scholarly journals 6′-O-Lactose Ester Surfactants as an Innovative Opportunity in the Pharmaceutical Field: From Synthetic Methods to Biological Applications

2021 ◽  
Vol 14 (12) ◽  
pp. 1306
Author(s):  
Michele Verboni ◽  
Simone Lucarini ◽  
Andrea Duranti
Keyword(s):  
Surface Tension ◽  
Food Production ◽  
Synthetic Methods ◽  
Biological Applications ◽  
Potential Applications ◽  
Synthetic Methodologies ◽  
Physicochemical Data ◽  
Synthetic Approaches ◽  
Agriculture And Food ◽  
Emulsifying Ability

Glycolipid surfactants are biocompatible and biodegradable compounds characterized by potential applications in various sectors including pharmaceuticals, cosmetics, agriculture, and food production. A specific overview regarding synthetic methodologies and properties of 6′-lactose-based surfactants is presented herein, particularly all the synthetic approaches to this class of lactose esters, such as enzymatic and traditional organic syntheses. Moreover, detailed descriptions of physicochemical data and biocompatibility properties of these molecules, that is, surface tension, critical micelle concentration, emulsifying ability, foaming, particle size distribution, biocompatibility, and safety, are described. Biological applications with a focus on permeability enhancing, antimicrobial activity, and antibiofilm properties of 6′-lactose-based esters are also reported.

Synthesis of Phosphonates via Michaelis-Arbuzov Reaction

2017 ◽  
Vol 14 (6) ◽  
pp. 883-903 ◽  
Author(s):  
Boppudi Hari Babu ◽  
Gandavaram Syam Prasad ◽  
Chamarthi Naga Raju ◽  
Mandava Venkata Basaveswara Rao
Keyword(s):  
Reaction Times ◽  
Biologically Active ◽  
Fine Tuning ◽  
Arbuzov Reaction ◽  
Reaction Conditions ◽  
Solvent Type ◽  
Potential Applications ◽  
Synthetic Methodologies ◽  
Optimal Reaction ◽  
The Arbuzov Reaction

Background: Michaelis–Arbuzov reaction has played a key role for the synthesis of dialkyl or diaryl phosphonates by reacting various alkyl or aryl halides with trialkyl or triaryl phosphite. This reaction is very versatile in the formation of P-C bond from the reaction of aliphatic halides with phosphinites or phosphites to yield phosphonates, phosphinates, phosphine oxides. The Arbuzov reaction developed some methodologies, possible mechanistic pathways, selectivity, potential applications and biologically active various phosphonates. Objective: The synthesis of phosphonates via Michaelis–Arbuzov reaction with many new and fascinating methodologies were developed and disclosed in the literature, and these are explored in this review. Conclusion: This review has discussed past developments and vast potential applications of Arbuzov reaction in the synthesis of organophosphonates. As presented in this review, various synthetic methodologies were developed to prepare a large variety of phosphonates. Improvements in the reaction conditions of Lewis-acid mediated Arbuzov rearrangement as well as the development of MW-assisted Arbuzov rearrangement were discussed. Finally, to achieve high selectivities and yields, fine-tuning of reaction conditions including solvent type, temperature, and optimal reaction times to be considered.

Diversity-Oriented Synthetic Approaches for Furoindoline: A Review

2019 ◽  
Vol 16 (3) ◽  
pp. 342-368 ◽  
Author(s):  
Ramandeep Kaur ◽  
Yagyesh Kapoor ◽  
Sundeep K. Manjal ◽  
Ravindra K. Rawal ◽  
Kapil Kumar
Keyword(s):  
Rheumatoid Arthritis ◽  
Cancer Cachexia ◽  
Biological Activities ◽  
Ring System ◽  
Synthetic Methods ◽  
Structural Units ◽  
Current Article ◽  
Tetrahydropyranyl Ether ◽  
Synthetic Approaches ◽  
Synthetic Target

The furo [2,3-b] indoline ring system is one of the most important structural units in various natural products. It has been known to have inherent biological activities and is utilized as a synthetic target for a number of natural compounds; therefore, this has contributed to a great demand for the growth of synthetic methods for this ring system. Most important compounds with furoindoline ring system are physovenine, madindoline A and B and makomotindoline etc. These compounds are well known to exhibit biological activity against different diseases such as glaucoma, cancer, cachexia, Castleman’s disease, rheumatoid arthritis, etc. The current article focuses on various synthetic approaches for furoindoline containing compounds and essential furoindoline moiety, such as oxindole-5-O-tetrahydropyranyl ether route etc., and various other diastereoand enantio- controlled approach in a very concise way.

Bubble Electrospinning and Bubble-Spun Nanofibers

2020 ◽  
Vol 14 (1) ◽  
pp. 10-13 ◽  
Author(s):  
Lynn Y. Wan
Keyword(s):  
Surface Tension ◽  
Low Energy ◽  
Efficient Technology ◽  
High Productivity ◽  
Needleless Electrospinning ◽  
Polymeric Nanofibers ◽  
Low Energy Consumption ◽  
Potential Applications ◽  
Surface Morphologies ◽  
Unique Surface

Electrospinning is a highly efficient technology for fabrication of a wide variety of polymeric nanofibers. However, the development of traditional needle-based electrospinning has been hampered by its low productivity and need of tedious work dealing with needles cleaning, installation and uninstallation. As one of the most promising needleless electrospinning means, bubble electrospinning is known for its advantages of high productivity and relatively low energy consumption due to the introduction of a third force, air flow, as a major force overcoming the surface tension. In this paper, the restrictions of conventional electrospinning and the advantages of needleless electrospinning, especially the bubble electrospinning were elaborated. Reports and patents on bubble-spun nanofibers with unique surface morphologies were also reviewed in respect of their potential applications.

scholarly journals A pH-Responsive Foam Formulated with PAA/Gemini 12-2-12 Complexes

2021 ◽  
Vol 5 (3) ◽  
pp. 37
Author(s):  
Hernán Martinelli ◽  
Claudia Domínguez ◽  
Marcos Fernández Leyes ◽  
Sergio Moya ◽  
Hernán Ritacco
Keyword(s):  
Surface Tension ◽  
Dynamic Surface Tension ◽  
Foam Formation ◽  
Ph Responsive ◽  
Dynamic Surface ◽  
X Ray ◽  
Equilibrium Surface Tension ◽  
Potential Applications ◽  
The Stability ◽  
Air Interfaces

In the search for responsive complexes with potential applications in the formulation of smart dispersed systems such as foams, we hypothesized that a pH-responsive system could be formulated with polyacrylic acid (PAA) mixed with a cationic surfactant, Gemini 12-2-12 (G12). We studied PAA-G12 complexes at liquid–air interfaces by equilibrium and dynamic surface tension, surface rheology, and X-ray reflectometry (XRR). We found that complexes adsorb at the interfaces synergistically, lowering the equilibrium surface tension at surfactant concentrations well below the critical micelle concentration (cmc) of the surfactant. We studied the stability of foams formulated with the complexes as a function of pH. The foams respond reversibly to pH changes: at pH 3.5, they are very stable; at pH > 6, the complexes do not form foams at all. The data presented here demonstrate that foam formation and its pH responsiveness are due to interfacial dynamics.

scholarly journals Self-assembly of TiO2/ZIF-8 nanocomposites for varied photocatalytic CO2 reduction with H2O vapor induced by different synthetic methods

2021 ◽  
Author(s):  
Yan-Hong Zou ◽  
Hai-Ning Wang ◽  
Xing Meng ◽  
Hong-Xu Sun ◽  
Zi-Yan Zhou
Keyword(s):  
Self Assembly ◽  
Co2 Reduction ◽  
Synthetic Methods ◽  
Photocatalytic Performances ◽  
Synthetic Approaches

Different synthetic approaches give birth to different structures, which result in varied photocatalytic performances.

Chemical Diversity of Volatile Macrocylic Lactones from Frogs

Synlett ◽  
2021 ◽  
Author(s):  
Stefan Schulz ◽  
Dennis Poth ◽  
Pardha Saradhi Peram ◽  
Susann Hötling ◽  
Markus Menke ◽  
...  
Keyword(s):  
Biosynthetic Pathway ◽  
Chemical Diversity ◽  
Synthetic Methods ◽  
Epoxide Opening ◽  
Scientific Approach ◽  
Long Time ◽  
Fatty Acid Biosynthetic Pathway ◽  
Unsaturated Lactones ◽  
Male Specific ◽  
Synthetic Approaches

AbstractFor a long time, frogs were believed to communicate primarily via the acoustic channel, but during the last decades it became obvious that various lineages also use chemical communication. In this Account we present our research on the identification of volatile lactones from Madagascan Mantellidae and African Hyperoliidae frogs. Both possess male specific glands that can disseminate a range of volatile compounds. Key constituents are macrocyclic lactones. They show high variability in structure and occurrence. We focus here on the synthetic approaches we have used to clarify constitution and configuration of the glandular compounds. Key synthetic methods are ring-closing metathesis and nucleophilic epoxide opening. Often, but not always, the natural compounds occurs in amounts that excludes their investigation by NMR spectroscopy. Instead, we use GC/MS analysis, GC/IR, microreactions, and synthesis to identify such components. Several aspects of our work will be described giving some insight in our scientific approach.1 Introduction2 Macrocylic Lactones from the Fatty Acid Biosynthetic Pathway3 Unsaturated Lactones4 Terpenoid Lactones5 Macrolide Occurrence6 Conclusions

An Update on the Synthesis and Applications of Bis(Naphthoquinones): An Important Class of Molecules against Infectious Diseases and Other Conditions

2021 ◽  
Vol 21 ◽  
Author(s):  
Luana da S. M. Forezi ◽  
Acácio S. de Souza ◽  
Carolina G. S. Lima ◽  
Amanda A. Borges ◽  
Patricia G. Ferreira ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
General Class ◽  
Biological Activities ◽  
Pharmaceutical Market ◽  
Synthetic Methods ◽  
Important Class ◽  
Biological Targets ◽  
Valuable Compounds ◽  
Synthetic Approaches

: Naphthoquinones are important molecules belonging to the general class of quinones, and many of these compounds have become drugs that are in the pharmaceutical market for the treatment of several diseases. A special subclass of compounds is that of the bis(naphthoquinones), which have two linked naphthoquinone units. In the last few years, several synthetic approaches toward such valuable compounds have been described, as well as their evaluation against numerous important biological targets. In this review, we provide a thorough discussion on the various synthetic methods reported for the synthesis of bis(naphthoquinone) analogues, also highlighting the biological activities of these substances.

scholarly journals Synthesis and coordination chemistry of cyclic seleno- and telluroureas

2018 ◽  
Vol 4 (1) ◽  
Author(s):  
Jamie S. Ritch
Keyword(s):  
Coordination Chemistry ◽  
Chemical Reactivity ◽  
Synthetic Methods ◽  
Materials Chemistry ◽  
Carbene Ligands ◽  
Potential Applications ◽  
Derivatives Of

Abstract Chalcogenated derivatives of N-heterocyclic carbene ligands have received increasing attention due to their diverse chemical reactivity and potential applications in fields such as medicine and materials chemistry. This chapter summarizes the synthetic methods for the preparation of cyclic heavy chalcogenoureas featuring heterocyclic cores and explores their diverse coordination chemistry with p- and d-block metals.

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