scholarly journals Recent Developments in the Synthesis of β-Diketones

2021 ◽  
Vol 14 (10) ◽  
pp. 1043
Author(s):  
Gonzalo de Gonzalo ◽  
Andrés R. Alcántara
Keyword(s):  
Chemical Synthesis ◽  
Neurological Disorders ◽  
Liver Diseases ◽  
Skin Diseases ◽  
Pharmaceutically Active Compounds ◽  
Huge Number ◽  
Decarboxylative Coupling ◽  
Recent Developments ◽  
Enol Tautomer ◽  
Valuable Compounds

Apart from being one of the most important intermediates in chemical synthesis, broadly used in the formation of C–C bonds among other processes, the β-dicarbonyl structure is present in a huge number of biologically and pharmaceutically active compounds. In fact, mainly derived from the well-known antioxidant capability associated with the corresponding enol tautomer, β-diketones are valuable compounds in the treatment of many pathological disorders, such as cardiovascular and liver diseases, hypertension, obesity, diabetes, neurological disorders, inflammation, skin diseases, fibrosis, or arthritis; therefore, the synthesis of these structures is an area of overwhelming interest for organic chemists. This paper is devoted to the advances achieved in the last ten years for the preparation of 1,3-diketones, using different chemical (Claisen, hydration of alkynones, decarboxylative coupling) or catalytic (biocatalysis, organocatalytic, metal-based catalysis) methodologies: Additionally, the preparation of branched β-dicarbonyl compounds by means of α-functionalization of non-substituted 1,3-diketones are also discussed.

scholarly journals A Review on Recent Progress of Glycan-Based Surfactant Micelles as Nanoreactor Systems for Chemical Synthesis Applications

2021 ◽  
Vol 2 (1) ◽  
pp. 168-186
Author(s):  
Bahareh Vafakish ◽  
Lee D. Wilson
Keyword(s):  
Chemical Synthesis ◽  
Chemical Reactions ◽  
Recent Progress ◽  
Chemical Species ◽  
Reaction Rates ◽  
Bulk Solution ◽  
Surfactant Micelles ◽  
Conventional Surfactant ◽  
Recent Developments ◽  
To Receive

The nanoreactor concept and its application as a modality to carry out chemical reactions in confined and compartmentalized structures continues to receive increasing attention. Micelle-based nanoreactors derived from various classes of surfactant demonstrate outstanding potential for chemical synthesis. Polysaccharide (glycan-based) surfactants are an emerging class of biodegradable, non-toxic, and sustainable alternatives over conventional surfactant systems. The unique structure of glycan-based surfactants and their micellar structures provide a nanoenvironment that differs from that of the bulk solution, and supported by chemical reactions with uniquely different reaction rates and mechanisms. In this review, the aggregation of glycan-based surfactants to afford micelles and their utility for the synthesis of selected classes of reactions by the nanoreactor technique is discussed. Glycan-based surfactants are ecofriendly and promising surfactants over conventional synthetic analogues. This contribution aims to highlight recent developments in the field of glycan-based surfactants that are relevant to nanoreactors, along with future opportunities for research. In turn, coverage of research for glycan-based surfactants in nanoreactor assemblies with tailored volume and functionality is anticipated to motivate advanced research for the synthesis of diverse chemical species.

scholarly journals Cell-Based Regeneration and Treatment of Liver Diseases

2021 ◽  
Vol 22 (19) ◽  
pp. 10276
Author(s):  
Julia Hofmann ◽  
Verena Hackl ◽  
Hannah Esser ◽  
Andras T. Meszaros ◽  
Margot Fodor ◽  
...  
Keyword(s):  
Liver Diseases ◽  
Ex Vivo ◽  
Organ Shortage ◽  
Clinical Implementation ◽  
Organ Function ◽  
Novel Technologies ◽  
Recent Developments ◽  
Underlying Mechanisms ◽  
The Moment ◽  
End Stage

The liver, in combination with a functional biliary system, is responsible for maintaining a great number of vital body functions. However, acute and chronic liver diseases may lead to irreversible liver damage and, ultimately, liver failure. At the moment, the best curative option for patients suffering from end-stage liver disease is liver transplantation. However, the number of donor livers required by far surpasses the supply, leading to a significant organ shortage. Cellular therapies play an increasing role in the restoration of organ function and can be integrated into organ transplantation protocols. Different types and sources of stem cells are considered for this purpose, but highly specific immune cells are also the focus of attention when developing individualized therapies. In-depth knowledge of the underlying mechanisms governing cell differentiation and engraftment is crucial for clinical implementation. Additionally, novel technologies such as ex vivo machine perfusion and recent developments in tissue engineering may hold promising potential for the implementation of cell-based therapies to restore proper organ function.

scholarly journals Multiparametric MR mapping in clinical decision-making for diffuse liver disease

2020 ◽  
Vol 45 (11) ◽  
pp. 3507-3522 ◽  
Author(s):  
Helena B. Thomaides-Brears ◽  
Rita Lepe ◽  
Rajarshi Banerjee ◽  
Carlos Duncker
Keyword(s):  
Liver Disease ◽  
Liver Diseases ◽  
Clinical Decision Making ◽  
Clinical Care ◽  
Clinical Decision ◽  
Chronic Liver ◽  
Diffuse Liver Disease ◽  
Treatment Pathway ◽  
Recent Developments ◽  
Potential Applications

Abstract Accurate diagnosis, monitoring and treatment decisions in patients with chronic liver disease currently rely on biopsy as the diagnostic gold standard, and this has constrained early detection and management of diseases that are both varied and can be concurrent. Recent developments in multiparametric magnetic resonance imaging (mpMRI) suggest real potential to bridge the diagnostic gap between non-specific blood-based biomarkers and invasive and variable histological diagnosis. This has implications for the clinical care and treatment pathway in a number of chronic liver diseases, such as haemochromatosis, steatohepatitis and autoimmune or viral hepatitis. Here we review the relevant MRI techniques in clinical use and their limitations and describe recent potential applications in various liver diseases. We exemplify case studies that highlight how these techniques can improve clinical practice. These techniques could allow clinicians to increase their arsenals available to utilise on patients and direct appropriate treatments.

scholarly journals Recent developments in the field of vascular liver diseases

2020 ◽  
Vol 40 (S1) ◽  
pp. 142-148
Author(s):  
Dominique C. Valla
Keyword(s):  
Liver Diseases ◽  
Recent Developments

scholarly journals Recent developments in the chemical synthesis of polynucleotides

1982 ◽  
Vol 10 (21) ◽  
pp. 6553-6570 ◽  
Author(s):  
Eiko Ohtsuka ◽  
Morio Ikehara ◽  
Dieter Söll
Keyword(s):  
Chemical Synthesis ◽  
Recent Developments

Corticotrophin Releasing Hormone: Chemistry and Recent Developments

2004 ◽  
Vol 57 (5) ◽  
pp. 393 ◽  
Author(s):  
James Garner ◽  
Paul A. Keller ◽  
Adam McCluskey
Keyword(s):  
Neurological Disorders ◽  
Biological Clock ◽  
The Body ◽  
Exciting Field ◽  
Releasing Hormone ◽  
The Past ◽  
Corticotrophin Releasing Factor ◽  
Recent Developments ◽  
Fight Or Flight Response ◽  
The Brain

Corticotrophin Releasing Hormone [CRH; also known as Corticotrophin Releasing Factor (CRF)], a 41-amino-acid hormone, is one of the body’ major modulators of the stress response. CRH coordinates the endocrine, autonomic, and behavioural responses to stress through actions in both the brain and the periphery activating the ‘fight or flight’ response. CRH is also implicated in various neurological disorders including Alzheimer’s, Parkinson’s, and anorexia nervosa, and it has been described as a biological clock controlling the length of gestation in humans and other higher-order primates. In the past decade there has been an enormous effort expended in the design and development of new therapeutic agents targetting CRHs in the central nervous and peripheral systems. In this review, we examine the chemistry and recent developments in this exciting field.

scholarly journals Synthesis of Imidazole-Based Medicinal Molecules Utilizing the van Leusen Imidazole Synthesis

2020 ◽  
Vol 13 (3) ◽  
pp. 37 ◽  
Author(s):  
Xunan Zheng ◽  
Zhengning Ma ◽  
Dawei Zhang
Keyword(s):  
Drug Discovery ◽  
Chemical Synthesis ◽  
Small Molecules ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Structural Features ◽  
Pharmaceutical Companies ◽  
Recent Developments ◽  
Van Leusen Reaction

Imidazole and its derivatives are one of the most vital and universal heterocycles in medicinal chemistry. Owing to their special structural features, these compounds exhibit a widespread spectrum of significant pharmacological or biological activities, and are widely researched and applied by pharmaceutical companies for drug discovery. The van Leusen reaction based on tosylmethylisocyanides (TosMICs) is one of the most appropriate strategies to synthetize imidazole-based medicinal molecules, which has been increasingly developed on account of its advantages. In this review, we summarize the recent developments of the chemical synthesis and bioactivity of imidazole-containing medicinal small molecules, utilizing the van Leusen imidazole synthesis from 1977.

scholarly journals Traditional Medicine in Syria: Folk Medicine in Aleppo Governorate

2011 ◽  
Vol 6 (1) ◽  
pp. 1934578X1100600 ◽  
Author(s):  
Amal Alachkar ◽  
Ahmad Jaddouh ◽  
Muhammad Salem Elsheikh ◽  
Anna Rita Bilia ◽  
Franco Francesco Vincieri
Keyword(s):  
Weight Loss ◽  
Liver Diseases ◽  
Scientific Literature ◽  
Skin Diseases ◽  
Folk Medicine ◽  
Gastrointestinal Disorders ◽  
Herbal Preparations ◽  
The North ◽  
Cardiac Disorders ◽  
The City

The use of Traditional Arabic Medicine (TAM) for various diseases has been popular but scarcely studied in Syria. In the present study, we carried out ethnobotanical and ethnopharmacological research on the plants traditionally used to cure various diseases in northern Syria. The information was collected from the city and villages of the Aleppo governorate “Mohaafazah” in the north of Syria, collecting data directly on the basis of a detailed survey of inhabitants and herbalists. In this survey, we found that hundreds of plant species are still in use in TAM for the treatment of various diseases. We selected the most common 100 species, used in the treatment of more than 25 diseases. Among these plants, 53 are used for treating gastrointestinal disorders, 38 for respiratory system diseases, including asthma, bronchitis and cough, 34 for skin diseases, 21 for diabetes, 17 for kidney and urinary disorders, 16 for cardiac disorders, 14 for infertility and sexual impotency, 13 for treating liver diseases, 13 for several types of cancer, 9 for enhancing breast milk excretion, 8 for weight loss, 5 for reducing cholesterol, and three for weight gain. Plants were collected and identified: scientific Latin names, local names, the used parts of the plant, the herbal preparations and the local medical uses are described. Scientific literature concerning the activity of the investigated species is also reported and discussed according to their traditional uses.

scholarly journals Enhanced Liver Fibrosis (ELF) Immunoassay Test for Identification of Significant Liver Diseases: Recent Developments

2015 ◽  
Vol 6 (1) ◽  
pp. 38-41
Author(s):  
Rubayat Sheik Giasuddin ◽  
Mobin Khan ◽  
ASM Giasuddin ◽  
Md Mahmudur Rahman Siddiqui
Keyword(s):  
Clinical Practice ◽  
Liver Disease ◽  
Liver Fibrosis ◽  
Needle Biopsy ◽  
Liver Diseases ◽  
Reference Standard ◽  
Prognostic Tool ◽  
Medical College ◽  
Blood Tests ◽  
Recent Developments

Liver Fibrosis (LF) is a common outcome in chronic liver disease (CLD). Over a period of time, the process results in cirrhosis leading to disruption in functional capacity of liver. Further serious complications may occur including portal hypertension, liver failure and cancer. The magnitude of CLD has increased being recognized as a major cause for morbidity and mortality globally and it is increasing progressively in Bangladesh also. Question arises "Is the transabdominal needle biopsy of liver, the traditional reference standard method, sufficient and efficient enough for detecting and assessing liver fibrosis particularly in the early stages of significant liver disease?" More simpler, convenient and less expensive blood tests such as 'Enhanced Liver Fibrosis (ELF) immunoassay test', Fibrotest and Aspartate transaminase-platelet ratio index (APRI), have been developed and reported for identification of significant CLD and use as prognostic tool in clinical practice. Among them, the ELF test had been found to be statistically the best for diagnosing and predicting clinical outcomes in patients with CLD and may be a useful prognostic tool in clinical practice. This ELF immunoassay test has been briefly reviewed in this article. Short title: ELF immunoassay test for CLDAnwer Khan Modern Medical College Journal Vol. 6, No. 1: January 2015, Pages 38-41

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