Diversity-Oriented Synthetic Approaches for Furoindoline: A Review

2019 ◽  
Vol 16 (3) ◽  
pp. 342-368 ◽  
Author(s):  
Ramandeep Kaur ◽  
Yagyesh Kapoor ◽  
Sundeep K. Manjal ◽  
Ravindra K. Rawal ◽  
Kapil Kumar
Keyword(s):  
Rheumatoid Arthritis ◽  
Cancer Cachexia ◽  
Biological Activities ◽  
Ring System ◽  
Synthetic Methods ◽  
Structural Units ◽  
Current Article ◽  
Tetrahydropyranyl Ether ◽  
Synthetic Approaches ◽  
Synthetic Target

The furo [2,3-b] indoline ring system is one of the most important structural units in various natural products. It has been known to have inherent biological activities and is utilized as a synthetic target for a number of natural compounds; therefore, this has contributed to a great demand for the growth of synthetic methods for this ring system. Most important compounds with furoindoline ring system are physovenine, madindoline A and B and makomotindoline etc. These compounds are well known to exhibit biological activity against different diseases such as glaucoma, cancer, cachexia, Castleman’s disease, rheumatoid arthritis, etc. The current article focuses on various synthetic approaches for furoindoline containing compounds and essential furoindoline moiety, such as oxindole-5-O-tetrahydropyranyl ether route etc., and various other diastereoand enantio- controlled approach in a very concise way.

An Update on the Synthesis and Applications of Bis(Naphthoquinones): An Important Class of Molecules against Infectious Diseases and Other Conditions

2021 ◽  
Vol 21 ◽  
Author(s):  
Luana da S. M. Forezi ◽  
Acácio S. de Souza ◽  
Carolina G. S. Lima ◽  
Amanda A. Borges ◽  
Patricia G. Ferreira ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
General Class ◽  
Biological Activities ◽  
Pharmaceutical Market ◽  
Synthetic Methods ◽  
Important Class ◽  
Biological Targets ◽  
Valuable Compounds ◽  
Synthetic Approaches

: Naphthoquinones are important molecules belonging to the general class of quinones, and many of these compounds have become drugs that are in the pharmaceutical market for the treatment of several diseases. A special subclass of compounds is that of the bis(naphthoquinones), which have two linked naphthoquinone units. In the last few years, several synthetic approaches toward such valuable compounds have been described, as well as their evaluation against numerous important biological targets. In this review, we provide a thorough discussion on the various synthetic methods reported for the synthesis of bis(naphthoquinone) analogues, also highlighting the biological activities of these substances.

scholarly journals Recent Advances in Synthesis of 4-Arylcoumarins

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2417 ◽  
Author(s):  
Jong-Wha Jung ◽  
Nam-Jung Kim ◽  
Hwayoung Yun ◽  
Young Han
Keyword(s):  
Biological Activities ◽  
Synthetic Methods ◽  
Metal Catalysis ◽  
Naturally Occurring ◽  
Recent Advances ◽  
Formation Type ◽  
Privileged Scaffold ◽  
Acid Catalyzed ◽  
A Minor ◽  
Synthetic Approaches

4-Arylcoumarins (4-aryl-2H-1-benzopyran-2-one), also known as neoflavones, comprise a minor subclass of naturally occurring flavonoids. Because of their broad-spectrum biological activities, arylcoumarins have been attracting the attention of the organic and medicinal chemistry communities, and are considered as an important privileged scaffold. Since the development of Pechmann condensation, a classical acid-catalyzed condensation between phenol and β-keto-carboxylic acid, several versatile and efficient synthetic approaches for 4-arylcoumarins have been reported. This review summarizes recent advances in the synthesis of the 4-arylcoumarin scaffold by classifying them based on the final bond-formation type. In particular, synthetic methods executed under mild and highly efficient conditions, such as solvent-free reactions and transition metal catalysis, are highlighted.

Convenient Synthesis of New Heterocycles Containing the Quinoxaline Ring System

2020 ◽  
Vol 17 (2) ◽  
pp. 121-126
Author(s):  
Hanan A. Mohamed ◽  
Mohammad Hayal Alotaibi ◽  
Benson M. Kariuki ◽  
Gamal A. El-Hiti
Keyword(s):  
Crystal Structures ◽  
Ring System ◽  
Synthetic Methods ◽  
Spectroscopic Methods ◽  
X Ray ◽  
Convenient Synthesis ◽  
Current Article ◽  
New Compounds ◽  
Quinoxaline Ring

: The aim of the current article was to describe simple procedures for the synthesis of new heterocycles incorporating the quinoxaline moiety using benzene-1,2-diamine and quinoxaline-2,3- dithiol as precursors. Simple synthetic methods are described for the synthesis of new heterocycles using commercially available chemicals. Also, the new compounds were determined using analytical and spectroscopic methods including single X-ray crystal structures. A series of new heterocycles containing the quinoxaline nucleus have been synthesized in good yields using simple and convenient procedures. A process has been described for the synthesis of new heterocycles containing the quinoxaline moiety that might be difficult to synthesize by other routes.

Resveratrol, a Molecule with Anti-Inflammatory and Anti-Cancer Activities: Natural Product to Chemical Synthesis

2020 ◽  
Vol 27 ◽  
Author(s):  
Sunil Kumar ◽  
Yu-Chia Chang ◽  
Kuei-Hung Lai ◽  
Tsong-Long Hwang
Keyword(s):  
Chemical Synthesis ◽  
Large Scale ◽  
Biosynthetic Pathway ◽  
Biological Activities ◽  
Synthetic Methods ◽  
Anti Cancer ◽  
Natural Polyphenol ◽  
Anti Inflammatory ◽  
Synthetic Approaches ◽  
Related Compounds

Background: Resveratrol, a natural polyphenol product, is used in plant defense from fungal and microbial aggression. It is found naturally, especially in plants such as grapes, peanuts, and berries. It has the highest concentrations in blueberries, mulberries, blackberries, and the skin of red grapes. Resveratrol has various pharmacological properties such as anti-inflammatory, cytoprotective, and antineoplastic activities. Methods: We conducted a literature survey using standard tools such as Google, Reaxys, Scifinder, Scihub, and patent Espacenet to compile the biosynthetic pathways, all organic synthetic methods, and biological activities reported for resveratrol till date. Results: More than one hundred research articles and patents were referred to write this review. About twenty-five of them are related to chemical synthesis, and the rests are about the source, pharmacological activity, and other properties of resveratrol. This study reveals that many common pathways are involved in various pharmacological activities, which can be useful for treating various diseases based on the pathways involved. Reactions such as Pfitzner-Moffatt oxidation, WittigHorner condensation, Mizoroki–Heck, Perkin, Wittig, etc. have been used in resveratrol synthesis. A structure-activity relationship was also established based on its analogs and derivatives. Conclusion: This review examined and reported all the published biological activities and chemical syntheses of resveratrol apart from the biosynthetic pathway. Due to its valuable biological activities, various synthetic approaches have been reported till date. The reported synthetic operations are suitable for large-scale industrial production. Moreover, these comprehensive synthetic procedures could be utilized in the preparation of stilbenes and other related compounds in future endeavors.

Synthetic Investigations On Medicinally Important Quinoxaline Scaffold: A Mini Review.

2020 ◽  
Vol 17 ◽  
Author(s):  
Nitin Kumar ◽  
Niranjan Kaushik ◽  
Shiv Kumar ◽  
Vikas Sharma
Keyword(s):  
Biological Activities ◽  
Review Article ◽  
Synthetic Methods ◽  
Present Review ◽  
The Past ◽  
Quinoxaline Derivatives ◽  
Almost All ◽  
Synthetic Approaches ◽  
Heterocyclic Moiety

: Quinoxaline is a versatile heterocyclic moiety that posses almost all types of biological activities. Present work is a sincere attempt to review synthetic investigations of quinoxaline. A wide plethora of literature is available possessing different synthetic methods utilized for the synthesis of quinoxaline based scaffolds. The present review focuses on the various synthetic approaches of quinoxaline derivatives, which includes a summary of the advancement made over the past years in the synthesis of quinoxaline nucleus and its derivatives. Some of these methods are mentioned in the review article associated with industrial applicability.

Recent Developments on Synthesis of Indole Derivatives Through Green Approaches and Their Pharmaceutical Applications

2020 ◽  
Vol 24 (22) ◽  
pp. 2665-2693
Author(s):  
Dipayan Mondal ◽  
Pankaj Lal Kalar ◽  
Shivam Kori ◽  
Shovanlal Gayen ◽  
Kalpataru Das
Keyword(s):  
Biological Activities ◽  
Synthetic Methods ◽  
Pharmaceutical Chemistry ◽  
Indole Derivatives ◽  
Biological Studies ◽  
Recent Developments ◽  
Pharmaceutical Industries ◽  
Green Methodology ◽  
Conventional Methods ◽  
High Yields

Indole moiety is often found in different classes of pharmaceutically active molecules having various biological activities including anticancer, anti-viral, anti-psychotic, antihypertensive, anti-migraine, anti-arthritis and analgesic activities. Due to enormous applications of indole derivatives in pharmaceutical chemistry, a number of conventional synthetic methods as well as green methodology have been developed for their synthesis. Green methodology has many advantages including high yields, short reaction time, and inexpensive reagents, highly efficient and environmentally benign over conventional methods. Currently, the researchers in academia as well as in pharmaceutical industries have been developing various methods for the chemical synthesis of indole based compounds via green approaches to overcome the drawbacks of conventional methods. This review reflects the last ten years developments of the various greener methods for the synthesis of indole derivatives by using microwave, ionic liquids, water, ultrasound, nanocatalyst, green catalyst, multicomponent reaction and solvent-free reactions etc. (please see the scheme below). Furthermore, the applications of green chemistry towards developments of indole containing pharmaceuticals and their biological studies have been represented in this review.

Resolving the Mystery of Ring Opening in the Synthesis of Benzo[d][1, 3]oxazin-4-one and Quinazolin-4(3H)-one

2019 ◽  
Vol 16 (11) ◽  
pp. 898-905
Author(s):  
Harun Patel ◽  
Rahul Pawara ◽  
Sanjay Surana
Keyword(s):  
Characteristic Feature ◽  
Ring Opening ◽  
Biological Activities ◽  
Heterocyclic Ring ◽  
Ring System ◽  
Time Saving ◽  
Fusion Strategy ◽  
Good Template ◽  
Lead Generation

Quinazoline is the six-membered heterocyclic ring system reported for its versatile biological activities. This characteristic feature of quinazoline makes it a good template for a lead generation library. Ring opening is one of the major concerns in the synthesis of quinazolin-4(3H)-one that results in diamide formation. Here, alternative fusion strategy is reported, which is a time-saving and costeffective method to overcome the ring opening problem associated with the synthesis of benzo[ d][1,3]oxazin-4-one and quinazolin-4(3H)-one.

Anticancer Active Heterocyclic Chalcones: Recent Developments

2020 ◽  
Vol 20 ◽  
Author(s):  
Prasad Dandawate ◽  
Khursheed Ahmed ◽  
Subhash Padhye ◽  
Aamir Ahmad ◽  
Bernhard Biersack
Keyword(s):  
Histone Deacetylases ◽  
Biological Activities ◽  
Synthetic Methods ◽  
Antitumor Activities ◽  
Web Based ◽  
Chemical Structures ◽  
Recent Developments ◽  
Number Of Publications ◽  
Tubulin Polymerization Inhibitors ◽  
Dna Binding Properties

Background: Chalcones are structurally simple compounds that are easily accessible by synthetic methods. Heterocyclic chalcones have gained the interest among scientists due to their diverse biological activities. The anti-tumor activities of heterocyclic chalcones are especially remarkable and the growing number of publications dealing with this topic warrants an up-to-date compilation. Methods: Search for antitumor active heterocyclic chalcones was carried out using Pubmed and Scifinder as common web-based literature searching tools. Pertinent and current literature is covered from 2015/2016 to 2019. Chemical structures, biological activities and modes of action of anti-tumor active heterocyclic chalcones are summarized. Results: Simply prepared chalcones have emerged over the last years with promising antitumor activities. Among them is a considerable number of tubulin polymerization inhibitors. But there are also new chalcones targeting special enzymes such as histone deacetylases or with DNA-binding properties. Conclusion: This review provides a summary of recent heterocyclic chalcone derivatives with distinct anti-tumor activities.

A Comprehensive Review on Pharmacology and Toxicology of Bioactive Compounds of Lagerstroemia Speciosa (L.) Pers.

2020 ◽  
Vol 06 ◽  
Author(s):  
Surya Kant Tripathi ◽  
Sunayna Behera ◽  
Munmun Panda ◽  
Gokhan Zengin ◽  
Bijesh K. Biswal
Keyword(s):  
Molecular Mechanisms ◽  
Biological Activities ◽  
Health Benefit ◽  
Biologically Active ◽  
Pharmacological Properties ◽  
Lagerstroemia Speciosa ◽  
Novel Drugs ◽  
Corosolic Acid ◽  
Current Article ◽  
Preclinical And Clinical Studies

Background: Lagerstroemia speciosa (L.) Pers is one of the most valuable plants due to its ornamental and pharmacological relevance. It is known for its anti-diabetic activity with proved potent blood sugar-lowering activity. The anti-diabetic activity is due to presence of its biologically active component corosolic acid. Moreover, L. speciosa and its novel purified compounds are also well-known for its several biological activities with beneficial health benefit on the human being. Objectives: This review provides a summary of pharmacokinetics, toxicity, and pharmacological properties of L. speciosa and its purified phytochemicals which may help researchers for building up new researches in near future. Methods: The current article is prepared by collecting through various online and offline databases. Preliminary source of study and data collection for outlining the review was research articles and reviews that have been already published by many reputed publishers, including Springer, Elsevier, Taylor & Francis imprints, BMC, Willy, The Norwegian Academy of Science and Letters, Environmental health prospective (EHP), and PLOS One. Result: The available studies results suggested that the L. speciosa and its phytochemicals showed antidiabetic, anticancer, anti-inflammatory, antimicrobial, antioxidant, antiviral, anti-obesity, and cardio-protective activities. Pharmacokinetic stud-ies suggested the low bioavailability of its purified compounds. However, nano-encapsulation can improve the bioavaila-bility related issue and effectively potentiate the medicinal properties of its constituents. Conclusion: Considering the worthy pharmacological properties, L. speciosa is considered as a potent source of several novel drugs. Though, still preclinical and clinical studies are needed to reveal the targets, molecular mechanisms, bioavail-ability, and toxicity of its constituents.

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