wilińska ◽  
Aleksandra Borecka ◽  
Artur Turek
Keyword(s):  
Drug Delivery ◽  
Water Absorption ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Body ◽  
Solution Casting ◽  
Drug Delivery Carrier ◽  
Drug Substances ◽  
Drug Technology ◽  
Treatment Of Wounds

In recent years, fibrin has been successfully used as a polymer drug delivery carrier. Passive properties of fibrin provide parenteral and local delivery of drug substances in controlled and prolonged manner and also tissue support, gluing and sealing. Fibrin also has hemostatic and proangiogenic effects. Discs, films, gels, beads and nanoparticles are among the most commonly proposed and used fibrin-based formulations. It is routinely obtained from fibrinogen and thrombin. Fibrin formulation methods are solution casting, dual syringe systems and emulsification. All fibrin formulations become gel after administration and water absorption. Biodegradation and biocompatibility are important advantages of fibrin, which make it possible to implant a formulation without the need to remove the carrier from the body after the drug is released. Fibrin-based drug delivery systems are proposed and applied in the treatment of wounds, infections and cancerous diseases.

scholarly journals A comprehensive review on polymeric micelles: a promising drug delivery carrier

2021 ◽  
Vol 10 (3) ◽  
pp. 102-107
Author(s):  
Ajay Kumar
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Polymeric Micelles ◽  
Delivery Systems ◽  
Hydrophobic Drug ◽  
Drug Release Profile ◽  
Physiological Conditions ◽  
Drug Molecules ◽  
Drug Delivery Carrier

The main aim of drug delivery systems is to regulate the rate of drug release as per the patient's physiological conditions as well as the progression of the illness or as per the circadian rhythms. To achieve such objectives, the new drug delivery systems have been developed to provide the drug release profile, which is based on each patient's needs. Different researches have been done to create drug delivery carriers, focusing on targeting and delivering hydrophobic drug molecules. This review focuses on Polymeric Micelles as the promising drug delivery carrier due to its high stability, protective property against the harsh gastrointestinal environment.

Surface modification of graphene and its derivatives for drug delivery systems

2020 ◽  
Vol 17 ◽  
Author(s):  
Zahra Akbari Jonoush ◽  
Masoumeh Farahani ◽  
Mahboubeh Bohlouli ◽  
Zahra Niknam ◽  
Ali Golchin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Surface Modification ◽  
Drug Delivery Systems ◽  
Water Solubility ◽  
Delivery Systems ◽  
Bioactive Molecules ◽  
Future Perspective ◽  
Hydroxyl Groups ◽  
Graphene Derivatives ◽  
Oxygen Groups

: Nowadays, carbon-based nanostructure materials are regarded as promising carriers for drug delivery to improve the effective treatment of diseases. The formation of covalent and non-covalent molecular bonds can be used for surface modification of nano-carriers in order to manipulate their toxicity, water solubility, and cellular internalization. Graphene and its derivatives have shown important potential in drug delivery systems. Among different graphene derivatives, graphene oxide (GO) is the most extensively used derivative. GO sheets have possess certain oxygen functional groups including carboxylic acid groups at the edges, epoxy and hydroxyl groups on the basal planes. The oxygen groups on the surface of GO sheets enhance their capabilities for functionalization them with chemical and bioactive molecules. In this review, we highlight the recent researches about the effect of reactive sites on the surface of GO and its derivatives in drug delivery systems. Therefore, the application of GO and its derivatives have been discussed as a delivery system in cancer treatment, gene therapy, and combination therapy, followed by discussions on their related issues. Finally, the review will provide a future perspective to the applications of GO based materials as part of drug delivery systems, and may open up new viewpoints to motivate broader interests across these interdisciplinary fields.

scholarly journals A Review on Drug Delivery System for Tumor Therapy

2021 ◽  
Vol 12 ◽  
Author(s):  
Guoxiang Liu ◽  
Lina Yang ◽  
Guang Chen ◽  
Fenghua Xu ◽  
Fanghao Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
High Efficiency ◽  
Tumor Therapy ◽  
Delivery Systems ◽  
Antitumor Drugs ◽  
Drug Nanoparticles ◽  
Cancer Nanomedicine ◽  
Targeting Ability ◽  
Personalized Cancer

In recent years, with the development of nanomaterials, the research of drug delivery systems has become a new field of cancer therapy. Compared with conventional antitumor drugs, drug delivery systems such as drug nanoparticles (NPs) are expected to have more advantages in antineoplastic effects, including easy preparation, high efficiency, low toxicity, especially active tumor-targeting ability. Drug delivery systems are usually composed of delivery carriers, antitumor drugs, and even target molecules. At present, there are few comprehensive reports on a summary of drug delivery systems applied for tumor therapy. This review introduces the preparation, characteristics, and applications of several common delivery carriers and expounds the antitumor mechanism of different antitumor drugs in delivery carriers in detail which provides a more theoretical basis for clinical application of personalized cancer nanomedicine in the future.

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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